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Pipeline血流导向装置治疗中小型颅内动脉瘤的安全性及有效性分析
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作者 李明洲 康慧斌 +6 位作者 谢采铃 温运宇 李鹏 张世超 王刚 张国忠 冯文峰 《中华神经外科杂志》 北大核心 2025年第3期262-267,共6页
目的探讨Pipeline血流导向装置(PED)治疗中小型颅内动脉瘤(动脉瘤最大径≤10 mm)的安全性及有效性。方法回顾性收集2018年1月至2021年12月南方医科大学南方医院神经外科采用PED治疗的90例中小型颅内动脉瘤患者的临床及影像学资料。术后6... 目的探讨Pipeline血流导向装置(PED)治疗中小型颅内动脉瘤(动脉瘤最大径≤10 mm)的安全性及有效性。方法回顾性收集2018年1月至2021年12月南方医科大学南方医院神经外科采用PED治疗的90例中小型颅内动脉瘤患者的临床及影像学资料。术后6、12、24个月对患者进行临床及数字减影血管造影(DSA)随访,采用O′Kelly-Marotta(OKM)分级评估动脉瘤的闭塞程度,采用改良Rankin量表(mRS)评分评估患者预后,其中mRS评分0~2分为预后良好。结果90例患者(108个动脉瘤)共置入90枚PED,均顺利完成。5例(5.6%)患者发生围手术期并发症,其中术后脑梗死4例,迟发性脑实质出血1例;术后支架内血栓形成1例,经溶栓治疗后管腔通畅;无一例患者发生术中或术后迟发性动脉瘤破裂或死亡。90例患者均获得临床随访,随访时间[M(Q_(1),Q_(3))]为11.0(5.0,13.0)个月;末次随访显示,预后良好率为92.2%(83/90)。79例患者(94个动脉瘤)获得DSA随访,随访时间[M(Q_(1),Q_(3))]为14.9(12.0,16.0)个月;末次随访显示,动脉瘤OKM分级A级1个(1.1%),B级5个(5.3%),C级10个(10.6%),D级78个(83.0%)。1例(1.3%)患者发生支架内狭窄,5例(6.3%)发生眼动脉分支狭窄或闭塞,2例(2.5%)发生支架外载瘤动脉近端狭窄,但均未出现明显临床症状。结论PED治疗中小型颅内动脉瘤安全、有效,且并发症发生率较低。 展开更多
关键词 颅内动脉瘤 血管内操作 治疗结果 手术后并发症 pipeline血流导向装置
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一种前后台结合的Pipelined ADC校准技术
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作者 薛颜 徐文荣 +2 位作者 于宗光 李琨 李加燊 《半导体技术》 CAS 北大核心 2025年第1期46-54,共9页
针对Pipelined模数转换器(ADC)中采样电容失配和运放增益误差带来的非线性问题,提出了一种前后台结合的Pipelined ADC校准技术。前台校准技术通过对ADC量化结果的余量分析,补偿相应流水级的量化结果,后台校准技术基于伪随机(PN)注入的方... 针对Pipelined模数转换器(ADC)中采样电容失配和运放增益误差带来的非线性问题,提出了一种前后台结合的Pipelined ADC校准技术。前台校准技术通过对ADC量化结果的余量分析,补偿相应流水级的量化结果,后台校准技术基于伪随机(PN)注入的方式,利用PN的统计特性校准增益误差。本校准技术在系统级建模和RTL级电路设计的基础上,实现了现场可编程门阵列(FPGA)验证并成功流片。测试结果显示,在1 GS/s采样速率下,校准精度为14 bit的Pipelined ADC的有效位数从9.30 bit提高到9.99 bit,信噪比提高约4 dB,无杂散动态范围提高9.5 dB,积分非线性(INL)降低约10 LSB。 展开更多
关键词 pipelined模数转换器(ADC) 电容失配 增益误差 前台校准 后台校准
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Novel Methodologies for Preventing Crack Propagation in Steel Gas Pipelines Considering the Temperature Effect
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作者 Nurlan Zhangabay Ulzhan Ibraimova +4 位作者 Marco Bonopera Ulanbator Suleimenov Konstantin Avramov Maryna Chernobryvko Aigerim Yessengali 《Structural Durability & Health Monitoring》 EI 2025年第1期1-23,共23页
Using the software ANSYS-19.2/Explicit Dynamics,this study performedfinite-element modeling of the large-diameter steel pipeline cross-section for the Beineu-Bozoy-Shymkent gas pipeline with a non-through straight crac... Using the software ANSYS-19.2/Explicit Dynamics,this study performedfinite-element modeling of the large-diameter steel pipeline cross-section for the Beineu-Bozoy-Shymkent gas pipeline with a non-through straight crack,strengthened by steel wire wrapping.The effects of the thread tensile force of the steel winding in the form of single rings at the crack edges and the wires with different winding diameters and pitches were also studied.The results showed that the strengthening was preferably executed at a minimum value of the thread tensile force,which was 6.4%more effective than that at its maximum value.The analysis of the influence of the winding dia-meters showed that the equivalent stresses increased by 32%from the beginning of the crack growth until the wire broke.The increment in winding diameter decelerated the disclosure of the edge crack and reduced its length by 8.2%.The analysis of the influence of the winding pitch showed that decreasing the distance between the winding turns also led to a 33.6%reduction in the length of the straight crack and a 7.9%reduction in the maximum stres-ses on the strengthened pipeline cross-section.The analysis of the temperature effect on the pipeline material,within a range from-40℃ to+50℃,resulted in a crack length change of up to 5.8%.As the temperature dropped,the crack length decreased.Within such a temperature range,the maximum stresses were observed along the cen-tral area of the crack,which were equal to 413 MPa at+50℃ and 440 MPa at-40℃.The results also showed that the presence of the steel winding in the pipeline significantly reduced the length of crack propagation up to 8.4 times,depending on the temperature effect and design parameters of prestressing.This work integrated the existing methods for crack localization along steel gas pipelines. 展开更多
关键词 Crack propagation finite-element internal pressure PRESTRESSING steel gas pipeline temperature effect
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Nonlinear stress analysis of aero-engine pipeline based on semi-analytical method
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作者 Weijiao CHEN Xiaochi QU +3 位作者 Ruixin ZHANG Xumin GUO Hui MA Bangchun WEN 《Applied Mathematics and Mechanics(English Edition)》 2025年第3期521-538,共18页
