The magnetohydrodynamic Sutterby fluid flow instigated by a spinning stretchable disk is modeled in this study.The Stefan blowing and heat and mass flux aspects are incorporated in the thermal phenomenon.The conventio...The magnetohydrodynamic Sutterby fluid flow instigated by a spinning stretchable disk is modeled in this study.The Stefan blowing and heat and mass flux aspects are incorporated in the thermal phenomenon.The conventional models for heat and mass flux,i.e.,Fourier and Fick models,are modified using the Cattaneo-Christov(CC)model for the more accurate modeling of the process.The boundary layer equations that govern this problem are solved using the apt similarity variables.The subsequent system of equations is tackled by the Runge-Kutta-Fehlberg(RKF)scheme.The graphical visualizations of the results are discussed with the physical significance.The rates of mass and heat transmission are evaluated for the augmentation in the pertinent parameters.The Stefan blowing leads to more species diffusion which in turn increases the concentration field of the fluid.The external magnetism is observed to decrease the velocity field.Also,more thermal relaxation leads to a lower thermal field which is due to the increased time required to transfer the heat among fluid particles.The heat transport is enhanced by the stretching of the rotating disk.展开更多
Among the proposed techniques for delivering drugs to specific sites within the human body, magnetic targeting drug delivery surpasses due to its non-invasive character and its high targeting efficiency. Although ther...Among the proposed techniques for delivering drugs to specific sites within the human body, magnetic targeting drug delivery surpasses due to its non-invasive character and its high targeting efficiency. Although there have been some analyses theoretically for magnetic drug targeting, very few researchers have addressed the hydrodynamic models of magnetic fluids in the blood vessel of human body. This paper presents a mathematical model to describe the hydrodynamics of ferrofluids as drug carriers flowing in a blood vessel under the applied magnetic field. A 3D flow field of magnetic particles in a blood vessel model is numerically simulated in order to further understand clinical application of magnetic targeting drug delivery. Simulation results show that magnetic nanoparticles can be enriched in a target region depending on the applied magnetic field intensity. Magnetic resonance imaging confirms the enrichment of ferrofluids in a desired body tissue of Sprague-Dawley rats. The simulation results coincide with those animal experiments. Results of the analysis provide the important information and can suggest strategies for improving delivery in favor of the clinical application.展开更多
To solve the problem of temperature rise caused by the high power density of high-speed permanent magnet synchronous traction motors,the temperature rise of various components in the motor is analyzed by coupling the ...To solve the problem of temperature rise caused by the high power density of high-speed permanent magnet synchronous traction motors,the temperature rise of various components in the motor is analyzed by coupling the equivalent thermal circuit method and computational fluid dynamics.Also,a cooling strategy is proposed to solve the problem of temperature rise,which is expected to prolong the service life of these devices.First,the theoretical bases of the approaches used to study heat transfer and fluid mechanics are discussed,then the fluid flow for the considered motor is analyzed,and the equivalent thermal circuit method is introduced for the calculation of the temperature rise.Finally,the stator,rotor loss,motor temperature rise,and the proposed cooling method are also explored through experiments.According to the results,the stator temperature at 50,000 r/min and 60,000 r/min at no-load operation is 68℃ and 76℃,respectively.By monitoring the temperature of the air outlets inside and outside the motor at different speeds,it is also found that the motor reaches a stable temperature rise after 65 min of operation.Coupling of the thermal circuit method and computational fluid dynamics is a strategy that can provide the average temperature rise of each component and can also comprehensively calculate the temperature of each local point.We conclude that a hybrid cooling strategy based on axial air cooling of the inner air duct of the motor and water cooling of the stator can meet the design requirements for the ventilation and cooling of this type of motors.展开更多
