Despite its utility in identifying patterns in celestial objects, the Hertzsprung-Russell diagram is not supported in dim or small stars;it struggles to provide insights into certain celestial objects such as brown dw...Despite its utility in identifying patterns in celestial objects, the Hertzsprung-Russell diagram is not supported in dim or small stars;it struggles to provide insights into certain celestial objects such as brown dwarfs [1]. The purpose of this experiment is to create an improved version of the diagram with a three-dimensional model that includes a third z-axis to accurately predict and chart the life cycles of all stars regardless of size. The values of the stars’ absolute magnitude and color indices were used to chart the surface gravity and metallicity, variables that were chosen due to their ease of collection and their likeliness to be within the range of values being assessed. To obtain the values for the model, data points from the database GAIA DR2 were utilized via the TAP protocol to query the SQL database. The data was transferred into a local CSV file to facilitate data manipulation. The data could be read and interpreted, as dim stars would likely have higher values of these variables, making it easier to include them in the diagram. The Pandas DataFrames tool on Python 3 was used to organize and manage the data efficiently. Matplotlib Graphs visualized the relationships between different stellar attributes by developing a linear regression line and an algorithm and creating scatter plots and sky maps to explore trends, hence designing three-dimensional diagrams. It was determined that the surface gravity diagram had a higher efficacy than metallicity due to their standard deviations of 0.4641441715272741 and 0.786577627976148, respectively.展开更多
The problem of taking an unorganized point cloud in 3D space and fitting a polyhedral surface to those points is both important and difficult. Aiming at increasing applications of full three dimensional digital terrai...The problem of taking an unorganized point cloud in 3D space and fitting a polyhedral surface to those points is both important and difficult. Aiming at increasing applications of full three dimensional digital terrain surface modeling, a new algorithm for the automatic generation of three dimensional triangulated irregular network from a point cloud is pro- posed. Based on the local topological consistency test, a combined algorithm of constrained 3D Delaunay triangulation and region-growing is extended to ensure topologically correct reconstruction. This paper also introduced an efficient neighbor- ing triangle location method by making full use of the surface normal information. Experimental results prove that this algo- rithm can efficiently obtain the most reasonable reconstructed mesh surface with arbitrary topology, wherein the automati- cally reconstructed surface has only small topological difference from the true surface. This algorithm has potential applica- tions to virtual environments, computer vision, and so on.展开更多
In gravity-anomaly-based prospecting, the computational and memory requirements for practical numerical modeling are potentially enormous. Achieving an efficient and precise inversion for gravity anomaly imaging over ...In gravity-anomaly-based prospecting, the computational and memory requirements for practical numerical modeling are potentially enormous. Achieving an efficient and precise inversion for gravity anomaly imaging over large-scale and complex terrain requires additional methods. To this end, we have proposed a new topography-capable By performing a two-dimensional Fourier transform in the horizontal directions, threedimensional partial differential equations in the spatial domain were transformed into a group of independent, one-dimensional differential equations engaged with different wave numbers. These independent differential equations are highly parallel across different wave numbers. differential equations with different wave numbers, and the efficiency of solving fixedbandwidth linear equations was further improved by a chasing method. In a synthetic test, a prism model was used to verify the accuracy and reliability of the proposed algorithm by comparing the numerical solution with the analytical solution. We studied the computational precision and efficiency with and without topography using different Fourier transform methods. The results showed that the Guass-FFT method has higher numerical precision, while the standard FFT method is superior, in terms of computation time, for inversion and quantitative interpretation under complicated terrain.展开更多
Three-dimensional(3D)culture systems are becoming increasingly popular due to their ability to mimic tissue-like structures more effectively than the monolayer cultures.In cancer and stem cell research,the natural cel...Three-dimensional(3D)culture systems are becoming increasingly popular due to their ability to mimic tissue-like structures more effectively than the monolayer cultures.In cancer and stem cell research,the natural cell characteristics and architectures are closely mimicked by the 3D cell models.Thus,the 3D cell cultures are promising and suitable systems for various proposes,ranging from disease modeling to drug target identification as well as potential therapeutic substances that may transform our lives.This review provides a comprehensive compendium of recent advancements in culturing cells,in particular cancer and stem cells,using 3D culture techniques.The major approaches highlighted here include cell spheroids,hydrogel embedding,bioreactors,scaffolds,and bioprinting.In addition,the progress of employing 3D cell culture systems as a platform for cancer and stem cell research was addressed,and the prominent studies of 3D cell culture systems were discussed.展开更多
The traditional fuzzy logic system （FLS） can only model and control the process in two-dimensional nature. Many of real-world systems are of multidimensional features, such as, thermal and fluid processes with spati...The traditional fuzzy logic system （FLS） can only model and control the process in two-dimensional nature. Many of real-world systems are of multidimensional features, such as, thermal and fluid processes with spatiotemporal dynamics, biological systems, or decision-making processes that contain stochastic and imprecise uncertainties. These types of systems are difficult for the traditional FLS to model and control because they require a third dimension for spatial or probabilistic information. The type-2 fuzzy set provides the possibility to develop a three-dimensional fuzzy logic system for modeling and controlling these processes in three-dimensional nature.展开更多
