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How Software Engineering Transforms Organizations: An Open and Qualitative Study on the Organizational Objectives and Motivations in Agile Transformations
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作者 Alonso Alvarez Borja Bordel Sánchez 《Computers, Materials & Continua》 SCIE EI 2024年第11期2935-2966,共32页
Agile Transformations are challenging processes for organizations that look to extend the benefits of Agile philosophy and methods beyond software engineering.Despite the impact of these transformations on orga-nizati... Agile Transformations are challenging processes for organizations that look to extend the benefits of Agile philosophy and methods beyond software engineering.Despite the impact of these transformations on orga-nizations,they have not been extensively studied in academia.We conducted a study grounded in workshops and interviews with 99 participants from 30 organizations,including organizations undergoing transformations(“final organizations”)and companies supporting these processes(“consultants”).The study aims to understand the motivations,objectives,and factors driving and challenging these transformations.Over 700 responses were collected to the question and categorized into 32 objectives.The findings show that organizations primarily aim to achieve customer centricity and adaptability,both with 8%of the mentions.Other primary important objectives,with above 4%of mentions,include alignment of goals,lean delivery,sustainable processes,and a flatter,more team-based organizational structure.We also detect discrepancies in perspectives between the objectives identified by the two kinds of organizations and the existing agile literature and models.This misalignment highlights the need for practitioners to understand with the practical realities the organizations face. 展开更多
关键词 Business agility AGILE agile transformations agile enterprises adaptive organizations ADAPTABILITY agile software development software engineering computer engineering
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An Exploration of Organizational Development in the Process of Innovation and Transformation of Pharmaceutical Enterprises-Taking X Pharmaceutical Enterprise as an Example
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作者 Gao Lin Sun Lihua 《Asian Journal of Social Pharmacy》 2024年第1期72-80,共9页
Objective To study how to promote the smooth innovation and transformation of enterprises and enhance the market competitiveness of enterprises from the perspective of human resources organization development.In the w... Objective To study how to promote the smooth innovation and transformation of enterprises and enhance the market competitiveness of enterprises from the perspective of human resources organization development.In the wave of pharmaceutical industry reform,some entrepreneurs realize the importance of innovation and technology in the future.However,domestic pharmaceutical enterprises are still in the production-oriented stage.In the process of transformative innovation,pharmaceutical enterprises should not only rely on the support of scientific and technological and economic forces,but also need a suitable organizational change and many excellent talents as the source of development.Methods Through retrieving relevant literature and combined with the organizational development practice of X pharmaceutical enterprise,the organizational development model was explored in this paper.Results and Conclusion By forming a system of strategy,organization,talent,culture and mechanism,and building an organizational development model,we can improve the organizational atmosphere and organizational efficiency in the process of enterprise innovation and transformation,so as to enhance the competitiveness of enterprises in the market. 展开更多
关键词 innovation transformation organization development organizational culture personnel training
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Molecular investigation into the transformation of recalcitrant dissolved organic sulfur in refinery sour water during stripping process
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作者 Yu-Guo Li Chen He +2 位作者 Chun-Mao Chen Fan Liu Quan Shi 《Petroleum Science》 SCIE EI CAS CSCD 2024年第3期2112-2119,共8页
