The integration of entire supply and value chain into a closed loop network is gaining more importance in recent times in order to ensure a business to be economically and environmentally sustainable with the changing...The integration of entire supply and value chain into a closed loop network is gaining more importance in recent times in order to ensure a business to be economically and environmentally sustainable with the changing trends in business and social environments, growing environmental consciousness in the society and government legislations to protect the environment as well as the business. In this context, this paper considers a multi-echelon closed loop supply chain network design with forward and reverse logistics components. An attempt has been made to develop a mixed integer non-linear programming model for this problem with different costs so that the sum of the total cost is minimized subject to different constraints pertaining to capacities of the entities of the system, demands of first customers and second customers. A generalized model is presented and then its application is illustrated using an example problem by solving the model using LINGO14. This model forms as a tool to compare future meta-heuristics to check the closeness of their solutions with corresponding optimal solutions.展开更多
An analytical model for current-voltage behavior of amorphous In-Ga-Zn-O thin-film transistors（a-IGZO TFTs）with dual-gate structures is developed.The unified expressions for synchronous and asynchronous operating mo...An analytical model for current-voltage behavior of amorphous In-Ga-Zn-O thin-film transistors（a-IGZO TFTs）with dual-gate structures is developed.The unified expressions for synchronous and asynchronous operating modes are derived on the basis of channel charges,which are controlled by gate voltage.It is proven that the threshold voltage of asynchronous dual-gate IGZO TFTs is adjusted in proportion to the ratio of top insulating capacitance to the bottom insulating capacitance（C_（TI）/C_（BI））.Incorporating the proposed model with Verilog-A,a touch-sensing circuit using dual-gate structure is investigated by SPICE simulations.Comparison shows that the touch sensitivity is increased by the dual-gate IGZO TFT structure.展开更多
With the development of meteorological services, there are more and more types of real-time observation data, and the timeliness requirements are getting higher and higher. The monitoring methods of existing meteorolo...With the development of meteorological services, there are more and more types of real-time observation data, and the timeliness requirements are getting higher and higher. The monitoring methods of existing meteorological observation data transmission can no longer meet the needs. This paper proposes a new monitoring model, namely the “integrated monitoring model” for provincial meteorological observation data transmission. The model can complete the whole network monitoring of meteorological observation data transmission process. Based on this model, the integrated monitoring system for meteorological observation data transmission in Guangdong Province is developed. The system uses Java as the programming language, and integrates J2EE, Hibernate, Quartz, Snmp4j and Slf4j frameworks, and uses Oracle database as the data storage carrier, following the MVC specification and agile development concept. The system development uses four key technologies, including simple network management protocol, network connectivity detection technology, remote host management technology and thread pool technology. The integrated monitoring system has been put into business application. As a highlight of Guangdong’s meteorological modernization, it has played an active role in many major meteorological services.展开更多
This study integrated instrumental and relational approaches to the teaching and learning of solids in a preservice teacher＇s class. The researcher guided the preservice teachers to gather various prisms, pyramids, a...This study integrated instrumental and relational approaches to the teaching and learning of solids in a preservice teacher＇s class. The researcher guided the preservice teachers to gather various prisms, pyramids, and spheres to study the total surface areas and volumes. At the end of the integrated models, the test scores showed closed relationships in the concurrent instructional strategies of the integrated models. The researcher therefore, recommended the design models for the teaching and learning of solids in mathematics.展开更多
According to the operational characteristics of the logistics networks for the third party logistics supplier （3PLS）, the forward and reverse logistics networks together for 3PLS under the uncertain environment are ...According to the operational characteristics of the logistics networks for the third party logistics supplier （3PLS）, the forward and reverse logistics networks together for 3PLS under the uncertain environment are designed. First, a fuzzy model is proposed by taking multiple customers, multiple commodities, capacitated facility location and integrated logistics facility layout into account. In the model, the fuzzy customer demands and transportation rates are illustrated by triangular fuzzy numbers. Secondly, the fuzzy model is converted into a crisp model by applying fuzzy chance constrained theory and possibility theory, and one hybrid genetic algorithm is designed for the crisp model. Finally, two different examples are designed to illustrate that the model and solution discussed are valid.展开更多
