Pseudoalteromonas is a group of marine bacteria widespread in diverse marine sediments,producing a wide range of bioactive compounds.However,only a limited number of Pseudoalteromonas phages have been isolated and stu...Pseudoalteromonas is a group of marine bacteria widespread in diverse marine sediments,producing a wide range of bioactive compounds.However,only a limited number of Pseudoalteromonas phages have been isolated and studied.In this study,a novel lytic Pseudoalteromonas phage,denoted as vB_PalP_Y7,was isolated from sewage samples collected at the Seafood Market in Qingdao,China.vB_PalP_Y7 remained stable across a wide range of temperatures(-20–50℃)and a wide pH range(3–12).The vB_PalP_Y7 phage harbors a linear double-stranded DNA molecule of 57699 base pairs(bp)with a G+C content of 45.90%.Furthermore,it is predicted to contain 58 open reading frames(ORFs).Phylogenetic analysis and protein network relationship analysis revealed low similarity between vB_PalP_Y7 and viruses in the ICTV and IMG/VR4 database,suggesting that vB_PalP_Y7 may be a potential new genus,Miuvirus.This study contributed valuable insights to comprehend the relationship between Pseudoalteromonas phages and their host organisms.展开更多
With the deterioration of the environment and the unbalanced relationship between man and nature,people are plagued by varieties of social problems and rising spiritual crises.This paper aims to analyze Thoreau’s cha...With the deterioration of the environment and the unbalanced relationship between man and nature,people are plagued by varieties of social problems and rising spiritual crises.This paper aims to analyze Thoreau’s characters in Walden and attempts to provide the implications for our contemporary life.Combined with Thoreau’s life experience and the background of Walden,the paper starts with the analysis of Thoreau’s characters from three aspects concerning his pursuit of inner serenity,search for true essence of life and abiding passion for life,which constitute his unique and independent characters and provide the enlightenment for contemporary life.We concluded that unique thoughts,attitudes,and spirit embedded in Thoreau’s characters are inextricably connected with our contemporary life.His personal experience and practice of solitary life at Walden Pond is a testimony to the necessity of closing to nature actively and confronting life passionately.展开更多
[Objective] The aim was to research and analyze characters and related correlation of indica hybrid rice containing high amylose. [Method] In the research, major characters of 16 species of groups of {ndica hybrid ric...[Objective] The aim was to research and analyze characters and related correlation of indica hybrid rice containing high amylose. [Method] In the research, major characters of 16 species of groups of {ndica hybrid rice and the correlation were explored in rice belts in Sichuan in 2011. [Result] The variation of chalkiness degree was the highest at 26.8%, followed by rate of head rice at 22.89%; varia- tions of head rice rate and chalkiness degree were lower at 0.72% and 2.61%. In addition, rate of unpolished rice was of significantly negative correlation with chalki- ness degree; rate of chalky rice was of extremely positive correlation with chalkiness degree and gel consistency; chalkiness degree was of significantly positive correla- tion with gel consistency; gel consistency was of significantly negative correlation with protein content; amylose content was of insignificant correlation with gel consis- tency （r=0.166 9） of the 16 hybrid groups. These indicated that gel consistency would be still high as the content of amylose grows （AC≥25%）. For example, when the content of anylose in Chuanxiang 29A/Luhui 37, Kangfeng AJ6684, and Lefeng A/SR536 exceeded 27%, the gel consistency was over 80 mm in the research. [Conclusion] The research provides references for improvement of amylose content in breeding hybrid rice.展开更多
[Objective] The aim was to study the variation of leaf characters from different provenance sources of Polygonum multiflorum Thunb,as well as to carry out cluster analysis on P.multiflorum from different provenance so...[Objective] The aim was to study the variation of leaf characters from different provenance sources of Polygonum multiflorum Thunb,as well as to carry out cluster analysis on P.multiflorum from different provenance sources to provide basis for the classification,identification,breeding and improved variety selection of P.multiflorum.[Method] Leaf shape characters of 31 copies of germplasm resources in the major distribution region of the whole country were determined,and the genetic variation of P.multiflorum leaves from different producing areas was analyzed.[Result] The leaf characters of single plant of the same experimental provenance source of P.multiflorum were relatively stable,the variation was mainly found on the single leaf area,1/2 leaf width,leaf width and other indicators;the variation of each leaf character among different provenance sources was obvious,and the variation was mainly found on the single leaf weight,leaf area,1/2 leaf width,leaf length and other indicators.The correlation analysis of each leaf character in P.multiflorum suggested that the single leaf area and single leaf weight showed extremely significant positive correlation with leaf length,1/2 leaf width,leaf width,leaf thickness and leaf stem length,while the single leaf area and single leaf weight showed significant negative correlation with WWR（leaf width/1/2 leaf width）and LWR（leaf length/1/2 leaf length）,in addition,several macroscopic leaf characters such as leaf length,1/2 leaf width,leaf width,leaf stem length showed extremely positive correlation.The main component analysis result suggested that the contribution rate of accumulation variance of the front three main components was up to 97.4%,which could better reflect the comprehensive performance of leaf characters of different provenance sources of P.multiflorum.The cluster analysis showed that the experimental 31 copies of P.multiflorum provenance sources should be divided into three classes,the first class was distributed in the Middle,Western of Guizhou,northwestern of Guangxi and western areas with higher altitude;the second class was distributed in Hunan,Hubei,Sichuan,Guangdong and the most area of Guangxi;the third class was distributed in Anhui,Jiangsu and Henan and Shandong.[Conclusion] Cluster analysis of leaf characters indicated that the kinds of provenance sources which the geographical position was closer could be got together.The study had provided a certain basis for the classification of P.multiflorum.展开更多
Abst[Objective] This study was to understand the genetic dynamics of three-line hybrid rice, and explore the respective effect of sterile line and restoring line on grain characters of hybrid rica. [Method] Four three...Abst[Objective] This study was to understand the genetic dynamics of three-line hybrid rice, and explore the respective effect of sterile line and restoring line on grain characters of hybrid rica. [Method] Four three-line stedle lines and 27 restoring lines（cultivars） commonly culti- vated in Central China region were regarded as expadmental materials to conduct 4 x27NCII cross design, and the grain characters of three-line hybrid rico were analyzed at genetic and correlation levels. [ Result] Four characters of grain length, grain width, 1 000-grain weight and length- width ratio play the leading role in additive gene effect; these four characters were simultaneously influenced by male parent and female parent, but the effect from male parent was relatively larger. The grain length, grain width, 1 000-grain weight and length-width ratio all have high brood hedtabUities（ respectively 99.65%, 98.31%, 95.27% and 98.81% ）. Correlation analysis showed that grain length was positively correlated with 1 000-grain weight and length-width ratio at extremely significant level; 1 000-grain weight was positively correlated with grain length and length- width ratio at extremely significant level, and was insignificantly correlated with grain width; grain width was negatively correlated with grain length and length-width ratio at extremely significant level. Path analysis showed that the direct path coefficients of grain length, grain width and 1 0（30- grain weight to length-width ratio were 0.624 6, -0.555 9 and -0.015 8, respectively. [ Conclusion] This study systematically analyzed the effects of stedle line and restoring line on grain characters of hybrid rice, which provided theoretical basis for breeding high quality and yield hy- brid dce.展开更多