Metastasis is the leading cause of most cancer deaths, as opposed to dysregulated cell growth of the primary tumor. Molecular mechanisms of metastasis have been studied for decades and the findings have evolved our un...Metastasis is the leading cause of most cancer deaths, as opposed to dysregulated cell growth of the primary tumor. Molecular mechanisms of metastasis have been studied for decades and the findings have evolved our understanding of the progression of malignancy. However, most of the molecular mechanisms fail to address the causes of cancer and its evolutionary origin, demonstrating an inability to find a solution for complete cure of cancer. After being a neglected area of tumor biology for quite some time, recently several studies have focused on the impact of the tumor microenvironment on cancer growth. The importance of the tumor microenvironment is gradually gaining attention, particularly from the per- spective of biophysics. In vitro three-dimensional （3-D） metastatic models are an indispensable platform for investigating the tumor microenvironment, as they mimic the in vivo tumor tissue. In 3-D metastatic in vitro models, static factors such as the mechanical properties, biochemical factors, as well as dynamic factors such as cell-cell, cell-ECM interactions, and fluid shear stress can be studied quantitatively. With increasing focus on basic cancer research and drug development, the in vitro 3-D models offer unique advantages in fundamental and clinical biomedical studies.展开更多
Three-dimensional modeling of virtual hoisting machinery is the critical works to structure the system of virtual construction, and the foundation to realize intelligent and interactive virtual hoisting. Aimed at enha...Three-dimensional modeling of virtual hoisting machinery is the critical works to structure the system of virtual construction, and the foundation to realize intelligent and interactive virtual hoisting. Aimed at enhancing the requests of image quality and stability of the virtual construction scene, taking a tower crane for example. We studied the technology of three-dimensional modeling and optimization of a virtual tower crane, and a method named two-stage model optimization was put forward. This depended on the modeling stage using Solidworks and 3DS Max and the performance optimization stage in EON. The practice of software development indicates that the proposed methods of three-dimensional modeling and optimization could satisfy the performance request of virtual construction system and be popularized to other virtual system.展开更多
Yingqiong basin is a proven hydrocarbon-rich basin in South China Sea. There are a number of large exploration prospects in high temperature and over-pressured formations, especially in Yacheng Block of Qiongdongnan b...Yingqiong basin is a proven hydrocarbon-rich basin in South China Sea. There are a number of large exploration prospects in high temperature and over-pressured formations, especially in Yacheng Block of Qiongdongnan basin and Dongfang District of Yinggehai Basin. Owing to good exploration situation, we have already achieved proven geological reserves over 1000 × 108 m3. In recent years, a few drilled HPHT wells have confirmed that pressure predicted by conventional method was wildly inaccurate. From the view of regional stress, the accuracy of the pressure prediction will be substantially improved. Accurate pressure prediction and three-dimensional pressure modeling which are based on three-dimensional lithology modeling are the cornerstone to achieve exploration breakthrough. In this paper, the use of the triple constraint trend lithology model broke through the traditional method of seismic lithology prediction only by means of impedance threshold value. Compared with actual data and prediction, it confirms that three-dimensional pressure modeling method is reasonable and effective, and has a wide prospect of application.展开更多
Multistation machining process is widely applied in contemporary manufacturing environment. Modeling of variation propagation in multistation machining process is one of the most important research scenarios. Due to t...Multistation machining process is widely applied in contemporary manufacturing environment. Modeling of variation propagation in multistation machining process is one of the most important research scenarios. Due to the existence of multiple variation streams, it is challenging to model and analyze variation propagation in a multi-station system. Current approaches to error modeling for multistation machining process are not explicit enough for error control and ensuring final product quality. In this paper, a mathematic model to depict the part dimensional variation of the complex multistation manufacturing process is formulated. A linear state space dimensional error propagation equation is established through kinematics analysis of the influence of locating parameter variations and locating datum variations on dimensional errors, so the dimensional error accumulation and transformation within the multistation process are quantitatively described. A systematic procedure to build the model is presented, which enhances the way to determine the variation sources in complex machining systems. A simple two-dimensional example is used to illustrate the proposed procedures. Finally, an industrial case of multistation machining part in a manufacturing shop is given to testify the validation and practicability of the method. The proposed analytical model is essential to quality control and improvement for multistation systems in machining quality forecasting and design optimization.展开更多