Current formulation development strongly relies on trial-and-error experiments in the laboratory by pharmaceutical scientists,which is time-consuming,high cost and waste materials.This research aims to integrate vario...Current formulation development strongly relies on trial-and-error experiments in the laboratory by pharmaceutical scientists,which is time-consuming,high cost and waste materials.This research aims to integrate various computational tools,including machine learning,molecular dynamic simulation and physiologically based absorption modeling(PBAM),to enhance andrographolide(AG)/cyclodextrins(CDs)formulation design.The light GBM prediction model we built before was utilized to predict AG/CDs inclusion's binding free energy.AG/γ-CD inclusion complexes showed the strongest binding affinity,which was experimentally validated by the phase solubility study.The molecular dynamic simulation was used to investigate the inclusion mechanism between AG andγ-CD,which was experimentally characterized by DSC,FTIR and NMR techniques.PBAM was applied to simulate the in vivo behavior of the formulations,which were validated by cell and animal experiments.Cell experiments revealed that the presence of D-α-Tocopherol polyethylene glycol succinate(TPGS)significantly increased the intracellular uptake of AG in MDCKMDR1 cells and the absorptive transport of AG in MDCK-MDR1 monolayers.The relative bioavailability of the AG-CD-TPGS ternary system in rats was increased to 2.6-fold and 1.59-fold compared with crude AG and commercial dropping pills,respectively.In conclusion,this is the first time to integrate various computational tools to develop a new AG-CD-TPGS ternary formulation with significant improvement of aqueous solubility,dissolution rate and bioavailability.The integrated computational tool is a novel and robust methodology to facilitate pharmaceutical formulation design.展开更多
This paper creates 3D solid model and assembly of U RJ 92-6 oil tank and analyses its strength by integrated CAD/CAE/CAM software I-D EAS. Through integrated simulation in computer, design efficiency and quality of oi...This paper creates 3D solid model and assembly of U RJ 92-6 oil tank and analyses its strength by integrated CAD/CAE/CAM software I-D EAS. Through integrated simulation in computer, design efficiency and quality of oil tank is greatly improved. Adopting integrated CAD/CAE/CAM software to carry out integrated research to equ ipment and products, we will be able to take overall analysis in aspects of 3-D solid modeling, pre-assembly and strength, etc., to realize non-paper designi ng and parallel designing. Problems can be found and settled during designing, w hich will increase designing efficiency and one-time success rate and realize o ptimum designing for products.展开更多
According to the variable toe-to-heel well spacing, combined with the dislocation theory, discrete lattice method, and finite-element-method(FEM) based fluid-solid coupling, an integrated geological-engineering method...According to the variable toe-to-heel well spacing, combined with the dislocation theory, discrete lattice method, and finite-element-method(FEM) based fluid-solid coupling, an integrated geological-engineering method of volume fracturing for fan-shaped well pattern is proposed considering the geomechanical modeling, induced stress calculation, hydraulic fracturing simulation, and post-frac productivity evaluation. Besides, we propose the differential fracturing design for the conventional productivity-area and the potential production area for fan-shaped horizontal wells. After the fracturing of the conventional production area for H1 fan-shaped well platform, the research shows that the maximum reduction of the horizontal principal stress difference in the potential productivity-area is 0.2 MPa, which cannot cause the stress reversal, but this reduction is still conducive to the lateral propagation of hydraulic fractures. According to the optimized fracturing design, in zone-Ⅰ of the potential production area, only Well 2 is fractured, with a cluster spacing of 30 m and an injection rate of 12 m^(3)/min per stage;in zone-Ⅱ, Well 2 is fractured before Well 3, with a cluster spacing of 30 m and an injection rate of 12 m^(3)/min per stage. The swept area of the pore pressure drop in the potential production area is small, showing that the reservoir is not well developed. The hydraulic fracturing in the toe area can be improved by, for example, properly densifying the fractures and adjusting the fracture distribution, in order to enhance the swept volume and increase the reservoir utilization.展开更多
A projection of the Canadian population shows that in 2024 one in five Canadians will be over 65 years old. This shift forces designers to consider the entire lifetime of occupants during the design of new buildings. ...A projection of the Canadian population shows that in 2024 one in five Canadians will be over 65 years old. This shift forces designers to consider the entire lifetime of occupants during the design of new buildings. Universal Design (UD), which is a design that accommodates all people to the greatest extent possible and aging in place design that is deeply rooted in the principles of UD, aim to house people irrespective of their age, ability, and chronic health conditions. Building Information Modeling (BIM) significantly helps advance the development of the Architecture, Engineering, and Construction (AEC) industry in a more collaborative and automated way. Integrating BIM and UD allows designers to incorporate UD standards easily and efficiently at the conceptual design stage of buildings by using the functionalities and capabilities of BIM tools. Therefore, this study presents the development of an automated computer model to facilitate the adoption of UD standards and processes. The novelty highlighted in this model resides in the creation of an automated method that employs a newly created plug-in and databases to assist designers to incorporate UD standards at the conceptual stage in a timely and cost-effective manner. Furthermore, the study introduces the methodology consisting of collecting, categorizing, and storing data from various universal design and accessible design guidelines in the developed databases and developing new plug-ins in BIM tool to link the developed databases in order to automate the process of retrieving necessary information and components to help designers and owners select optimal design alternatives based on their predefined criteria.展开更多