In order to scientifically evaluate the values of Cucurbita moschata cultivars, main botanical characters including the initial flowering date, the first fruiting node, fruit length, fruit stem length, stem diameter, ...In order to scientifically evaluate the values of Cucurbita moschata cultivars, main botanical characters including the initial flowering date, the first fruiting node, fruit length, fruit stem length, stem diameter, internode length, the transverse and longitudinal diameters of the largest leaf, single fruit weight, flesh thickness and soluble solid content of 41 cultivars were measured for conducting diversity, correlation and cluster analysis. The results revealed that the pumpkin cultivars showed large variations in fruit stem length, single fruit weight, fruit length and flesh thickness, but small variations in initial flowering date. Significant, even highly significant correlations were found among the tested traits. Cluster analysis demonstrated that the 41 old Cucurbita moschata cultivars were divided into three groups, of which multiple traits of Group 1 were better than those in the other two groups. High similarities existed in three groups and the cultivars in each group. This research provided basis for selecting excellent traits and parents for the breeding of hybrids.展开更多
[Objective] The study aimed at exploring the relationship among the agronomic characters of B. juncea in western China, in order to provide scientific basis for the breeding of B. juncea in western China. [Method] 39 ...[Objective] The study aimed at exploring the relationship among the agronomic characters of B. juncea in western China, in order to provide scientific basis for the breeding of B. juncea in western China. [Method] 39 B. juncea materials from western China were used for the canonical correlation analysis, and canonical correlations between each pair of the four ecological character （containing 18 variables） were verified, including yield characters （5 variables）, caulis characters （6 variables）, branch characters （3 variables） and pod characters （3 variables）. [Result] Yield per plant of B. juncea in western China suffered a tremendous influence from effective pod number per plant while was not significantly affected by the total pod number per plant, seed number per pod and 1 000-seed weight; the most important character related with the yield character of B. juncea in western China was caulis character, followed by the branch character and pod character; yield characters, caulis characters, branch characters and pod characters of B. juncea in western China were closely correlated. [Conclusion] In order to improve the yield characters of B. juncea in western China, caulis characters should be focused on, followed by branch characters and pod characters; rapeseed varieties with high performance in total pod number per plant and effective pod number per plant should be chosen through the perspectives of effective branch number, plant height, pod number of main inflorescence, fruit stalk number of main inflorescence and other traits, while rapeseed varieties with high performance in seed number per pod and 1 000-seed weight should be chosen through the perspectives of beak length and other traits.展开更多
Fifteen combinations crossed by five JA cytoplasmic male sterile lines （A1, A2, A3, A4, A5） and three restoring lines （R1, R2, R3） were selected to analyze the combining ability and heritability of nine main agron...Fifteen combinations crossed by five JA cytoplasmic male sterile lines （A1, A2, A3, A4, A5） and three restoring lines （R1, R2, R3） were selected to analyze the combining ability and heritability of nine main agronomic characters of Brassica na-pus L. to definite the application potential of these parent materials. The result showed that （i） the general combining ability （GCA） of male parents was R3＆gt;R2＆gt;R1 and that of female parents was A4＆gt;A1＆gt;A2＆gt;A5＆gt;A3; （i ） the special combining ability （SCA） of A2＆#215;R3 in plant height, number of branches, number of pods per plant and yield per plant was the best. The yield per plant of A2＆#215;R3, A1＆#215;R1 and A2＆#215;R1 ranked the first three places in the 15 combinations; （i i） the broad heritability of yield per plant was the highest, and that of the height of branches was the lowest. The com-prehensive characters of R3, A2 and A4 were better, which could be used to create new materials; （iv） good offspring were more likely to be chosen from the combina-tion with higher parental GCA, so the GCA and SCA should be considered com-prehensively when choosing parent and determining the optimal combinations.展开更多
Objective] This study was performed to investigate the trait changes and their correlations as wel as the dynamic changes of biological yield of Xuzishu 3, which wil help to enhance the yield and anthocyanin content o...Objective] This study was performed to investigate the trait changes and their correlations as wel as the dynamic changes of biological yield of Xuzishu 3, which wil help to enhance the yield and anthocyanin content of sweetpotato by cul-tivation. [Method] We systematical y measured the agronomic traits, qualitative char-acters and biological yield of Xuzishu 3 during six growing periods to investigate the dynamic changes of its essential characters and yield accumulation. [Result] The characters of Xuzishu 3 appeared most prosperous after the 90th d except for an-thocyanin content. Extremely significant positive correlations were found between ev-ery two of the dry matter rates of above-ground parts （including leaf petioles, leaves and stems）, reducing sugar content and potato weight per plant. Assimilated product distributed more in stems and leaves than in storage roots before the 90th d in growing period. Photosynthetic capacity and net assimilation rate gradual y de-creased after the 90th d, but the assimilated product distributing to storage roots in-creased quickly and maximized in the 135th d. [Conclusion] Xuzishu 3 is a late ma-turing variety requiring more fertilizer, and the accumulation of anthocyanin fluctuates during the growth period of Xuzishu 3. So yield of Xuzishu 3 can be increased by applying more fertilizer and extending the growth period reasonably, meanwhile the anthocyanin content can be increased by means of control ing temperature, light, water and phytohormone within 60 d after planting.展开更多
Joint Multimodal Aspect-based Sentiment Analysis(JMASA)is a significant task in the research of multimodal fine-grained sentiment analysis,which combines two subtasks:Multimodal Aspect Term Extraction(MATE)and Multimo...Joint Multimodal Aspect-based Sentiment Analysis(JMASA)is a significant task in the research of multimodal fine-grained sentiment analysis,which combines two subtasks:Multimodal Aspect Term Extraction(MATE)and Multimodal Aspect-oriented Sentiment Classification(MASC).Currently,most existing models for JMASA only perform text and image feature encoding from a basic level,but often neglect the in-depth analysis of unimodal intrinsic features,which may lead to the low accuracy of aspect term extraction and the poor ability of sentiment prediction due to the insufficient learning of intra-modal features.Given this problem,we propose a Text-Image Feature Fine-grained Learning(TIFFL)model for JMASA.First,we construct an enhanced adjacency matrix of word dependencies and adopt graph convolutional network to learn the syntactic structure features for text,which addresses the context interference problem of identifying different aspect terms.Then,the adjective-noun pairs extracted from image are introduced to enable the semantic representation of visual features more intuitive,which addresses the ambiguous semantic extraction problem during image feature learning.Thereby,the model performance of aspect term extraction and sentiment polarity prediction can be further optimized and enhanced.Experiments on two Twitter benchmark datasets demonstrate that TIFFL achieves competitive results for JMASA,MATE and MASC,thus validating the effectiveness of our proposed methods.展开更多
