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Tulip bundle technique and fibrin glue injection:Unusual treatment of colonic perforation 被引量:2
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作者 Filippo Mocciaro Gabriele Curcio +4 位作者 Ilaria Tarantino Luca Barresi Marco Spada Sergio Li Petri Mario Traina 《World Journal of Gastroenterology》 SCIE CAS CSCD 2011年第8期1088-1090,共3页
We report a case of a 63-year-old male who experienced an iatrogenic sigmoid perforation repaired combining three endoscopic techniques.The lesion was large and irregular with three discrete perforations,therefore,we ... We report a case of a 63-year-old male who experienced an iatrogenic sigmoid perforation repaired combining three endoscopic techniques.The lesion was large and irregular with three discrete perforations,therefore,we decided to close it by placing one clip per perforation,and then connecting all the clips with two endoloops.Finally we chose to use a fibrin glue injection to obtain a complete sealing.Four days after the colonoscopy the patient underwent a laparoscopic right hemicolectomy due to evidence of a large polyp of the caecum with high grade dysplasia and focal carcinoma in situ.Inspection of the sigma showed complete repair of the perforation.This report underlines how a conservative approach,together with a combination of various endoscopic techniques,can resolve complicated iatrogenic perforations of the colon. 展开更多
关键词 Colonic perforation Endoscopic treatment Fibrin glue injection Tulip bundle technique
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Modified unilateral periureteral injection technique in the treatment of patients with high-grade vesicoureteral reflux: A study of primary findings
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作者 Seyed Alaeddin Asgari Afshin Safaei-Asl +5 位作者 Mandana Mansour-Ghanaie Seyed Mohammad Asgari Asghar Faryabi Mohammadreza Bazli Faezeh Emami Sigaroudi Seyed Ahmad Naseri Alavi 《Asian Journal of Urology》 CSCD 2023年第1期96-100,共5页
Objective:Although endoscopic treatment has been used by many pediatric urologists for the treatment of vesicoureteral reflux(VUR),it has no considerable success in high-grade VUR.We aimed to describe the primary outc... Objective:Although endoscopic treatment has been used by many pediatric urologists for the treatment of vesicoureteral reflux(VUR),it has no considerable success in high-grade VUR.We aimed to describe the primary outcomes of unilateral periureteral injection technique(PIT),as well as bilateral PIT in high-grade VUR.Methods:In this prospective study,we examined 92 ureters in 45 boys and 40 girls from February 2010 to May 2018.Bilateral PIT and unilateral PIT were applied in 67 and 25 refluxing units,respectively.In the unilateral PIT,the subureteral injection site was only at the 5-or 7-o’clock position.However,in the bilateral PIT,the subureteral injection sites were at 5-and 7-o’clock position.Pre-and post-operative reflux grades were evaluated by voiding cystourethrography 6 months after surgery.Results:Seven patients had bilateral reflux.Overall,75(81.5%)ureters showed Grade IV VUR,while 17(18.5%)had primary Grade V VUR.The mean age of the subjects was 39.2 months.In unilateral PIT ureters,VUR was resolved in 23(92.0%)refluxing units.It was downgraded to Grade III in one ureter(4.0%)and to Grade II in another ureter(4.0%).In addition,in bilateral PIT cases,VUR was resolved in 60(89.6%)ureters;it downgraded to Grades II and III in 3(4.5%)and 4(6.0%)refluxing units,respectively.Conclusion:Unilateral PIT can be highly effective in the treatment of selected ureters of high-grade VUR.However,further studies are needed to confirm our results. 展开更多