Fatigue failure caused by vibration is the most common type of pipeline failure.The core of this research is to obtain the nonlinear dynamic stress of a pipeline system accurately and efficiently,a topic that needs to... Fatigue failure caused by vibration is the most common type of pipeline failure.The core of this research is to obtain the nonlinear dynamic stress of a pipeline system accurately and efficiently,a topic that needs to be explored in the existing literature.The shell theory can better simulate the circumferential stress distribution,and thus the Mindlin-Reissner shell theory is used to model the pipeline.In this paper,the continuous pipeline system is combined with clamps through modal expansion for the first time,which realizes the coupling problem between a shell and a clamp.While the Bouc-Wen model is used to simulate the nonlinear external force generated by a clamp,the nonlinear coupling characteristics of the system are effectively captured.Then,the dynamic equation of the clamp-pipeline system is established according to the Lagrange energy equation.Based on the resonance frequency and stress amplitude obtained from the experiment,the nonlinear parameters of the clamp are identified with the semi-analytical method(SAM)and particle swarm optimization(PSO)algorithm.This study provides a theoretical basis for the clamp-pipeline system and an efficient and universal solution for stress prediction and analysis of pipelines in engineering. 展开更多
关键词 pipeline modeling stress analysis nonlinear-clamp support nonlinear vibration
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Hydrate Blockage in Subsea Oil/Gas Pipelines:Characterization,Detection,and Engineering Solutions
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作者 Yang Meng Bingyue Han +6 位作者 Jiguang Wang Jiawei Chu Haiyuan Yao Jiafei Zhao Lunxiang Zhang Qingping Li Yongchen Song 《Engineering》 2025年第3期363-382,共20页
With the development of offshore oil and gas resources,hydrates pose a significant challenge to flow assurance.Hydrates can form,accumulate,and settle in pipelines,causing blockages,reducing transport capacity,and lea... With the development of offshore oil and gas resources,hydrates pose a significant challenge to flow assurance.Hydrates can form,accumulate,and settle in pipelines,causing blockages,reducing transport capacity,and leading to significant economic losses and fatalities.As oil and gas exploration moves deeper into the ocean,the issue of hydrate blockages has become more severe.It is essential to take adequate measures promptly to mitigate the hazards of hydrate blockages after they form.However,a prerequisite for effective mitigation is accurately detecting the location and amount of hydrate formation.This article summarizes the temperature–pressure,acoustic,electrical,instrumental–response,and flow characteristics of hydrate formation and blocking under various conditions.It also analyzes the principles,limitations,and applicability of various blockage detection methods,including acoustic,transient,and fiber-optic-based methods.Finally,it lists the results of field experiments and commercially used products.Given their advantages of accuracy and a wide detection range,acoustic pulse reflectometry and transient-based methods are considered effective for detecting hydrate blockages in future underwater pipelines.Using strict backpressure warnings combined with accurate detection via acoustic pulse reflectometry or transient-based methods,efficient and timely diagnosis of hydrate blockages can be achieved.The use of a hydrate model combined with fiber optics could prove to be an effective method for detecting blockages in newly laid pipelines in the future. 展开更多
关键词 Oil and gas pipeline Flow assurance Hydrate blockage detection ACOUSTIC TRANSIENT
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Significant Advancements in UAV Technology for Reliable Oil and Gas Pipeline Monitoring
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作者 Ibrahim Akinjobi Aromoye Hai Hiung Lo +2 位作者 Patrick Sebastian Ghulam E Mustafa Abro Shehu Lukman Ayinla 《Computer Modeling in Engineering & Sciences》 2025年第2期1155-1197,共43页