Maintaining the integrity and longevity of structures is essential in many industries,such as aerospace,nuclear,and petroleum.To achieve the cost-effectiveness of large-scale systems in petroleum drilling,a strong emp...Maintaining the integrity and longevity of structures is essential in many industries,such as aerospace,nuclear,and petroleum.To achieve the cost-effectiveness of large-scale systems in petroleum drilling,a strong emphasis on structural durability and monitoring is required.This study focuses on the mechanical vibrations that occur in rotary drilling systems,which have a substantial impact on the structural integrity of drilling equipment.The study specifically investigates axial,torsional,and lateral vibrations,which might lead to negative consequences such as bit-bounce,chaotic whirling,and high-frequency stick-slip.These events not only hinder the efficiency of drilling but also lead to exhaustion and harm to the system’s components since they are difficult to be detected and controlled in real time.The study investigates the dynamic interactions of these vibrations,specifically in their high-frequency modes,usingfield data obtained from measurement while drilling.Thefindings have demonstrated the effect of strong coupling between the high-frequency modes of these vibrations on drilling sys-tem performance.The obtained results highlight the importance of considering the interconnected impacts of these vibrations when designing and implementing robust control systems.Therefore,integrating these compo-nents can increase the durability of drill bits and drill strings,as well as improve the ability to monitor and detect damage.Moreover,by exploiting thesefindings,the assessment of structural resilience in rotary drilling systems can be enhanced.Furthermore,the study demonstrates the capacity of structural health monitoring to improve the quality,dependability,and efficiency of rotary drilling systems in the petroleum industry.展开更多
Jane Eyre is considered Charlotte Bronte's masterpiece and one of the most memorable novels in nineteenth-century literature. This paper is to analyze the main characters in Jane Eyre.
As a mathematical analysis method,fractal analysis can be used to quantitatively describe irregular shapes with self-similar or self-affine properties.Fractal analysis has been used to characterize the shapes of metal...As a mathematical analysis method,fractal analysis can be used to quantitatively describe irregular shapes with self-similar or self-affine properties.Fractal analysis has been used to characterize the shapes of metal materials at various scales and dimensions.Conventional methods make it difficult to quantitatively describe the relationship between the regular characteristics and properties of metal material surfaces and interfaces.However,fractal analysis can be used to quantitatively describe the shape characteristics of metal materials and to establish the quantitative relationships between the shape characteristics and various properties of metal materials.From the perspective of two-dimensional planes and three-dimensional curved surfaces,this paper reviews the current research status of the fractal analysis of metal precipitate interfaces,metal grain boundary interfaces,metal-deposited film surfaces,metal fracture surfaces,metal machined surfaces,and metal wear surfaces.The relationship between the fractal dimensions and properties of metal material surfaces and interfaces is summarized.Starting from three perspectives of fractal analysis,namely,research scope,image acquisition methods,and calculation methods,this paper identifies the direction of research on fractal analysis of metal material surfaces and interfaces that need to be developed.It is believed that revealing the deep influence mechanism between the fractal dimensions and properties of metal material surfaces and interfaces will be the key research direction of the fractal analysis of metal materials in the future.展开更多
App reviews are crucial in influencing user decisions and providing essential feedback for developers to improve their products.Automating the analysis of these reviews is vital for efficient review management.While t...App reviews are crucial in influencing user decisions and providing essential feedback for developers to improve their products.Automating the analysis of these reviews is vital for efficient review management.While traditional machine learning(ML)models rely on basic word-based feature extraction,deep learning(DL)methods,enhanced with advanced word embeddings,have shown superior performance.This research introduces a novel aspectbased sentiment analysis(ABSA)framework to classify app reviews based on key non-functional requirements,focusing on usability factors:effectiveness,efficiency,and satisfaction.We propose a hybrid DL model,combining BERT(Bidirectional Encoder Representations from Transformers)with BiLSTM(Bidirectional Long Short-Term Memory)and CNN(Convolutional Neural Networks)layers,to enhance classification accuracy.Comparative analysis against state-of-the-art models demonstrates that our BERT-BiLSTM-CNN model achieves exceptional performance,with precision,recall,F1-score,and accuracy of 96%,87%,91%,and 94%,respectively.Thesignificant contributions of this work include a refined ABSA-based relabeling framework,the development of a highperformance classifier,and the comprehensive relabeling of the Instagram App Reviews dataset.These advancements provide valuable insights for software developers to enhance usability and drive user-centric application development.展开更多
The main characters and yield of 22 new indica hybrid rice combinations were analyzed in order to sort out the common characteristics in the performance of main characters of high-yielding varieties （combinations）.T...The main characters and yield of 22 new indica hybrid rice combinations were analyzed in order to sort out the common characteristics in the performance of main characters of high-yielding varieties （combinations）.The results showed at the confidence level of 95%, the whole growth pedod ranged from 131.3 to 137.3 d, the effective ear number ranged from 2 495 000 to 3 179 000 ears/hm2, the plant height was in the range of 119.5-131.7 cm, the average ear length ranged from 24.6 to 27.2 cm, the spikelet number per panicle was in the range of 164.2-225.4, the seed setting percentage ranged from 69.4% to 82.3%, and the 1 000-grain weight was in the range of 26.9-31.2 g. The correlation analysis between single traits and yield of rice varieties （combinations） showed that in order to achieve high yield, the medium indica hybrid rice variety with moderate growth period, higher plant height or biological yield, larger panicle and bigger kernel should be selected. In addition, the maximum tiller number should be controlled and adjust- ed, and the spike rate should be improved to ensure sufficient effective ears in the cultivation process.展开更多
Background:Pistacia chinensis Bunge has been traditionally used to manage various conditions,including asthma,pain,inflammation,hepatoprotection,and diabetes.The study was conducted to investigate the antioxidant and ...Background:Pistacia chinensis Bunge has been traditionally used to manage various conditions,including asthma,pain,inflammation,hepatoprotection,and diabetes.The study was conducted to investigate the antioxidant and anti-lipoxygenase(LOX)properties of the isolated compound 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one from Pistacia chinensis.Methods:LOX assay and antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl(DPPH)assay were performed.Molecular docking studies were conducted using a molecular operating environment.Results:The LOX assay revealed significant inhibitory effects at 0.2µM concentration,with an IC50 value of 37.80µM.The antioxidant effect demonstrated dose-dependency across 5 to 100µg/mL concentrations,reaching 93.09%at 100µg/mL,comparable to ascorbic acid’s 95.43%effect.Molecular docking studies highlighted strong interactions with the lipoxygenase enzyme,presenting an excellent docking score of-10.98 kcal/mol.Conclusion:These findings provide valuable insights into Pistacia chinensis’chemical components and biological effects,reinforcing its traditional medicinal applications.展开更多