Existing models of bulk modulus for aerated hydraulic fluids primarily focus on the effects of pressure and air fraction,whereas the effect of temperature on bulk modulus is disregarded.Based on the lumped parameter m...Existing models of bulk modulus for aerated hydraulic fluids primarily focus on the effects of pressure and air fraction,whereas the effect of temperature on bulk modulus is disregarded.Based on the lumped parameter method and the full cavitation model,combined with the improved Henry’s law and the air polytropic course equation,a theoretical model of dynamic bulk modulus for an aerated hydraulic fluid is derived.The effects of system pressure,air fraction,and temperature on bulk modulus are investigated using the controlled variable method.The results show that the dynamic bulk modulus of the aerated hydraulic fluid is inconsistent during the compression process.At the same pressure point,the dynamic bulk modulus during expansion is higher than that during compression.Under the same initial air faction and pressure changing period,a higher temperature results in a lower dynamic bulk modulus.When the pressure is lower,the dynamic bulk modulus of each temperature point is more similar to each other.By comparing the theoretical results with the actual dynamic bulk modulus of the Shell Tellus S ISO32 standard air-containing oil,the goodness-of-fit between the theoretical model and experimental value at three temperatures is 0.9726,0.9732,and 0.9675,which validates the theoretical model.In this study,a calculation model of dynamic bulk modulus that considers temperature factors is proposed.It predicts the dynamic bulk modulus of aerated hydraulic fluids at different temperatures and provides a theoretical basis for improving the analytical model of bulk modulus.展开更多
An approximate method is presented to investigate the earthquake response of the fluid-single leg (shortened for S. L.) gravity platform-soil interaction system. By assuming a suitable form of the velocity potential o...An approximate method is presented to investigate the earthquake response of the fluid-single leg (shortened for S. L.) gravity platform-soil interaction system. By assuming a suitable form of the velocity potential of the radiation waves and by using the motion equation and the boundary conditions, the unknown coefficients can be obtained. Thereafter the function of frequency for the interaction system may also be obtained. In this paper, the difference of the system dynamic response between rigid foundation is analyzed and the influences of the various foundation geometric dimension and the various water-depth on the hydrodynamic loading and dynamic response of the system is illustrated.展开更多
Selecting bridging agents properly is a critical factor in designing non-damaging or low-damaging drill-in fluids. Historically, Abrams＇ rule has been used for this purpose. However, Abrams＇ rule only addresses the ...Selecting bridging agents properly is a critical factor in designing non-damaging or low-damaging drill-in fluids. Historically, Abrams＇ rule has been used for this purpose. However, Abrams＇ rule only addresses the size of particle required to initiate a bridge. The rule does not give an optimum size nor an ideal packing sequence for minimizing fluid invasion and optimizing sealing. This paper elaborates an ideal packing approach to solving the sealing problem by sealing pores with different sizes, especially those large pores which usually make dominant contribution to permeability and thereby effectively preventing the solids and filtrate of drill-in fluids from invading into formations, compared with the conventionally used techniques. Practical software has been developed to optimize the blending proportion of several bridging agents, so as to achieve ideal packing effectiveness. The method and its use in selecting the best blending proportion of several bridging agents are also discussed in this paper. A carefully designed drill-in fluid by using the ideal packing technique （named the IPT fluid） for offshore drilling operations at the Weizhou Oilfield, Nanhai West Company, CNOOC is presented. The near 100% return permeabilities from the dynamic damage tests using reservoir cores demonstrated the excellent bridging effect provided by this drill-in fluid.展开更多