The use of three dimensional in vitro systems in cancer research is a promising path for developing effective anticancer therapies.The aim of this study was to engineer a functional 3-D in vitro model of normal and ca...The use of three dimensional in vitro systems in cancer research is a promising path for developing effective anticancer therapies.The aim of this study was to engineer a functional 3-D in vitro model of normal and cancerous cervical tissue.Normal epithelial and immortalized cervical epithelial carcinoma cell lines were used to construct 3-D artificial normal cervical and cervical cancerous tissues.De-epidermised dermis（DED） was used as a scaffold for both models.Morphological analyses were conducted by using hematoxylin and eosin staining and characteristics of the models were studied by analyzing the expression of different structural cytokeratins and differential protein marker MAX dimerisation protein 1（Mad1） using immunohistochemical technique.Haematoxylin and eosin staining results showed that normal cervical tissue had multi epithelial layers while cancerous cervical tissue showed dysplastic changes.Immunohistochemistry staining revealed that for normal cervix model cytokeratin 10 was expressed in the upper stratified layer of the epithelium while cytokeratin 5 was expressed mainly in the middle and basal layer.Cytokeratin 19 was weakly expressed in a few basal cells.Cervical cancer model showed cytokeratin 19 expression in different epithelial layers and weak or no expression for cytokeratin 5 and cytokeratin 10.Madl expression was detected in some suprabasal cells.The 3-D in vitro models showed stratified epithelial layers and expressed the same types and patterns of differentiation marker proteins as seen in corresponding in vivo tissue in either normal cervical or cervical cancerous tissue.These findings imply that they can serve as functional normal and cervical cancer models.展开更多
The dynamic updating of the model included: the change of space border,addi- tion and reduction of spatial component (disappearing,dividing and merging),the change of the topological relationship and synchronous dynam...The dynamic updating of the model included: the change of space border,addi- tion and reduction of spatial component (disappearing,dividing and merging),the change of the topological relationship and synchronous dynamic updating of database.Firstly, arming at the deficiency of OO-Solid model in the aspect of dynamic updating,modeling primitives of OO-Solid model were modified.And then the algorithms of dynamic updating of 3D geological model with the node data,line data or surface data change were dis- cussed.The core algorithms was done by establishing space index,following the way of facing the object from bottom to top,namely the dynamic updating from the node to arc, and then to polygon,then to the face of the component and finally to the geological object. The research has important theoretical and practical values in the field of three dimen- sional geological modeling and is significant in the field of mineral resources.展开更多
The advent of the digital era has provided unprecedented opportunities for businesses to collect and analyze customer behavior data. Precision marketing, as a key means to improve marketing efficiency, highly depends ...The advent of the digital era has provided unprecedented opportunities for businesses to collect and analyze customer behavior data. Precision marketing, as a key means to improve marketing efficiency, highly depends on a deep understanding of customer behavior. This study proposes a theoretical framework for multi-dimensional customer behavior analysis, aiming to comprehensively capture customer behavioral characteristics in the digital environment. This framework integrates concepts of multi-source data including transaction history, browsing trajectories, social media interactions, and location information, constructing a theoretically more comprehensive customer profile. The research discusses the potential applications of this theoretical framework in precision marketing scenarios such as personalized recommendations, cross-selling, and customer churn prevention. Through analysis, the study points out that multi-dimensional analysis may significantly improve the targeting and theoretical conversion rates of marketing activities. However, the research also explores theoretical challenges that may be faced in the application process, such as data privacy and information overload, and proposes corresponding conceptual coping strategies. This study provides a new theoretical perspective on how businesses can optimize marketing decisions using big data thinking while respecting customer privacy, laying a foundation for future empirical research.展开更多
A new three-dimensional semi-implicit finite-volume ocean model has been developed for simulating the coastal ocean circulation, which is based on the staggered C-unstructured non-orthogonal grid in the hor- izontal d...A new three-dimensional semi-implicit finite-volume ocean model has been developed for simulating the coastal ocean circulation, which is based on the staggered C-unstructured non-orthogonal grid in the hor- izontal direction and z-level grid in the vertical direction. The three-dimensional model is discretized by the semi-implicit finite-volume method, in that the free-surface and the vertical diffusion are semi-implicit, thereby removing stability limitations associated with the surface gravity wave and vertical diffusion terms. The remaining terms in the momentum equations are discretized explicitly by an integral method. The partial cell method is used for resolving topography, which enables the model to better represent irregular topography. The model has been tested against analytical cases for wind and tidal oscillation circulation, and is applied to simulating the tidal flow in the Bohal Sea. The results are in good agreement both with the analytical solutions and measurement results.展开更多
To regenerate three-dimensional endometrium in vitro as a novel model for studying the mechanism of implantation of embryos, the luminal epithelial cells and stromal cells of the rabbit uterus were separated and cultu...To regenerate three-dimensional endometrium in vitro as a novel model for studying the mechanism of implantation of embryos, the luminal epithelial cells and stromal cells of the rabbit uterus were separated and cultured in vitro. The type Ⅰ mouse tail collagen was used as scaffolding material. The stromal cells were inoculated in the type I mouse tail collagen, and the luminal epithelial cells were inoculated on the type i mouse tall collagen to regenerate the endometrium in vitro. The regenerated endometrium was cultured in DMEM-F/12 media containing 100 nmol L^-1 progesterone, 10 nM β-estradiol, and 10% fetal bovine serum （FBS） for 3 d. The media were then replaced with CZB containing 100 nM progesterone, 10 nmol L-1 β-estradiol, and 10% FBS, and the mouse blastulas were co-cultured with it. The results of scanning electronic micrography showed that the epithelial cells on the surface of the reconstructed endometrium were covered with numerous slender microvilli and some epithelial cells protruded pinopodes. After culturing for 12 h with the mouse blastula, the shedding, attachment, and implantation of the blastula were observed. The blastula can escape from zona pellucida and attach to the three-dimensional endometrium and is then implanted into it. This study showed that the reconstructed three-dimensional endometrium can serve as a robust embryo implantation model in vitro.展开更多