BACKGROUND Cleidocranial dysplasia(CCD)is an infrequent clinical condition with an autosomal dominant inheritance pattern.It is characterized by abnormal clavicles,patent sutures and fontanelles,supernumerary teeth,an...BACKGROUND Cleidocranial dysplasia(CCD)is an infrequent clinical condition with an autosomal dominant inheritance pattern.It is characterized by abnormal clavicles,patent sutures and fontanelles,supernumerary teeth,and short stature.Approximately 60%-70%of patients with CCD have mutations in the RUNX family transcription factor 2 gene.However,prenatal diagnosis of CCD is difficult when the family history is unknown.CASE SUMMARY We report a rare case of fetal CCD with an unknown family history,confirmed by prenatal ultrasonography and genetic testing at a gestational age of 16 weeks.The genetic reports indicated that the fetus carried pathogenic mutations in the RUNX family transcription factor 2 gene(c.674G>A).After careful consideration,the pregnant woman and her family decided to continue the pregnancy.CONCLUSION Definitive prenatal diagnosis of CCD should include family history,ultrasound diagnosis,and genetic analysis,especially if family history is unknown.展开更多
BACKGROUND Pancreatic cancer remains one of the most lethal malignancies worldwide,with a poor prognosis often attributed to late diagnosis.Understanding the correlation between pathological type and imaging features ...BACKGROUND Pancreatic cancer remains one of the most lethal malignancies worldwide,with a poor prognosis often attributed to late diagnosis.Understanding the correlation between pathological type and imaging features is crucial for early detection and appropriate treatment planning.AIM To retrospectively analyze the relationship between different pathological types of pancreatic cancer and their corresponding imaging features.METHODS We retrospectively analyzed the data of 500 patients diagnosed with pancreatic cancer between January 2010 and December 2020 at our institution.Pathological types were determined by histopathological examination of the surgical spe-cimens or biopsy samples.The imaging features were assessed using computed tomography,magnetic resonance imaging,and endoscopic ultrasound.Statistical analyses were performed to identify significant associations between pathological types and specific imaging characteristics.RESULTS There were 320(64%)cases of pancreatic ductal adenocarcinoma,75(15%)of intraductal papillary mucinous neoplasms,50(10%)of neuroendocrine tumors,and 55(11%)of other rare types.Distinct imaging features were identified in each pathological type.Pancreatic ductal adenocarcinoma typically presents as a hypodense mass with poorly defined borders on computed tomography,whereas intraductal papillary mucinous neoplasms present as characteristic cystic lesions with mural nodules.Neuroendocrine tumors often appear as hypervascular lesions in contrast-enhanced imaging.Statistical analysis revealed significant correlations between specific imaging features and pathological types(P<0.001).CONCLUSION This study demonstrated a strong association between the pathological types of pancreatic cancer and imaging features.These findings can enhance the accuracy of noninvasive diagnosis and guide personalized treatment approaches.展开更多
Objective] The alm was to survey 10 characters of 8 fresh edibIe soy-bean varieties, analyze maln Ioading factors using principal component analysis, and estabIish muItipIe regression equation on fresh pod yield. [Met...Objective] The alm was to survey 10 characters of 8 fresh edibIe soy-bean varieties, analyze maln Ioading factors using principal component analysis, and estabIish muItipIe regression equation on fresh pod yield. [Methods] Through princi-pal component analysis on 10 characters of 8 fresh edibIe soybean varieties, char-acters reIated to fresh pod yield of fresh edibIe soybean were cIarified. [Results] Af-ter the principal components analysis, pod weight per pIant, 100-seed weight and pod number per pIant of fresh edibIe soybean were chosen to study their reIation with the yield of fresh edibIe soybean, moreover, it was demonstrated that the reIa-tion was Iinear reIation, thus it was suitabIe for muItivariate regression analysis. Fi-nal y, the mathematical expression formuIa about fresh pod yield was estabIished. [Conclusions] There were three characters affecting fresh pod yield, nameIy, pod weight per pIant, 100-seed weight and pod number per pIant, the mathematical equation was y=816.732＋4.145X6-0.718X8-0.985X9 （X6： pod weight per pIant; X8： 100-seed weight; X9： pod number per pIant）.展开更多
BACKGROUND Bipolar disorder(BD)is a severe mental illness characterized by significant mood swings.Effective drug treatment modalities are crucial for managing BD.AIM To analyze the current status and future trends of...BACKGROUND Bipolar disorder(BD)is a severe mental illness characterized by significant mood swings.Effective drug treatment modalities are crucial for managing BD.AIM To analyze the current status and future trends of global research on BD drug treatment over the last decade.METHODS The Web of Science Core Collection database spanning from 2015 to 2024 was utilized to retrieve literature related to BD drug treatment.A total of 2624 articles were extracted.Data visualization and analysis were conducted using CiteSpace,VOSviewer,Pajek,Scimago Graphica,and R-studio bibliometrix to identify RESULTS The United States,China,and the United Kingdom have made the most significant contributions to research on BD drug treatment and formed notable research collaboration networks.The University of Pittsburgh,Massachusetts General Hospital,and the University of Michigan have been identified as the major research institutions in this field.The Journal of Affective Disorders is the most influential journal.A keyword analysis revealed research hotspots related to clinical symptoms,drug efficacy,and genetic mechanisms.A citation analysis identified the management guidelines published by Yatham et al in 2018 as the most cited paper.CONCLUSION This study provides a detailed overview of the field of BD drug treatment,highlighting key contributors,research hotspots,and future directions.The study findings can be employed as a reference for future research and policymaking,which may enable further development and optimization of BD pharmacotherapy.展开更多
基金the National Natural Science Foundation of China(Nos.42188102,42120104006,41976117,42176111)the Fundamental Research Funds for the Central Universities(Nos.202172002,201812002)the funding from Andrew Mc Minn。
文摘Pseudoalteromonas is a group of marine bacteria widespread in diverse marine sediments,producing a wide range of bioactive compounds.However,only a limited number of Pseudoalteromonas phages have been isolated and studied.In this study,a novel lytic Pseudoalteromonas phage,denoted as vB_PalP_Y7,was isolated from sewage samples collected at the Seafood Market in Qingdao,China.vB_PalP_Y7 remained stable across a wide range of temperatures(-20–50℃)and a wide pH range(3–12).The vB_PalP_Y7 phage harbors a linear double-stranded DNA molecule of 57699 base pairs(bp)with a G+C content of 45.90%.Furthermore,it is predicted to contain 58 open reading frames(ORFs).Phylogenetic analysis and protein network relationship analysis revealed low similarity between vB_PalP_Y7 and viruses in the ICTV and IMG/VR4 database,suggesting that vB_PalP_Y7 may be a potential new genus,Miuvirus.This study contributed valuable insights to comprehend the relationship between Pseudoalteromonas phages and their host organisms.
