This paper describes a hierarchical architecture and a high-performance and interoperability protocol for centralized monitoring and controlling systems (CMCS) . The protocol we proposed can interoperate different mon...This paper describes a hierarchical architecture and a high-performance and interoperability protocol for centralized monitoring and controlling systems (CMCS) . The protocol we proposed can interoperate different monitoring and controlling systems constructed by different companies, each with different functions and communication protocols. The protocol reduces the amount of traffic and has real-time and high-perfor-mance advantages. The protocol was implemented in CMCS for telecommunication power supply and air-condi-tioner used by the Telecommunication Bureau of Zhejiang Province. This paper deals with the hierarchical architecture and function of CMCS and packet format, command ID, and SDL description of its protocol. We also discuss the properties of the interoperability and performance of the protocol in this paper.展开更多
The relationships and the features of integration between Enterprise ProcessMonitoring and Controlling System (EPMCS) and Enterprise Process Related Applications (EPRA) wereanalyzed. An integration architecture center...The relationships and the features of integration between Enterprise ProcessMonitoring and Controlling System (EPMCS) and Enterprise Process Related Applications (EPRA) wereanalyzed. An integration architecture centered on EPMCS was presented, in which there were fourlayers to connect from EPMCS to EPRA: EPMCS, application integration layer, transport layer andEPRA, and there were four layers used to etstablish integration: presentation layer, function layer,data layer and system layer. The frameworks to connect EPMCS and EPRA were designed, thatEnterprise-Independent Model (EIM), Enterprise-Specific Model (ESM) and meta-model to describe thesetwo models were defined. The method to integrate data based on XML was designed to exchange datafrom EPMCS to EPRA according to the mapping between EIM and ESM. The approches are suitable forintegrating EPMCS and systems in Product Data Management (PDM), project management and enterprisebusiness management.展开更多
The new energy power generation is becoming increasingly important in the power system.Such as photovoltaic power generation has become a research hotspot,however,due to the characteristics of light radiation changes,...The new energy power generation is becoming increasingly important in the power system.Such as photovoltaic power generation has become a research hotspot,however,due to the characteristics of light radiation changes,photovoltaic power generation is unstable and random,resulting in a low utilization rate and directly affecting the stability of the power grid.To solve this problem,this paper proposes a coordinated control strategy for a newenergy power generation system with a hybrid energy storage unit based on the lithium iron phosphate-supercapacitor hybrid energy storage unit.Firstly,the variational mode decomposition algorithm is used to separate the high and low frequencies of the power signal,which is conducive to the rapid and accurate suppression of the power fluctuation of the energy storage system.Secondly,the fuzzy control algorithm is introduced to balance the power between energy storage.In this paper,the actual data is used for simulation,and the simulation results show that the strategy realizes the effective suppression of the bus voltage fluctuation and the accurate control of the internal state of the energy storage unit,effectively avoiding problems such as overshoot and over-discharge,and can significantly improve the stability of the photovoltaic power generation systemand the stability of the Direct Current bus.It is of great significance to promote the development of collaborative control technology for photovoltaic hybrid energy storage units.展开更多
Renewable Energy Systems(RES)provide a sustainable solution to climate warming and environmental pollution by enhancing stability and reliability through status acquisition and analysis on cloud platforms and intellig...Renewable Energy Systems(RES)provide a sustainable solution to climate warming and environmental pollution by enhancing stability and reliability through status acquisition and analysis on cloud platforms and intelligent processing on edge servers(ES).However,securely distributing encrypted data stored in the cloud to terminals that meet decryption requirements has become a prominent research topic.Additionally,managing attributes,including addition,deletion,and modification,is a crucial issue in the access control scheme for RES.To address these security concerns,a trust-based ciphertext-policy attribute-based encryption(CP-ABE)device access control scheme is proposed for RES(TB-CP-ABE).This scheme effectivelymanages the distribution and control of encrypted data on the cloud through robust attribute key management.By introducing trust management mechanisms and outsourced decryption technology,the ES system can effectively assess and manage the trust worthiness of terminal devices,ensuring that only trusted devices can participate in data exchange and access sensitive information.Besides,the ES system dynamically evaluates trust scores to set decryption trust thresholds,thereby regulating device data access permissions and enhancing the system’s security.To validate the security of the proposed TB-CP-ABE against chosen plaintext attacks,a comprehensive formal security analysis is conducted using the widely accepted random oraclemodel under the decisional q-Bilinear Diffie-Hellman Exponent(q-BDHE)assumption.Finally,comparative analysis with other schemes demonstrates that the TB-CP-ABE scheme cuts energy/communication costs by 43%,and scaleswell with rising terminals,maintaining average latency below 50ms,ensuring real-time service feasibility.The proposed scheme not only provides newinsights for the secure management of RES but also lays a foundation for future secure energy solutions.展开更多
Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health challenge.Identifying optimal ...Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health challenge.Identifying optimal therapies and improving the long-term neurological functions of patients with acute central nervous system injuries are urgent priorities.Mitochondria are susceptible to damage after acute central nervous system injury,and this leads to the release of toxic levels of reactive oxygen species,which induce cell death.Mitophagy,a selective form of autophagy,is crucial in eliminating redundant or damaged mitochondria during these events.Recent evidence has highlighted the significant role of mitophagy in acute central nervous system injuries.In this review,we provide a comprehensive overview of the process,classification,and related mechanisms of mitophagy.We also highlight the recent developments in research into the role of mitophagy in various acute central nervous system injuries and drug therapies that regulate mitophagy.In the final section of this review,we emphasize the potential for treating these disorders by focusing on mitophagy and suggest future research paths in this area.展开更多