Refinery sour water primarily originates from the tops of towers in various units and coker condensate,and cannot be discharged directly to a wastewater treatment plant due to high levels of chemical oxygen demand(COD... Refinery sour water primarily originates from the tops of towers in various units and coker condensate,and cannot be discharged directly to a wastewater treatment plant due to high levels of chemical oxygen demand(COD)and organic sulfur contents.Even after the recovery of H_(2)S from the sour water by the stripping process,the effluent still contains a high concentration of dissolved organic sulfur(DOS),which can have a huge bad influence.While chemical composition of dissolved organic matter(DOM)in refinery wastewater has been extensively studied,the investigation of recalcitrant DOS from sour waters remains unclear.In the present study,chemical composition of sour water DOMs(especially DOS)was investigated using fluorescence spectroscopy(excitation-emission matrix,EEM)and mass spectrometry,including gas chromatography-mass spectrometry(GC-MS)and high-resolution Orbitrap MS.The GC-MS and EEM results showed that volatile and low-aromaticity compounds were effectively removed during the stripping process,while compounds with high hydrophilicity and humification degree were found to be more recalcitrant.The Orbitrap MS results showed that weak-polar oxygenated sulfur compounds were easier to be removed than oxygenated compounds.However,the effluent still contained significant amounts of sulfur-containing compounds with multiple sulfur atoms,particularly in the form of highly unsaturated and aromatic compounds.The Orbitrap MS/MS results of CHOS-containing compounds from the effluent indicate that the sulfur atoms may exist as sulfonates,disulfide bonds,thioethers.Understanding the composition and structure of sour water DOS is crucial for the development of effective treatment processes that can target polysulfide compounds and minimize their impact on the environment. 展开更多
关键词 Molecular transformation Dissolved organic sulfur Stripping process Refinery sourwater Orbitrap MS
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Could One Transformational Leader Convert the Organization From Knowledge Based Into Learning Organization, Then Into Innovation? 被引量:1
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作者 Fawzy Soliman 《Journal of Modern Accounting and Auditing》 2011年第12期1352-1361,共10页
This paper examines the role of transformational leadership in transforming an organization into a knowledge based, then into learning organization so that it becomes an innovative company. Important features of the l... This paper examines the role of transformational leadership in transforming an organization into a knowledge based, then into learning organization so that it becomes an innovative company. Important features of the leader such and ability to assist in developing and accommodating the implementation of knowledge management programs, learning organization concepts and innovation protocols are discussed in this paper. This paper demonstrates that shifting the organization to become a knowledge based and then to be learning organization and finally to become innovative company could involve some unique attributes of a transformation leadership. In that regards, the paper also demonstrates that organizations need first to create, capture, transfer, and mobilize knowledge before it can be used for learning and then for innovation. The paper will present a method of a studying how successful innovation leaders of companies could found themselves acting in three roles namely: knowledge leader, learning leader and then innovation leader. 展开更多
关键词 transformational leadership INNOVATION knowledge management learning organization
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The Polish SMEs as Intelligent Organizations in an Era of Digital Transformation
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作者 Piotr Adamczewski 《Chinese Business Review》 2023年第3期116-126,共11页
The impact that the digital transformation(DT)has on businesses,suppliers,and other third parties has increased significantly now.Digital transformation means improving traditional manufacturing processes with the hel... The impact that the digital transformation(DT)has on businesses,suppliers,and other third parties has increased significantly now.Digital transformation means improving traditional manufacturing processes with the help of digital technologies.The goal of digital transformation is to increase production efficiency and reduce costs,improve the quality of goods and services produced,and quickly adapt to changes in the global market.The state of industrial production is constantly changing due to the instability of global,economic and