Applying the methods of on-site observation and dynamic model, the research on the fronts at the Jiulong Estuary has been carried out, during which spatial and temporal distribution, dynamic characteristics and format...Applying the methods of on-site observation and dynamic model, the research on the fronts at the Jiulong Estuary has been carried out, during which spatial and temporal distribution, dynamic characteristics and formation mechanism of salinity fronts are analyzed and discussed. The research shows that the estuarine fronts mainly lie in the area from the Jiyu Islet to the Haimen Island, outside of Yuweizai to Hulishan cross-section, the near coast of Yuweizai and the south of the Songyu-Gulangyu Channel. The fronts in the former two regions are formed directly by plume, while the one near the coast of Yuweizai is a tidal intrusion front caused by flood current and the one at the south of the Songyu-Gulangyu Channel is the result of current shear transformation. Under normal circumstances, fresh water of the Jiulong River mainly influences the inside of the Xiamen Bay, and when it is in typhoon seasons, plume front can affect the Taiwan Strait and has an effect on the biogeochemical Drocesses in the strait.展开更多
The key to develop 3-D GISs is the study on 3-D data model and data structure. Some of the data models and data structures have been presented by scholars. Because of the complexity of 3-D spatial phenomenon, there ar...The key to develop 3-D GISs is the study on 3-D data model and data structure. Some of the data models and data structures have been presented by scholars. Because of the complexity of 3-D spatial phenomenon, there are no perfect data structures that can describe all spatial entities. Every data structure has its own advantages and disadvantages. It is difficult to design a single data structure to meet different needs. The important subject in the3-D data models is developing a data model that has integrated vector and raster data structures. A special 3-D spatial data model based on distributing features of spatial entities should be designed. We took the geological exploration engineering as the research background and designed an integrated data model whose data structures integrats vector and raster data byadopting object-oriented technique. Research achievements are presented in this paper.展开更多
To analyze the effects on motion characteristics of mechanisms of dimensional variations, a study on random dimensional deviation generation techniques for 3D models on the basis of the present mechanical modeling sof...To analyze the effects on motion characteristics of mechanisms of dimensional variations, a study on random dimensional deviation generation techniques for 3D models on the basis of the present mechanical modeling software was carried out, which utilized the redeveloped interfaces provided by the modeling software to develop a random dimensional deviation generation system with certain probability distribution characteristics. This system has been used to perform modeling and simulation of the specific mechanical time delayed mechanism under multiple deviation varieties, simulation results indicate the dynamic characteristics of the mechanism are influenced significantly by the dimensional deviation in the tolerance distribution range, which should be emphasized in the design.展开更多
A three-dimensional coupled physical and water quality model was developed and applied to the Jiaozhou Bay to study water quality involving nutrients, biochemical oxygen demand, dissolved oxygen, and phytoplankton tha...A three-dimensional coupled physical and water quality model was developed and applied to the Jiaozhou Bay to study water quality involving nutrients, biochemical oxygen demand, dissolved oxygen, and phytoplankton that are closely related to eutrophication process. The physical model is a modified ECOM-si version with inclusion of flooding/draining processes over the intertidal zone. The water quality model is based on WASP5 which quantifies processes governing internal nutrients cycling, dissolved oxygen balance and phytoplankton growth. The model was used to simulate the spatial distribution and the temporal variation of water quality in the Jiaozhou Bay for the period of May 2005 to May 2006. In addition, the effect of reduction of riverine nutrients load was simulated and evaluated. The simulated results show that under the influence of nutrients discharged from river, the concentrations of nutrients and phytoplankton were higher in the northwest and northeast of the bay, and decreased from the inner bay to the outer. Affected by strong tidal mixing, the concentrations of all state variables were vertically homogeneous except in the deeper regions where a small gradient was found. Obvious seasonal variation of phytoplankton biomass was found, which exhibited two peaks in March and July, respectively. The variation of riverine waste loads had remarkable impact on nutrients concentration in coastal areas, but slightly altered the distribution in the center of the bay.展开更多
Coupling with a three dimensional (3D) hydrodynamic model and a suspended solids model, a 3D model for the transport of Fe and Mn in Arha Reservoir, China, was developed. The 3D velocity fields for the flood season a...Coupling with a three dimensional (3D) hydrodynamic model and a suspended solids model, a 3D model for the transport of Fe and Mn in Arha Reservoir, China, was developed. The 3D velocity fields for the flood season are computed to drive the 3D model of Fe and Mn in which the processes of advection, diffusion, redox, sorption, desorption, deposition, and re suspension are included. The model has been calibrated by matching observed fluid, suspended solids, and total concentrations of Fe and Mn in the water column and in the sediment, successively. The model simulated both horizontal and vertical gradients of Fe and Mn in Arha Reservoir. It was found that Fe and especially Mn stratify in accordance with the stratification of DO during summer. The redox cycles across the water sediment interface has a principal role in the rise of Fe and Mn concentrations in the overlying water. It was also found that Fe and Mn loadings from the tributaries have a carryover effect on the water quality through a secondary contamination in the reservoir.展开更多