关键词 Periureteral injection technique Bilateral periureteral injection technique Unilateral periureteral injection technique ENDOSCOPY Vesicoureteral reflux
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Efficacy and Safety in Intramuscular Injection Techniques Using Ultrasonographic Data
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作者 Tetsuya Tanioka Kensaku Takase +4 位作者 Yuko Yasuhara Yueren Zhao Chizuru Noda Saki Hisashige Rozzano Locsin 《Health》 2018年第3期334-350,共17页
Delivered by intramuscular (IM) injections, Long Acting Injections (LAI), offering comparatively long term medicinal effects from several weeks to several months, are gaining much attention. The aim of this article wa... Delivered by intramuscular (IM) injections, Long Acting Injections (LAI), offering comparatively long term medicinal effects from several weeks to several months, are gaining much attention. The aim of this article was to indicate a safe and effective IM injection technique based on evidenced data derived from ultrasonographic data. Accurate anatomical knowledge is necessary in order to administer IM injections. It is possible to gain an adequate understanding of injection site anatomical structures by using ultrasound diagnostic devices. In particular, ultrasonography offers real-time diagnostic data allowing for observation of injection site, subcutaneous tissues, fat layers, muscle membrane, muscles and bones. To deliver the drug accurately into the muscle is essential, to achieve maximum drug efficacy and prevent injection site reactions. Therefore, when administering IM injections to the buttocks area, a suitable injection needle between 23G 25 mm to 21G or 22G 38 mm must be chosen depending on physique and drug characteristics. Needles determined as safe and effective through ultrasonographic evidence are needed such as in the case of a deltoid injection site, in which a 23G 25 mm injection needle is used in the absence of notable obesity. Not only the needle type is essential, but also the IM procedure itself. It is important to stretch the skin, inserting the needle at 90 degree angle to ensure depth of needle insertion to the muscle. Until new con-firmed evidence becomes available, it is necessary to increase the understanding of injection site selection methods, needle insertion depth, needle angle, and established IM injection techniques. The application of ultrasound devices in the development of next-generation techniques for IM injection is promising. Importantly, these techniques provide critical information from a risk management perspective. 展开更多
关键词 INTRAMUSCULAR injectION Long ACTING injectABLE injectION SITE Reaction Ultrasound DIAGNOSTIC Device INTRAMUSCULAR injectION technique
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Intramuscular vaccine administrations including the adoption of"Zeta-track technique"&"without aspiration slow injection technique"(ZTT&WASiT):a prospective review
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作者 Elena Sblendorio 《Frontiers of Nursing》 2023年第1期21-42,共22页
Objective:To review the current literature on the practice of intramuscular injections(IMIs),focusing on immunizations.Methods:The present study comprises 2 reviews,characterized by high-quality evidence,per taining t... Objective:To review the current literature on the practice of intramuscular injections(IMIs),focusing on immunizations.Methods:The present study comprises 2 reviews,characterized by high-quality evidence,per taining to the deployment of the slow injection technique without aspiration(referred to in this paper as the without-aspiration slow injection technique[WASi T])and combined with the Zeta-track technique(ZTT).The literature review is oriented toward the analysis of 2 