Terrain plays a key role in landscape pattern formation, particularly in the transition zones from mountains to plains.Exploring the relationships between terrain characteristics and landscape types in terrain-complex...Terrain plays a key role in landscape pattern formation, particularly in the transition zones from mountains to plains.Exploring the relationships between terrain characteristics and landscape types in terrain-complex areas can help reveal the mechanisms underlying the relationships. In this study, Qihe River Basin, situated in the transition zone from the Taihang Mountains to the North-China Plain, was selected as a case study area. First, the spatial variations in the relief amplitudes(i.e.,high-amplitude terrain undulations) were analyzed. Second, the effects of relief amplitudes on the landscape patterns were indepth investigated from the perspectives of both landscape types and landscape indices. Finally, a logistic regression model was employed to examine the relationships between the landscape patterns and the influencing factors(natural and human) at different relief amplitudes. The results show that with increasing relief amplitude, anthropogenic landscapes gradually give in to natral landscapes. Specifically, human factors normally dominate the gentle areas(e.g., flat areas) in influencing the distribution of landscape types, and natural factors normally dominate the highly-undulating areas(e.g., moderate relief areas). As for the intermediately undulating areas(i.e.,medium relief amplitudes), a combined influence of natural and human factors result in the highest varieties of landscape types. The results also show that in micro-relief areas and small relief areas where natural factors and human factors are more or less equally active,landscape types are affected by a combination of natural and human factors.The combination leads to a high fragmentation and a high diversity of landscape patterns. It seems that appropriate human interferences in these areas can be conducive to enhancing landscape diversity and that inappropriate human interferences can aggravate the problems of landscape fragmentation.展开更多
A decade ago mainstream molecular biologists regarded it impossible or biologically ill-motivated to understand the dynamics of complex biological phenomena, such as cancer genesis and progression, from a network pers...A decade ago mainstream molecular biologists regarded it impossible or biologically ill-motivated to understand the dynamics of complex biological phenomena, such as cancer genesis and progression, from a network perspective. Indeed, there are numerical difficulties even for those who were determined to explore along this direction. Undeterred, seven years ago a group of Chinese scientists started a program aiming to obtain quantitative connections between tumors and network dynamics. Many interesting results have been obtained. In this paper we wish to test such idea from a different angle: the connection between a normal biological process and the network dynamics. We have taken early myelopoiesis as our biological model. A standard roadmap for the cell-fate diversification during hematopoiesis has already been well established experimentally, yet little was known for its underpinning dynamical mechanisms. Compounding this difficulty there were additional experimental challenges, such as the seemingly conflicting hematopoietic roadmaps and the cell-fate inter-conversion events. With early myeloid cell-fate determination in mind, we constructed a core molecular endogenous network from well-documented gene regulation and signal transduction knowledge. Turning the network into a set of dynamical equations, we found computationally several structurally robust states. Those states nicely correspond to known cell phenotypes. We also found the states connecting those stable states.They reveal the developmental routes—how one stable state would most likely turn into another stable state. Such interconnected network among stable states enabled a natural organization of cell-fates into a multi-stable state landscape. Accordingly, both the myeloid cell phenotypes and the standard roadmap were explained mechanistically in a straightforward manner. Furthermore,recent challenging observations were also explained naturally. Moreover, the landscape visually enables a prediction of a pool of additional cell states and developmental routes, including the non-sequential and cross-branch transitions, which are testable by future experiments. In summary, the endogenous network dynamics provide an integrated quantitative framework to understand the heterogeneity and lineage commitment in myeloid progenitors.展开更多
基金supported by the National Basic Research Program of China(Grant No.2015CB452702)the National Natural Science Foundation of China(Grant Nos.41671090&41601091)
文摘Terrain plays a key role in landscape pattern formation, particularly in the transition zones from mountains to plains.Exploring the relationships between terrain characteristics and landscape types in terrain-complex areas can help reveal the mechanisms underlying the relationships. In this study, Qihe River Basin, situated in the transition zone from the Taihang Mountains to the North-China Plain, was selected as a case study area. First, the spatial variations in the relief amplitudes(i.e.,high-amplitude terrain undulations) were analyzed. Second, the effects of relief amplitudes on the landscape patterns were indepth investigated from the perspectives of both landscape types and landscape indices. Finally, a logistic regression model was employed to examine the relationships between the landscape patterns and the influencing factors(natural and human) at different relief amplitudes. The results show that with increasing relief amplitude, anthropogenic landscapes gradually give in to natral landscapes. Specifically, human factors normally dominate the gentle areas(e.g., flat areas) in influencing the distribution of landscape types, and natural factors normally dominate the highly-undulating areas(e.g., moderate relief areas). As for the intermediately undulating areas(i.e.,medium relief amplitudes), a combined influence of natural and human factors result in the highest varieties of landscape types. The results also show that in micro-relief areas and small relief areas where natural factors and human factors are more or less equally active,landscape types are affected by a combination of natural and human factors.The combination leads to a high fragmentation and a high diversity of landscape patterns. It seems that appropriate human interferences in these areas can be conducive to enhancing landscape diversity and that inappropriate human interferences can aggravate the problems of landscape fragmentation.
基金supported by the National Basic Research Program of China(2010CB529200)National Natural Science Foundation of China(91029738)
文摘A decade ago mainstream molecular biologists regarded it impossible or biologically ill-motivated to understand the dynamics of complex biological phenomena, such as cancer genesis and progression, from a network perspective. Indeed, there are numerical difficulties even for those who were determined to explore along this direction. Undeterred, seven years ago a group of Chinese scientists started a program aiming to obtain quantitative connections between tumors and network dynamics. Many interesting results have been obtained. In this paper we wish to test such idea from a different angle: the connection between a normal biological process and the network dynamics. We have taken early myelopoiesis as our biological model. A standard roadmap for the cell-fate diversification during hematopoiesis has already been well established experimentally, yet little was known for its underpinning dynamical mechanisms. Compounding this difficulty there were additional experimental challenges, such as the seemingly conflicting hematopoietic roadmaps and the cell-fate inter-conversion events. With early myeloid cell-fate determination in mind, we constructed a core molecular endogenous network from well-documented gene regulation and signal transduction knowledge. Turning the network into a set of dynamical equations, we found computationally several structurally robust states. Those states nicely correspond to known cell phenotypes. We also found the states connecting those stable states.They reveal the developmental routes—how one stable state would most likely turn into another stable state. Such interconnected network among stable states enabled a natural organization of cell-fates into a multi-stable state landscape. Accordingly, both the myeloid cell phenotypes and the standard roadmap were explained mechanistically in a straightforward manner. Furthermore,recent challenging observations were also explained naturally. Moreover, the landscape visually enables a prediction of a pool of additional cell states and developmental routes, including the non-sequential and cross-branch transitions, which are testable by future experiments. In summary, the endogenous network dynamics provide an integrated quantitative framework to understand the heterogeneity and lineage commitment in myeloid progenitors.