Unmanned aerial vehicles(UAVs)technology is rapidly advancing,offering innovative solutions for various industries,including the critical task of oil and gas pipeline surveillance.However,the limited flight time of co... Unmanned aerial vehicles(UAVs)technology is rapidly advancing,offering innovative solutions for various industries,including the critical task of oil and gas pipeline surveillance.However,the limited flight time of conventional UAVs presents a significant challenge to comprehensive and continuous monitoring,which is crucial for maintaining the integrity of pipeline infrastructure.This review paper evaluates methods for extending UAV flight endurance,focusing on their potential application in pipeline inspection.Through an extensive literature review,this study identifies the latest advancements in UAV technology,evaluates their effectiveness,and highlights the existing gaps in achieving prolonged flight operations.Advanced techniques,including artificial intelligence(AI),machine learning(ML),and deep learning(DL),are reviewed for their roles in pipeline monitoring.Notably,DL algorithms like You Only Look Once(YOLO)are explored for autonomous flight in UAV-based inspections,real-time defect detection,such as cracks,corrosion,and leaks,enhancing reliability and accuracy.A vital aspect of this research is the proposed deployment of a hybrid drone design combining lighter-than-air(LTA)and heavier-than-air(HTA)principles,achieving a balance of endurance and maneuverability.LTA vehicles utilize buoyancy to reduce energy consumption,thereby extending flight durations.The paper details the methodology for designing LTA vehicles,presenting an analysis of design parameters that align with the requirements for effective pipeline surveillance.The ongoing work is currently at Technology Readiness Level(TRL)4,where key components have been validated in laboratory conditions,with fabrication and flight testing planned for the next phase.Initial design analysis indicates that LTA configurations could offer significant advantages in flight endurance compared to traditional UAV designs.These findings lay the groundwork for future fabrication and testing phases,which will be critical in validating and assessing the proposed approach’s real-world applicability.By outlining the technical complexities and proposing specialized techniques tailored for pipeline monitoring,this paper provides a foundational framework for advancing UAV capabilities in the oil and gas sector.Researchers and industry practitioners can use this roadmap to further develop UAV-enabled surveillance solutions,aiming to improve the reliability,efficiency,and safety of pipeline monitoring. 展开更多
关键词 Airship vehicle UAV technology endurance enhancement lighter-than-air vehicle pipeline monitor-ing sustainable infrastructure DRONES
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Numerical Simulation of Residual Strength for Corroded Pipelines
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作者 Yaojin Fan Huaqing Dong +3 位作者 Zixuan Zong Tingting Long Qianglin Huang Guoqiang Huang 《Structural Durability & Health Monitoring》 2025年第3期731-769,共39页
This study presents a comprehensive investigation of residual strength in corroded pipelines within the Yichang-Qianjiang section of the Sichuan-East Gas Pipeline,integrating advanced numerical simulation with experim... This study presents a comprehensive investigation of residual strength in corroded pipelines within the Yichang-Qianjiang section of the Sichuan-East Gas Pipeline,integrating advanced numerical simulation with experimental validation.The research methodology incorporates three distinct parameter grouping approaches:a random group based on statistical analysis of 389 actual corrosion defects detected during 2023 MFL inspection,a deviation group representing historically documented failure scenarios,and a structural group examining systematic parameter variations.Using ABAQUS finite element software,we developed a dynamic implicit analysis model incorporating geometric nonlinearity and validated it through 1:12.7 scaled model testing,achieving prediction deviations consistently within 5%for standard cases.Our analysis revealed distinct failure mechanisms between large and small defects,with large defects exhibiting stress concentration at circumferential edges and small defects concentrating stress centrally.Quantitative analysis identified defect depth as themost significant factor,with every 1mmincrease reducing strength by 0.054MPa,while defect length showed moderate influence at 0.0018MPa reduction per mm.Comparative analysis demonstrated that circumferential defects exhibited 15%higher burst failure pressure compared to axial defects,though this advantage diminished significantly at depths exceeding 40%wall thickness.These findings,validated through experimental testing with deviations within 5%,provide valuable insights for pipeline integrity management,particularly emphasizing the importance of defect depth monitoring and the need for orientation-specific assessment criteria in corrosion evaluation protocols. 展开更多