features associated with IMIs techniques:safety and pain,integrating new evidence on vaccinee positioning for each muscle site and general relaxation techniques in the multi-parametric analysis.Results:The rigorous and in-depth reviews in the current study reveal the usefulness of including,among the international guidelines for via intramuscular immunizations,the adoption of WASi T only for compliant vaccinees,and in combination with all validated techniques for IMIs,and the use of ZTT limitedly if specific well-developed muscles are indicated.All the technique's limitations are exposed.Conclusions:Future research directions are presented by including the author's study designs to provide indirect evidence for the validity of the rationale of the slow injection technique using scientific methods,and for the conduction of future randomized controlled trials(RCTs)focused on revisiting the adoption of ZTT in a dynamic and integrated immunizations protocol in anterolateral thigh(ALT),ventrogluteal(VG),and also in the deltoid muscle,in the specific cases analyzed. 展开更多
关键词 local reactogenicity injection site reactions injection technique safety intramuscular injections immunogenicity vaccinal solution leakage without-aspiration slow technique Zeta-track technique
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LDAP Injection Techniques
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作者 Jose Maria ALONSO Antonio GUZMAN +1 位作者 Marta BELTRAN Rodolfo BORDON 《Wireless Sensor Network》 2009年第4期233-244,共12页
The increase in the number of databases accessed only by some applications has made code injection attacks an important threat to almost any current system. If one of these applications accepts inputs from a client an... The increase in the number of databases accessed only by some applications has made code injection attacks an important threat to almost any current system. If one of these applications accepts inputs from a client and executes these inputs without first validating them, the attackers are free to execute their own queries and therefore, to extract, modify or delete the content of the database associated to the application. In this paper a deep analysis of the LDAP injection techniques is presented. Furthermore, a clear distinction between classic and blind injection techniques is made. 展开更多
关键词 WEB Applications SECURITY CODE injectION techniqueS LDAP
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Construction of a model of autologous blood intracerebral hemorrhage in rats with a double injection and double needle withdrawal and the characteristics of the operative technique
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作者 Siyi Yin Zhenhui Jiang 《Neural Regeneration Research》 SCIE CAS CSCD 2006年第4期355-357,共3页
BACKGROUND : Experimental animal models of intracerebral hemorrhag (ICH) are greatly needed, so the process of establishment should be ideal in hematoma formation and easy to operate. OBJECTIVE : To construct mode... BACKGROUND : Experimental animal models of intracerebral hemorrhag (ICH) are greatly needed, so the process of establishment should be ideal in hematoma formation and easy to operate. OBJECTIVE : To construct model of ICH in rats with double injection of autologous blood taken from the cut tail cut and double withdrawal of the needle (shortened as two-step injection model), and compare with those induced by single and double injections. DESIGN : A randomized controlled tria SETTING: Department of Neurology, General Hospital of Military Area Command of Chinese PLA. MATERIALS: Thirty male Wistar rats of 10 to 12 months, weighing (400±25) g, provided by the Experimental Center of Medical Animals, General Hospital of Shenyang Military