A calculation scheme, which combines a horizontal upwind finite element method with vertical implicit differences, is used to establish a three-dimensional mathematical model of tidal motion and sediment transport in...A calculation scheme, which combines a horizontal upwind finite element method with vertical implicit differences, is used to establish a three-dimensional mathematical model of tidal motion and sediment transport in tidal current. Compared with those of the relative theoretical formula, the results are satisfactory. The model mentioned above has been applied to the water area of the Lianzhou Bay, Guangxi Province. On the basis of the analysis and comparison with the field data, it shows clearly that the model calculation results are reasonable.展开更多
文摘Despite its utility in identifying patterns in celestial objects, the Hertzsprung-Russell diagram is not supported in dim or small stars;it struggles to provide insights into certain celestial objects such as brown dwarfs [1]. The purpose of this experiment is to create an improved version of the diagram with a three-dimensional model that includes a third z-axis to accurately predict and chart the life cycles of all stars regardless of size. The values of the stars’ absolute magnitude and color indices were used to chart the surface gravity and metallicity, variables that were chosen due to their ease of collection and their likeliness to be within the range of values being assessed. To obtain the values for the model, data points from the database GAIA DR2 were utilized via the TAP protocol to query the SQL database. The data was transferred into a local CSV file to facilitate data manipulation. The data could be read and interpreted, as dim stars would likely have higher values of these variables, making it easier to include them in the diagram. The Pandas DataFrames tool on Python 3 was used to organize and manage the data efficiently. Matplotlib Graphs visualized the relationships between different stellar attributes by developing a linear regression line and an algorithm and creating scatter plots and sky maps to explore trends, hence designing three-dimensional diagrams. It was determined that the surface gravity diagram had a higher efficacy than metallicity due to their standard deviations of 0.4641441715272741 and 0.786577627976148, respectively.
基金Supported by the National Natural Science Foundation of China （No.40671158）, the National 863 Program of China（No.2006AA12Z224） and the Program for New Century Excellent Talents in University （No.NCET-05-0626）.
文摘The problem of taking an unorganized point cloud in 3D space and fitting a polyhedral surface to those points is both important and difficult. Aiming at increasing applications of full three dimensional digital terrain surface modeling, a new algorithm for the automatic generation of three dimensional triangulated irregular network from a point cloud is pro- posed. Based on the local topological consistency test, a combined algorithm of constrained 3D Delaunay triangulation and region-growing is extended to ensure topologically correct reconstruction. This paper also introduced an efficient neighbor- ing triangle location method by making full use of the surface normal information. Experimental results prove that this algo- rithm can efficiently obtain the most reasonable reconstructed mesh surface with arbitrary topology, wherein the automati- cally reconstructed surface has only small topological difference from the true surface. This algorithm has potential applica- tions to virtual environments, computer vision, and so on.
基金supported by the Natural Science Foundation of China(No.41574127)the China Postdoctoral Science Foundation(No.2017M622608)the project for the independent exploration of graduate students at Central South University(No.2017zzts008)
文摘In gravity-anomaly-based prospecting, the computational and memory requirements for practical numerical modeling are potentially enormous. Achieving an efficient and precise inversion for gravity anomaly imaging over large-scale and complex terrain requires additional methods. To this end, we have proposed a new topography-capable By performing a two-dimensional Fourier transform in the horizontal directions, threedimensional partial differential equations in the spatial domain were transformed into a group of independent, one-dimensional differential equations engaged with different wave numbers. These independent differential equations are highly parallel across different wave numbers. differential equations with different wave numbers, and the efficiency of solving fixedbandwidth linear equations was further improved by a chasing method. In a synthetic test, a prism model was used to verify the accuracy and reliability of the proposed algorithm by comparing the numerical solution with the analytical solution. We studied the computational precision and efficiency with and without topography using different Fourier transform methods. The results showed that the Guass-FFT method has higher numerical precision, while the standard FFT method is superior, in terms of computation time, for inversion and quantitative interpretation under complicated terrain.
文摘Three-dimensional(3D)culture systems are becoming increasingly popular due to their ability to mimic tissue-like structures more effectively than the monolayer cultures.In cancer and stem cell research,the natural cell characteristics and architectures are closely mimicked by the 3D cell models.Thus,the 3D cell cultures are promising and suitable systems for various proposes,ranging from disease modeling to drug target identification as well as potential therapeutic substances that may transform our lives.This review provides a comprehensive compendium of recent advancements in culturing cells,in particular cancer and stem cells,using 3D culture techniques.The major approaches highlighted here include cell spheroids,hydrogel embedding,bioreactors,scaffolds,and bioprinting.In addition,the progress of employing 3D cell culture systems as a platform for cancer and stem cell research was addressed,and the prominent studies of 3D cell culture systems were discussed.