基金supported by a grant(2023SJYB1830)from Philosophy and Social Sciences Research Project for Universities in Jiangsu Provincea grant(24YJA740017)from Humanities and Social Sciences Research Planning Fund Project of Ministry of Education,China.
文摘With the deterioration of the environment and the unbalanced relationship between man and nature,people are plagued by varieties of social problems and rising spiritual crises.This paper aims to analyze Thoreau’s characters in Walden and attempts to provide the implications for our contemporary life.Combined with Thoreau’s life experience and the background of Walden,the paper starts with the analysis of Thoreau’s characters from three aspects concerning his pursuit of inner serenity,search for true essence of life and abiding passion for life,which constitute his unique and independent characters and provide the enlightenment for contemporary life.We concluded that unique thoughts,attitudes,and spirit embedded in Thoreau’s characters are inextricably connected with our contemporary life.His personal experience and practice of solitary life at Walden Pond is a testimony to the necessity of closing to nature actively and confronting life passionately.
基金Supported by Sichuan Financial Genetic Engineering Program of the 12th Five-year Plan(2011JYGC11-029)National Modern Agricultural and Industrial Technology System+1 种基金Sichuan Rice Breeding Key Program of the 12th Five-year Plan(2011NZ-0098-1)Luzhou Key Project for Science and Technology Development(2011-N-09)~~
文摘[Objective] The aim was to research and analyze characters and related correlation of indica hybrid rice containing high amylose. [Method] In the research, major characters of 16 species of groups of {ndica hybrid rice and the correlation were explored in rice belts in Sichuan in 2011. [Result] The variation of chalkiness degree was the highest at 26.8%, followed by rate of head rice at 22.89%; varia- tions of head rice rate and chalkiness degree were lower at 0.72% and 2.61%. In addition, rate of unpolished rice was of significantly negative correlation with chalki- ness degree; rate of chalky rice was of extremely positive correlation with chalkiness degree and gel consistency; chalkiness degree was of significantly positive correla- tion with gel consistency; gel consistency was of significantly negative correlation with protein content; amylose content was of insignificant correlation with gel consis- tency （r=0.166 9） of the 16 hybrid groups. These indicated that gel consistency would be still high as the content of amylose grows （AC≥25%）. For example, when the content of anylose in Chuanxiang 29A/Luhui 37, Kangfeng AJ6684, and Lefeng A/SR536 exceeded 27%, the gel consistency was over 80 mm in the research. [Conclusion] The research provides references for improvement of amylose content in breeding hybrid rice.
基金Supported by High-tech Research Project of Jiangsu Province(BG2004314)~~
文摘[Objective] The aim was to study the variation of leaf characters from different provenance sources of Polygonum multiflorum Thunb,as well as to carry out cluster analysis on P.multiflorum from different provenance sources to provide basis for the classification,identification,breeding and improved variety selection of P.multiflorum.[Method] Leaf shape characters of 31 copies of germplasm resources in the major distribution region of the whole country were determined,and the genetic variation of P.multiflorum leaves from different producing areas was analyzed.[Result] The leaf characters of single plant of the same experimental provenance source of P.multiflorum were relatively stable,the variation was mainly found on the single leaf area,1/2 leaf width,leaf width and other indicators;the variation of each leaf character among different provenance sources was obvious,and the variation was mainly found on the single leaf weight,leaf area,1/2 leaf width,leaf length and other indicators.The correlation analysis of each leaf character in P.multiflorum suggested that the single leaf area and single leaf weight showed extremely significant positive correlation with leaf length,1/2 leaf width,leaf width,leaf thickness and leaf stem length,while the single leaf area and single leaf weight showed significant negative correlation with WWR（leaf width/1/2 leaf width）and LWR（leaf length/1/2 leaf length）,in addition,several macroscopic leaf characters such as leaf length,1/2 leaf width,leaf width,leaf stem length showed extremely positive correlation.The main component analysis result suggested that the contribution rate of accumulation variance of the front three main components was up to 97.4%,which could better reflect the comprehensive performance of leaf characters of different provenance sources of P.multiflorum.The cluster analysis showed that the experimental 31 copies of P.multiflorum provenance sources should be divided into three classes,the first class was distributed in the Middle,Western of Guizhou,northwestern of Guangxi and western areas with higher altitude;the second class was distributed in Hunan,Hubei,Sichuan,Guangdong and the most area of Guangxi;the third class was distributed in Anhui,Jiangsu and Henan and Shandong.[Conclusion] Cluster analysis of leaf characters indicated that the kinds of provenance sources which the geographical position was closer could be got together.The study had provided a certain basis for the classification of P.multiflorum.