Area Command of Chinese PLA, were divided randomly into 3 groups with 10 rats in each group: two-step injection group, single injection group, double injection group. METHODS : The experiment was carried out in the Department of Neurology, General Hospital of Military Area Command of Chinese PLA from March to June in 2004. Autologous blood ICH model in rats were established as follows: In the two-step injection group, 50 μL unclotted autologous blood was taken from the rat tail cut, then injected with microsyringe into the caudate nucleus, 10 μL injected at first, paused for 2 minutes, and then the rest 40 μL injected slowly and continuously within 2 minutes. After the injection, the needle was kept immovable for about 4 minutes, withdrawn 2.0 mm, again kept immovable for about 4 minute, and then removed wholly at a slow speed. In the single injection group, 50 μL unclotted tail blood was injected slowly and continuously all within 2 minutes and the needle was slowly removed;(4) In the double injection group, 10 mL blood was injected at first, paused for 2 minutes, the rest 40 μL injected evenly within 2 minutes, and then the needle was withdrawn slowly and uninterruptedly. Neurologic findings were scored in accordance with Longa's five-point scale (0-4 scores, the higher the score, the severer the neurological dysfunction). The rats were killed to remove and sections were prepared, the morphological features of hematomas were grossly observed, the maximal diameter and size of hematomas in each slice were measured with the imaging analytical system, and the volume was calculated. Meanwhile, the conveniences of the techniques were compared. MAIN OUTCOME MEASURES: The morphological features and volume of hematomas, neurologic deficit score (NDS), and the convenience of the techniques were compared. RESULTS: All the 30 rats were involved in the analysis of results without deletion. (1) Results of the morphological observation of volume of hematoma: In the two-step injection group, hematomas located in the right caudate nucleus area regularly in circular or analogously circular shape in each slice. The formation rate of hematomas in the single injection group and double injection group were lower than those in the two-step injection group [60% (6/10), 80% (8/10), 100% (10/10), P〈 0.01, 0.05]. The volume of hematomas in the single injection group and double injection group were smaller than those in the two-step injection group [(28.5±14.8), (33.4±7.4), (41.6±3.9) mm3, P〈 0.01, 0.05]. (2) NDS results: The NDS scores in the single injection group and double injection group were smaller than that in the two-step injection group (0.90±0.83, 1.30±0.78, 1.90±0.57, P〈 0.05). (3)Comparison of the convenience of the techniques: The double injection method allowed generating reproducible hematomas in rats with shortcomings that it needed autologous arterial blood from femoral artery, and precision instruments such as microinfusion pump. The two-step injection injected fresh unclotting blood taken directly from the tail cut with microsyringe into the rat brain, and it has the advantages of easy operation, no influence on the activity of thrombase, shorter duration for model establishment, and higher rate of hematoma formation, which could generate ideal and economical models of ICH. The two-step injection induced hemotoma regularly in circular or analogously circular shape in each slice, but those induced by single and double injections were mostly in strip or fusiform shapes and extending along the needle tracks or into the ventricle or subarachnoid space. CONCLUSION : The autologous blood ICH model induced by the two-step injection method is a reproducible and reliable one in regular shape, which is better than those induced by double and single injections. 展开更多
