艾滋病作为一种目前尚未有治愈的药物和方法的严重传染病,高效抗逆转录病毒联合疗法(highly active antiretroviral therapy,HAART)是目前国际上推广使用的治疗方法,临床疗效确切,覆盖人群不断扩大。中医药防治艾滋病也有报道,尤其是艾...艾滋病作为一种目前尚未有治愈的药物和方法的严重传染病,高效抗逆转录病毒联合疗法(highly active antiretroviral therapy,HAART)是目前国际上推广使用的治疗方法,临床疗效确切,覆盖人群不断扩大。中医药防治艾滋病也有报道,尤其是艾滋病无症状期应用中医辨证论治的早期干预能够延缓人类免疫缺陷病毒(human immunodeficiency virus,HIV)感染者进入艾滋病期的进程。但在后HAART时期中医药在减轻HAART治疗的毒副作用、提高HAART治疗的临床疗效、降低HAART治疗的耐药率及治疗艾滋病常见机会性感染这4个方面的临床和基础研究也具有重要意义。展开更多
The aim of this study was to investigate epidemiological characteristics of co-infection of HIV and intestinal parasites in a HIV/AIDS highly endemic area in China.A cross-sectional survey was carried out in two villa...The aim of this study was to investigate epidemiological characteristics of co-infection of HIV and intestinal parasites in a HIV/AIDS highly endemic area in China.A cross-sectional survey was carried out in two villages where HIV/AIDS prevalence in residents was over 1%.Stool samples of all residents in the two targeted villages were examined for the presence of intestinal parasites.Blood examination was performed for the HIV infection detection and anemia test.A questionnaire survey was carried out in all residents participating in the study.A total of 769 individuals were enrolled in the investigation,720 of whom were involved in stool examination of intestinal parasites.The infection rates of parasites in the residents of the targeted villages were as follows:0.56%for Ascaris lumbricoides,4.03%for Hookworm,0.28%for Trichuris trichiura,0.42%for Clonorchis sinensis,21.39%for Blastocystis hominis,3.89%for Giardia lamblia,1.67%for Entamoeba spp.,4.44%for Cryptosporidium spp.,and no infection for Strongyloides stercoralis.The overall infection rate of intestinal worms was 4.72%,intestinal parasite infection rate was 24.31%,the anemia prevalence rate was 34.68%,the co-infection rate of HIV and intestinal helminthes 2.17%,the co-infection rate of HIV and intestinal protozoa 28.26%,of which the co-infection rates of HIV and Blastocystis hominis,and HIV and Cryptosporidium spp.were 19.57%and 13.04%,respectively.A significant difference of Cryptosporidium spp.infection rate was found between HIV-positive group(13.04%)and HIV-negative group(4.70%)(P<0.05).Higher prevalence of anemia(34.68%)occurred in the study villages,particularly in children(>50%)and women(>39%).It was concluded that the infection rate of intestinal protozoa in the residents was higher than that of intestinal helminthes in the local setting,and a same pattern appeared in the co-infection rate of HIV and parasites.An interestingfinding is that the infection rate of Cryptosporidium spp.among the HIV-positives was significantly higher than that in the HIV-negatives,and children and women had higher anemia prevalence.展开更多
The inhibitory activities of more than 40 species of Chinese medicinal herbs or their singlechemical components against simian immunodeficiency virus (SIV) have been studied. The study revealedthat four species of med...The inhibitory activities of more than 40 species of Chinese medicinal herbs or their singlechemical components against simian immunodeficiency virus (SIV) have been studied. The study revealedthat four species of medicinal herbs and a single chemical component had a more than 50% inhtbition ef-fect on SIV antigen expression. and the inhibitory rate of five other herbs on SIV antigen expression wasbetween 30%-50%. The results suggest Chinese medicinal herbs could inhibit SIV activity.展开更多
基金supported by the Major Projects of National Science and Technology(No.2008ZX10004-011)UNICEF/UNDP/World Bank/WHO Special Programme on Research and Training in Tropical Diseases.
文摘The aim of this study was to investigate epidemiological characteristics of co-infection of HIV and intestinal parasites in a HIV/AIDS highly endemic area in China.A cross-sectional survey was carried out in two villages where HIV/AIDS prevalence in residents was over 1%.Stool samples of all residents in the two targeted villages were examined for the presence of intestinal parasites.Blood examination was performed for the HIV infection detection and anemia test.A questionnaire survey was carried out in all residents participating in the study.A total of 769 individuals were enrolled in the investigation,720 of whom were involved in stool examination of intestinal parasites.The infection rates of parasites in the residents of the targeted villages were as follows:0.56%for Ascaris lumbricoides,4.03%for Hookworm,0.28%for Trichuris trichiura,0.42%for Clonorchis sinensis,21.39%for Blastocystis hominis,3.89%for Giardia lamblia,1.67%for Entamoeba spp.,4.44%for Cryptosporidium spp.,and no infection for Strongyloides stercoralis.The overall infection rate of intestinal worms was 4.72%,intestinal parasite infection rate was 24.31%,the anemia prevalence rate was 34.68%,the co-infection rate of HIV and intestinal helminthes 2.17%,the co-infection rate of HIV and intestinal protozoa 28.26%,of which the co-infection rates of HIV and Blastocystis hominis,and HIV and Cryptosporidium spp.were 19.57%and 13.04%,respectively.A significant difference of Cryptosporidium spp.infection rate was found between HIV-positive group(13.04%)and HIV-negative group(4.70%)(P<0.05).Higher prevalence of anemia(34.68%)occurred in the study villages,particularly in children(>50%)and women(>39%).It was concluded that the infection rate of intestinal protozoa in the residents was higher than that of intestinal helminthes in the local setting,and a same pattern appeared in the co-infection rate of HIV and parasites.An interestingfinding is that the infection rate of Cryptosporidium spp.among the HIV-positives was significantly higher than that in the HIV-negatives,and children and women had higher anemia prevalence.
文摘The inhibitory activities of more than 40 species of Chinese medicinal herbs or their singlechemical components against simian immunodeficiency virus (SIV) have been studied. The study revealedthat four species of medicinal herbs and a single chemical component had a more than 50% inhtbition ef-fect on SIV antigen expression. and the inhibitory rate of five other herbs on SIV antigen expression wasbetween 30%-50%. The results suggest Chinese medicinal herbs could inhibit SIV activity.