基金supported by the National 973 Fundamental Research Program of China (No.2005CB724102,2006CB705404)
文摘The traditional fuzzy logic system （FLS） can only model and control the process in two-dimensional nature. Many of real-world systems are of multidimensional features, such as, thermal and fluid processes with spatiotemporal dynamics, biological systems, or decision-making processes that contain stochastic and imprecise uncertainties. These types of systems are difficult for the traditional FLS to model and control because they require a third dimension for spatial or probabilistic information. The type-2 fuzzy set provides the possibility to develop a three-dimensional fuzzy logic system for modeling and controlling these processes in three-dimensional nature.
基金supported by the National Basic Research Program of China(Grant No.2013CB837200)the National Natural Science Foundation of China(Grant No.11474345)the Beijing Natural Science Foundation,China(Grant No.7154221)
文摘Metastasis is the leading cause of most cancer deaths, as opposed to dysregulated cell growth of the primary tumor. Molecular mechanisms of metastasis have been studied for decades and the findings have evolved our understanding of the progression of malignancy. However, most of the molecular mechanisms fail to address the causes of cancer and its evolutionary origin, demonstrating an inability to find a solution for complete cure of cancer. After being a neglected area of tumor biology for quite some time, recently several studies have focused on the impact of the tumor microenvironment on cancer growth. The importance of the tumor microenvironment is gradually gaining attention, particularly from the per- spective of biophysics. In vitro three-dimensional （3-D） metastatic models are an indispensable platform for investigating the tumor microenvironment, as they mimic the in vivo tumor tissue. In 3-D metastatic in vitro models, static factors such as the mechanical properties, biochemical factors, as well as dynamic factors such as cell-cell, cell-ECM interactions, and fluid shear stress can be studied quantitatively. With increasing focus on basic cancer research and drug development, the in vitro 3-D models offer unique advantages in fundamental and clinical biomedical studies.
基金supported by Special Project of Scientific Research of Education Department of Shaanxi Provincial Government under Grant No.11JK0967
文摘Three-dimensional modeling of virtual hoisting machinery is the critical works to structure the system of virtual construction, and the foundation to realize intelligent and interactive virtual hoisting. Aimed at enhancing the requests of image quality and stability of the virtual construction scene, taking a tower crane for example. We studied the technology of three-dimensional modeling and optimization of a virtual tower crane, and a method named two-stage model optimization was put forward. This depended on the modeling stage using Solidworks and 3DS Max and the performance optimization stage in EON. The practice of software development indicates that the proposed methods of three-dimensional modeling and optimization could satisfy the performance request of virtual construction system and be popularized to other virtual system.
文摘Yingqiong basin is a proven hydrocarbon-rich basin in South China Sea. There are a number of large exploration prospects in high temperature and over-pressured formations, especially in Yacheng Block of Qiongdongnan basin and Dongfang District of Yinggehai Basin. Owing to good exploration situation, we have already achieved proven geological reserves over 1000 × 108 m3. In recent years, a few drilled HPHT wells have confirmed that pressure predicted by conventional method was wildly inaccurate. From the view of regional stress, the accuracy of the pressure prediction will be substantially improved. Accurate pressure prediction and three-dimensional pressure modeling which are based on three-dimensional lithology modeling are the cornerstone to achieve exploration breakthrough. In this paper, the use of the triple constraint trend lithology model broke through the traditional method of seismic lithology prediction only by means of impedance threshold value. Compared with actual data and prediction, it confirms that three-dimensional pressure modeling method is reasonable and effective, and has a wide prospect of application.
基金supported by National Department Fundamental Research Foundation of China (Grant No. B222090014)National Department Technology Fundatmental Foundaiton of China (Grant No. C172009C001)
文摘Multistation machining process is widely applied in contemporary manufacturing environment. Modeling of variation propagation in multistation machining process is one of the most important research scenarios. Due to the existence of multiple variation streams, it is challenging to model and analyze variation propagation in a multi-station system. Current approaches to error modeling for multistation machining process are not explicit enough for error control and ensuring final product quality. In this paper, a mathematic model to depict the part dimensional variation of the complex multistation manufacturing process is formulated. A linear state space dimensional error propagation equation is established through kinematics analysis of the influence of locating parameter variations and locating datum variations on dimensional errors, so the dimensional error accumulation and transformation within the multistation process are quantitatively described. A systematic procedure to build the model is presented, which enhances the way to determine the variation sources in complex machining systems. A simple two-dimensional example is used to illustrate the proposed procedures. Finally, an industrial case of multistation machining part in a manufacturing shop is given to testify the validation and practicability of the method. The proposed analytical model is essential to quality control and improvement for multistation systems in machining quality forecasting and design optimization.