political decisions,so the adoption and expansion of digital solutions based on Industry 4.0,the Internet of things,machine learning,and other technologies of the future is accelerating.With the help of these technologies,companies are trying to change approaches and find new ways to solve problems.In this article the author analyzed the phenomenon of a complex system of knowledge management with tools as SMAC,AI,IoT and Edge computing in intelligent organizations as a part of intelligent economy.The arguments are illustrated with the results of own research conducted by the author in 2021-2022 in selected SMEs from the Polish Wielkopolska Province and their reference to the general development trends in this area. 展开更多
关键词 digital transformation ICT intelligent organization SMAC SME
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Changes in Transformation of Soil Organic C and Functional Diversity of Soil Microbial Community Under Different Land Uses 被引量:22
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作者 LI Zhong-pei WU Xiao-chen CHEN Bi-yun 《Agricultural Sciences in China》 CAS CSCD 2007年第10期1235-1245,共11页
Changes in soil biological and biochemical properties under different land uses in the subtropical region of China were investigated in order to develop rational cultivation and fertilization management. A small water... Changes in soil biological and biochemical properties under different land uses in the subtropical region of China were investigated in order to develop rational cultivation and fertilization management. A small watershed of subtropical region of China was selected for this study. Land uses covered paddy fields, vegetable farming, fruit trees, upland crops, bamboo stands, and forestry. Soil biological and biochemical properties included soil organic C and nutrient contents, mineralization of soil organic C, and soil microbial biomass and community functional diversity. Soil organic C and total N contents, microbial biomass C and N, and respiration intensity under different land uses were changed in the following order: paddy fields (and vegetable farming) 〉 bamboo stands 〉 fruit trccs (and upland). The top surface (0-15 cm) paddy fields (and vegetable farming) were 76.4 and 80.8% higher in soil organic C and total N contents than fruit trees (and upland) soils, respectively. Subsurface paddy soils (15-30 cm) were 59.8 and 67.3% higher in organic C and total N than upland soils, respectively. Soil microbial C, N and respiration intensity in paddy soils (0-15 cm) were 6.36, 3.63 and 3.20 times those in fruit tree (and upland) soils respectively. Soil microbial metabolic quotient was in the order: fruit trees (and upland) 〉 forestry 〉 paddy fields. Metabolic quotient in paddy soils was only 47.7% of that in fruit tree (and upland) soils. Rates of soil organic C mineralization during incubation changed in the order: paddy fields 〉 bamboo stands 〉 fruit trees (and upland) and soil bacteria population: paddy fields 〉 fruit trees (and upland) 〉 forestry. No significant difference was found for fungi and actinomycetes populations. BIOLOG analysis indicated a changing order of paddy fields 〉 fruit trees (and upland) 〉 forestry in values of the average well cell development (AWCD) and functional diversity indexes of microbial community. Results also showed that the conversion from paddy fields to vegetable farming for 5 years resulted in a dramatic increase in soil available phosphorus content while insignificant changes in soil organic C and total N content due to a large inputs of phosphate fertilizers. This conversion caused 53, 41.5, and 41.3% decreases in soil microbial biomass C, N, and respiration intensity, respectively, while 23.6% increase in metabolic quotient and a decrease in soil organic C mineralization rate. Moreover, soil bacteria and actinomycetes populations were increased slightly, while fungi population increased dramatically. Functional diversity indexes of soil microbial community decreased significantly. It was concluded that land uses in the subtropical region of China strongly affected soil biological and biochemical properties. Soil organic C and nutrient contents, mineralization of organic C and functional diversity of microbial community in paddy fields were higher than those in upland and forestry. Overuse of chemical fertilizers in paddy fields with high fertility might degrade soil biological properties and biochemical function, resulting in deterioration of soil biological quality. 展开更多