An integration system was developed to satisfy the need of information integration in the process of designing, investment casting and monitoring aero-engine's turbo blade. The general architecture is detailed pre...An integration system was developed to satisfy the need of information integration in the process of designing, investment casting and monitoring aero-engine's turbo blade. The general architecture is detailed presented in this paper. The system mainly comprises of product master model, design information management, anti-deformation design of mould cavity, intelligence mould design and blade testing. The developed system can manage mould design and blade test data flow, optimize mould design process and achieve the goal of integration design.展开更多
Axiomatic design (AD) and theory of inventive problem solving (TRIZ) are widely used in conceptual design. Both of them have limitations, however. We presented an integrated model of these two methods to increase the ...Axiomatic design (AD) and theory of inventive problem solving (TRIZ) are widely used in conceptual design. Both of them have limitations, however. We presented an integrated model of these two methods to increase the efficiency and quality of the problem solving process for conceptual design. AD is used for systematically defining and structuring a problem into a hierarchy. Sometimes, the design matrix is coupled in AD which indicates the functional requirements are coupled. TRIZ separation principles can be used to separate non-independent design parameters, which provide innovative solutions at each hierarchical level. We applied the integrated model to the heating and drying equipment of bitumen reproduction device. The result verifies that the integrated model can work very well in conceptual design.展开更多
Given a set of requirements structured as design problems, we can apply design patterns to solve each problem individually. Much of the published literature on design patterns addresses this problem—pattern associati...Given a set of requirements structured as design problems, we can apply design patterns to solve each problem individually. Much of the published literature on design patterns addresses this problem—pattern association;however, there is no systematic and practical way that shows how to integrate those individual solutions together. We propose a compositional model based on design patterns by abstracting their behavioral model using role modeling constructs. This approach describes how to transform a design pattern into a role model that can be used to assemble a software application. The role model captures the behavioral relationship between participant components in the design pattern. Our approach offers a complete practical design and implementation strategies, adapted from DCI (Data, Context, and Interaction) architecture. We demonstrate our technique by presenting a simple case study complete with design and implementation code. We also present a simple to follow process that provides guidelines of what to do and how to do it.展开更多
文摘The integration of entire supply and value chain into a closed loop network is gaining more importance in recent times in order to ensure a business to be economically and environmentally sustainable with the changing trends in business and social environments, growing environmental consciousness in the society and government legislations to protect the environment as well as the business. In this context, this paper considers a multi-echelon closed loop supply chain network design with forward and reverse logistics components. An attempt has been made to develop a mixed integer non-linear programming model for this problem with different costs so that the sum of the total cost is minimized subject to different constraints pertaining to capacities of the entities of the system, demands of first customers and second customers. A generalized model is presented and then its application is illustrated using an example problem by solving the model using LINGO14. This model forms as a tool to compare future meta-heuristics to check the closeness of their solutions with corresponding optimal solutions.
基金Supported by the National Key Research and Development Program of China under Grant No 2017YFA0204600the National Natural Science Foundation of China under Grant No 61404002the Science and Technology Project of Hunan Province under Grant No 2015JC3041
文摘An analytical model for current-voltage behavior of amorphous In-Ga-Zn-O thin-film transistors（a-IGZO TFTs）with dual-gate structures is developed.The unified expressions for synchronous and asynchronous operating modes are derived on the basis of channel charges,which are controlled by gate voltage.It is proven that the threshold voltage of asynchronous dual-gate IGZO TFTs is adjusted in proportion to the ratio of top insulating capacitance to the bottom insulating capacitance（C_（TI）/C_（BI））.Incorporating the proposed model with Verilog-A,a touch-sensing circuit using dual-gate structure is investigated by SPICE simulations.Comparison shows that the touch sensitivity is increased by the dual-gate IGZO TFT structure.