Nanoparticle-mediated drug delivery is recognized as a promising option for targeted treatment of atherosclerosis. In this paper, the Eulerian-Lagrangian technique is adopted to simulate the delivery of drug-loaded na...Nanoparticle-mediated drug delivery is recognized as a promising option for targeted treatment of atherosclerosis. In this paper, the Eulerian-Lagrangian technique is adopted to simulate the delivery of drug-loaded nanoparticles to patient-specific atherosclerotic plaque with the aid of an external magnetic field. Plaques and vascular walls are introduced as porous media formulated by the Darcy-Forchheimer model in this targeted transport process. The results demonstrate that the delivery efficiency of particles to atherosclerosis depends on the external magnetic field, such as configuration and intensity, in which the configuration angle of the current wire is a key factor and the double current wires have advantages over the single current wire. Meanwhile, the delivery efficiency gradually decreases as the distance between the plaque cap and the current wire increases. Further, although augmenting the current or magnetic susceptibility can generally improve the delivery efficiency of nanoparticles, this increase is not apparent when small-sized nanoparticles are employed as drug transport particles. The results obtained can potentially serve as the guideline to optimize regimens for the targeted therapy of atherosclerosis.展开更多
Gao＇s viscous/in-viscid interacting shear flows （ISF） theory, proposed by professor Gao Zhi in Institute of Mechanics, China Academy of Science, and its inferences and their applications in computational fluid dyna...Gao＇s viscous/in-viscid interacting shear flows （ISF） theory, proposed by professor Gao Zhi in Institute of Mechanics, China Academy of Science, and its inferences and their applications in computational fluid dynamics （CFD） are reviewed and some subjects worthy to be studied are pro- posed in this paper. The flow-field and motion law of ISF, mathematics definition of strong viscous shear layer flow in ISF, ISF equations, wall-surface compatibility criteria （Gao＇s criteria ）, space scale variety law of strong viscous shear layer reveals flow mechanism and local space small scale triggered by strong interaction that cause some abnormal severe local pneumatic heating phenomenon in hypersonic flow. Gao＇s ISF theory was used in near wall flow, free ISF flow simulation and design of computing grids, Gao＇s wall-surface criteria were used to verify calculation reliability and accuracy of near wall flows, ISF theory approximate analytical result of shock waves-boundary layer interac- tion and ISF equations were used to obtain the numerical exact solution of local area flow （ such as stationary point flow）. Some new subjects, such as, improving near-wall turbulent models according to the turbulent flow simulation satisfying the wall-criteria and illustrating relation between grid-con- vergence based on the wall criteria and other convergence tactics, are suggested. The necessity of applying Gao＇s ISF theory and wall criteria is revealed. Difficulties and importance of hypersonic vis- cous/in-viscid interaction phenomenon were also emphasized.展开更多
To improve the energy efficiency of ships and to predict ship motion response under actual sea conditions,the far-field theory,strip theory,and Fujii and Takahashi’s modified semi-empirical method are based and studi...To improve the energy efficiency of ships and to predict ship motion response under actual sea conditions,the far-field theory,strip theory,and Fujii and Takahashi’s modified semi-empirical method are based and studied to calculate the wave-induced added resistance.Firstly,a new modified formula based on the Maruo method is presented to calculate the radiation added resistance for the ship with a complex surface.Meanwhile,some calculation details such as the Green function,the shape of the sections(shape below the still water level or shape below the wave level)in the strip theory,and so on are discussed.Finally,the CFD method is used to simulate the motions of the hull and the added resistance,and the results of the CFD method and those of other numerical methods are analyzed and compared with the experiment results.The modified method in the paper can predict the added resistance in waves for the complex-hull-surface ships well and quickly.展开更多
Computer chip is always accompanied by the increase of heat dissipation and miniaturization. The miniature heat pipes are widely used in notebook computer to resolve the heat dissipation problems. Maximum heat removed...Computer chip is always accompanied by the increase of heat dissipation and miniaturization. The miniature heat pipes are widely used in notebook computer to resolve the heat dissipation problems. Maximum heat removed model of miniature heat pipes building by grey model is presented. In order to know the foundation for modeling, the smooth grade of error examination is inquired and the accuracy of grey relational grade is verified. The model can be used to select a suitable heat pipes to solve electric heat problems in the future. Final results show that the grey model only needs four experiment data and its error value is less than 10%, further, it is better than computational fluid dynamics （CFD） model.展开更多