关键词 land use patterns transformation of soil organic carbon functional diversity of soil microbial community
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Organic matter transformation ratio, hydrocarbon expulsion efficiency and shale oil enrichment type in Chang 7_(3) shale of Upper Triassic Yanchang Formation in Ordos Basin, NW China 被引量:2
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作者 ZHAO Wenzhi BIAN Congsheng +4 位作者 LI Yongxin LIU Wei DONG Jin WANG Kun ZENG Xu 《Petroleum Exploration and Development》 2023年第1期14-26,共13页
The major enrichment type of shale oil in the Chang 7_(3) shale of Upper Triassic Yanchang Formation in the Ordos Basin is unknown.This paper analyzes the organic matter transformation ratio,hydrocarbon expulsion effi... The major enrichment type of shale oil in the Chang 7_(3) shale of Upper Triassic Yanchang Formation in the Ordos Basin is unknown.This paper analyzes the organic matter transformation ratio,hydrocarbon expulsion efficiency and roof/floor sealing conditions of the Chang 7_(3) shale,and evaluates the major enrichment type of shale oil in this interval.The average organic matter transformation ratio of the Chang 7_(3) shale is about 45%;in other words,more than 50%of the organic matters have not transformed to hydrocarbons,and the lower the maturity,the greater the proportion of untransformed organic matters.The cumulative hydrocarbon expulsion efficiency of the transformed hydrocarbon is 27.5% on average,and the total proportion of untransformed organic matters plus retained hydrocarbons is greater than 70%.The relative hydrocarbon expulsion efficiency of the Chang 7_(3) shale is 60%on average,that is,about 40% of hydrocarbons retain in the shale.The Chang 7_(3) shale corresponds to Chang 7_(1+2) and Chang 8 sandstones as the roof and floor,respectively,and is further overlaid by Chang 6 shale,where extensive low porosity and low permeability–tight oil reservoirs have formed in the parts with relatively good porosity and permeability.Moreover,the Chang 7_(3) shale is tested to be in a negative pressure system(the pressure coefficient of 0.80–0.85).Therefore,the roof/floor sealing conditions of the Chang 7_(3) shale are poor.The retained hydrocarbons appear mostly in absorbed status,with low mobility.It is concluded that the medium–high mature shale oil is not the major enrichment type of shale oil in the Chang 7_(3) shale,but there may be enrichment opportunity for shale oil with good mobility in the areas where the sealing conditions are good without faults and fractures and oil reservoirs are formed off Chang 7_(1+2),Chang 6 and Chang 8.Furthermore,low–medium mature shale oil is believed to have great potential and is the major enrichment type of shale oil in the Chang 7_(3) shale.It is recommended to prepare relevant in-situ conversion technologies by pilot test and figure out the resource availability and distribution. 展开更多
关键词 organic matter transformation ratio hydrocarbon expulsion efficiency sealing condition continental shale oil major enrichment type Chang 7_(3)shale Triassic Ordos Basin
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Study on Migration and Transformation Rule of Organic Pollutants (COD) in Aerated Zone
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作者 GaoTaizhong HuangQunxian +3 位作者 LiuYe QiPeng ZhangHuanzhen CaiHesheng 《Journal of China University of Geosciences》 SCIE CSCD 2003年第1期73-78,共6页
Collecting waste water with a certain c onc entration of organic pollutants COD (chemical oxygen demand), static adsorption, static biodegradation and dynamic soil column experiments were made in laborato ry, we rese... Collecting waste water with a certain c onc entration of organic pollutants COD (chemical oxygen demand), static adsorption, static biodegradation and dynamic soil column experiments were made in laborato ry, we researched migration and transformation of COD in aerated zone, and put f orward a mathematical model showing the process. The results show that adsorptio n of organism in aerated zone is linear, which is represented by Henry's law s =K dc+s d, adsorption coefficient K d=0.069 3; biodegradati on diagram accord basically with first order kinetics equation c=c 0e -K 1t , biodegradation coefficient K 1 = 0.049 9 d -1 ; dispersio n coefficient D= 0.002 42 m 2/d in experiments. The migration and transform ation of organic pollutants (COD) in aerated zone jointly result from many f actors such as dispersion, adsorption and biodegradation etc.. 展开更多
关键词 chemical oxygen demand of organic pollutants aerated zone migration and transformation.