基金supported by the Middlesex University,particularly in the award of a Postgraduate Research Studentship that provided the necessary financial support for this research
文摘The use of three dimensional in vitro systems in cancer research is a promising path for developing effective anticancer therapies.The aim of this study was to engineer a functional 3-D in vitro model of normal and cancerous cervical tissue.Normal epithelial and immortalized cervical epithelial carcinoma cell lines were used to construct 3-D artificial normal cervical and cervical cancerous tissues.De-epidermised dermis（DED） was used as a scaffold for both models.Morphological analyses were conducted by using hematoxylin and eosin staining and characteristics of the models were studied by analyzing the expression of different structural cytokeratins and differential protein marker MAX dimerisation protein 1（Mad1） using immunohistochemical technique.Haematoxylin and eosin staining results showed that normal cervical tissue had multi epithelial layers while cancerous cervical tissue showed dysplastic changes.Immunohistochemistry staining revealed that for normal cervix model cytokeratin 10 was expressed in the upper stratified layer of the epithelium while cytokeratin 5 was expressed mainly in the middle and basal layer.Cytokeratin 19 was weakly expressed in a few basal cells.Cervical cancer model showed cytokeratin 19 expression in different epithelial layers and weak or no expression for cytokeratin 5 and cytokeratin 10.Madl expression was detected in some suprabasal cells.The 3-D in vitro models showed stratified epithelial layers and expressed the same types and patterns of differentiation marker proteins as seen in corresponding in vivo tissue in either normal cervical or cervical cancerous tissue.These findings imply that they can serve as functional normal and cervical cancer models.
基金the National Natural Science Foundation of China(40572165)
文摘The dynamic updating of the model included: the change of space border,addi- tion and reduction of spatial component (disappearing,dividing and merging),the change of the topological relationship and synchronous dynamic updating of database.Firstly, arming at the deficiency of OO-Solid model in the aspect of dynamic updating,modeling primitives of OO-Solid model were modified.And then the algorithms of dynamic updating of 3D geological model with the node data,line data or surface data change were dis- cussed.The core algorithms was done by establishing space index,following the way of facing the object from bottom to top,namely the dynamic updating from the node to arc, and then to polygon,then to the face of the component and finally to the geological object. The research has important theoretical and practical values in the field of three dimen- sional geological modeling and is significant in the field of mineral resources.
文摘The advent of the digital era has provided unprecedented opportunities for businesses to collect and analyze customer behavior data. Precision marketing, as a key means to improve marketing efficiency, highly depends on a deep understanding of customer behavior. This study proposes a theoretical framework for multi-dimensional customer behavior analysis, aiming to comprehensively capture customer behavioral characteristics in the digital environment. This framework integrates concepts of multi-source data including transaction history, browsing trajectories, social media interactions, and location information, constructing a theoretically more comprehensive customer profile. The research discusses the potential applications of this theoretical framework in precision marketing scenarios such as personalized recommendations, cross-selling, and customer churn prevention. Through analysis, the study points out that multi-dimensional analysis may significantly improve the targeting and theoretical conversion rates of marketing activities. However, the research also explores theoretical challenges that may be faced in the application process, such as data privacy and information overload, and proposes corresponding conceptual coping strategies. This study provides a new theoretical perspective on how businesses can optimize marketing decisions using big data thinking while respecting customer privacy, laying a foundation for future empirical research.
基金The Major State Basic Research Program of China under contract No. 2012CB417002the National Natural Science Foundation of China under contract Nos 50909065 and 51109039
文摘A new three-dimensional semi-implicit finite-volume ocean model has been developed for simulating the coastal ocean circulation, which is based on the staggered C-unstructured non-orthogonal grid in the hor- izontal direction and z-level grid in the vertical direction. The three-dimensional model is discretized by the semi-implicit finite-volume method, in that the free-surface and the vertical diffusion are semi-implicit, thereby removing stability limitations associated with the surface gravity wave and vertical diffusion terms. The remaining terms in the momentum equations are discretized explicitly by an integral method. The partial cell method is used for resolving topography, which enables the model to better represent irregular topography. The model has been tested against analytical cases for wind and tidal oscillation circulation, and is applied to simulating the tidal flow in the Bohal Sea. The results are in good agreement both with the analytical solutions and measurement results.
文摘To regenerate three-dimensional endometrium in vitro as a novel model for studying the mechanism of implantation of embryos, the luminal epithelial cells and stromal cells of the rabbit uterus were separated and cultured in vitro. The type Ⅰ mouse tail collagen was used as scaffolding material. The stromal cells were inoculated in the type I mouse tail collagen, and the luminal epithelial cells were inoculated on the type i mouse tall collagen to regenerate the endometrium in vitro. The regenerated endometrium was cultured in DMEM-F/12 media containing 100 nmol L^-1 progesterone, 10 nM β-estradiol, and 10% fetal bovine serum （FBS） for 3 d. The media were then replaced with CZB containing 100 nM progesterone, 10 nmol L-1 β-estradiol, and 10% FBS, and the mouse blastulas were co-cultured with it. The results of scanning electronic micrography showed that the epithelial cells on the surface of the reconstructed endometrium were covered with numerous slender microvilli and some epithelial cells protruded pinopodes. After culturing for 12 h with the mouse blastula, the shedding, attachment, and implantation of the blastula were observed. The blastula can escape from zona pellucida and attach to the three-dimensional endometrium and is then implanted into it. This study showed that the reconstructed three-dimensional endometrium can serve as a robust embryo implantation model in vitro.