Vascular endothelial growth factor and its mimic peptide KLTWQELYQLKYKGI(QK)are widely used as the most potent angiogenic factors for the treatment of multiple ischemic diseases.However,conventional topical drug deliv...Vascular endothelial growth factor and its mimic peptide KLTWQELYQLKYKGI(QK)are widely used as the most potent angiogenic factors for the treatment of multiple ischemic diseases.However,conventional topical drug delivery often results in a burst release of the drug,leading to transient retention(inefficacy)and undesirable diffusion(toxicity)in vivo.Therefore,a drug delivery system that responds to changes in the microenvironment of tissue regeneration and controls vascular endothelial growth factor release is crucial to improve the treatment of ischemic stroke.Matrix metalloproteinase-2(MMP-2)is gradually upregulated after cerebral ischemia.Herein,vascular endothelial growth factor mimic peptide QK was self-assembled with MMP-2-cleaved peptide PLGLAG(TIMP)and customizable peptide amphiphilic(PA)molecules to construct nanofiber hydrogel PA-TIMP-QK.PA-TIMP-QK was found to control the delivery of QK by MMP-2 upregulation after cerebral ischemia/reperfusion and had a similar biological activity with vascular endothelial growth factor in vitro.The results indicated that PA-TIMP-QK promoted neuronal survival,restored local blood circulation,reduced blood-brain barrier permeability,and restored motor function.These findings suggest that the self-assembling nanofiber hydrogel PA-TIMP-QK may provide an intelligent drug delivery system that responds to the microenvironment and promotes regeneration and repair after cerebral ischemia/reperfusion injury.展开更多
In order to enhance the control performance of piezo-positioning system,the influence of hysteresis characteristics and its compensation method are studied.Hammerstein model is used to represent the dynamic hysteresis...In order to enhance the control performance of piezo-positioning system,the influence of hysteresis characteristics and its compensation method are studied.Hammerstein model is used to represent the dynamic hysteresis nonlinear characteristics of piezo-positioning actuator.The static nonlinear part and dynamic linear part of the Hammerstein model are represented by models obtained through the Prandtl-Ishlinskii(PI)model and Hankel matrix system identification method,respectively.This model demonstrates good generalization capability for typical input frequencies below 200 Hz.A sliding mode inverse compensation tracking control strategy based on P-I inverse model and integral augmentation is proposed.Experimental results show that compared with PID inverse compensation control and sliding mode control without inverse compensation,the sliding mode inverse compensation control has a more ideal step response and no overshoot,moreover,the settling time is only 6.2 ms.In the frequency domain,the system closed-loop tracking bandwidth reaches 119.9 Hz,and the disturbance rejection bandwidth reaches 86.2 Hz.The proposed control strategy can effectively compensate the hysteresis nonlinearity,and improve the tracking accuracy and antidisturbance capability of piezo-positioning system.展开更多
Enhancing the stability and performance of practical control systems in the presence of nonlinearity,time delay,and uncertainty remains a significant challenge.Particularly,a class of strict-feedback nonlinear uncerta...Enhancing the stability and performance of practical control systems in the presence of nonlinearity,time delay,and uncertainty remains a significant challenge.Particularly,a class of strict-feedback nonlinear uncertain systems characterized by unknown control directions and time-varying input delay lacks comprehensive solutions.In this paper,we propose an observerbased adaptive tracking controller to address this gap.Neural networks are utilized to handle uncertainty,and a unique coordinate transformation is employed to untangle the coupling between input delay and unknown control directions.Subsequently,a new auxiliary signal counters the impact of time-varying input delay,while a Nussbaum function is introduced to solve the problem of unknown control directions.The leverage of an advanced dynamic surface control technique avoids the“complexity explosion”and reduces boundary layer errors.Synthesizing these techniques ensures that all the closed-loop signals are semi-globally uniformly ultimately bounded(SGUUB),and the tracking error converges to a small region around the origin by selecting suitable parameters.Simulation examples are provided to demonstrate the feasibility of the proposed approach.展开更多
As Model-Based Systems Engineering(MBSE)was applied to the Electric Multiple Unit(EMU)braking system control logic,a preliminary exploration was conducted for bullet train braking system control logic research using a...As Model-Based Systems Engineering(MBSE)was applied to the Electric Multiple Unit(EMU)braking system control logic,a preliminary exploration was conducted for bullet train braking system control logic research using an MBSE practice framework.The framework mainly includes the requirement analysis phase,functional analysis phase,and design phase.Systems Modeling Language(SysML)was used as the modeling language,and Cameo Systems Modeler(CSM)was employed as the modeling tool.By integrating the EMU braking system control logic and utilizing a top-down design approach,the implementation of MBSE in the bullet train braking system was analyzed and studied.The results show that,according to the MBSE practice framework,a unified description of the requirement analysis,functional analysis,and design synthesis of the EMU braking system control logic can be achieved.Additionally,the correlation and traceability between models can be established.展开更多
It’s possible for malicious operators to seize hold of electrical control systems, for instance, the engine control unit of driverless vehicles, from various vectors, e.g. autonomic control system, remote vehicle acc...It’s possible for malicious operators to seize hold of electrical control systems, for instance, the engine control unit of driverless vehicles, from various vectors, e.g. autonomic control system, remote vehicle access, or human drivers. To mitigate potential risks, this paper provides the inauguration study by proposing a theoretical framework in the physical, human and cyber triad. Its goal is to, at each time point, detect adversary control behaviors and protect control systems against malicious operations via integrating a variety of methods. This paper only proposes a theoretical framework which tries to indicate possible threats. With the support of the framework, the security system can lightly reduce the risk. The development and implementation of the system are out of scope.展开更多
BACKGROUND Systematic reviews(SRs)synthesize and evaluate data,mainly from randomized trials,which then guides the development of clinical recommendations in evidence-based medicine.However,the data and methodological...BACKGROUND Systematic reviews(SRs)synthesize and evaluate data,mainly from randomized trials,which then guides the development of clinical recommendations in evidence-based medicine.However,the data and methodological information in the included papers can often be lacking or unclear,and reviewers usually need to contact the authors of included studies for clarifications.Contacting authors is recommended,but it is unclear how often SR teams do it,or what the level of response is.AIM To investigate how often reviewers undertake contact with the authors of included randomized controlled trials(RCTs)for clarification on data and risk of bias concerns,to explore the factors that influence whether SR authors contact or do not contact the authors,and the content and level of responses.METHODS We conducted a systematic electronic database search in MEDLINE using the search string“(systematic review)”AND“(RCT OR randomized OR trial)”for articles published between 1 January 2024 and 19 February 2024,without language restrictions.Screening and data extraction was done independently by two reviewers,and conflicts resolved by a senior author.Contact authors of included SRs were contacted for clarifications.RESULTS Of the 329 included SRs,38%(n=125)explicitly mentioned contact with the authors of included studies.The remaining 62%(n=204)did not.We attempted contact with all SR teams for clarifications and received 90 responses(19.4%).Of the 50 respondents who did not explicitly mention contact in their SRs,25(50%)replied that they did make contact.We received a total of 64 responses on the level and content of information sought.The mean±SD contacts SR teams made were 10(10),replies received 5(6.7),and response waiting time 10.1(28.3)weeks.Resources,time,poor previous experience,perceived likelihood of poor response and bias concerns were reported as barriers to attempting contact.CONCLUSION The majority of SRs published in 2024 did not confirm seeking clarifying or missing information from primary study authors.However,SR teams reported that 50%of contacted primary authors respond.Additional research can clarify this rate of response and establish methods to increase the integration of this core methodological element in SRs.展开更多