关键词 Construction of a model of autologous blood intracerebral hemorrhage in rats with a double injection and double needle withdrawal and the characteristics of the operative technique ICH
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Production Techniques Highlighted in Banqiao Gas Condensate Field
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作者 Qin Baoyan(Science & Technohay Development Dept., Dagang Oilfield Group Ltd Company) 《China Oil & Gas》 CAS 1997年第4期218-219,共2页
关键词 GAS CONDENSATE CYCLIC injectION technique
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Modelling Key Population Attrition in the HIV and AIDS Programme in Kenya Using Random Survival Forests with Synthetic Minority Oversampling Technique-Nominal Continuous
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作者 Evan Kahacho Charity Wamwea +1 位作者 Bonface Malenje Gordon Aomo 《Journal of Data Analysis and Information Processing》 2023年第1期11-36,共26页
HIV and AIDS has continued to be a major public health concern, and hence one of the epidemics that the world resolved to end by 2030 as highlighted in sustainable development goals (SDGs). A colossal amount of effort... HIV and AIDS has continued to be a major public health concern, and hence one of the epidemics that the world resolved to end by 2030 as highlighted in sustainable development goals (SDGs). A colossal amount of effort has been taken to reduce new HIV infections, but there are still a significant number of new infections reported. HIV prevalence is more skewed towards the key population who include female sex workers (FSW), men who have sex with men (MSM), and people who inject drugs (PWID). The study design was retrospective and focused on key population enrolled in a comprehensive HIV and AIDS programme by the Kenya Red Cross Society from July 2019 to June 2021. Individuals who were either lost to follow up, defaulted (dropped out, transferred out, or relocated) or died were classified as attrition;while those who were active and alive by the end of the study were classified as retention. The study used density analysis to determine the spatial differences of key population attrition in the 19 targeted counties, and used Kilifi county as an example to map attrition cases in smaller administrative areas (sub-county level). The study used synthetic minority oversampling technique-nominal continuous (SMOTE-NC) to balance the datasets since the cases of attrition were much less than retention. The random survival forests model was then fitted to the balanced dataset. The model correctly identified attrition cases using the predicted ensemble mortality and their survival time using the estimated Kaplan-Meier survival function. The predictive performance of the model was strong and way better than random chance with concordance indices greater than 0.75. 展开更多
关键词 Random Survival Forests Synthetic Minority Oversampling technique-Nominal Continuous (SMOTE-NC) Key Population Female Sex Workers (FSW) Men Who Have Sex with Men (MSM) People Who inject Drugs (PWID)
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基于数字化美学设计的流动树脂注射充填修复技术
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作者 李依玲 邹丽 +4 位作者 陈红梅 刘杰 张琳 张玲 薛晶 《华西口腔医学杂志》 北大核心 2025年第2期289-296,共8页
如何精准恢复患牙功能、个性化还原天然牙美观,一直是牙体直接修复领域的重大挑战。传统牙体直接修复技术受限于医生的主观操作,存在技术敏感性高、操作时间长、修复效果难以预测等问题,难以满足患者对于修复效果的个性化需求。本文介... 如何精准恢复患牙功能、个性化还原天然牙美观,一直是牙体直接修复领域的重大挑战。传统牙体直接修复技术受限于医生的主观操作,存在技术敏感性高、操作时间长、修复效果难以预测等问题,难以满足患者对于修复效果的个性化需求。本文介绍了一种创新性的流动树脂注射充填修复技术,该技术通过数字化美学设计与个性化修复导板相结合,实现了牙体直接修复的精准化和个性化,颠覆了传统牙体直接修复的技术范式。该技术以患者的主观美学需求为导向,利用数字化技术预先设计修复效果,并制作出个性化的修复导板。在临床操作中,医生只需将流动树脂精准注射到导板内,即可快速完成修复,大幅缩短了操作时间,提高了修复的精准度和可预测性。数字化设计与流动树脂注射技术的结合,不但显著提升了牙体直接修复的效果,而且节省了临床操作时间,降低了对医生技术水平的要求。该技术可适用于各种牙体缺损的修复,提升患者的满意度,减轻医生的工作负担,有望成为未来临床牙体直接粘接修复的新质生产力。 展开更多