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Transformation of organic N newly added to red soil treated with different cultural practices
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作者 ZhangQin-Zheng YeQing-Fu 《Nuclear Science and Techniques》 SCIE CAS CSCD 1998年第1期59-61,共3页
TransformationoforganicNnewlyaddedtoredsoiltreatedwithdiferentculturalpracticesZhangQinZheng,YeQingFu,XiHaiF... TransformationoforganicNnewlyaddedtoredsoiltreatedwithdiferentculturalpracticesZhangQinZheng,YeQingFu,XiHaiFuandWuGang(In... 展开更多
关键词 红色土壤 有机氮 不同栽培技术
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基于CNN和Transformer并行编码的腹部多器官图像分割
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作者 赵欣 李森 李智生 《吉林大学学报(理学版)》 CAS 北大核心 2024年第5期1145-1154,共10页
针对现有方法在腹部中小器官图像分割性能方面存在的不足,提出一种基于局部和全局并行编码的网络模型用于腹部多器官图像分割.首先,设计一种提取多尺度特征信息的局部编码分支;其次,全局特征编码分支采用分块Transformer,通过块内Transf... 针对现有方法在腹部中小器官图像分割性能方面存在的不足,提出一种基于局部和全局并行编码的网络模型用于腹部多器官图像分割.首先,设计一种提取多尺度特征信息的局部编码分支;其次,全局特征编码分支采用分块Transformer,通过块内Transformer和块间Transformer的组合,既捕获了全局的长距离依赖信息又降低了计算量;再次,设计特征融合模块,以融合来自两条编码分支的上下文信息;最后,设计解码模块,实现全局信息与局部上下文信息的交互,更好地补偿解码阶段的信息损失.在Synapse多器官CT数据集上进行实验,与目前9种先进方法相比,在平均Dice相似系数(DSC)和Hausdorff距离(HD)指标上都达到了最佳性能,分别为83.10%和17.80 mm. 展开更多
关键词 多器官图像分割 分块transformer 特征融合
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Transformation of Carbon and Nitrogen by Earthworms in the Decomposition Processes of Broad-leaved Litters 被引量:14
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作者 DONG Weihua YIN Xiuqin 《Chinese Geographical Science》 SCIE CSCD 2007年第2期166-172,共7页
Earthworms are the important constituents in the decayed food web and the main ecological conditioners in the process of decomposition and nutrient mineralization. The transformation of organic carbon (C) and total ni... Earthworms are the important constituents in the decayed food web and the main ecological conditioners in the process of decomposition and nutrient mineralization. The transformation of organic carbon (C) and total nitrogen (N) in the broad-leaved litters ingested by earthworms was researched by means of a laboratory experiment. Experimental samples were collected from broad-leaved Korea Pine mixed forest in Liangshui National Natural Reserve (47°10′50″N, 128°53′20″E) in the northeastern Xiao Hinggan Mountains of Northeast China. The contents of organic C and total N in earthworms, leaf litters and earthworm faeces were analyzed. Results show that the organic C content was in the fol- lowing order: leaf litters>faeces>earthworms, while total N content was contrary to that of the organic C. The organic C contents in the different leaf litters were in the following order: Tilia amurensis>Betula costata>Acer mono, whereas the total N contents in the different leaf litters were: Betula costata>Tilia amurensis>Acer mono. The contents of organic C and total N in the faeces from the different leaf litters were almost consistent with the contents of the leaf litters. After the leaf litters were ingested by earthworms, the organic C, which was transformed to increase earthworms' weights, ac- counted for 3.90%-13.31% of the total ingestion by earthworms, while that in the earthworm faeces accounted for 6.14%-13.70%. The transformed organic C through the other metabolism (e.g., respiration) of earthworms accounted for 75.04%-89.92%. The ingested organic C by earthworms was mostly used for metabolic activities. The N ingested by earthworms was less than organic C. It is estimated that 37.08% of total N was transformed to increase the earthworm's weight, 19.97% into earthworm faeces and 47.86% for the consumption of the earthworm's activities. The earthworms not only increased the content of organic C and total N in the soil, but also decreased the values of C/N in the soil and leaf litters. Earthworms play a major role in the leaf litters' decomposition and transformation. 展开更多