The alpine ecosystem has great potential for carbon sequestration.Soil organic carbon(SOC)and total nitrogen(TN)are highly sensitive to climate change,and their dynamics are crucial to revealing the effect of climate ...The alpine ecosystem has great potential for carbon sequestration.Soil organic carbon(SOC)and total nitrogen(TN)are highly sensitive to climate change,and their dynamics are crucial to revealing the effect of climate change on the structure,function,and services of the ecosystem.However,the spatial distribution and controlling factors of SOC and TN across various soil layers and vegetation types within this unique ecosystem remain inadequately understood.In this study,256 soil samples in 89 sites were collected from the Three River Headwaters Region(TRHR)in China to investigate SOC and TN and to explore the primary factors affecting their distribution,including soil,vegetation,climate,and geography factors.The results show that SOC and TN contents in 0-20,20-40,40-60,and 60-80 cm soil layers are 24.40,18.03,14.04,12.40 g/kg and 2.46,1.90,1.51,1.17 g/kg,respectively;with higher concentrations observed in the southeastern region compared to the northwest of the TRHR.One-way analysis of variance reveals that SOC and TN levels are elevated in the alpine meadow and the alpine shrub relative to the alpine steppe in the 0-60 cm soil layers.The structural equation model explores that soil water content is the main controlling factor affecting the variation of SOC and TN.Moreover,the geography,climate,and vegetation factors notably indirectly affect SOC and TN through soil factors.Therefore,it can effectively improve soil water and nutrient conditions through vegetation restoration,soil improvement,and grazing management,and the change of SOC and TN can be fully understood by establishing monitoring networks to better protect soil carbon and nitrogen.展开更多
Digital twin can simulate and monitor the state and behavior of physical entities in the real world,helping enterprises to better understand and manage real-world physical systems,improve production efficiency,reduce ...Digital twin can simulate and monitor the state and behavior of physical entities in the real world,helping enterprises to better understand and manage real-world physical systems,improve production efficiency,reduce costs,and improve safety and reliability.In this paper,we use GTS motion control card and Unity engine to build a digital twin system,and control a virtual industrial automation handling platform including two screw servo axes and multiple sensors through the physical GTS motion control card.The control card program controls the motion of the virtual model through transmission control protocol(TCP)communication,and the virtual model system feeds back the signal to the control card program to achieve the virtual and real synchronous digital twin effect.The digital twin system uses Unity engine to create a highly realistic virtual environment,and can run on multi-platform terminals.展开更多
In this work,an oscillating-body wave energy converter(OBWEC)with a hydraulic power take-off(PTO)system named“Dolphin 1”is designed,in which the hydraulic PTO system is equivalent to a transfer station and plays a c...In this work,an oscillating-body wave energy converter(OBWEC)with a hydraulic power take-off(PTO)system named“Dolphin 1”is designed,in which the hydraulic PTO system is equivalent to a transfer station and plays a crucial role in ensuring the stability of the electrical energy output and the efficiency of the overall system.A corresponding mathematical model for the hydraulic PTO system has been established,the factors that influence its performance have been studied,and an algorithm for solving the optimal working pressure has been derived in this paper.Moreover,a PID control method to enable the hydraulic PTO system to automatically achieve optimal performance under different wave conditions has been designed.The results indicate that,compared with single-chamber hydraulic cylinders,double-chamber hydraulic cylinders have a wider application range and greater performance;the accumulator can stabilize the output power of the hydraulic PTO system and slightly increase it;excessively large or small hydraulic motor displacement hinders system performance;and each wave condition corresponds to a unique optimal working pressure for the hydraulic PTO system.In addition,the relationship between the optimal working pressure P_(m)and the pressure P_(h)of the wave force acting on the piston satisfies P_(m)^(2)=∫_(t_(1))^(t_(2))P_(h)^(2)dt/(t_(2)-t_(1)).Furthermore,adjusting the hydraulic motor displacement automatically via a PID controller ensures that the actual working pressure of the hydraulic PTO system consistently reaches or approaches its theoretically optimal value under various wave conditions,which is a very effective control method for enhancing the performance of the hydraulic PTO system.展开更多
BACKGROUND As living biodrugs,mesenchymal stem cells(MSCs)have progressed to phase 3 clinical trials for cardiovascular applications.However,their limited immediate availability hampers their routine clinical use.AIM ...BACKGROUND As living biodrugs,mesenchymal stem cells(MSCs)have progressed to phase 3 clinical trials for cardiovascular applications.However,their limited immediate availability hampers their routine clinical use.AIM To validate our hypothesis that cryopreserved MSCs(CryoMSCs)are as safe and effective as freshly cultured MSC counterparts but carry logistical advantages.METHODS Four databases were systematically reviewed for relevant randomized controlled trials(RCTs)evaluating the safety and efficacy of CryoMSCs from various tissue sources in treating patients with heart disease.A subgroup analysis was performed based on MSC source and post-thaw cell viability to determine treatment effects across different CryoMSCs sources and viability status.Weighted mean differences(WMDs)and odds ratios were calculated to measure changes in the estimated treatment effects.All statistical analyses were performed using RevMan version 5.4.1 software.RESULTS Seven RCTs(285 patients)met the eligibility criteria for inclusion in the metaanalysis.During short-term follow-up,^(Cryo)MSCs demonstrated a significant 2.11%improvement in left ventricular ejection fraction(LVEF)[WMD(95%CI)=2.11(0.66-3.56),P=0.004,I2=1%],with umbilical cord-derived MSCs being the most effective cell type.However,the significant effect on LVEF was not sustained over the 12 months of follow-up.Subgroup analysis demonstrated a substantial 3.44%improvement in LVEF[WMD(95%CI)=3.44(1.46-5.43),P=0.0007,I2=0%]when using MSCs with post-thaw viability exceeding 80%.There was no statistically significant difference in the frequency of major cardiac adverse events observed in rehospitalization or mortality in patients treated with ^(Cryo)MSCs vs the control group.CONCLUSION ^(Cryo)MSCs are a promising option for heart failure patients,particularly considering the current treatment options for cardiovascular diseases.Our data suggest that ^(Cryo)MSCs could be a viable alternative or complementary treatment to the current options,potentially improving patient outcomes.展开更多