文摘Applying the methods of on-site observation and dynamic model, the research on the fronts at the Jiulong Estuary has been carried out, during which spatial and temporal distribution, dynamic characteristics and formation mechanism of salinity fronts are analyzed and discussed. The research shows that the estuarine fronts mainly lie in the area from the Jiyu Islet to the Haimen Island, outside of Yuweizai to Hulishan cross-section, the near coast of Yuweizai and the south of the Songyu-Gulangyu Channel. The fronts in the former two regions are formed directly by plume, while the one near the coast of Yuweizai is a tidal intrusion front caused by flood current and the one at the south of the Songyu-Gulangyu Channel is the result of current shear transformation. Under normal circumstances, fresh water of the Jiulong River mainly influences the inside of the Xiamen Bay, and when it is in typhoon seasons, plume front can affect the Taiwan Strait and has an effect on the biogeochemical Drocesses in the strait.
基金Project supported by the National Outstanding Youth Researchers Foundation (No.49525101)the Opening Research Foundation from LIESMARS(WKL(96)0302)
文摘The key to develop 3-D GISs is the study on 3-D data model and data structure. Some of the data models and data structures have been presented by scholars. Because of the complexity of 3-D spatial phenomenon, there are no perfect data structures that can describe all spatial entities. Every data structure has its own advantages and disadvantages. It is difficult to design a single data structure to meet different needs. The important subject in the3-D data models is developing a data model that has integrated vector and raster data structures. A special 3-D spatial data model based on distributing features of spatial entities should be designed. We took the geological exploration engineering as the research background and designed an integrated data model whose data structures integrats vector and raster data byadopting object-oriented technique. Research achievements are presented in this paper.
基金Sponsored by the Ministerial Level Advanced Research Foundation (9153C9387029389C775)
文摘To analyze the effects on motion characteristics of mechanisms of dimensional variations, a study on random dimensional deviation generation techniques for 3D models on the basis of the present mechanical modeling software was carried out, which utilized the redeveloped interfaces provided by the modeling software to develop a random dimensional deviation generation system with certain probability distribution characteristics. This system has been used to perform modeling and simulation of the specific mechanical time delayed mechanism under multiple deviation varieties, simulation results indicate the dynamic characteristics of the mechanism are influenced significantly by the dimensional deviation in the tolerance distribution range, which should be emphasized in the design.
文摘A three-dimensional coupled physical and water quality model was developed and applied to the Jiaozhou Bay to study water quality involving nutrients, biochemical oxygen demand, dissolved oxygen, and phytoplankton that are closely related to eutrophication process. The physical model is a modified ECOM-si version with inclusion of flooding/draining processes over the intertidal zone. The water quality model is based on WASP5 which quantifies processes governing internal nutrients cycling, dissolved oxygen balance and phytoplankton growth. The model was used to simulate the spatial distribution and the temporal variation of water quality in the Jiaozhou Bay for the period of May 2005 to May 2006. In addition, the effect of reduction of riverine nutrients load was simulated and evaluated. The simulated results show that under the influence of nutrients discharged from river, the concentrations of nutrients and phytoplankton were higher in the northwest and northeast of the bay, and decreased from the inner bay to the outer. Affected by strong tidal mixing, the concentrations of all state variables were vertically homogeneous except in the deeper regions where a small gradient was found. Obvious seasonal variation of phytoplankton biomass was found, which exhibited two peaks in March and July, respectively. The variation of riverine waste loads had remarkable impact on nutrients concentration in coastal areas, but slightly altered the distribution in the center of the bay.
文摘Coupling with a three dimensional (3D) hydrodynamic model and a suspended solids model, a 3D model for the transport of Fe and Mn in Arha Reservoir, China, was developed. The 3D velocity fields for the flood season are computed to drive the 3D model of Fe and Mn in which the processes of advection, diffusion, redox, sorption, desorption, deposition, and re suspension are included. The model has been calibrated by matching observed fluid, suspended solids, and total concentrations of Fe and Mn in the water column and in the sediment, successively. The model simulated both horizontal and vertical gradients of Fe and Mn in Arha Reservoir. It was found that Fe and especially Mn stratify in accordance with the stratification of DO during summer. The redox cycles across the water sediment interface has a principal role in the rise of Fe and Mn concentrations in the overlying water. It was also found that Fe and Mn loadings from the tributaries have a carryover effect on the water quality through a secondary contamination in the reservoir.
文摘A calculation scheme, which combines a horizontal upwind finite element method with vertical implicit differences, is used to establish a three-dimensional mathematical model of tidal motion and sediment transport in tidal current. Compared with those of the relative theoretical formula, the results are satisfactory. The model mentioned above has been applied to the water area of the Lianzhou Bay, Guangxi Province. On the basis of the analysis and comparison with the field data, it shows clearly that the model calculation results are reasonable.