关键词 数字化设计 流动树脂 注射充填 美学修复 粘接修复
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Combination of Plugging and Acidization Improves Injection Profile
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作者 赵普春 赵化廷 杨新明 《Petroleum Science》 SCIE CAS CSCD 2004年第4期77-87,共11页
Plugging agent treatment and acid stimulation have completely different mechanisms for improving injection profiles. In this paper, a hybrid procedure is introduced to reduce the damage of the plugging agent to low a... Plugging agent treatment and acid stimulation have completely different mechanisms for improving injection profiles. In this paper, a hybrid procedure is introduced to reduce the damage of the plugging agent to low and medium permeability zones and the penetration radius of acid into high permeability zones. The procedure is: First inject plugging agent to block high permeability zones, and then inject acid to remove plugging agent damage from the low and medium permeability zones and stimulate them. To perform this procedure successfully, three kinds of plugging agents, namely strong strength plugging agent for the wells with fractures or high permeability streaks, weak gel for those with thick layer in which serious heterogeneity exists, temporary plugging agent for those in which the absorption ability of high permeability zones needs maintaining, were screened out for use in different reservoirs. Several acid systems were evaluated to be compatible with the three kinds of plugging agents. The objectives of this paper are:(1)To show the screen results about the compatible plugging agent and acid; 2 To show how to optimize the operation process;(3)To tell some experience gained ( ) from the oilfield applications of this technique. From Jan. 2001 to Dec. 2002, 46 operations using this procedure were carried out in Weicheng and Mazhai Oilfields of SINOPEC. Results show that the average benefit/cost ratio is over 3.5. Experience acquired from these applications was summarized in the paper. 展开更多
关键词 Profile Control plugging and acid inject profile IMPROVE technique
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1型糖尿病患儿住院期间发生低血糖的相关因素分析
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作者 邓迎迎 胡云 +3 位作者 龚艳艳 陶虹 邹兰 黄玉 《中国医学创新》 2025年第5期148-152,共5页
目的:分析1型糖尿病(T1DM)患儿住院期间发生低血糖的相关因素。方法:研究对象为江西省儿童医院自2021年12月-2023年12月收治的638例T1DM住院患儿,根据住院期间是否发生低血糖将患儿分为低血糖组(504例)和未发生低血糖组(134例),统计T1D... 目的:分析1型糖尿病(T1DM)患儿住院期间发生低血糖的相关因素。方法:研究对象为江西省儿童医院自2021年12月-2023年12月收治的638例T1DM住院患儿,根据住院期间是否发生低血糖将患儿分为低血糖组(504例)和未发生低血糖组(134例),统计T1DM患儿各时段低血糖发生情况,并对比两组患儿的临床资料,应用logistic回归分析筛选T1DM患儿住院期间发生低血糖的影响因素。结果:638例T1DM患儿住院期间低血糖发生率为79.00%;在检测的8个时间段中,早餐前低血糖发生密度最高,其中1级低血糖发生率为9.20%,2级低血糖发生密度为5.04%,其次为夜间,1级低血糖发生密度为6.19%,2级低血糖发生密度为4.50%,晚餐后2 h低血糖发生密度最低,1级低血糖发生密度为1.05%,2级低血糖发生密度为0.54%;两组性别、体重指数、胰岛素使用种类、空腹血糖(FPG)、甘油三酯(TG)、合并肝脏疾病、合并眼部疾病、住院天数、照护者与患儿的关系,照护者的性别、年龄、受教育年限比较差异均无统计学意义(P>0.05),两组年龄、近期确诊、胰岛素注射方式、糖化血红蛋白(HbA1c)比较,差异均有统计学意义(P<0.05);logistic回归分析显示,年龄、近期确诊、胰岛素注射方式均是T1DM患儿住院期间发生低血糖的影响因素(P<0.05)。结论:T1DM患儿住院期间低血糖发生率较高,多发生在早餐前、夜间,年龄、近期确诊、胰岛素注射方式、HbA1c均是T1DM患儿住院期间发生低血糖的独立影响因素,针对危险因素制定预防策略或能降低T1DM患儿低血糖风险。 展开更多
关键词 1型糖尿病 儿童 低血糖 胰岛素注射方式 糖化血红蛋白
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REINJECTOR注胶结合碳纤维粘贴技术在开裂桥梁加固中的应用 被引量:2
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作者 徐超 《福建建设科技》 2005年第4期19-19,56,共2页
本文介绍了采用REINJECTOR注浆技术及粘贴碳纤维布对裂缝进行综合加固,施工便利,效果可靠。
关键词 REinjectOR注胶技术 粘贴碳纤维 粘贴技术 碳纤维布 桥梁加固 应用 开裂 胶结 综合加固 注浆技术
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基于加权优劣解距离法的苦碟子注射液药物利用评价标准建立与应用
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作者 张培 马超 《中国当代医药》 2025年第3期101-105,共5页