文摘Abst[Objective] This study was to understand the genetic dynamics of three-line hybrid rice, and explore the respective effect of sterile line and restoring line on grain characters of hybrid rica. [Method] Four three-line stedle lines and 27 restoring lines（cultivars） commonly culti- vated in Central China region were regarded as expadmental materials to conduct 4 x27NCII cross design, and the grain characters of three-line hybrid rico were analyzed at genetic and correlation levels. [ Result] Four characters of grain length, grain width, 1 000-grain weight and length- width ratio play the leading role in additive gene effect; these four characters were simultaneously influenced by male parent and female parent, but the effect from male parent was relatively larger. The grain length, grain width, 1 000-grain weight and length-width ratio all have high brood hedtabUities（ respectively 99.65%, 98.31%, 95.27% and 98.81% ）. Correlation analysis showed that grain length was positively correlated with 1 000-grain weight and length-width ratio at extremely significant level; 1 000-grain weight was positively correlated with grain length and length- width ratio at extremely significant level, and was insignificantly correlated with grain width; grain width was negatively correlated with grain length and length-width ratio at extremely significant level. Path analysis showed that the direct path coefficients of grain length, grain width and 1 0（30- grain weight to length-width ratio were 0.624 6, -0.555 9 and -0.015 8, respectively. [ Conclusion] This study systematically analyzed the effects of stedle line and restoring line on grain characters of hybrid rice, which provided theoretical basis for breeding high quality and yield hy- brid dce.
基金Supported by Special Fund for Agro-scientific Research in the Public Interest from the Ministry of Agriculture of China(201303112)the 12th National Five-year Plan for Science and Technology Program of Rural Areas(2012BAD02B03-17)~~
文摘In order to scientifically evaluate the values of Cucurbita moschata cultivars, main botanical characters including the initial flowering date, the first fruiting node, fruit length, fruit stem length, stem diameter, internode length, the transverse and longitudinal diameters of the largest leaf, single fruit weight, flesh thickness and soluble solid content of 41 cultivars were measured for conducting diversity, correlation and cluster analysis. The results revealed that the pumpkin cultivars showed large variations in fruit stem length, single fruit weight, fruit length and flesh thickness, but small variations in initial flowering date. Significant, even highly significant correlations were found among the tested traits. Cluster analysis demonstrated that the 41 old Cucurbita moschata cultivars were divided into three groups, of which multiple traits of Group 1 were better than those in the other two groups. High similarities existed in three groups and the cultivars in each group. This research provided basis for selecting excellent traits and parents for the breeding of hybrids.
基金Supported by National Natural Science Foundation(30760122)National High-Tech Research and Development Program(863Program)(2009AA101105)+1 种基金Faculty Construction of 211 Project(SZTD-211-02)Project of Introducing Advanced Agricultural Science and Technology of Ministry of Agriculture(948Program)(2010-Z54)~~
文摘[Objective] The study aimed at exploring the relationship among the agronomic characters of B. juncea in western China, in order to provide scientific basis for the breeding of B. juncea in western China. [Method] 39 B. juncea materials from western China were used for the canonical correlation analysis, and canonical correlations between each pair of the four ecological character （containing 18 variables） were verified, including yield characters （5 variables）, caulis characters （6 variables）, branch characters （3 variables） and pod characters （3 variables）. [Result] Yield per plant of B. juncea in western China suffered a tremendous influence from effective pod number per plant while was not significantly affected by the total pod number per plant, seed number per pod and 1 000-seed weight; the most important character related with the yield character of B. juncea in western China was caulis character, followed by the branch character and pod character; yield characters, caulis characters, branch characters and pod characters of B. juncea in western China were closely correlated. [Conclusion] In order to improve the yield characters of B. juncea in western China, caulis characters should be focused on, followed by branch characters and pod characters; rapeseed varieties with high performance in total pod number per plant and effective pod number per plant should be chosen through the perspectives of effective branch number, plant height, pod number of main inflorescence, fruit stalk number of main inflorescence and other traits, while rapeseed varieties with high performance in seed number per pod and 1 000-seed weight should be chosen through the perspectives of beak length and other traits.
基金Supported by the National High Technology Research and Development Program of China(863 Program,2011AA10A104)Special Funds of the Modern Agricultural Industry Technology System(CAES-13)+5 种基金National Science and Technology Support Program(2010BAD01B08,2011BAD35B04)Sichuan Breeding Key Project(2011NZ0098-5)Financial Genetic Engineering Program of Sichuan Province(2011JYGC04013)Special Funds for Sichuan Agricultural Innovation Team ConstructionOutstanding Youth AcademicTechnical Leader Training Program of Sichuan Province(2010JQ0054)~~
文摘Fifteen combinations crossed by five JA cytoplasmic male sterile lines （A1, A2, A3, A4, A5） and three restoring lines （R1, R2, R3） were selected to analyze the combining ability and heritability of nine main agronomic characters of Brassica na-pus L. to definite the application potential of these parent materials. The result showed that （i） the general combining ability （GCA） of male parents was R3＆gt;R2＆gt;R1 and that of female parents was A4＆gt;A1＆gt;A2＆gt;A5＆gt;A3; （i ） the special combining ability （SCA） of A2＆#215;R3 in plant height, number of branches, number of pods per plant and yield per plant was the best. The yield per plant of A2＆#215;R3, A1＆#215;R1 and A2＆#215;R1 ranked the first three places in the 15 combinations; （i i） the broad heritability of yield per plant was the highest, and that of the height of branches was the lowest. The com-prehensive characters of R3, A2 and A4 were better, which could be used to create new materials; （iv） good offspring were more likely to be chosen from the combina-tion with higher parental GCA, so the GCA and SCA should be considered com-prehensively when choosing parent and determining the optimal combinations.
基金Supported by Earmarked Fund for China Agriculture Research System(CARS-11-B03)Key Technology Research and Development Program of Jiangsu Province(BE2013437)the Agricultural Science Independent Innovation Foundation of Jiangsu Province[CX(11)4057]~~
文摘Objective] This study was performed to investigate the trait changes and their correlations as wel as the dynamic changes of biological yield of Xuzishu 3, which wil help to enhance the yield and anthocyanin content of sweetpotato by cul-tivation. [Method] We systematical y measured the agronomic traits, qualitative char-acters and biological yield of Xuzishu 3 during six growing periods to investigate the dynamic changes of its essential characters and yield accumulation. [Result] The characters of Xuzishu 3 appeared most prosperous after the 90th d except for an-thocyanin content. Extremely significant positive correlations were found between ev-ery two of the dry matter rates of above-ground parts （including leaf petioles, leaves and stems）, reducing sugar content and potato weight per plant. Assimilated product distributed more in stems and leaves than in storage roots before the 90th d in growing period. Photosynthetic capacity and net assimilation rate gradual y de-creased after the 90th d, but the assimilated product distributing to storage roots in-creased quickly and maximized in the 135th d. [Conclusion] Xuzishu 3 is a late ma-turing variety requiring more fertilizer, and the accumulation of anthocyanin fluctuates during the growth period of Xuzishu 3. So yield of Xuzishu 3 can be increased by applying more fertilizer and extending the growth period reasonably, meanwhile the anthocyanin content can be increased by means of control ing temperature, light, water and phytohormone within 60 d after planting.