关键词 pipeline residual strength corrosion defect finite element analysis burst test failure mechanism
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Vibration safety assessment and parameter analysis of buried oil pipelines based on vibration isolation holes under strong surface impact
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作者 Wang Guobo Mei Hua +4 位作者 Wang Jianning He Wei Yin Yao Zhai Yuxin Zuo Pengfei 《Earthquake Engineering and Engineering Vibration》 2025年第1期69-82,共14页
Strong surface impact will produce strong vibration,which will pose a threat to the safety of nearby buried pipelines and other important lifeline projects.Based on the verified numerical method,a comprehensive numeri... Strong surface impact will produce strong vibration,which will pose a threat to the safety of nearby buried pipelines and other important lifeline projects.Based on the verified numerical method,a comprehensive numerical parameter analysis is conducted on the key influencing factors of the vibration isolation hole(VIH),which include hole diameter,hole net spacing,hole depth,hole number,hole arrangement,and soil parameters.The results indicate that a smaller ratio of net spacing to hole diameter,the deeper the hole,the multi-row hole,the hole adoption of staggered arrangements,and better site soil conditions can enhance the efficiency of the VIH barrier.The average maximum vibration reduction efficiency within the vibration isolation area can reach 42.2%.The vibration safety of adjacent oil pipelines during a dynamic compaction projection was evaluated according to existing standards,and the measurement of the VIH was recommended to reduce excessive vibration.The single-row vibration isolation scheme and three-row staggered arrangement with the same hole parameters are suggested according to different cases.The research findings can serve as a reference for the vibration safety analysis,assessment,and control of adjacent underground facilities under the influence of strong surface impact loads. 展开更多
关键词 vibration isolation hole buried oil pipeline strong surface impact vibration velocity vibration safety assessment
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Separation occurring during the drop weight tear test of thick-walled X80 pipeline steels 被引量:3
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作者 Qing-yun Sha Da-hang Li +1 位作者 Guo-jian Huang Ju Guan 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2013年第8期741-747,共7页
A separation phenomenon occurring during the drop weight tear test of commercial thick-walled API (American Petroleum Institute) X80 strip steel was investigated in this work. Microstructural analysis showed that th... A separation phenomenon occurring during the drop weight tear test of commercial thick-walled API (American Petroleum Institute) X80 strip steel was investigated in this work. Microstructural analysis showed that the band structure of bainite elongated along the rolling direction works as the initiation sites of separation. The propagation of separation can be promoted not only by the occurrence of the band structure of martensite/austenite constituent, prior austenite grain boundaries, and elongated bainite, but also by fine acicular ferrite and bainite. Wide separation formed in the former case, while the narrow one appeared in the latter case. acicular ferrite in thick-walled X80 pipeline steel in order Some methods were proposed to obtain fine and homogeneous to minimize the occurrence of separation. 展开更多
关键词 pipeline steel drop weight tear test SEPARATION cracking band structure
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Pipeline Flex血流导向装置治疗颅内动脉瘤疗效观察
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作者 谢兵 韩昊锦 +2 位作者 李锐韬 韩志安 丁明祥 《海南医学》 CAS 2024年第1期39-42,共4页
目的观察使用Pipeline Flex血流导向装置(PED)治疗颅内动脉瘤的疗效及安全性。方法回顾性分析2020年6月至2022年6月中山市人民医院使用PED治疗的25例颅内动脉瘤(共29个动脉瘤)患者的临床资料,25例患者中2例存在2个串联动脉瘤,1例有3个... 目的观察使用Pipeline Flex血流导向装置(PED)治疗颅内动脉瘤的疗效及安全性。方法回顾性分析2020年6月至2022年6月中山市人民医院使用PED治疗的25例颅内动脉瘤(共29个动脉瘤)患者的临床资料,25例患者中2例存在2个串联动脉瘤,1例有3个串联动脉瘤。29个动脉瘤分布在颈内动脉26个,大脑中动脉1个,椎基底动脉2个。术后进行临床及影像学随访,评估术后即刻动脉瘤栓塞情况和出院时患者改良Rankin评分量表(mRS),并在术后6个月及12个月时随访进行影像学检查以明确动脉瘤闭塞情况。结果25例患者均成功置入PED,其中15个动脉瘤联合弹簧圈栓塞,14个动脉瘤单独置入PED支架。术中有1例使用球囊扩张,24例经导丝微导管按摩均贴壁良好,术后临床随访中1例(4%)患者有缺血症状。术后6个月随访22个(75.9%)动脉瘤完全闭合,术后12个月随访2个(6.9%)动脉瘤影像学随访中未见闭合,27个(93.1%)动脉瘤完全闭合。结论PED治疗颅内动脉瘤短期随访安全有效,并发症较少,动脉瘤闭塞率较高。 展开更多
关键词 颅内动脉瘤 血流导向装置 治疗效果 并发症
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中短期随访时未发生支架内狭窄的Pipeline血流导向装置的长期随访结果
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作者 李元智 张航 +5 位作者 马亚静 司明磊 付宇 郭新宾 王林玉 管生 《介入放射学杂志》 CSCD 北大核心 2024年第10期1057-1063,共7页