目的建立苦碟子注射液的药物利用评价(DUE)标准,基于加权优劣解距离(TOPSIS)法对该药临床使用合理性进行评价,为促进临床合理用药提供参考。方法根据相关资料建立苦碟子注射液的DUE细则,采用加权TOPSIS法对2024年1月至4月北京丰台医院的... 目的建立苦碟子注射液的药物利用评价(DUE)标准,基于加权优劣解距离(TOPSIS)法对该药临床使用合理性进行评价,为促进临床合理用药提供参考。方法根据相关资料建立苦碟子注射液的DUE细则,采用加权TOPSIS法对2024年1月至4月北京丰台医院的154例苦碟子注射液的使用情况进行评价和分析。结果154份病历的相对接近程度系数(Ci)为38.39%~100%,其中合理病历(Ci≥80%)有62例(40.26%),基本合理病历(60%≤Ci<80%)有72例(46.75%),不合理病历(Ci<60%)有20例(12.99%)。不合理用药主要表现在疗程、用法用量、禁忌证、适应证等方面。结论基于加权TOPSIS法的苦碟子注射液用药合理性评价具有可行性,评价结果可以直观反映临床用药的总体合理性及存在的问题,更好地指导临床用药。 展开更多
关键词 苦碟子注射液 加权优劣解距离法 药物利用评价 合理用药
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油田地面注水系统的优化技术
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作者 岳鹏 《全面腐蚀控制》 2025年第1期154-156,共3页
油田的开发和开采已经成为我国一项极其重要的产业,同时在这一过程中还必须更好的了解和重视注水系统的作用和影响。另外通过应用油田地面注水系统还能够及时补充地下油层中存在的能源亏损问题,从而可使油田的开采效率得到大幅度提升。... 油田的开发和开采已经成为我国一项极其重要的产业,同时在这一过程中还必须更好的了解和重视注水系统的作用和影响。另外通过应用油田地面注水系统还能够及时补充地下油层中存在的能源亏损问题,从而可使油田的开采效率得到大幅度提升。而且通过相关研究和调查能够了解到当前我国油田地面注水系统施工过程中仍然存在一定问题。因此,本文针对油田地面注水概述和油田地面注水系统中存在的问题进行详细分析,同时也对油田地面注水系统的优化技术进行深入探讨。 展开更多
关键词 油田地面 注水系统 优化技术
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1例输液港注射座翻转手法复位经验总结
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作者 孙梦茹 郭燕平 龚媛 《中西医结合护理》 2025年第1期151-154,共4页
本文总结1例直肠癌患者手臂港术后发生注射座翻转行手法复位的护理经验。全面评估患者病情,分析注射座翻转原因。制定护理对策,给予营养支持、心理护理,加强健康宣教和输液港维护,降低输液港再次发生翻转的风险,减轻患者痛苦,确保患者... 本文总结1例直肠癌患者手臂港术后发生注射座翻转行手法复位的护理经验。全面评估患者病情,分析注射座翻转原因。制定护理对策,给予营养支持、心理护理,加强健康宣教和输液港维护,降低输液港再次发生翻转的风险,减轻患者痛苦,确保患者顺利完成治疗。 展开更多
关键词 输液港 注射座翻转 手法复位 营养支持 健康宣教 肿瘤
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基于AHM赋权联合TOPSIS法的西妥昔单抗注射液用药合理性评价
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作者 梁国栋 张威峰 +1 位作者 葛明明 范娟 《中国药业》 2025年第4期32-36,共5页
目的 为临床合理使用西妥昔单抗注射液提供参考。方法 以西妥昔单抗注射液药品说明书为基础,并以其国内外诊疗指南为依据,结合中国知网、万方、维普、美国国立综合癌症网络(NCCN)、Pub Med数据库等相关文献及医院临床用药实际情况,制订... 目的 为临床合理使用西妥昔单抗注射液提供参考。方法 以西妥昔单抗注射液药品说明书为基础,并以其国内外诊疗指南为依据,结合中国知网、万方、维普、美国国立综合癌症网络(NCCN)、Pub Med数据库等相关文献及医院临床用药实际情况,制订该药的药物利用评价(DUE)标准。通过医院信息系统(HIS)随机抽取2021年10月至2023年10月以西妥昔单抗注射液治疗的住院患者病历239份,基于属性层次模型(AHM)赋权法联合优劣解距离(TOPSIS)法计算相对接近程度(Ci),评价患者用药合理性。结果 共设定11个评价指标,分别为体力状况、适应证、用法用量、配伍禁忌、注意事项、禁忌证、联合用药、临床疗效评价、不良反应监测与处理、用药监护、医师权限,权重值分别为6.468%,13.930%,16.418%,5.970%,9.950%,3.980%,7.463%,10.448%,9.453%,12.935%,2.985%。239份病例的Ci介于38%~100%,其中≥80%(合理)161例(67.36%),60%~<80%(基本合理)55例(23.01%),<60%(不合理)23例(9.62%);不合理用药主要集中在用法用量、适应证、不良反应监测与处理等方面。结论 AHM赋权联合TOPSIS法能很好地反映西妥昔单抗注射液用药合理性,且结果直观、准确,可为优化其临床用药提供借鉴。 展开更多
关键词 属性层次模型赋权法 优劣解距离法 西妥昔单抗注射液 药物利用评价 合理用药
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Determination of Trace Non Rare Earth Elements in High Purity Rare Earth Oxides by ICP-AES with Microcolumn Preconcentration in a Flow Injection System 被引量:1
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作者 吉红念 廖振环 +1 位作者 江祖成 谢金娥 《Journal of Rare Earths》 SCIE EI CAS CSCD 1995年第2期119-124,共6页
A new method for the determination of trace non-rare earth elements in high purity rare earth oxides by ICP-AES with preconcentration on an active carbon-silica gel microcolumn in a flow injection system is described ... A new method for the determination of trace non-rare earth elements in high purity rare earth oxides by ICP-AES with preconcentration on an active carbon-silica gel microcolumn in a flow injection system is described in this paper. Experimental parameters such as pH, flow rate,reagent concentration,length of reaction coil,eluent acidity,etc. were optimized. In the buffer solution of NH3. H2O/NH4Cl at pH 4. 6,Al,Cr,Cu,Fe, Pb, V and Zn can be preconcentrated and then eluted with 4. 5 mol/L nitric acid utilizing stop-flow technique. The enrichment factors were in range of 8. 1 ̄12. 6 with detection limits of μg/m level ,and the RSD with metals at μg/g level were 2. 3 ̄5. 0% (n= 7). The method proposed can reduce the matrix interference effectively , and has been applied to the determination of non-rare earth metals atμg/g level in high purity Eu2O3 with satisfactory results. 展开更多