文摘With the development of meteorological services, there are more and more types of real-time observation data, and the timeliness requirements are getting higher and higher. The monitoring methods of existing meteorological observation data transmission can no longer meet the needs. This paper proposes a new monitoring model, namely the “integrated monitoring model” for provincial meteorological observation data transmission. The model can complete the whole network monitoring of meteorological observation data transmission process. Based on this model, the integrated monitoring system for meteorological observation data transmission in Guangdong Province is developed. The system uses Java as the programming language, and integrates J2EE, Hibernate, Quartz, Snmp4j and Slf4j frameworks, and uses Oracle database as the data storage carrier, following the MVC specification and agile development concept. The system development uses four key technologies, including simple network management protocol, network connectivity detection technology, remote host management technology and thread pool technology. The integrated monitoring system has been put into business application. As a highlight of Guangdong’s meteorological modernization, it has played an active role in many major meteorological services.
文摘This study integrated instrumental and relational approaches to the teaching and learning of solids in a preservice teacher＇s class. The researcher guided the preservice teachers to gather various prisms, pyramids, and spheres to study the total surface areas and volumes. At the end of the integrated models, the test scores showed closed relationships in the concurrent instructional strategies of the integrated models. The researcher therefore, recommended the design models for the teaching and learning of solids in mathematics.
文摘According to the operational characteristics of the logistics networks for the third party logistics supplier （3PLS）, the forward and reverse logistics networks together for 3PLS under the uncertain environment are designed. First, a fuzzy model is proposed by taking multiple customers, multiple commodities, capacitated facility location and integrated logistics facility layout into account. In the model, the fuzzy customer demands and transportation rates are illustrated by triangular fuzzy numbers. Secondly, the fuzzy model is converted into a crisp model by applying fuzzy chance constrained theory and possibility theory, and one hybrid genetic algorithm is designed for the crisp model. Finally, two different examples are designed to illustrate that the model and solution discussed are valid.
基金financially supported by the FDCT Project 0029/2018/A1the University of Macao Research Grants(MYRG2019-00041-ICMS)performed in part at the High-Performance Computing Cluster(HPCC)which is supported by Information and Communication Technology Office(ICTO)of the University of Macao。
文摘Current formulation development strongly relies on trial-and-error experiments in the laboratory by pharmaceutical scientists,which is time-consuming,high cost and waste materials.This research aims to integrate various computational tools,including machine learning,molecular dynamic simulation and physiologically based absorption modeling(PBAM),to enhance andrographolide(AG)/cyclodextrins(CDs)formulation design.The light GBM prediction model we built before was utilized to predict AG/CDs inclusion's binding free energy.AG/γ-CD inclusion complexes showed the strongest binding affinity,which was experimentally validated by the phase solubility study.The molecular dynamic simulation was used to investigate the inclusion mechanism between AG andγ-CD,which was experimentally characterized by DSC,FTIR and NMR techniques.PBAM was applied to simulate the in vivo behavior of the formulations,which were validated by cell and animal experiments.Cell experiments revealed that the presence of D-α-Tocopherol polyethylene glycol succinate(TPGS)significantly increased the intracellular uptake of AG in MDCKMDR1 cells and the absorptive transport of AG in MDCK-MDR1 monolayers.The relative bioavailability of the AG-CD-TPGS ternary system in rats was increased to 2.6-fold and 1.59-fold compared with crude AG and commercial dropping pills,respectively.In conclusion,this is the first time to integrate various computational tools to develop a new AG-CD-TPGS ternary formulation with significant improvement of aqueous solubility,dissolution rate and bioavailability.The integrated computational tool is a novel and robust methodology to facilitate pharmaceutical formulation design.
文摘This paper creates 3D solid model and assembly of U RJ 92-6 oil tank and analyses its strength by integrated CAD/CAE/CAM software I-D EAS. Through integrated simulation in computer, design efficiency and quality of oil tank is greatly improved. Adopting integrated CAD/CAE/CAM software to carry out integrated research to equ ipment and products, we will be able to take overall analysis in aspects of 3-D solid modeling, pre-assembly and strength, etc., to realize non-paper designi ng and parallel designing. Problems can be found and settled during designing, w hich will increase designing efficiency and one-time success rate and realize o ptimum designing for products.