关键词 broad-leaved litters organic carbon total nitrogen EARTHWORM C transformation N transformation
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Carbon and Nitrogen Transformations in Surface Soils Under Ermans Birch and Dark Coniferous Forests 被引量:5
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作者 DENG Xiao-Wen HAN Shi-Jie +1 位作者 HU Yan-Ling ZHOU Yu-Mei 《Pedosphere》 SCIE CAS CSCD 2009年第2期230-237,共8页
Soil samples were taken from an Ermans birch (Betula ermanii)-dark coniferous forest (Picea jezoensis and Abies nephrolepis) ecotone growing on volcanic ejecta in the northern slope of Changbai Mountains of Northe... Soil samples were taken from an Ermans birch (Betula ermanii)-dark coniferous forest (Picea jezoensis and Abies nephrolepis) ecotone growing on volcanic ejecta in the northern slope of Changbai Mountains of Northeast China, to compare soil carbon (C) and nitrogen (N) transformations in the two forests. The soil type is Umbri-Gelic Cambosols in Chinese Soil Taxonomy. Soil samples were incubated aerobically at 20℃ and field capacity of 700 g kg^-1 over a period of 27 weeks. The amount of soil microbial biomass and net N mineralization were higher in the Ermans birch than the dark coniferous forest (P 〈 0.05), whereas the cumulative C mineralization (as CO2 emission) in the dark coniferous forest exceeded that in the Ermans birch (P 〈 0.05). Release of the cumulative dissolved organic C and dissolved organic N were greater in the Ermans birch than the dark coniferous forest (P 〈 0.05). The results suggested that differences of forest types could result in considerable change in soil C and N transformations. 展开更多
关键词 dissolved organic C dissolved organic N Ermans birch-dark coniferous forest soil C transformation soil N transformation
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Effects of long-term fertilization on soil gross N transformation rates and their implications 被引量:3
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作者 DAI Shen-yan WANG Jing +2 位作者 CHENG Yi ZHANG Jin-bo CAI Zu-cong 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2017年第12期2863-2870,共8页
Application of fertilizer has been found to significantly affect soil N cycling. However, a comprehensive understanding of the effects of long-term fertilization on soil gross N transformation rates is still lacking. ... Application of fertilizer has been found to significantly affect soil N cycling. However, a comprehensive understanding of the effects of long-term fertilization on soil gross N transformation rates is still lacking. We compiled data of observations from 10 long-term fertilization experiments and conducted a meta-analysis of the effects of long-term fertilization on soil gross N transformation rates. The results showed that if chemical fertilizers of N, P and K were applied in balance, soil p H decreased very slightly. There was a significantly positive effect of long-term fertilization, either chemical or organic fertilizers or their combinations, on gross N mineralization rate compared to the control treatment(the mean effect size ranged from 1.21 to 1.25 at 95% confidence intervals(CI) with a mean of 1.23), mainly due to the increasing soil total N content. The long-term application of organic fertilizer alone and combining organic and chemical fertilizer could increase the mineralization-immobilization turnover, thus enhance available N for plant while reduce N losses potential compared to the control treatment. However, long-term chemical fertilizer application did not significantly affect the gross NH4+ immobilization rate, but accelerated gross nitrification rate(1.19; 95% CI: 1.08 to 1.31). Thus, long-term chemical fertilizer alone would probably induce higher N losses potential through NO3– leaching and runoff than organic fertilizer application compared to the control treatment. Therefore, in the view of the effects of long-term fertilization on gross N transformation rates, it also supports that organic fertilizer alone or combination of organic and chemical fertilizer could not only improve crop yield, but also increase soil fertility and reduce the N losses potential. 展开更多