基金supported by the Science and Technology Project of Henan Province(No.222102210081).
文摘Joint Multimodal Aspect-based Sentiment Analysis(JMASA)is a significant task in the research of multimodal fine-grained sentiment analysis,which combines two subtasks:Multimodal Aspect Term Extraction(MATE)and Multimodal Aspect-oriented Sentiment Classification(MASC).Currently,most existing models for JMASA only perform text and image feature encoding from a basic level,but often neglect the in-depth analysis of unimodal intrinsic features,which may lead to the low accuracy of aspect term extraction and the poor ability of sentiment prediction due to the insufficient learning of intra-modal features.Given this problem,we propose a Text-Image Feature Fine-grained Learning(TIFFL)model for JMASA.First,we construct an enhanced adjacency matrix of word dependencies and adopt graph convolutional network to learn the syntactic structure features for text,which addresses the context interference problem of identifying different aspect terms.Then,the adjective-noun pairs extracted from image are introduced to enable the semantic representation of visual features more intuitive,which addresses the ambiguous semantic extraction problem during image feature learning.Thereby,the model performance of aspect term extraction and sentiment polarity prediction can be further optimized and enhanced.Experiments on two Twitter benchmark datasets demonstrate that TIFFL achieves competitive results for JMASA,MATE and MASC,thus validating the effectiveness of our proposed methods.
文摘Maintaining the integrity and longevity of structures is essential in many industries,such as aerospace,nuclear,and petroleum.To achieve the cost-effectiveness of large-scale systems in petroleum drilling,a strong emphasis on structural durability and monitoring is required.This study focuses on the mechanical vibrations that occur in rotary drilling systems,which have a substantial impact on the structural integrity of drilling equipment.The study specifically investigates axial,torsional,and lateral vibrations,which might lead to negative consequences such as bit-bounce,chaotic whirling,and high-frequency stick-slip.These events not only hinder the efficiency of drilling but also lead to exhaustion and harm to the system’s components since they are difficult to be detected and controlled in real time.The study investigates the dynamic interactions of these vibrations,specifically in their high-frequency modes,usingfield data obtained from measurement while drilling.Thefindings have demonstrated the effect of strong coupling between the high-frequency modes of these vibrations on drilling sys-tem performance.The obtained results highlight the importance of considering the interconnected impacts of these vibrations when designing and implementing robust control systems.Therefore,integrating these compo-nents can increase the durability of drill bits and drill strings,as well as improve the ability to monitor and detect damage.Moreover,by exploiting thesefindings,the assessment of structural resilience in rotary drilling systems can be enhanced.Furthermore,the study demonstrates the capacity of structural health monitoring to improve the quality,dependability,and efficiency of rotary drilling systems in the petroleum industry.
文摘Jane Eyre is considered Charlotte Bronte's masterpiece and one of the most memorable novels in nineteenth-century literature. This paper is to analyze the main characters in Jane Eyre.
基金financially supported by the National Key R&D Program of China(No.2022YFE0121300)the National Natural Science Foundation of China(No.52374376)the Introduction Plan for High-end Foreign Experts(No.G2023105001L)。
文摘As a mathematical analysis method,fractal analysis can be used to quantitatively describe irregular shapes with self-similar or self-affine properties.Fractal analysis has been used to characterize the shapes of metal materials at various scales and dimensions.Conventional methods make it difficult to quantitatively describe the relationship between the regular characteristics and properties of metal material surfaces and interfaces.However,fractal analysis can be used to quantitatively describe the shape characteristics of metal materials and to establish the quantitative relationships between the shape characteristics and various properties of metal materials.From the perspective of two-dimensional planes and three-dimensional curved surfaces,this paper reviews the current research status of the fractal analysis of metal precipitate interfaces,metal grain boundary interfaces,metal-deposited film surfaces,metal fracture surfaces,metal machined surfaces,and metal wear surfaces.The relationship between the fractal dimensions and properties of metal material surfaces and interfaces is summarized.Starting from three perspectives of fractal analysis,namely,research scope,image acquisition methods,and calculation methods,this paper identifies the direction of research on fractal analysis of metal material surfaces and interfaces that need to be developed.It is believed that revealing the deep influence mechanism between the fractal dimensions and properties of metal material surfaces and interfaces will be the key research direction of the fractal analysis of metal materials in the future.
基金supported by the Deanship of Scientific Research(DSR)at King Abdulaziz University,Jeddah,under grant no.(GPIP:13-612-2024).
文摘App reviews are crucial in influencing user decisions and providing essential feedback for developers to improve their products.Automating the analysis of these reviews is vital for efficient review management.While traditional machine learning(ML)models rely on basic word-based feature extraction,deep learning(DL)methods,enhanced with advanced word embeddings,have shown superior performance.This research introduces a novel aspectbased sentiment analysis(ABSA)framework to classify app reviews based on key non-functional requirements,focusing on usability factors:effectiveness,efficiency,and satisfaction.We propose a hybrid DL model,combining BERT(Bidirectional Encoder Representations from Transformers)with BiLSTM(Bidirectional Long Short-Term Memory)and CNN(Convolutional Neural Networks)layers,to enhance classification accuracy.Comparative analysis against state-of-the-art models demonstrates that our BERT-BiLSTM-CNN model achieves exceptional performance,with precision,recall,F1-score,and accuracy of 96%,87%,91%,and 94%,respectively.Thesignificant contributions of this work include a refined ABSA-based relabeling framework,the development of a highperformance classifier,and the comprehensive relabeling of the Instagram App Reviews dataset.These advancements provide valuable insights for software developers to enhance usability and drive user-centric application development.
文摘The main characters and yield of 22 new indica hybrid rice combinations were analyzed in order to sort out the common characteristics in the performance of main characters of high-yielding varieties （combinations）.The results showed at the confidence level of 95%, the whole growth pedod ranged from 131.3 to 137.3 d, the effective ear number ranged from 2 495 000 to 3 179 000 ears/hm2, the plant height was in the range of 119.5-131.7 cm, the average ear length ranged from 24.6 to 27.2 cm, the spikelet number per panicle was in the range of 164.2-225.4, the seed setting percentage ranged from 69.4% to 82.3%, and the 1 000-grain weight was in the range of 26.9-31.2 g. The correlation analysis between single traits and yield of rice varieties （combinations） showed that in order to achieve high yield, the medium indica hybrid rice variety with moderate growth period, higher plant height or biological yield, larger panicle and bigger kernel should be selected. In addition, the maximum tiller number should be controlled and adjust- ed, and the spike rate should be improved to ensure sufficient effective ears in the cultivation process.