This paper addresses the time-varying formation-containment(FC) problem for nonholonomic multi-agent systems with a desired trajectory constraint, where only the leaders can acquire information about the desired traje...This paper addresses the time-varying formation-containment(FC) problem for nonholonomic multi-agent systems with a desired trajectory constraint, where only the leaders can acquire information about the desired trajectory. Input the fixed time-varying formation template to the leader and start executing, this process also needs to track the desired trajectory, and the follower needs to converge to the convex hull that the leader crosses. Firstly, the dynamic models of nonholonomic systems are linearized to second-order dynamics. Then, based on the desired trajectory and formation template, the FC control protocols are proposed. Sufficient conditions to achieve FC are introduced and an algorithm is proposed to resolve the control parameters by solving an algebraic Riccati equation. The system is demonstrated to achieve FC, with the average position and velocity of the leaders converging asymptotically to the desired trajectory. Finally, the theoretical achievements are verified in simulations by a multi-agent system composed of virtual human individuals.展开更多
The integration of artificial intelligence into the development and production of mechatronic products offers a substantial opportunity to enhance efficiency, adaptability, and system performance. This paper examines ...The integration of artificial intelligence into the development and production of mechatronic products offers a substantial opportunity to enhance efficiency, adaptability, and system performance. This paper examines the utilization of reinforcement learning as a control strategy, with a particular focus on its deployment in pivotal stages of the product development lifecycle, specifically between system architecture and system integration and verification. A controller based on reinforcement learning was developed and evaluated in comparison to traditional proportional-integral controllers in dynamic and fault-prone environments. The results illustrate the superior adaptability, stability, and optimization potential of the reinforcement learning approach, particularly in addressing dynamic disturbances and ensuring robust performance. The study illustrates how reinforcement learning can facilitate the transition from conceptual design to implementation by automating optimization processes, enabling interface automation, and enhancing system-level testing. Based on the aforementioned findings, this paper presents future directions for research, which include the integration of domain-specific knowledge into the reinforcement learning process and the validation of this process in real-world environments. The results underscore the potential of artificial intelligence-driven methodologies to revolutionize the design and deployment of intelligent mechatronic systems.展开更多
The Australian farming sector is continuing to intensify, particularly within 300 km of the east and southern coastlines. In the future there will be fewer and larger farms, which will use more fertilizer, support mor...The Australian farming sector is continuing to intensify, particularly within 300 km of the east and southern coastlines. In the future there will be fewer and larger farms, which will use more fertilizer, support more stock, grow more monoculture crops, and utilise more marginal soils. This is likely to increase the major environmental impacts of soil degradation, salt, nutrient and sediment contamination of waterways, and greenhouse gas emissions. Australian national water policy continues to focus on land, stream and groundwater salinity issues, although there is now a greater recognition of the importance of nitrogen and phosphorus losses from agriculture. The general philosophy of policy for dealing with non- point source pollution has been towards a voluntary rather than regulatory approach, with state and national governments supporting a range of programs to encourage sustainable agricultural practices. A catchment (watershed) based approach, through the use of integrated catchment management plans, is the primary way that non-point source pollution is addressed at the farm and local level. At an industry level, cotton, grains, meat, sugarcane and dairy amongst others, as well as the Australian fertilizer industry, have responded to non-point source issues by investing in research and development, and developing codes of practice aimed at abating these environmental impacts. Understanding the economic, social, political and cultural contexts of farming as well as the environmental impacts of agriculture are very important in determining the appropriateness of policy responses for Australian farming systems.展开更多
In the case where the knowledge of goal states is not known, the controllers are constructed to stabilize unstable steady states for a coupled dynamos system. A delayed feedback control technique is used to suppress c...In the case where the knowledge of goal states is not known, the controllers are constructed to stabilize unstable steady states for a coupled dynamos system. A delayed feedback control technique is used to suppress chaos to unstable focuses and unstable periodic orbits. To overcome the topological limitation that the saddle-type steady state cannot be stabilized, an adaptive control based on LaSalle＇s invariance principle is used to control chaos to unstable equilibrium （i.e. saddle point, focus, node, etc.）. The control technique does not require any computer analysis of the system dynamics, and it operates without needing to know any explicit knowledge of the desired steady-state position.展开更多
In this paper we present the control and synchronization of a coupled Bragg acousto-optic bistable map system using nonlinear feedback technology. This nonlinear feedback technology is useful to control a temporally c...In this paper we present the control and synchronization of a coupled Bragg acousto-optic bistable map system using nonlinear feedback technology. This nonlinear feedback technology is useful to control a temporally chaotic system as well as a spatiotemporally chaotic system. It can be extended to synchronize the spatiotemporal chaos. It can work in a wide range of the controlled and synchronized signals, so it can decrease the sensitivity down to a noise level. The synchronization can be obtained by the analysis of the largest conditional Lyapunov exponent spectrum, and easily implemented in practical systems just by adjusting the coupled strength without any pre-knowledge of the dynamic system required.展开更多
文摘This paper describes a hierarchical architecture and a high-performance and interoperability protocol for centralized monitoring and controlling systems (CMCS) . The protocol we proposed can interoperate different monitoring and controlling systems constructed by different companies, each with different functions and communication protocols. The protocol reduces the amount of traffic and has real-time and high-perfor-mance advantages. The protocol was implemented in CMCS for telecommunication power supply and air-condi-tioner used by the Telecommunication Bureau of Zhejiang Province. This paper deals with the hierarchical architecture and function of CMCS and packet format, command ID, and SDL description of its protocol. We also discuss the properties of the interoperability and performance of the protocol in this paper.
