In this study,six kinetics models of indomethacin hydrophilic gel patch transdermal in vitro release was established,including zero-level,first-order,Higuchi-level,Ritger-Peppas,Weibull and Hixcon-Crowell dynamic equa...In this study,six kinetics models of indomethacin hydrophilic gel patch transdermal in vitro release was established,including zero-level,first-order,Higuchi-level,Ritger-Peppas,Weibull and Hixcon-Crowell dynamic equations.The chemical permeation enhancers,including 3%and 5%Azone,and iontophoresis were used as the control.Transdermal diffusion tests were performed in vitro and indomethacin was quantified by high performance liquid chromatography system.The transdermal parameter of the Higuchi and Weibull dynamic equations,indicated that Fu’s cupping therapy(FCT)could significantly improve Higuchi and Weibull kinetic parameters in vitro transdermal,increased transdermal rate and permeability coefficient,reduced lagging time.Additionally,statistical analysis speculated the skin barrier function could be restored after 46 h treatment.Hence,as a new physical transdermal drug delivery technology,transdermal permeation effects produced by FCT are obvious,which has the characteristics of traditional Chinese medicine and has important clinical application value.展开更多
The human social development saw the formation of five unique civilizations,with the latter forming their own distinctive cultures.China’s traditional culture is its most fundamental ideological weapon for solving pr...The human social development saw the formation of five unique civilizations,with the latter forming their own distinctive cultures.China’s traditional culture is its most fundamental ideological weapon for solving problems.The Chinese are good at comprehensive thinking,dialectical thinking,and systematic analysis.These ideological weapons can solve the problems of formal science and technology and create scientific and technological achievements on par with global advanced scale.Ancient China is filled with original scientific and technological achievements,which strongly prove ancient China’s possession of its own science and technology different from that of Western Renaissance.Therefore,a comprehensive understanding of science,technology,experience,and intuition is necessary.The long-held superstition regarding the West,the lack of confidence,self-denial,blind imitation of ideas,and shackles must be thrown away.Only then can we take the road toward an authentic Chinese creative design as we learn from others.展开更多
基金This work was supported by the Projects[NO.20154030 and NO.(2017)5655]from the Science and Technology Department of Guizhou Province and the National Natural Science Foundation of China(No.81873020).
文摘In this study,six kinetics models of indomethacin hydrophilic gel patch transdermal in vitro release was established,including zero-level,first-order,Higuchi-level,Ritger-Peppas,Weibull and Hixcon-Crowell dynamic equations.The chemical permeation enhancers,including 3%and 5%Azone,and iontophoresis were used as the control.Transdermal diffusion tests were performed in vitro and indomethacin was quantified by high performance liquid chromatography system.The transdermal parameter of the Higuchi and Weibull dynamic equations,indicated that Fu’s cupping therapy(FCT)could significantly improve Higuchi and Weibull kinetic parameters in vitro transdermal,increased transdermal rate and permeability coefficient,reduced lagging time.Additionally,statistical analysis speculated the skin barrier function could be restored after 46 h treatment.Hence,as a new physical transdermal drug delivery technology,transdermal permeation effects produced by FCT are obvious,which has the characteristics of traditional Chinese medicine and has important clinical application value.
文摘The human social development saw the formation of five unique civilizations,with the latter forming their own distinctive cultures.China’s traditional culture is its most fundamental ideological weapon for solving problems.The Chinese are good at comprehensive thinking,dialectical thinking,and systematic analysis.These ideological weapons can solve the problems of formal science and technology and create scientific and technological achievements on par with global advanced scale.Ancient China is filled with original scientific and technological achievements,which strongly prove ancient China’s possession of its own science and technology different from that of Western Renaissance.Therefore,a comprehensive understanding of science,technology,experience,and intuition is necessary.The long-held superstition regarding the West,the lack of confidence,self-denial,blind imitation of ideas,and shackles must be thrown away.Only then can we take the road toward an authentic Chinese creative design as we learn from others.