目的探究Pipeline血流导向装置(pipeline embolization device,PED)治疗颅内动脉瘤术后中短期随访时无支架内狭窄(in-stent stenosis,ISS)的患者在长期随访时ISS的发生率。方法回顾性收集2015年4月至2022年6月在郑州大学第一附属医院神... 目的探究Pipeline血流导向装置(pipeline embolization device,PED)治疗颅内动脉瘤术后中短期随访时无支架内狭窄(in-stent stenosis,ISS)的患者在长期随访时ISS的发生率。方法回顾性收集2015年4月至2022年6月在郑州大学第一附属医院神经介入科接受PED治疗的患者资料,筛选出首次DSA随访时未发生ISS并完成术后12个月以上长期随访的颅内动脉瘤患者。收集其相关的临床及影像资料,统计在术后12个月以上的长期随访时ISS的发生率。ISS定义为随访时支架所在范围载瘤动脉较术后即刻管腔丢失>25%。结果本研究57例患者共61枚动脉瘤,置入68枚PED,41枚(67.21%)动脉瘤采用单独PED植入,20枚(32.79%)动脉瘤采用PED联合弹簧圈栓塞。中位初次随访时间184.0(119.0,212.5)d,术后12个月以上的长期随访时,35枚(57.38%)动脉瘤采用DSA随访,22枚(36.07%)动脉瘤采用CTA随访,4枚(6.56%)动脉瘤采用磁共振3D-SPACE序列随访。中位术后长期随访时间538.0(407.5,678.0)d,ISS发生率为0。所有患者均未出现ISS相关神经系统症状。结论PED治疗颅内动脉瘤术后ISS发生率低,短期随访时未发现ISS者,长期随访倾向于无ISS事件发生。 展开更多
关键词 颅内动脉瘤 pipeline血流导向装置 支架内狭窄 长期随访
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Pipeline治疗椎-基底动脉未破裂夹层动脉瘤疗效分析 被引量:1
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作者 陈宏祥 杨芳宇 +5 位作者 赵玉龙 刘佳明 杜舜尧 唐一淳 范泽政 高旭 《临床军医杂志》 CAS 2024年第4期351-355,359,共6页
目的探讨Pipeline血流导向装置(PED)治疗椎-基底动脉未破裂夹层动脉瘤的安全性和有效性,以及影响动脉瘤完全愈合的相关因素。方法选取自2019年3月至2023年3月于北部战区总医院神经外科行PED治疗的31例椎-基底动脉夹层动脉瘤患者为研究... 目的探讨Pipeline血流导向装置(PED)治疗椎-基底动脉未破裂夹层动脉瘤的安全性和有效性,以及影响动脉瘤完全愈合的相关因素。方法选取自2019年3月至2023年3月于北部战区总医院神经外科行PED治疗的31例椎-基底动脉夹层动脉瘤患者为研究对象。采用改良Rankin量表评分评估患者临床预后。术前及术后均通过数字减影血管造影(DSA)影像观察动脉瘤愈合程度,对DSA影像采用O‘Kelly-Marotta分级量表进行评估,并根据动脉瘤是否完全愈合将患者分为完全愈合组与不完全愈合组。收集患者的相关临床资料,并通过单因素分析和多因素Logistic回归分析影像动脉瘤愈合完全的因素。结果所有患者均顺利完成手术,其中,单用PED栓塞17例,PED+弹簧圈栓塞14例。缺血性并发症共发生4例(12.9%),其中,围术期发生缺血性并发症2例(6.5%),均为急性血栓形成,均予以溶栓或取栓处理,术后恢复尚可,术后远期发生缺血并发症2例(6.5%);出血性并发症共发生1例(3.2%),为术中动脉瘤破裂。随访患者中,动脉瘤完全愈合21例设为完全愈合组,不完全愈合10例设为不完全愈合组。单因素分析显示,完全愈合组和不完全愈合组的有无填圈及有无造影剂滞留静脉期患者比例比较,差异均有统计学意义(P<0.05);多因素分析结果显示,填圈和造影剂滞留静脉期均为促使动脉瘤完全愈合的影响因素(P<0.05)。结论对于后循环夹层动脉瘤,PED治疗的动脉瘤闭塞率较高,效果良好,但术后并发症不容忽视,临床应注意防治,结合弹簧圈治疗更有利于动脉瘤的愈合。 展开更多
关键词 pipeline血流导向装置 夹层动脉瘤 结合弹簧圈
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Experimental and numerical simulation study on the erosion behavior of the elbow of gathering pipeline in shale gas field 被引量:1
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作者 En-Bin Liu Shen Huang +3 位作者 Ding-Chao Tian Lai-Min Shi Shan-Bi Peng He Zheng 《Petroleum Science》 SCIE EI CAS CSCD 2024年第2期1257-1274,共18页
During the production period of shale gas, proppant particles and rock debris are produced together,which will seriously erode the elbows of gathering pipelines. In response to this problem, this paper takes the elbow... During the production period of shale gas, proppant particles and rock debris are produced together,which will seriously erode the elbows of gathering pipelines. In response to this problem, this paper takes the elbow of the gathering pipeline in the Changning Shale Gas Field as an example to test the erosion rate and material removal mechanism of the test piece at different angles of the elbow through experiments and compares the four erosion models with the experimental results. Through analysis, it is found that the best prediction model for quartz sand-carbon steel erosion is the Oka model. Based on the Oka model, FLUENT software was used to simulate and analyze the law of erosion of the elbow of the gas gathering pipeline under different gas flow velocities, gas gathering pressure, particle size, length of L1,and bending directions of the elbow. And a spiral pipeline structure is proposed to reduce the erosion rate of the elbow under the same working conditions. The results show that this structure can reduce erosion by 34%. 展开更多
关键词 Shale gas Gas gathering pipeline ELBOW EROSION CFD
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Pipeline血流导向装置治疗复杂性颅内动脉瘤预后的影响因素及列线图预测模型构建
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作者 张紫寅 邱冬 +9 位作者 郑萍 安阳 张涛 唐雪松 严智星 李苏雯 尹丽萍 姜永继 胡利刚 唐景峰 《介入放射学杂志》 CSCD 北大核心 2024年第9期944-949,共6页
目的 探讨Pipeline血流导向装置(PED)治疗复杂性颅内动脉瘤预后的影响因素。方法选择2021年1月至2023年4月安岳县人民医院和桂林医学院第二附属医院接诊的复杂性颅内动脉瘤患者98例。患者入组后均行PED治疗,收集可能影响复杂性颅内动脉... 目的 探讨Pipeline血流导向装置(PED)治疗复杂性颅内动脉瘤预后的影响因素。方法选择2021年1月至2023年4月安岳县人民医院和桂林医学院第二附属医院接诊的复杂性颅内动脉瘤患者98例。患者入组后均行PED治疗,收集可能影响复杂性颅内动脉瘤预后的影响因素。据改良Rankin量表得分将患者分为2组,≤2分为预后良好组,>2分为预后不良组,比较2组的临床资料。建立Nomograms模型并对模型进行验证。结果 98例患者中,10例(10.20%)出现预后不良。预后不良组与预后良好组患者年龄、高血压病史、糖尿病史、氯吡格雷抵抗、Fisher分级、动脉瘤多次破裂、动脉瘤位置、瘤体大小、瘤颈、多发及入院时Hunt-Hess分级差异均有统计学意义(P<0.05)。多因素分析结果显示,高血压病史、氯吡格雷抵抗、动脉瘤多次破裂、动脉瘤位置、多发及入院时Hunt-Hess分级为PED治疗复杂性颅内动脉瘤预后的独立性影响因素。Nomograms模型预测PED治疗复杂性颅内动脉瘤预后的AUC为0.849(95%CI:0.758~0.939)。模型组与验证组预测曲线与标准曲线基本拟合。决策曲线分析结果显示,当Nomograms模型预测PED治疗复杂性颅内动脉瘤预后不良的概率阈值为0.10~0.90时,患者的净受益率大于0。结论 PED治疗复杂性颅内动脉瘤预后不良的影响因素主要有高血压病史、氯吡格雷抵抗、动脉瘤多次破裂等,Nomograms模型可预测PED治疗复杂性颅内动脉瘤预后不良风险。 展开更多
关键词 pipeline血流导向装置 复杂性颅内动脉瘤 多因素分析 列线图预测模型
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New insights into the deposition of natural gas hydrate on pipeline surfaces:A molecular dynamics simulation study 被引量:1