文摘The relationships and the features of integration between Enterprise ProcessMonitoring and Controlling System (EPMCS) and Enterprise Process Related Applications (EPRA) wereanalyzed. An integration architecture centered on EPMCS was presented, in which there were fourlayers to connect from EPMCS to EPRA: EPMCS, application integration layer, transport layer andEPRA, and there were four layers used to etstablish integration: presentation layer, function layer,data layer and system layer. The frameworks to connect EPMCS and EPRA were designed, thatEnterprise-Independent Model (EIM), Enterprise-Specific Model (ESM) and meta-model to describe thesetwo models were defined. The method to integrate data based on XML was designed to exchange datafrom EPMCS to EPRA according to the mapping between EIM and ESM. The approches are suitable forintegrating EPMCS and systems in Product Data Management (PDM), project management and enterprisebusiness management.
基金supported by the State Grid Corporation of China Science and Technology Project,grant number 52270723000900K.
文摘The new energy power generation is becoming increasingly important in the power system.Such as photovoltaic power generation has become a research hotspot,however,due to the characteristics of light radiation changes,photovoltaic power generation is unstable and random,resulting in a low utilization rate and directly affecting the stability of the power grid.To solve this problem,this paper proposes a coordinated control strategy for a newenergy power generation system with a hybrid energy storage unit based on the lithium iron phosphate-supercapacitor hybrid energy storage unit.Firstly,the variational mode decomposition algorithm is used to separate the high and low frequencies of the power signal,which is conducive to the rapid and accurate suppression of the power fluctuation of the energy storage system.Secondly,the fuzzy control algorithm is introduced to balance the power between energy storage.In this paper,the actual data is used for simulation,and the simulation results show that the strategy realizes the effective suppression of the bus voltage fluctuation and the accurate control of the internal state of the energy storage unit,effectively avoiding problems such as overshoot and over-discharge,and can significantly improve the stability of the photovoltaic power generation systemand the stability of the Direct Current bus.It is of great significance to promote the development of collaborative control technology for photovoltaic hybrid energy storage units.
基金supported by the Science and Technology Project of the State Grid Corporation of China,Grant number 5700-202223189A-1-1-ZN.
文摘Renewable Energy Systems(RES)provide a sustainable solution to climate warming and environmental pollution by enhancing stability and reliability through status acquisition and analysis on cloud platforms and intelligent processing on edge servers(ES).However,securely distributing encrypted data stored in the cloud to terminals that meet decryption requirements has become a prominent research topic.Additionally,managing attributes,including addition,deletion,and modification,is a crucial issue in the access control scheme for RES.To address these security concerns,a trust-based ciphertext-policy attribute-based encryption(CP-ABE)device access control scheme is proposed for RES(TB-CP-ABE).This scheme effectivelymanages the distribution and control of encrypted data on the cloud through robust attribute key management.By introducing trust management mechanisms and outsourced decryption technology,the ES system can effectively assess and manage the trust worthiness of terminal devices,ensuring that only trusted devices can participate in data exchange and access sensitive information.Besides,the ES system dynamically evaluates trust scores to set decryption trust thresholds,thereby regulating device data access permissions and enhancing the system’s security.To validate the security of the proposed TB-CP-ABE against chosen plaintext attacks,a comprehensive formal security analysis is conducted using the widely accepted random oraclemodel under the decisional q-Bilinear Diffie-Hellman Exponent(q-BDHE)assumption.Finally,comparative analysis with other schemes demonstrates that the TB-CP-ABE scheme cuts energy/communication costs by 43%,and scaleswell with rising terminals,maintaining average latency below 50ms,ensuring real-time service feasibility.The proposed scheme not only provides newinsights for the secure management of RES but also lays a foundation for future secure energy solutions.
基金supported by the National Natural Science Foundation of China,Nos.81920108017(to YX),82130036(to YX),82371326(to XC),82171310(to XC)the STI2030-Major Projects,No.2022ZD0211800(to YX)Jiangsu Province Key Medical Discipline,No.ZDXK202216(to YX)。
文摘Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health challenge.Identifying optimal therapies and improving the long-term neurological functions of patients with acute central nervous system injuries are urgent priorities.Mitochondria are susceptible to damage after acute central nervous system injury,and this leads to the release of toxic levels of reactive oxygen species,which induce cell death.Mitophagy,a selective form of autophagy,is crucial in eliminating redundant or damaged mitochondria during these events.Recent evidence has highlighted the significant role of mitophagy in acute central nervous system injuries.In this review,we provide a comprehensive overview of the process,classification,and related mechanisms of mitophagy.We also highlight the recent developments in research into the role of mitophagy in various acute central nervous system injuries and drug therapies that regulate mitophagy.In the final section of this review,we emphasize the potential for treating these disorders by focusing on mitophagy and suggest future research paths in this area.