基金Supported by National Natural Science Foundation of China (52104029,U2139204)PetroChina Science and Technology Innovation Foundation (2021 DQ02-0501)。
文摘According to the variable toe-to-heel well spacing, combined with the dislocation theory, discrete lattice method, and finite-element-method(FEM) based fluid-solid coupling, an integrated geological-engineering method of volume fracturing for fan-shaped well pattern is proposed considering the geomechanical modeling, induced stress calculation, hydraulic fracturing simulation, and post-frac productivity evaluation. Besides, we propose the differential fracturing design for the conventional productivity-area and the potential production area for fan-shaped horizontal wells. After the fracturing of the conventional production area for H1 fan-shaped well platform, the research shows that the maximum reduction of the horizontal principal stress difference in the potential productivity-area is 0.2 MPa, which cannot cause the stress reversal, but this reduction is still conducive to the lateral propagation of hydraulic fractures. According to the optimized fracturing design, in zone-Ⅰ of the potential production area, only Well 2 is fractured, with a cluster spacing of 30 m and an injection rate of 12 m^(3)/min per stage;in zone-Ⅱ, Well 2 is fractured before Well 3, with a cluster spacing of 30 m and an injection rate of 12 m^(3)/min per stage. The swept area of the pore pressure drop in the potential production area is small, showing that the reservoir is not well developed. The hydraulic fracturing in the toe area can be improved by, for example, properly densifying the fractures and adjusting the fracture distribution, in order to enhance the swept volume and increase the reservoir utilization.
文摘A projection of the Canadian population shows that in 2024 one in five Canadians will be over 65 years old. This shift forces designers to consider the entire lifetime of occupants during the design of new buildings. Universal Design (UD), which is a design that accommodates all people to the greatest extent possible and aging in place design that is deeply rooted in the principles of UD, aim to house people irrespective of their age, ability, and chronic health conditions. Building Information Modeling (BIM) significantly helps advance the development of the Architecture, Engineering, and Construction (AEC) industry in a more collaborative and automated way. Integrating BIM and UD allows designers to incorporate UD standards easily and efficiently at the conceptual design stage of buildings by using the functionalities and capabilities of BIM tools. Therefore, this study presents the development of an automated computer model to facilitate the adoption of UD standards and processes. The novelty highlighted in this model resides in the creation of an automated method that employs a newly created plug-in and databases to assist designers to incorporate UD standards at the conceptual stage in a timely and cost-effective manner. Furthermore, the study introduces the methodology consisting of collecting, categorizing, and storing data from various universal design and accessible design guidelines in the developed databases and developing new plug-ins in BIM tool to link the developed databases in order to automate the process of retrieving necessary information and components to help designers and owners select optimal design alternatives based on their predefined criteria.
基金National High-tech R&D Program (863 Program) (2006AA04Z144)Key Technologies R&D Program (2006BAF04B02).
文摘An integration system was developed to satisfy the need of information integration in the process of designing, investment casting and monitoring aero-engine's turbo blade. The general architecture is detailed presented in this paper. The system mainly comprises of product master model, design information management, anti-deformation design of mould cavity, intelligence mould design and blade testing. The developed system can manage mould design and blade test data flow, optimize mould design process and achieve the goal of integration design.
基金Funded by the Natural Science Foundation of China (No. 50575083)
文摘Axiomatic design (AD) and theory of inventive problem solving (TRIZ) are widely used in conceptual design. Both of them have limitations, however. We presented an integrated model of these two methods to increase the efficiency and quality of the problem solving process for conceptual design. AD is used for systematically defining and structuring a problem into a hierarchy. Sometimes, the design matrix is coupled in AD which indicates the functional requirements are coupled. TRIZ separation principles can be used to separate non-independent design parameters, which provide innovative solutions at each hierarchical level. We applied the integrated model to the heating and drying equipment of bitumen reproduction device. The result verifies that the integrated model can work very well in conceptual design.
文摘Given a set of requirements structured as design problems, we can apply design patterns to solve each problem individually. Much of the published literature on design patterns addresses this problem—pattern association;however, there is no systematic and practical way that shows how to integrate those individual solutions together. We propose a compositional model based on design patterns by abstracting their behavioral model using role modeling constructs. This approach describes how to transform a design pattern into a role model that can be used to assemble a software application. The role model captures the behavioral relationship between participant components in the design pattern. Our approach offers a complete practical design and implementation strategies, adapted from DCI (Data, Context, and Interaction) architecture. We demonstrate our technique by presenting a simple case study complete with design and implementation code. We also present a simple to follow process that provides guidelines of what to do and how to do it.
