Sporadic E(Es)layers in the ionosphere are characterized by intense plasma irregularities in the E region at altitudes of 90-130 km.Because they can significantly influence radio communications and navigation systems,...Sporadic E(Es)layers in the ionosphere are characterized by intense plasma irregularities in the E region at altitudes of 90-130 km.Because they can significantly influence radio communications and navigation systems,accurate forecasting of Es layers is crucial for ensuring the precision and dependability of navigation satellite systems.In this study,we present Es predictions made by an empirical model and by a deep learning model,and analyze their differences comprehensively by comparing the model predictions to satellite RO measurements and ground-based ionosonde observations.The deep learning model exhibited significantly better performance,as indicated by its high coefficient of correlation(r=0.87)with RO observations and predictions,than did the empirical model(r=0.53).This study highlights the importance of integrating artificial intelligence technology into ionosphere modelling generally,and into predicting Es layer occurrences and characteristics,in particular.展开更多
In order to shorten the design cycle of the excavator working device, we have proposed a rapid modeling method for the excavator working device which uses parameters. Based on the Pro/toolkit, which is secondary devel...In order to shorten the design cycle of the excavator working device, we have proposed a rapid modeling method for the excavator working device which uses parameters. Based on the Pro/toolkit, which is secondary development tool of Pro/E4.0,and combined with Vs C＋＋2005 programming software. It developed a flexible set of MFC visualization-friendly interfaces. Users can enter data in the visual interface according to their needs and it will generate a new part model quickly. So it improves the design quality, shortens the design cycle, and makes the cost lower significantly.展开更多
BACKGROUND Models for predicting hepatitis B e antigen(HBeAg)seroconversion in patients with HBeAg-positive chronic hepatitis B(CHB)after nucleos(t)ide analog treatment are rare.AIM To establish a simple scoring model...BACKGROUND Models for predicting hepatitis B e antigen(HBeAg)seroconversion in patients with HBeAg-positive chronic hepatitis B(CHB)after nucleos(t)ide analog treatment are rare.AIM To establish a simple scoring model based on a response-guided therapy(RGT)strategy for predicting HBeAg seroconversion and hepatitis B surface antigen(HBsAg)clearance.METHODS In this study,75 previously treated patients with HBeAg-positive CHB underwent a 52-week peginterferon-alfa(PEG-IFNα)treatment and a 24-wk follow-up.Logistic regression analysis was used to assess parameters at baseline,week 12,and week 24 to predict HBeAg seroconversion at 24 wk post-treatment.The two best predictors at each time point were used to establish a prediction model for PEG-IFNαtherapy efficacy.Parameters at each time point that met the corresponding optimal cutoff thresholds were scored as 1 or 0.RESULTS The two most meaningful predictors were HBsAg≤1000 IU/mL and HBeAg≤3 S/CO at baseline,HBsAg≤600 IU/mL and HBeAg≤3 S/CO at week 12,and HBsAg≤300 IU/mL and HBeAg≤2 S/CO at week 24.With a total score of 0 vs 2 at baseline,week 12,and week 24,the response rates were 23.8%,15.2%,and 11.1%vs 81.8%,80.0%,and 82.4%,respectively,and the HBsAg clearance rates were 2.4%,3.0%,and 0.0%,vs 54.5%,40.0%,and 41.2%,respectively.CONCLUSION We successfully established a predictive model and diagnosis-treatment process using the RGT strategy to predict HBeAg and HBsAg seroconversion in patients with HBeAg-positive CHB undergoing PEG-IFNαtherapy.展开更多
从定性和定量两方面分析了目标医院现有手术室的流程。首先,通过现场调研获得医院手术流程数据,并采用Minitab进行处理;其次,利用故障树分析法(Fault Tree Analysis,FTA),在定性方面分析现有流程的问题;最后,对现有流程进行Pro-model仿...从定性和定量两方面分析了目标医院现有手术室的流程。首先,通过现场调研获得医院手术流程数据,并采用Minitab进行处理;其次,利用故障树分析法(Fault Tree Analysis,FTA),在定性方面分析现有流程的问题;最后,对现有流程进行Pro-model仿真建模,得到流程各节点运行效果,又从定量方面得到了流程的相关优化指标。展开更多
This paper took Pro/ENGINEER wildfire2.0 as the development environment and realized the involute helical gears’three-dimensional model parameterized designing which made use of the parameter and relation function of...This paper took Pro/ENGINEER wildfire2.0 as the development environment and realized the involute helical gears’three-dimensional model parameterized designing which made use of the parameter and relation function of Pro/E.This paper also provided a method of editing the equation of the tooth curve,and it can ensure the high precision of the involute helical gear model.It developed the man-machine interactive parameterized designing interface making use of the secondary development function offered by Pro/TOOLKIT.The users can revise the involute helical gear easily by this man-machine interactive.It de- tailedly introduced the method of designing the man-machine interactive interface Using Pro/TOOLKIT and Visual C++.When the users input correlation parameters according to the prompt of the man-machine interactive interface,the three-dimensional model of the involute helical gear is auto-generated.This method simplified the product design process,shortened the period of de- veloping and improved the design efficiency of the gear greatly.展开更多