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作者 Jun Zhang Hai-Qiang Fu +7 位作者 Mu-Zhi Guo Zhao Wang Li-Wen Li Qi Yin You-Guo Yan Wei Wei Wei-Feng Han Jie Zhong 《Petroleum Science》 SCIE EI CAS CSCD 2024年第1期694-704,共11页
Natural gas hydrate(NGH)can cause pipeline blockages during the transportation of oil and gas under high pressures and low temperatures.Reducing hydrate adhesion on pipelines is viewed as an efficient way to prevent N... Natural gas hydrate(NGH)can cause pipeline blockages during the transportation of oil and gas under high pressures and low temperatures.Reducing hydrate adhesion on pipelines is viewed as an efficient way to prevent NGH blockages.Previous studies suggested the water film can greatly increase hydrate adhesion in gas-dominant system.Herein,by performing the molecular dynamics simulations,we find in water-dominant system,the water film plays different roles in hydrate deposition on Fe and its corrosion surfaces.Specifically,due to the strong affinity of water on Fe surface,the deposited hydrate cannot convert the adsorbed water into hydrate,thus,a water film exists.As water affinities decrease(Fe>Fe_(2)O_(3)>FeO>Fe_(3)O_(4)),adsorbed water would convert to amorphous hydrate on Fe_(2)O_(3)and form the ordered hydrate on FeO and Fe_(3)O_(4)after hydrate deposition.While absorbed water film converts to amorphous or to hydrate,the adhesion strength of hydrate continuously increases(Fe<Fe_(2)O_(3)<FeO<Fe_(3)O_(4)).This is because the detachment of deposited hydrate prefers to occur at soft region of liquid layer,the process of which becomes harder as liquid layer vanishes.As a result,contrary to gas-dominant system,the water film plays the weakening roles on hydrate adhesion in water-dominant system.Overall,our results can help to better understand the hydrate deposition mechanisms on Fe and its corrosion surfaces and suggest hydrate deposition can be adjusted by changing water affinities on pipeline surfaces. 展开更多
关键词 DEPOSITION Natural gas hydrate pipelines Water affinity Adhesion strength
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Pipeline thickness estimation using the dispersion of higher-order SH guided waves 被引量:1
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作者 代政辰 刘金霞 +3 位作者 龙云飞 张建海 Tribikram Kundu 崔志文 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第7期389-396,共8页
Thickness measurement plays an important role in the monitoring of pipeline corrosion damage. However, the requirement for prior knowledge of the shear wave velocity in the pipeline material for popular ultrasonic thi... Thickness measurement plays an important role in the monitoring of pipeline corrosion damage. However, the requirement for prior knowledge of the shear wave velocity in the pipeline material for popular ultrasonic thickness measurement limits its widespread application. This paper proposes a method that utilizes cylindrical shear horizontal(SH) guided waves to estimate pipeline thickness without prior knowledge of shear wave velocity. The inversion formulas are derived from the dispersion of higher-order modes with the high-frequency approximation. The waveform of the example problems is simulated using the real-axis integral method. The data points on the dispersion curves are processed in the frequency domain using the wave-number method. These extracted data are then substituted into the derived formulas. The results verify that employing higher-order SH guided waves for the evaluation of thickness and shear wave velocity yields less than1% error. This method can be applied to both metallic and non-metallic pipelines, thus opening new possibilities for health monitoring of pipeline structures. 展开更多
关键词 pipeline wall thickness higher-order modes SH guided waves DISPERSION
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SDH-FCOS:An Efficient Neural Network for Defect Detection in Urban Underground Pipelines 被引量:1
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作者 Bin Zhou Bo Li +2 位作者 Wenfei Lan Congwen Tian Wei Yao 《Computers, Materials & Continua》 SCIE EI 2024年第1期633-652,共20页