Several aspects related with Lorentz force are discussed in the light of the presence of vibrating strings. Strings are considered as a compact,?tension and viscosity-free incompressible liquid. The motion of a charge...Several aspects related with Lorentz force are discussed in the light of the presence of vibrating strings. Strings are considered as a compact,?tension and viscosity-free incompressible liquid. The motion of a charge particle, obviously, represents the “line of vortex” in the medium of fluid. The term (VXB) turns out to be the natural consequence of Vortex dynamics. The present investigation also reveals the nature of the magnetic field and explains why and how this additional term takes part in Lorentz force.展开更多
Magnetic resonance imaging(MRI), magnetic resonance angiography(MRA) and magnetic resonance spectroscopy(MRS) are fundamental concepts used in modern medicine to improve health care. These concepts are based on the pr...Magnetic resonance imaging(MRI), magnetic resonance angiography(MRA) and magnetic resonance spectroscopy(MRS) are fundamental concepts used in modern medicine to improve health care. These concepts are based on the principle of nuclear magnetic resonance(NMR). Over the years, various laboratories around the world have applied different numerical techniques based on the Bloch NMR equations to solve specific problems in physics, biology, chemistry, engineering and medicine. The ultimate goal of any physician is to obtain maximum physical, biophysical, chemical and biological information on any tissue or cell under examination. This goal can be achieved by solving the Bloch NMR flow equations analytically. In this review, we present the basic principle of NMR/MRI in a way that can be easily understood by any researcher who needs an NMR concept to solve a specific medical problems. After a very brief history of the subject, a second order, non homogeneous, time-dependent differential equation derived from the Bloch NMR equation is presented. This equation has the basic intrinsic properties of MRI, MRA and MRS that can be extracted by means of classical and quantum mechanics for possible application in nanomedicine.展开更多
The introduction of functionalized magnetizable particles for the purification of enzymes or for the multi-use of pre-immobilized biocatalysts offers a great potential for time and cost savings in biotechnological pro...The introduction of functionalized magnetizable particles for the purification of enzymes or for the multi-use of pre-immobilized biocatalysts offers a great potential for time and cost savings in biotechnological process design. The selective separation of the magnetizable particles is performed for example by a high-gradient magnetic separator. In this study FEM and CFD simulations of the magnetic field and the fluid flow field within a filter chamber of a magnetic separator were carried out, to find an optimal separator design. The motion of virtual magnetizable particles was calculated with a one-way coupled Lagrangian approach in order to test many geometric and parametric variations in reduced time. It was found that a flow homogenisator smoothed the fluid flow, so that the linear velocity became nearly equal over the cross section in the direction of flow. Furthermore the retention of magnetizable particles increases with a high total edge length within the filter matrix.展开更多
文摘The magnetohydrodynamic Sutterby fluid flow instigated by a spinning stretchable disk is modeled in this study.The Stefan blowing and heat and mass flux aspects are incorporated in the thermal phenomenon.The conventional models for heat and mass flux,i.e.,Fourier and Fick models,are modified using the Cattaneo-Christov(CC)model for the more accurate modeling of the process.The boundary layer equations that govern this problem are solved using the apt similarity variables.The subsequent system of equations is tackled by the Runge-Kutta-Fehlberg(RKF)scheme.The graphical visualizations of the results are discussed with the physical significance.The rates of mass and heat transmission are evaluated for the augmentation in the pertinent parameters.The Stefan blowing leads to more species diffusion which in turn increases the concentration field of the fluid.The external magnetism is observed to decrease the velocity field.Also,more thermal relaxation leads to a lower thermal field which is due to the increased time required to transfer the heat among fluid particles.The heat transport is enhanced by the stretching of the rotating disk.
基金supported by National Natural Science Foundation of China (Grant No. 50875169)National Basic Research Program of China (973 Program, Grant No. 2007CB936004).