基金supported by the Natural Science Foundation of Shandong Province,No.ZR2023MC168the National Natural Science Foundation of China,No.31670989the Key R&D Program of Shandong Province,No.2019GSF107037(all to CS).
文摘Vascular endothelial growth factor and its mimic peptide KLTWQELYQLKYKGI(QK)are widely used as the most potent angiogenic factors for the treatment of multiple ischemic diseases.However,conventional topical drug delivery often results in a burst release of the drug,leading to transient retention(inefficacy)and undesirable diffusion(toxicity)in vivo.Therefore,a drug delivery system that responds to changes in the microenvironment of tissue regeneration and controls vascular endothelial growth factor release is crucial to improve the treatment of ischemic stroke.Matrix metalloproteinase-2(MMP-2)is gradually upregulated after cerebral ischemia.Herein,vascular endothelial growth factor mimic peptide QK was self-assembled with MMP-2-cleaved peptide PLGLAG(TIMP)and customizable peptide amphiphilic(PA)molecules to construct nanofiber hydrogel PA-TIMP-QK.PA-TIMP-QK was found to control the delivery of QK by MMP-2 upregulation after cerebral ischemia/reperfusion and had a similar biological activity with vascular endothelial growth factor in vitro.The results indicated that PA-TIMP-QK promoted neuronal survival,restored local blood circulation,reduced blood-brain barrier permeability,and restored motor function.These findings suggest that the self-assembling nanofiber hydrogel PA-TIMP-QK may provide an intelligent drug delivery system that responds to the microenvironment and promotes regeneration and repair after cerebral ischemia/reperfusion injury.
文摘In order to enhance the control performance of piezo-positioning system,the influence of hysteresis characteristics and its compensation method are studied.Hammerstein model is used to represent the dynamic hysteresis nonlinear characteristics of piezo-positioning actuator.The static nonlinear part and dynamic linear part of the Hammerstein model are represented by models obtained through the Prandtl-Ishlinskii(PI)model and Hankel matrix system identification method,respectively.This model demonstrates good generalization capability for typical input frequencies below 200 Hz.A sliding mode inverse compensation tracking control strategy based on P-I inverse model and integral augmentation is proposed.Experimental results show that compared with PID inverse compensation control and sliding mode control without inverse compensation,the sliding mode inverse compensation control has a more ideal step response and no overshoot,moreover,the settling time is only 6.2 ms.In the frequency domain,the system closed-loop tracking bandwidth reaches 119.9 Hz,and the disturbance rejection bandwidth reaches 86.2 Hz.The proposed control strategy can effectively compensate the hysteresis nonlinearity,and improve the tracking accuracy and antidisturbance capability of piezo-positioning system.
基金National Natural Science Foundation of China(62373102)Jiangsu Natural Science Foundation(BK20221455)Anhui Provincial Key Research and Development Project(2022i01020013)。
文摘Enhancing the stability and performance of practical control systems in the presence of nonlinearity,time delay,and uncertainty remains a significant challenge.Particularly,a class of strict-feedback nonlinear uncertain systems characterized by unknown control directions and time-varying input delay lacks comprehensive solutions.In this paper,we propose an observerbased adaptive tracking controller to address this gap.Neural networks are utilized to handle uncertainty,and a unique coordinate transformation is employed to untangle the coupling between input delay and unknown control directions.Subsequently,a new auxiliary signal counters the impact of time-varying input delay,while a Nussbaum function is introduced to solve the problem of unknown control directions.The leverage of an advanced dynamic surface control technique avoids the“complexity explosion”and reduces boundary layer errors.Synthesizing these techniques ensures that all the closed-loop signals are semi-globally uniformly ultimately bounded(SGUUB),and the tracking error converges to a small region around the origin by selecting suitable parameters.Simulation examples are provided to demonstrate the feasibility of the proposed approach.
文摘As Model-Based Systems Engineering(MBSE)was applied to the Electric Multiple Unit(EMU)braking system control logic,a preliminary exploration was conducted for bullet train braking system control logic research using an MBSE practice framework.The framework mainly includes the requirement analysis phase,functional analysis phase,and design phase.Systems Modeling Language(SysML)was used as the modeling language,and Cameo Systems Modeler(CSM)was employed as the modeling tool.By integrating the EMU braking system control logic and utilizing a top-down design approach,the implementation of MBSE in the bullet train braking system was analyzed and studied.The results show that,according to the MBSE practice framework,a unified description of the requirement analysis,functional analysis,and design synthesis of the EMU braking system control logic can be achieved.Additionally,the correlation and traceability between models can be established.
文摘It’s possible for malicious operators to seize hold of electrical control systems, for instance, the engine control unit of driverless vehicles, from various vectors, e.g. autonomic control system, remote vehicle access, or human drivers. To mitigate potential risks, this paper provides the inauguration study by proposing a theoretical framework in the physical, human and cyber triad. Its goal is to, at each time point, detect adversary control behaviors and protect control systems against malicious operations via integrating a variety of methods. This paper only proposes a theoretical framework which tries to indicate possible threats. With the support of the framework, the security system can lightly reduce the risk. The development and implementation of the system are out of scope.