文摘Background:Pistacia chinensis Bunge has been traditionally used to manage various conditions,including asthma,pain,inflammation,hepatoprotection,and diabetes.The study was conducted to investigate the antioxidant and anti-lipoxygenase(LOX)properties of the isolated compound 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one from Pistacia chinensis.Methods:LOX assay and antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl(DPPH)assay were performed.Molecular docking studies were conducted using a molecular operating environment.Results:The LOX assay revealed significant inhibitory effects at 0.2µM concentration,with an IC50 value of 37.80µM.The antioxidant effect demonstrated dose-dependency across 5 to 100µg/mL concentrations,reaching 93.09%at 100µg/mL,comparable to ascorbic acid’s 95.43%effect.Molecular docking studies highlighted strong interactions with the lipoxygenase enzyme,presenting an excellent docking score of-10.98 kcal/mol.Conclusion:These findings provide valuable insights into Pistacia chinensis’chemical components and biological effects,reinforcing its traditional medicinal applications.
基金Supported by Science and Technology Development Plan Project of Weifang,No.2023YX005。
文摘BACKGROUND Cleidocranial dysplasia(CCD)is an infrequent clinical condition with an autosomal dominant inheritance pattern.It is characterized by abnormal clavicles,patent sutures and fontanelles,supernumerary teeth,and short stature.Approximately 60%-70%of patients with CCD have mutations in the RUNX family transcription factor 2 gene.However,prenatal diagnosis of CCD is difficult when the family history is unknown.CASE SUMMARY We report a rare case of fetal CCD with an unknown family history,confirmed by prenatal ultrasonography and genetic testing at a gestational age of 16 weeks.The genetic reports indicated that the fetus carried pathogenic mutations in the RUNX family transcription factor 2 gene(c.674G>A).After careful consideration,the pregnant woman and her family decided to continue the pregnancy.CONCLUSION Definitive prenatal diagnosis of CCD should include family history,ultrasound diagnosis,and genetic analysis,especially if family history is unknown.
文摘BACKGROUND Pancreatic cancer remains one of the most lethal malignancies worldwide,with a poor prognosis often attributed to late diagnosis.Understanding the correlation between pathological type and imaging features is crucial for early detection and appropriate treatment planning.AIM To retrospectively analyze the relationship between different pathological types of pancreatic cancer and their corresponding imaging features.METHODS We retrospectively analyzed the data of 500 patients diagnosed with pancreatic cancer between January 2010 and December 2020 at our institution.Pathological types were determined by histopathological examination of the surgical spe-cimens or biopsy samples.The imaging features were assessed using computed tomography,magnetic resonance imaging,and endoscopic ultrasound.Statistical analyses were performed to identify significant associations between pathological types and specific imaging characteristics.RESULTS There were 320(64%)cases of pancreatic ductal adenocarcinoma,75(15%)of intraductal papillary mucinous neoplasms,50(10%)of neuroendocrine tumors,and 55(11%)of other rare types.Distinct imaging features were identified in each pathological type.Pancreatic ductal adenocarcinoma typically presents as a hypodense mass with poorly defined borders on computed tomography,whereas intraductal papillary mucinous neoplasms present as characteristic cystic lesions with mural nodules.Neuroendocrine tumors often appear as hypervascular lesions in contrast-enhanced imaging.Statistical analysis revealed significant correlations between specific imaging features and pathological types(P<0.001).CONCLUSION This study demonstrated a strong association between the pathological types of pancreatic cancer and imaging features.These findings can enhance the accuracy of noninvasive diagnosis and guide personalized treatment approaches.
文摘Objective] The alm was to survey 10 characters of 8 fresh edibIe soy-bean varieties, analyze maln Ioading factors using principal component analysis, and estabIish muItipIe regression equation on fresh pod yield. [Methods] Through princi-pal component analysis on 10 characters of 8 fresh edibIe soybean varieties, char-acters reIated to fresh pod yield of fresh edibIe soybean were cIarified. [Results] Af-ter the principal components analysis, pod weight per pIant, 100-seed weight and pod number per pIant of fresh edibIe soybean were chosen to study their reIation with the yield of fresh edibIe soybean, moreover, it was demonstrated that the reIa-tion was Iinear reIation, thus it was suitabIe for muItivariate regression analysis. Fi-nal y, the mathematical expression formuIa about fresh pod yield was estabIished. [Conclusions] There were three characters affecting fresh pod yield, nameIy, pod weight per pIant, 100-seed weight and pod number per pIant, the mathematical equation was y=816.732＋4.145X6-0.718X8-0.985X9 （X6： pod weight per pIant; X8： 100-seed weight; X9： pod number per pIant）.
基金Supported by the National College Students’Innovative Entrepreneurial Training Plan Program,No.202410403067the Innovation and Entrepreneurship Training Program for College Students in Jiangxi Province,No.S202410403035.
文摘BACKGROUND Bipolar disorder(BD)is a severe mental illness characterized by significant mood swings.Effective drug treatment modalities are crucial for managing BD.AIM To analyze the current status and future trends of global research on BD drug treatment over the last decade.METHODS The Web of Science Core Collection database spanning from 2015 to 2024 was utilized to retrieve literature related to BD drug treatment.A total of 2624 articles were extracted.Data visualization and analysis were conducted using CiteSpace,VOSviewer,Pajek,Scimago Graphica,and R-studio bibliometrix to identify RESULTS The United States,China,and the United Kingdom have made the most significant contributions to research on BD drug treatment and formed notable research collaboration networks.The University of Pittsburgh,Massachusetts General Hospital,and the University of Michigan have been identified as the major research institutions in this field.The Journal of Affective Disorders is the most influential journal.A keyword analysis revealed research hotspots related to clinical symptoms,drug efficacy,and genetic mechanisms.A citation analysis identified the management guidelines published by Yatham et al in 2018 as the most cited paper.CONCLUSION This study provides a detailed overview of the field of BD drug treatment,highlighting key contributors,research hotspots,and future directions.The study findings can be employed as a reference for future research and policymaking,which may enable further development and optimization of BD pharmacotherapy.