文摘Among the proposed techniques for delivering drugs to specific sites within the human body, magnetic targeting drug delivery surpasses due to its non-invasive character and its high targeting efficiency. Although there have been some analyses theoretically for magnetic drug targeting, very few researchers have addressed the hydrodynamic models of magnetic fluids in the blood vessel of human body. This paper presents a mathematical model to describe the hydrodynamics of ferrofluids as drug carriers flowing in a blood vessel under the applied magnetic field. A 3D flow field of magnetic particles in a blood vessel model is numerically simulated in order to further understand clinical application of magnetic targeting drug delivery. Simulation results show that magnetic nanoparticles can be enriched in a target region depending on the applied magnetic field intensity. Magnetic resonance imaging confirms the enrichment of ferrofluids in a desired body tissue of Sprague-Dawley rats. The simulation results coincide with those animal experiments. Results of the analysis provide the important information and can suggest strategies for improving delivery in favor of the clinical application.
文摘To solve the problem of temperature rise caused by the high power density of high-speed permanent magnet synchronous traction motors,the temperature rise of various components in the motor is analyzed by coupling the equivalent thermal circuit method and computational fluid dynamics.Also,a cooling strategy is proposed to solve the problem of temperature rise,which is expected to prolong the service life of these devices.First,the theoretical bases of the approaches used to study heat transfer and fluid mechanics are discussed,then the fluid flow for the considered motor is analyzed,and the equivalent thermal circuit method is introduced for the calculation of the temperature rise.Finally,the stator,rotor loss,motor temperature rise,and the proposed cooling method are also explored through experiments.According to the results,the stator temperature at 50,000 r/min and 60,000 r/min at no-load operation is 68℃ and 76℃,respectively.By monitoring the temperature of the air outlets inside and outside the motor at different speeds,it is also found that the motor reaches a stable temperature rise after 65 min of operation.Coupling of the thermal circuit method and computational fluid dynamics is a strategy that can provide the average temperature rise of each component and can also comprehensively calculate the temperature of each local point.We conclude that a hybrid cooling strategy based on axial air cooling of the inner air duct of the motor and water cooling of the stator can meet the design requirements for the ventilation and cooling of this type of motors.
基金National Natural Science Foundation of China(Grant Nos.52175066,51805468)Hebei Provincial National Natural Science Foundation of China(Grant No.E2020203090)+1 种基金Science and Technology Project of Hebei Education Department of China(Grant No.ZD2022052)Open Foundation of the Key Laboratory of Fire Emergency Rescue Equipment of China(Grant No.2020XFZB07).
文摘Existing models of bulk modulus for aerated hydraulic fluids primarily focus on the effects of pressure and air fraction,whereas the effect of temperature on bulk modulus is disregarded.Based on the lumped parameter method and the full cavitation model,combined with the improved Henry’s law and the air polytropic course equation,a theoretical model of dynamic bulk modulus for an aerated hydraulic fluid is derived.The effects of system pressure,air fraction,and temperature on bulk modulus are investigated using the controlled variable method.The results show that the dynamic bulk modulus of the aerated hydraulic fluid is inconsistent during the compression process.At the same pressure point,the dynamic bulk modulus during expansion is higher than that during compression.Under the same initial air faction and pressure changing period,a higher temperature results in a lower dynamic bulk modulus.When the pressure is lower,the dynamic bulk modulus of each temperature point is more similar to each other.By comparing the theoretical results with the actual dynamic bulk modulus of the Shell Tellus S ISO32 standard air-containing oil,the goodness-of-fit between the theoretical model and experimental value at three temperatures is 0.9726,0.9732,and 0.9675,which validates the theoretical model.In this study,a calculation model of dynamic bulk modulus that considers temperature factors is proposed.It predicts the dynamic bulk modulus of aerated hydraulic fluids at different temperatures and provides a theoretical basis for improving the analytical model of bulk modulus.