Hepatitis E virus(HEV)is one of the leading causes of acute viral hepatitis worldwide.Although most of HEV infections are asymptomatic,some patients will develop the symptoms,especially pregnant women,the elderly,and ...Hepatitis E virus(HEV)is one of the leading causes of acute viral hepatitis worldwide.Although most of HEV infections are asymptomatic,some patients will develop the symptoms,especially pregnant women,the elderly,and patients with preexisting liver diseases,who often experience anorexia,nausea,vom-iting,malaise,abdominal pain,and jaundice.HEV infection may become chronic in immunosuppressed individuals.In addition,HEV infection can also cause several extrahepatic manifestations.HEV exists in a wide range of hosts in nature and can be transmitted across species.Hence,animals susceptible to HEV can be used as models.The establishment of animal models is of great significance for studying HEV transmission,clinical symptoms,extrahepatic manifestations,and therapeutic strategies,which will help us understand the pathogenesis,prevention,and treatment of hepatitis E.This review summarized the animal models of HEV,including pigs,monkeys,rabbits,mice,rats,and other animals.For each animal species,we provided a concise summary of the HEV genotypes that they can be infected with,the cross-species transmission pathways,as well as their role in studying extrahepatic manifestations,prevention,and treatment of HEV infection.The advantages and disadvantages of these animal models were also emphasized.This review offers new perspectives to enhance the current understanding of the research landscape surrounding HEV animal models.展开更多
The prophylactic effects of Chinese propolis against cypermethrin toxicity were evaluated by performing ovary and uterus histopathology, as well as by characterizing ovarian function, embryos, and litters. Cypermethri...The prophylactic effects of Chinese propolis against cypermethrin toxicity were evaluated by performing ovary and uterus histopathology, as well as by characterizing ovarian function, embryos, and litters. Cypermethrin induced atypia in the ovary and uterus, and decreased the ovulation sites and the number of embryos. Cypermethrin-induced oxidative stress during pregnancy, decreased the parturition rate as well as the number and weight of offspring and increased the incidence of morphological malformations in the offspring. Administration of propolis to cypermethrin-treated animals mitigated cypermethrin-induced reproductive toxicity.展开更多
Possible alternatives are studied. By comparing the rail-wheel model constructed by these two packages, the benefits of mixed-use of Pro/E and ANSYS for complex assembly modeling are verified.
At present,the development of e-commerce is slow for agricultural products in China. Taking agricultural workers as the research object,this paper analyzed factors influencing the implementation of e-commerce of agric...At present,the development of e-commerce is slow for agricultural products in China. Taking agricultural workers as the research object,this paper analyzed factors influencing the implementation of e-commerce of agricultural products. Besides,from the enterprise status,market conditions,and groundings,with the aid of the GEM( Groundings-Enterprises-Markets) model,it evaluated the factors influencing the development of e-commerce of agricultural products. Then,using SPSS software,it analyzed factors and came up with improvement recommendations. The results show that 59% of the respondents are willing to conduct e-commerce,and the status of the enterprises,market conditions and groundings are main factors influencing the implementation of e-commerce of agricultural products. Therefore,it is required to increase industrial concentration,promote cooperation between small and medium-sized enterprises( SMEs),and strengthen infrastructure construction,so as to promote the development of e-commerce of agricultural products.展开更多
By introducing aparameter of difference in ferrite formation temperature between binary Fe-C and multicomponent system,and referring to the thermodynamic model for Fe-C binary system,a simplified thermodynamic model f...By introducing aparameter of difference in ferrite formation temperature between binary Fe-C and multicomponent system,and referring to the thermodynamic model for Fe-C binary system,a simplified thermodynamic model for pro-eutectoid ferrite formation in Fe-ΣXiC multicomponent structural steels(Xi=Mn,Si,Mo,Cr,Ni or Ti,etc)was suggested.The comparison of the calculated Ae3 temperatures with the measured data of steels 42 shows that the relative standard deviation and root-mean-square(RMS)error between them are only 0.71% and 8.92 K,respectively.However,the deviations between the same measured data and the values calculated from the superelement model are as high as 1.86% and 23.83 K,respectively.It can be concluded that the simplified thermodynamic model for pro-eutectoid ferrite formation in multicomponent structural steels is acceptable and the calculated Ae3 temperatures are in good agreement with the experimental data.展开更多
基金supported by the Project of Stable Support for Youth Team in Basic Research Field,CAS(grant No.YSBR-018)the National Natural Science Foundation of China(grant Nos.42188101,42130204)+4 种基金the B-type Strategic Priority Program of CAS(grant no.XDB41000000)the National Natural Science Foundation of China(NSFC)Distinguished Overseas Young Talents Program,Innovation Program for Quantum Science and Technology(2021ZD0300301)the Open Research Project of Large Research Infrastructures of CAS-“Study on the interaction between low/mid-latitude atmosphere and ionosphere based on the Chinese Meridian Project”.The project was supported also by the National Key Laboratory of Deep Space Exploration(Grant No.NKLDSE2023A002)the Open Fund of Anhui Provincial Key Laboratory of Intelligent Underground Detection(Grant No.APKLIUD23KF01)the China National Space Administration(CNSA)pre-research Project on Civil Aerospace Technologies No.D010305,D010301.