Urban underground pipelines are an important infrastructure in cities,and timely investigation of problems in underground pipelines can help ensure the normal operation of cities.Owing to the growing demand for defect... Urban underground pipelines are an important infrastructure in cities,and timely investigation of problems in underground pipelines can help ensure the normal operation of cities.Owing to the growing demand for defect detection in urban underground pipelines,this study developed an improved defect detection method for urban underground pipelines based on fully convolutional one-stage object detector(FCOS),called spatial pyramid pooling-fast(SPPF)feature fusion and dual detection heads based on FCOS(SDH-FCOS)model.This study improved the feature fusion component of the model network based on FCOS,introduced an SPPF network structure behind the last output feature layer of the backbone network,fused the local and global features,added a top-down path to accelerate the circulation of shallowinformation,and enriched the semantic information acquired by shallow features.The ability of the model to detect objects with multiple morphologies was strengthened by introducing dual detection heads.The experimental results using an open dataset of underground pipes show that the proposed SDH-FCOS model can recognize underground pipe defects more accurately;the average accuracy was improved by 2.7% compared with the original FCOS model,reducing the leakage rate to a large extent and achieving real-time detection.Also,our model achieved a good trade-off between accuracy and speed compared with other mainstream methods.This proved the effectiveness of the proposed model. 展开更多
关键词 Urban underground pipelines defect detection SDH-FCOS feature fusion SPPF dual detection heads
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An Update on the Clinical Pipelines of New Antibacterial Drugs Developed in China 被引量:1
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作者 Xinyi Yang Congran Li +8 位作者 Xiukun Wang Zhonghui Zheng Peiyi Sun Chunjie Xu Luni Chen Jiandong Jiang Staffan Normark Birgitta Henriques-Normark Xuefu You 《Engineering》 SCIE EI CAS CSCD 2024年第7期52-68,共17页
Antibacterial resistance is a global health threat that requires further concrete action on the part of all countries.In this context,one of the biggest concerns is whether enough new antibacterial drugs are being dis... Antibacterial resistance is a global health threat that requires further concrete action on the part of all countries.In this context,one of the biggest concerns is whether enough new antibacterial drugs are being discovered and developed.Although several high-quality reviews on clinical antibacterial drug pipelines from a global perspective were published recently,none provides comprehensive information on original antibacterial drugs at clinical stages in China.In this review,we summarize the latest progress of novel antibacterial drugs approved for marketing and under clinical evaluation in China since 2019.Information was obtained by consulting official websites,searching commercial databases,retrieving literature,asking personnel from institutions or companies,and other means,and a considerable part of the data covered here has not been included in other reviews.As of June 30,2023,a total of 20 antibacterial projects from 17 Chinese pharmaceutical companies or developers were identified and updated.Among them,two new antibacterial drugs that belong to traditional antibiotic classes were approved by the National Medical Products Administration(NMPA)in China in 2019 and 2021,respectively,and 18 antibacterial agents are in clinical development,with one under regulatory evaluation,five in phase-3,six in phase-2,and six in phase-1.Most of the clinical candidates are new analogs or monocomponents of traditional antibacterial pharmacophore types,including two dual-acting hybrid antibiotics and a recombinant antibacterial protein.Overall,despite there being 17 antibacterial clinical candidates,our analysis indicates that there are still relatively few clinically differentiated antibacterial agents in stages of clinical development in China.Hopefully,Chinese pharmaceutical companies and institutions will develop more innovative and clinically differentiated candidates with good market potential in the future research and development(R&D)of original antibacterial drugs. 展开更多
关键词 Antimicrobial resistance New antibiotics Clinical pipelines WHO priority pathogens National Mega-Project for Innovative Drugs
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Numerical study on local scour characteristics around submarine pipelines in the Yellow River Delta silty sandy soil under waves and currents 被引量:1
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作者 Peng Yu Ruigeng Hu +4 位作者 Jike Zhang Qi Yang Jieru Zhao Lei Cao Chenghao Zhu 《Deep Underground Science and Engineering》 2024年第2期182-196,共15页