文摘BACKGROUND Systematic reviews(SRs)synthesize and evaluate data,mainly from randomized trials,which then guides the development of clinical recommendations in evidence-based medicine.However,the data and methodological information in the included papers can often be lacking or unclear,and reviewers usually need to contact the authors of included studies for clarifications.Contacting authors is recommended,but it is unclear how often SR teams do it,or what the level of response is.AIM To investigate how often reviewers undertake contact with the authors of included randomized controlled trials(RCTs)for clarification on data and risk of bias concerns,to explore the factors that influence whether SR authors contact or do not contact the authors,and the content and level of responses.METHODS We conducted a systematic electronic database search in MEDLINE using the search string“(systematic review)”AND“(RCT OR randomized OR trial)”for articles published between 1 January 2024 and 19 February 2024,without language restrictions.Screening and data extraction was done independently by two reviewers,and conflicts resolved by a senior author.Contact authors of included SRs were contacted for clarifications.RESULTS Of the 329 included SRs,38%(n=125)explicitly mentioned contact with the authors of included studies.The remaining 62%(n=204)did not.We attempted contact with all SR teams for clarifications and received 90 responses(19.4%).Of the 50 respondents who did not explicitly mention contact in their SRs,25(50%)replied that they did make contact.We received a total of 64 responses on the level and content of information sought.The mean±SD contacts SR teams made were 10(10),replies received 5(6.7),and response waiting time 10.1(28.3)weeks.Resources,time,poor previous experience,perceived likelihood of poor response and bias concerns were reported as barriers to attempting contact.CONCLUSION The majority of SRs published in 2024 did not confirm seeking clarifying or missing information from primary study authors.However,SR teams reported that 50%of contacted primary authors respond.Additional research can clarify this rate of response and establish methods to increase the integration of this core methodological element in SRs.
基金supported by the National Science Foundation for Distinguished Young Scholars(No.42425107)Ecological Civilization Special Project of Key Research&and Development Program in Gansu Province(No.24YFFA009)the Top Talent Project of Gansu Province,Chinese Academy of Sciences Young Crossover Team Project(No.JCTD-2022-18)。
文摘The alpine ecosystem has great potential for carbon sequestration.Soil organic carbon(SOC)and total nitrogen(TN)are highly sensitive to climate change,and their dynamics are crucial to revealing the effect of climate change on the structure,function,and services of the ecosystem.However,the spatial distribution and controlling factors of SOC and TN across various soil layers and vegetation types within this unique ecosystem remain inadequately understood.In this study,256 soil samples in 89 sites were collected from the Three River Headwaters Region(TRHR)in China to investigate SOC and TN and to explore the primary factors affecting their distribution,including soil,vegetation,climate,and geography factors.The results show that SOC and TN contents in 0-20,20-40,40-60,and 60-80 cm soil layers are 24.40,18.03,14.04,12.40 g/kg and 2.46,1.90,1.51,1.17 g/kg,respectively;with higher concentrations observed in the southeastern region compared to the northwest of the TRHR.One-way analysis of variance reveals that SOC and TN levels are elevated in the alpine meadow and the alpine shrub relative to the alpine steppe in the 0-60 cm soil layers.The structural equation model explores that soil water content is the main controlling factor affecting the variation of SOC and TN.Moreover,the geography,climate,and vegetation factors notably indirectly affect SOC and TN through soil factors.Therefore,it can effectively improve soil water and nutrient conditions through vegetation restoration,soil improvement,and grazing management,and the change of SOC and TN can be fully understood by establishing monitoring networks to better protect soil carbon and nitrogen.
基金Research Startup Project of Shenzhen Polytechnic University“Research and Development of High-Speed and High-Resolution 2D/3D Combined Vision Sensor”(Project No.6022312003K).
文摘Digital twin can simulate and monitor the state and behavior of physical entities in the real world,helping enterprises to better understand and manage real-world physical systems,improve production efficiency,reduce costs,and improve safety and reliability.In this paper,we use GTS motion control card and Unity engine to build a digital twin system,and control a virtual industrial automation handling platform including two screw servo axes and multiple sensors through the physical GTS motion control card.The control card program controls the motion of the virtual model through transmission control protocol(TCP)communication,and the virtual model system feeds back the signal to the control card program to achieve the virtual and real synchronous digital twin effect.The digital twin system uses Unity engine to create a highly realistic virtual environment,and can run on multi-platform terminals.
基金financially supported by the National Natural Science Foundation of China(Grant Nos.52071094 and 51979065).
文摘In this work,an oscillating-body wave energy converter(OBWEC)with a hydraulic power take-off(PTO)system named“Dolphin 1”is designed,in which the hydraulic PTO system is equivalent to a transfer station and plays a crucial role in ensuring the stability of the electrical energy output and the efficiency of the overall system.A corresponding mathematical model for the hydraulic PTO system has been established,the factors that influence its performance have been studied,and an algorithm for solving the optimal working pressure has been derived in this paper.Moreover,a PID control method to enable the hydraulic PTO system to automatically achieve optimal performance under different wave conditions has been designed.The results indicate that,compared with single-chamber hydraulic cylinders,double-chamber hydraulic cylinders have a wider application range and greater performance;the accumulator can stabilize the output power of the hydraulic PTO system and slightly increase it;excessively large or small hydraulic motor displacement hinders system performance;and each wave condition corresponds to a unique optimal working pressure for the hydraulic PTO system.In addition,the relationship between the optimal working pressure P_(m)and the pressure P_(h)of the wave force acting on the piston satisfies P_(m)^(2)=∫_(t_(1))^(t_(2))P_(h)^(2)dt/(t_(2)-t_(1)).Furthermore,adjusting the hydraulic motor displacement automatically via a PID controller ensures that the actual working pressure of the hydraulic PTO system consistently reaches or approaches its theoretically optimal value under various wave conditions,which is a very effective control method for enhancing the performance of the hydraulic PTO system.