文摘Sporadic E(Es)layers in the ionosphere are characterized by intense plasma irregularities in the E region at altitudes of 90-130 km.Because they can significantly influence radio communications and navigation systems,accurate forecasting of Es layers is crucial for ensuring the precision and dependability of navigation satellite systems.In this study,we present Es predictions made by an empirical model and by a deep learning model,and analyze their differences comprehensively by comparing the model predictions to satellite RO measurements and ground-based ionosonde observations.The deep learning model exhibited significantly better performance,as indicated by its high coefficient of correlation(r=0.87)with RO observations and predictions,than did the empirical model(r=0.53).This study highlights the importance of integrating artificial intelligence technology into ionosphere modelling generally,and into predicting Es layer occurrences and characteristics,in particular.
文摘In order to shorten the design cycle of the excavator working device, we have proposed a rapid modeling method for the excavator working device which uses parameters. Based on the Pro/toolkit, which is secondary development tool of Pro/E4.0,and combined with Vs C＋＋2005 programming software. It developed a flexible set of MFC visualization-friendly interfaces. Users can enter data in the visual interface according to their needs and it will generate a new part model quickly. So it improves the design quality, shortens the design cycle, and makes the cost lower significantly.
基金Supported by the Anhui Provincial Natural Science Foundation,No.2108085MH298the Scientific Research Project of the Second Affiliated Hospital of Anhui Medical University,No.2019GMFY02 and 2021lcxk027the Scientific Research Project of Colleges and Universities in Anhui Province,No.KJ2021A0323.
文摘BACKGROUND Models for predicting hepatitis B e antigen(HBeAg)seroconversion in patients with HBeAg-positive chronic hepatitis B(CHB)after nucleos(t)ide analog treatment are rare.AIM To establish a simple scoring model based on a response-guided therapy(RGT)strategy for predicting HBeAg seroconversion and hepatitis B surface antigen(HBsAg)clearance.METHODS In this study,75 previously treated patients with HBeAg-positive CHB underwent a 52-week peginterferon-alfa(PEG-IFNα)treatment and a 24-wk follow-up.Logistic regression analysis was used to assess parameters at baseline,week 12,and week 24 to predict HBeAg seroconversion at 24 wk post-treatment.The two best predictors at each time point were used to establish a prediction model for PEG-IFNαtherapy efficacy.Parameters at each time point that met the corresponding optimal cutoff thresholds were scored as 1 or 0.RESULTS The two most meaningful predictors were HBsAg≤1000 IU/mL and HBeAg≤3 S/CO at baseline,HBsAg≤600 IU/mL and HBeAg≤3 S/CO at week 12,and HBsAg≤300 IU/mL and HBeAg≤2 S/CO at week 24.With a total score of 0 vs 2 at baseline,week 12,and week 24,the response rates were 23.8%,15.2%,and 11.1%vs 81.8%,80.0%,and 82.4%,respectively,and the HBsAg clearance rates were 2.4%,3.0%,and 0.0%,vs 54.5%,40.0%,and 41.2%,respectively.CONCLUSION We successfully established a predictive model and diagnosis-treatment process using the RGT strategy to predict HBeAg and HBsAg seroconversion in patients with HBeAg-positive CHB undergoing PEG-IFNαtherapy.