基金This project is financially supported by the National Natural Science Foundation of China
文摘An approximate method is presented to investigate the earthquake response of the fluid-single leg (shortened for S. L.) gravity platform-soil interaction system. By assuming a suitable form of the velocity potential of the radiation waves and by using the motion equation and the boundary conditions, the unknown coefficients can be obtained. Thereafter the function of frequency for the interaction system may also be obtained. In this paper, the difference of the system dynamic response between rigid foundation is analyzed and the influences of the various foundation geometric dimension and the various water-depth on the hydrodynamic loading and dynamic response of the system is illustrated.
基金supported by the National Natural Science Foundation(Project No.50574061)the Changjiang Scholars and Innovative Research Team(No.IRT0411),Ministry of Education
文摘Selecting bridging agents properly is a critical factor in designing non-damaging or low-damaging drill-in fluids. Historically, Abrams＇ rule has been used for this purpose. However, Abrams＇ rule only addresses the size of particle required to initiate a bridge. The rule does not give an optimum size nor an ideal packing sequence for minimizing fluid invasion and optimizing sealing. This paper elaborates an ideal packing approach to solving the sealing problem by sealing pores with different sizes, especially those large pores which usually make dominant contribution to permeability and thereby effectively preventing the solids and filtrate of drill-in fluids from invading into formations, compared with the conventionally used techniques. Practical software has been developed to optimize the blending proportion of several bridging agents, so as to achieve ideal packing effectiveness. The method and its use in selecting the best blending proportion of several bridging agents are also discussed in this paper. A carefully designed drill-in fluid by using the ideal packing technique （named the IPT fluid） for offshore drilling operations at the Weizhou Oilfield, Nanhai West Company, CNOOC is presented. The near 100% return permeabilities from the dynamic damage tests using reservoir cores demonstrated the excellent bridging effect provided by this drill-in fluid.
基金Project supported by the National Natural Science Foundation of China(Nos.11772046 and 81870345)。
文摘Nanoparticle-mediated drug delivery is recognized as a promising option for targeted treatment of atherosclerosis. In this paper, the Eulerian-Lagrangian technique is adopted to simulate the delivery of drug-loaded nanoparticles to patient-specific atherosclerotic plaque with the aid of an external magnetic field. Plaques and vascular walls are introduced as porous media formulated by the Darcy-Forchheimer model in this targeted transport process. The results demonstrate that the delivery efficiency of particles to atherosclerosis depends on the external magnetic field, such as configuration and intensity, in which the configuration angle of the current wire is a key factor and the double current wires have advantages over the single current wire. Meanwhile, the delivery efficiency gradually decreases as the distance between the plaque cap and the current wire increases. Further, although augmenting the current or magnetic susceptibility can generally improve the delivery efficiency of nanoparticles, this increase is not apparent when small-sized nanoparticles are employed as drug transport particles. The results obtained can potentially serve as the guideline to optimize regimens for the targeted therapy of atherosclerosis.
基金Supported by the National Natural Science Foundation(10702009)
文摘Gao＇s viscous/in-viscid interacting shear flows （ISF） theory, proposed by professor Gao Zhi in Institute of Mechanics, China Academy of Science, and its inferences and their applications in computational fluid dynamics （CFD） are reviewed and some subjects worthy to be studied are pro- posed in this paper. The flow-field and motion law of ISF, mathematics definition of strong viscous shear layer flow in ISF, ISF equations, wall-surface compatibility criteria （Gao＇s criteria ）, space scale variety law of strong viscous shear layer reveals flow mechanism and local space small scale triggered by strong interaction that cause some abnormal severe local pneumatic heating phenomenon in hypersonic flow. Gao＇s ISF theory was used in near wall flow, free ISF flow simulation and design of computing grids, Gao＇s wall-surface criteria were used to verify calculation reliability and accuracy of near wall flows, ISF theory approximate analytical result of shock waves-boundary layer interac- tion and ISF equations were used to obtain the numerical exact solution of local area flow （ such as stationary point flow）. Some new subjects, such as, improving near-wall turbulent models according to the turbulent flow simulation satisfying the wall-criteria and illustrating relation between grid-con- vergence based on the wall criteria and other convergence tactics, are suggested. The necessity of applying Gao＇s ISF theory and wall criteria is revealed. Difficulties and importance of hypersonic vis- cous/in-viscid interaction phenomenon were also emphasized.