Due to their high reliability and cost-efficiency,submarine pipelines are widely used in offshore oil and gas resource engineering.Due to the interaction of waves,currents,seabed,and pipeline structures,the soil aroun... Due to their high reliability and cost-efficiency,submarine pipelines are widely used in offshore oil and gas resource engineering.Due to the interaction of waves,currents,seabed,and pipeline structures,the soil around submarine pipelines is prone to local scour,severely affecting their operational safety.With the Yellow River Delta as the research area and based on the renormalized group(RNG)k-εturbulence model and Stokes fifth-order wave theory,this study solves the Navier-Stokes(N-S)equation using the finite difference method.The volume of fluid(VOF)method is used to describe the fluid-free surface,and a threedimensional numerical model of currents and waves-submarine pipeline-silty sandy seabed is established.The rationality of the numerical model is verified using a self-built waveflow flume.On this basis,in this study,the local scour development and characteristics of submarine pipelines in the Yellow River Delta silty sandy seabed in the prototype environment are explored and the influence of the presence of pipelines on hydrodynamic features such as surrounding flow field,shear stress,and turbulence intensity is analyzed.The results indicate that(1)local scour around submarine pipelines can be divided into three stages:rapid scour,slow scour,and stable scour.The maximum scour depth occurs directly below the pipeline,and the shape of the scour pits is asymmetric.(2)As the water depth decreases and the pipeline suspension height increases,the scour becomes more intense.(3)When currents go through a pipeline,a clear stagnation point is formed in front of the pipeline,and the flow velocity is positively correlated with the depth of scour.This study can provide a valuable reference for the protection of submarine pipelines in this area. 展开更多
关键词 local scour numerical simulation submarine pipelines Yellow River Delta
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Analysis of faulting destruction and water supply pipeline damage from the first mainshock of the February 6,2023 Türkiye earthquake doublet 被引量:1
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作者 Xiaoqing Fan Libao Zhang +2 位作者 Juke Wang Yefei Ren Aiwen Liu 《Earthquake Science》 2024年第1期78-90,共13页
In 2023,two consecutive earthquakes exceeding a magnitude of 7 occurred in Türkiye,causing severe casualties and economic losses.The damage to critical urban infrastructure and building structures,including highw... In 2023,two consecutive earthquakes exceeding a magnitude of 7 occurred in Türkiye,causing severe casualties and economic losses.The damage to critical urban infrastructure and building structures,including highways,railroads,and water supply pipelines,was particularly severe in areas where these structures intersected the seismogenic fault.Critical infrastructure projects that traverse active faults are susceptible to the influence of fault movement,pulse velocity,and ground motions.In this study,we used a unique approach to analyze the acceleration records obtained from the seismic station array(9 strong ground motion stations)located along the East Anatolian Fault(the seismogenic fault of the MW7.8 mainshock of the 2023 Türkiye earthquake doublet).The acceleration records were filtered and integrated to obtain the velocity and displacement time histories.We used the results of an on-site investigation,jointly conducted by China Earthquake Administration and Türkiye’s AFAD,to analyze the distribution of PGA,PGV,and PGD recorded by the strong motion array of the East Anatolian Fault.We found that the maximum horizontal PGA in this earthquake was 3.0 g,and the maximum co-seismic surface displacement caused by the East Anatolian Fault rupture was 6.50 m.As the fault rupture propagated southwest,the velocity pulse caused by the directional effect of the rupture increased gradually,with the maximum PGA reaching 162.3 cm/s.We also discussed the seismic safety of critical infrastructure projects traversing active faults,using two case studies of water supply pipelines in Türkiye that were damaged by earthquakes.We used a three-dimensional finite element model of the PE(polyethylene)water pipeline at the Islahiye State Hospital and fault displacement observations obtained through on-site investigation to analyze pipeline failure mechanisms.We further investigated the effect of the fault-crossing angle on seismic safety of a pipeline,based on our analysis and the failure performance of the large-diameter Thames Water pipeline during the 1999 Kocaeli earthquake.The seismic method of buried pipelines crossing the fault was summarized. 展开更多
关键词 Türkiye earthquake fault displacement near-fault ground motion velocity pulse water supply pipeline
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