文摘从定性和定量两方面分析了目标医院现有手术室的流程。首先,通过现场调研获得医院手术流程数据,并采用Minitab进行处理;其次,利用故障树分析法(Fault Tree Analysis,FTA),在定性方面分析现有流程的问题;最后,对现有流程进行Pro-model仿真建模,得到流程各节点运行效果,又从定量方面得到了流程的相关优化指标。
文摘This paper took Pro/ENGINEER wildfire2.0 as the development environment and realized the involute helical gears’three-dimensional model parameterized designing which made use of the parameter and relation function of Pro/E.This paper also provided a method of editing the equation of the tooth curve,and it can ensure the high precision of the involute helical gear model.It developed the man-machine interactive parameterized designing interface making use of the secondary development function offered by Pro/TOOLKIT.The users can revise the involute helical gear easily by this man-machine interactive.It de- tailedly introduced the method of designing the man-machine interactive interface Using Pro/TOOLKIT and Visual C++.When the users input correlation parameters according to the prompt of the man-machine interactive interface,the three-dimensional model of the involute helical gear is auto-generated.This method simplified the product design process,shortened the period of de- veloping and improved the design efficiency of the gear greatly.
基金This study was supported by grants from the National Natural Science Foundation of China(82272396)the Fundamental Research Funds for the Central Universities(226-2022-00061).
文摘Hepatitis E virus(HEV)is one of the leading causes of acute viral hepatitis worldwide.Although most of HEV infections are asymptomatic,some patients will develop the symptoms,especially pregnant women,the elderly,and patients with preexisting liver diseases,who often experience anorexia,nausea,vom-iting,malaise,abdominal pain,and jaundice.HEV infection may become chronic in immunosuppressed individuals.In addition,HEV infection can also cause several extrahepatic manifestations.HEV exists in a wide range of hosts in nature and can be transmitted across species.Hence,animals susceptible to HEV can be used as models.The establishment of animal models is of great significance for studying HEV transmission,clinical symptoms,extrahepatic manifestations,and therapeutic strategies,which will help us understand the pathogenesis,prevention,and treatment of hepatitis E.This review summarized the animal models of HEV,including pigs,monkeys,rabbits,mice,rats,and other animals.For each animal species,we provided a concise summary of the HEV genotypes that they can be infected with,the cross-species transmission pathways,as well as their role in studying extrahepatic manifestations,prevention,and treatment of HEV infection.The advantages and disadvantages of these animal models were also emphasized.This review offers new perspectives to enhance the current understanding of the research landscape surrounding HEV animal models.
文摘The prophylactic effects of Chinese propolis against cypermethrin toxicity were evaluated by performing ovary and uterus histopathology, as well as by characterizing ovarian function, embryos, and litters. Cypermethrin induced atypia in the ovary and uterus, and decreased the ovulation sites and the number of embryos. Cypermethrin-induced oxidative stress during pregnancy, decreased the parturition rate as well as the number and weight of offspring and increased the incidence of morphological malformations in the offspring. Administration of propolis to cypermethrin-treated animals mitigated cypermethrin-induced reproductive toxicity.
基金Supported by the Natural Science Foundation of China (50475164) and Natural Science Foundation of Jiangsu Province (BK2002116).
文摘Possible alternatives are studied. By comparing the rail-wheel model constructed by these two packages, the benefits of mixed-use of Pro/E and ANSYS for complex assembly modeling are verified.
文摘At present,the development of e-commerce is slow for agricultural products in China. Taking agricultural workers as the research object,this paper analyzed factors influencing the implementation of e-commerce of agricultural products. Besides,from the enterprise status,market conditions,and groundings,with the aid of the GEM( Groundings-Enterprises-Markets) model,it evaluated the factors influencing the development of e-commerce of agricultural products. Then,using SPSS software,it analyzed factors and came up with improvement recommendations. The results show that 59% of the respondents are willing to conduct e-commerce,and the status of the enterprises,market conditions and groundings are main factors influencing the implementation of e-commerce of agricultural products. Therefore,it is required to increase industrial concentration,promote cooperation between small and medium-sized enterprises( SMEs),and strengthen infrastructure construction,so as to promote the development of e-commerce of agricultural products.
基金Item Sponsored by National Natural Science Foundation of China(50075053)
文摘By introducing aparameter of difference in ferrite formation temperature between binary Fe-C and multicomponent system,and referring to the thermodynamic model for Fe-C binary system,a simplified thermodynamic model for pro-eutectoid ferrite formation in Fe-ΣXiC multicomponent structural steels(Xi=Mn,Si,Mo,Cr,Ni or Ti,etc)was suggested.The comparison of the calculated Ae3 temperatures with the measured data of steels 42 shows that the relative standard deviation and root-mean-square(RMS)error between them are only 0.71% and 8.92 K,respectively.However,the deviations between the same measured data and the values calculated from the superelement model are as high as 1.86% and 23.83 K,respectively.It can be concluded that the simplified thermodynamic model for pro-eutectoid ferrite formation in multicomponent structural steels is acceptable and the calculated Ae3 temperatures are in good agreement with the experimental data.