文摘BACKGROUND As living biodrugs,mesenchymal stem cells(MSCs)have progressed to phase 3 clinical trials for cardiovascular applications.However,their limited immediate availability hampers their routine clinical use.AIM To validate our hypothesis that cryopreserved MSCs(CryoMSCs)are as safe and effective as freshly cultured MSC counterparts but carry logistical advantages.METHODS Four databases were systematically reviewed for relevant randomized controlled trials(RCTs)evaluating the safety and efficacy of CryoMSCs from various tissue sources in treating patients with heart disease.A subgroup analysis was performed based on MSC source and post-thaw cell viability to determine treatment effects across different CryoMSCs sources and viability status.Weighted mean differences(WMDs)and odds ratios were calculated to measure changes in the estimated treatment effects.All statistical analyses were performed using RevMan version 5.4.1 software.RESULTS Seven RCTs(285 patients)met the eligibility criteria for inclusion in the metaanalysis.During short-term follow-up,^(Cryo)MSCs demonstrated a significant 2.11%improvement in left ventricular ejection fraction(LVEF)[WMD(95%CI)=2.11(0.66-3.56),P=0.004,I2=1%],with umbilical cord-derived MSCs being the most effective cell type.However,the significant effect on LVEF was not sustained over the 12 months of follow-up.Subgroup analysis demonstrated a substantial 3.44%improvement in LVEF[WMD(95%CI)=3.44(1.46-5.43),P=0.0007,I2=0%]when using MSCs with post-thaw viability exceeding 80%.There was no statistically significant difference in the frequency of major cardiac adverse events observed in rehospitalization or mortality in patients treated with ^(Cryo)MSCs vs the control group.CONCLUSION ^(Cryo)MSCs are a promising option for heart failure patients,particularly considering the current treatment options for cardiovascular diseases.Our data suggest that ^(Cryo)MSCs could be a viable alternative or complementary treatment to the current options,potentially improving patient outcomes.
文摘This paper addresses the time-varying formation-containment(FC) problem for nonholonomic multi-agent systems with a desired trajectory constraint, where only the leaders can acquire information about the desired trajectory. Input the fixed time-varying formation template to the leader and start executing, this process also needs to track the desired trajectory, and the follower needs to converge to the convex hull that the leader crosses. Firstly, the dynamic models of nonholonomic systems are linearized to second-order dynamics. Then, based on the desired trajectory and formation template, the FC control protocols are proposed. Sufficient conditions to achieve FC are introduced and an algorithm is proposed to resolve the control parameters by solving an algebraic Riccati equation. The system is demonstrated to achieve FC, with the average position and velocity of the leaders converging asymptotically to the desired trajectory. Finally, the theoretical achievements are verified in simulations by a multi-agent system composed of virtual human individuals.
文摘The integration of artificial intelligence into the development and production of mechatronic products offers a substantial opportunity to enhance efficiency, adaptability, and system performance. This paper examines the utilization of reinforcement learning as a control strategy, with a particular focus on its deployment in pivotal stages of the product development lifecycle, specifically between system architecture and system integration and verification. A controller based on reinforcement learning was developed and evaluated in comparison to traditional proportional-integral controllers in dynamic and fault-prone environments. The results illustrate the superior adaptability, stability, and optimization potential of the reinforcement learning approach, particularly in addressing dynamic disturbances and ensuring robust performance. The study illustrates how reinforcement learning can facilitate the transition from conceptual design to implementation by automating optimization processes, enabling interface automation, and enhancing system-level testing. Based on the aforementioned findings, this paper presents future directions for research, which include the integration of domain-specific knowledge into the reinforcement learning process and the validation of this process in real-world environments. The results underscore the potential of artificial intelligence-driven methodologies to revolutionize the design and deployment of intelligent mechatronic systems.
基金supported by the China Council for International Cooperation on Environment and Development (CCICED)
文摘The Australian farming sector is continuing to intensify, particularly within 300 km of the east and southern coastlines. In the future there will be fewer and larger farms, which will use more fertilizer, support more stock, grow more monoculture crops, and utilise more marginal soils. This is likely to increase the major environmental impacts of soil degradation, salt, nutrient and sediment contamination of waterways, and greenhouse gas emissions. Australian national water policy continues to focus on land, stream and groundwater salinity issues, although there is now a greater recognition of the importance of nitrogen and phosphorus losses from agriculture. The general philosophy of policy for dealing with non- point source pollution has been towards a voluntary rather than regulatory approach, with state and national governments supporting a range of programs to encourage sustainable agricultural practices. A catchment (watershed) based approach, through the use of integrated catchment management plans, is the primary way that non-point source pollution is addressed at the farm and local level. At an industry level, cotton, grains, meat, sugarcane and dairy amongst others, as well as the Australian fertilizer industry, have responded to non-point source issues by investing in research and development, and developing codes of practice aimed at abating these environmental impacts. Understanding the economic, social, political and cultural contexts of farming as well as the environmental impacts of agriculture are very important in determining the appropriateness of policy responses for Australian farming systems.
基金supported by the Doctoral Foundation of North China Electric Power University (Grant No. kH0433)the International Science and Technology Cooperation Program (Grant No. 2007DFA71250)
文摘In the case where the knowledge of goal states is not known, the controllers are constructed to stabilize unstable steady states for a coupled dynamos system. A delayed feedback control technique is used to suppress chaos to unstable focuses and unstable periodic orbits. To overcome the topological limitation that the saddle-type steady state cannot be stabilized, an adaptive control based on LaSalle＇s invariance principle is used to control chaos to unstable equilibrium （i.e. saddle point, focus, node, etc.）. The control technique does not require any computer analysis of the system dynamics, and it operates without needing to know any explicit knowledge of the desired steady-state position.
文摘In this paper we present the control and synchronization of a coupled Bragg acousto-optic bistable map system using nonlinear feedback technology. This nonlinear feedback technology is useful to control a temporally chaotic system as well as a spatiotemporally chaotic system. It can be extended to synchronize the spatiotemporal chaos. It can work in a wide range of the controlled and synchronized signals, so it can decrease the sensitivity down to a noise level. The synchronization can be obtained by the analysis of the largest conditional Lyapunov exponent spectrum, and easily implemented in practical systems just by adjusting the coupled strength without any pre-knowledge of the dynamic system required.