关键词 Flow injection ICP-AES Active carbon-silica gel Sodium diethyldithiocarbamate Stop-flow technique Microcolumn preconcentration High purity Eu_2O_3
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基于“脾胃升降理论”的中医适宜技术在胃肠疾病的规范化应用
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作者 尤金枝 王捷虹 +9 位作者 许永攀 沙志慧 王倩 穆恒 杨燕燕 刘芳芳 张豪斌 任耀龙 李力 赵理智 《陕西中医药大学学报》 2025年第2期74-78,共5页
脾胃是人体气机输布的中枢,脾主升清是脾运化、散精、统血、维系脏腑等功能的总结,若升清功能失常,治疗宜用“升清法”,如健脾以升清、理胃以升清、补肾以升清等,而灸法、穴位贴敷、中药蒸汽浴、沐足等作用于经络脏腑,协助发挥健脾、理... 脾胃是人体气机输布的中枢,脾主升清是脾运化、散精、统血、维系脏腑等功能的总结,若升清功能失常,治疗宜用“升清法”,如健脾以升清、理胃以升清、补肾以升清等,而灸法、穴位贴敷、中药蒸汽浴、沐足等作用于经络脏腑,协助发挥健脾、理胃、补肾以达升清之功。而胃通降失司、气机升降失调,宜用“通降法”,针刺、药物灌肠、中频治疗等外治法可调节气机升降,条达脏腑气化功能,祛邪扶正以疗疾。以此理论为指导辨证应用中医适宜技术协同治疗胃食管反流病、慢性胃炎、消化性溃疡、功能性消化不良、胃下垂、肠易激综合症、炎症性肠病、麻痹性肠梗阻、脓毒症胃肠功能障碍、术后胃肠功能紊乱、胃轻瘫综合征等疾病,通过升降脾胃气机、调理脏腑功能,临床疗效显著。 展开更多
关键词 脾胃升降理论 中医适宜技术 针灸疗法 穴位贴敷 穴位注射 中频治疗 中药灌肠 中药蒸汽浴 中药足浴 胃肠疾病
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Optimization of Process Parameters for Injection Moulding of Nylon6/SiC and Nylon6/B_(4)C Polymer Matrix Composites
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作者 G.Boopathy K.Gurusami +1 位作者 M.Chinnapandian K.R.Vijayakumar 《Fluid Dynamics & Materials Processing》 EI 2022年第2期223-232,共10页
In this research study,the mechanical properties of several Polymer matrix composites are investigated.These composites are multi-phase materials in which reinforcing materials are properly mixed with a polymer matrix... In this research study,the mechanical properties of several Polymer matrix composites are investigated.These composites are multi-phase materials in which reinforcing materials are properly mixed with a polymer matrix.More precisely,Nylon 6 reinforced with 5,15 and 25 wt.%of silicon carbide(SiC)and Nylon 6 reinforced with 5,15 and 25 wt.%of boron carbide(B_(4)C),prepared by means of an injection moulding process at three different injection pressures are considered.Specific attention is paid to the tensile and impact strength of these composites.The Taguchi technique is used to optimize the process parameters such as reinforcement material,its percentage and the injection pressure.It is observed that the specimens 5%SiC with 80 MPa injection pressure display a better tensile strength and similarly the specimen 5%B_(4)C with 90 MPa injection pressure have a superior impact strength. 展开更多
关键词 PMCs Nylon 6 injection moulding Taguchi technique ANOVA
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A Low Phase Noise Ring-VCO Based PLL Using Injection Locking for ZigBee Applications
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作者 Fatemeh Talebi Hassan Ghafoorifard +1 位作者 Samad Sheikhaei Sajjad Shieh Ali Saleh 《Circuits and Systems》 2013年第3期304-315,共12页
A low power low phase noise frequency synthesizer with subharmonic injection locking is proposed for ZigBee applications. The PLL is based on a ring VCO to decrease area and production cost. In order to improve phase ... A low power low phase noise frequency synthesizer with subharmonic injection locking is proposed for ZigBee applications. The PLL is based on a ring VCO to decrease area and production cost. In order to improve phase noise performance, a high frequency injection signal of which frequency varies with channel number is used. The circuit is designed in TSMC 0.18 μm CMOS technology and simulated in ADS (Advanced Design System). The phase noise at 3.5 and 10 MHz offsets is -116 and -118 dBc/Hz, respectively, and total circuit consumes 2.2 mA current. 展开更多
关键词 ZIGBEE Frequency SYNTHESIZER Phased Locked Loop injection LOCKING technique
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