基金The research was financially supported by the National Natural Science Foundation of China(Grant No.51009087)the Shanghai Natural Science Fund Project(Grant No.14ZR1419500).
文摘To improve the energy efficiency of ships and to predict ship motion response under actual sea conditions,the far-field theory,strip theory,and Fujii and Takahashi’s modified semi-empirical method are based and studied to calculate the wave-induced added resistance.Firstly,a new modified formula based on the Maruo method is presented to calculate the radiation added resistance for the ship with a complex surface.Meanwhile,some calculation details such as the Green function,the shape of the sections(shape below the still water level or shape below the wave level)in the strip theory,and so on are discussed.Finally,the CFD method is used to simulate the motions of the hull and the added resistance,and the results of the CFD method and those of other numerical methods are analyzed and compared with the experiment results.The modified method in the paper can predict the added resistance in waves for the complex-hull-surface ships well and quickly.
文摘Computer chip is always accompanied by the increase of heat dissipation and miniaturization. The miniature heat pipes are widely used in notebook computer to resolve the heat dissipation problems. Maximum heat removed model of miniature heat pipes building by grey model is presented. In order to know the foundation for modeling, the smooth grade of error examination is inquired and the accuracy of grey relational grade is verified. The model can be used to select a suitable heat pipes to solve electric heat problems in the future. Final results show that the grey model only needs four experiment data and its error value is less than 10%, further, it is better than computational fluid dynamics （CFD） model.
文摘Several aspects related with Lorentz force are discussed in the light of the presence of vibrating strings. Strings are considered as a compact,?tension and viscosity-free incompressible liquid. The motion of a charge particle, obviously, represents the “line of vortex” in the medium of fluid. The term (VXB) turns out to be the natural consequence of Vortex dynamics. The present investigation also reveals the nature of the magnetic field and explains why and how this additional term takes part in Lorentz force.
文摘Magnetic resonance imaging(MRI), magnetic resonance angiography(MRA) and magnetic resonance spectroscopy(MRS) are fundamental concepts used in modern medicine to improve health care. These concepts are based on the principle of nuclear magnetic resonance(NMR). Over the years, various laboratories around the world have applied different numerical techniques based on the Bloch NMR equations to solve specific problems in physics, biology, chemistry, engineering and medicine. The ultimate goal of any physician is to obtain maximum physical, biophysical, chemical and biological information on any tissue or cell under examination. This goal can be achieved by solving the Bloch NMR flow equations analytically. In this review, we present the basic principle of NMR/MRI in a way that can be easily understood by any researcher who needs an NMR concept to solve a specific medical problems. After a very brief history of the subject, a second order, non homogeneous, time-dependent differential equation derived from the Bloch NMR equation is presented. This equation has the basic intrinsic properties of MRI, MRA and MRS that can be extracted by means of classical and quantum mechanics for possible application in nanomedicine.
文摘The introduction of functionalized magnetizable particles for the purification of enzymes or for the multi-use of pre-immobilized biocatalysts offers a great potential for time and cost savings in biotechnological process design. The selective separation of the magnetizable particles is performed for example by a high-gradient magnetic separator. In this study FEM and CFD simulations of the magnetic field and the fluid flow field within a filter chamber of a magnetic separator were carried out, to find an optimal separator design. The motion of virtual magnetizable particles was calculated with a one-way coupled Lagrangian approach in order to test many geometric and parametric variations in reduced time. It was found that a flow homogenisator smoothed the fluid flow, so that the linear velocity became nearly equal over the cross section in the direction of flow. Furthermore the retention of magnetizable particles increases with a high total edge length within the filter matrix.