关键词 chemical fertilizer organic fertilizer gross N transformation rate long-term fertilization experiment META-ANALYSIS
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融合卷积和Transformer的腹部多器官分割网络 被引量:1
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作者 杨萍 陈立伟 +1 位作者 王庆凤 周莹 《计算机技术与发展》 2024年第9期47-54,共8页
腹部多器官分割在计算机辅助诊断中起着至关重要的作用,具有重要的研究价值。但由于腹部多器官边界模糊、背景复杂以及形状大小多变,使这项任务极具挑战性。为此,提出了一种融合卷积和Transformer的腹部多器官分割网络TCMSUnet。首先,... 腹部多器官分割在计算机辅助诊断中起着至关重要的作用,具有重要的研究价值。但由于腹部多器官边界模糊、背景复杂以及形状大小多变,使这项任务极具挑战性。为此,提出了一种融合卷积和Transformer的腹部多器官分割网络TCMSUnet。首先,在特征提取阶段设计了多尺度引导融合模块(GFM),利用高层特征提取的显著语义信息来引导低层特征以增强相邻特征的语义一致性,从而促进不同尺度特征的融合;随后设计了全局局部增强模块(GLE),通过空洞卷积和Transformer块结合来增强模型对全局局部上下文信息的提取,使模型在建立长距离依赖关系的同时加强特征的局部关联性;最后,在解码器部分引入多阶段损失聚合结构以加快模型的收敛并优化模型的性能。在Synapse数据集上评估了模型的性能,其平均Dice相似系数(DSC)为81.20%。实验结果表明,所提方法整体性能优于多种比较网络,并对形状大小多变的器官有更好的分割效果。 展开更多
关键词 医学图像分割 特征融合 多尺度 空洞卷积 transformER 多器官
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Plasma Levels of Transforming Growth Factor-Beta 1 in Women with Pelvic Organ Prolapse
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作者 Kimio Sugaya Katsumi Kadekawa +2 位作者 Katsuhiro Ashitomi Saori Nishijima Seiji Matsumoto 《Open Journal of Urology》 2023年第5期133-142,共10页
Objective: In women with pelvic organ prolapse (POP), decreased expression of transforming growth factor-beta 1 (TGF-β1) has been shown in POP tissues. However, no studies have evaluated plasma TGF-β1 levels in pati... Objective: In women with pelvic organ prolapse (POP), decreased expression of transforming growth factor-beta 1 (TGF-β1) has been shown in POP tissues. However, no studies have evaluated plasma TGF-β1 levels in patients with POP, so it is unknown whether they are also changed or not. Therefore, we compared plasma TGF-β1 levels in women with and without POP. Methods: Participants were 49 women with POP and 23 healthy control women. All participants were postmenopausal. We measured plasma TGF-β1 and compared data between patients with POP and controls, and between patients with uterine prolapse (UP, n = 19) and those with a cystocele (CC, n = 30). In addition, in patients, we assessed the POP quantification system (POP-Q) stage. Results: Plasma TGF-β1 levels were significantly lower in patients than in healthy controls. POP-Q stage was not significantly different between the UP and CC subgroups, but POP-Q stage IV was diagnosed in 63% of patients with UP and 7% of those with CC. Plasma TGF-β1 levels were significantly lower in the CC subgroup than in the UP subgroup. Conclusion: Plasma TGF-β1 is decreased in POP. It remains unclear whether the lower levels indicate a reduction in systemic TGF-β1 activity, but they can be assumed to reflect reduced TGF-β1 expression in POP tissues. 展开更多
关键词 CYSTOCELE Pelvic organ Prolapse transforming Growth Factor-Beta 1 (TGF-β1) Uterine Prolapse
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A Fatal Case of Chronic Eosinophilic Leukemia Not Otherwise Specified (CEL-NOS) in a 19-Year-Old Male with Acute Transformation into Blast Crisis
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作者 Basheer Al-Sanouri Basheer Al-Sanouri +1 位作者 Yahya Maslamani Ibrahim Al-Sanouri 《Case Reports in Clinical Medicine》 2016年第12期528-540,共14页
Chronic eosinophilic leukemia (CEL) is a rare disorder that is characterized by hypereosinophilia with increased number of blood or marrow blasts (>5% and <20%). CEL is distinguished from hypereosinophilic syndr... Chronic eosinophilic leukemia (CEL) is a rare disorder that is characterized by hypereosinophilia with increased number of blood or marrow blasts (>5% and <20%). CEL is distinguished from hypereosinophilic syndrome (HES) by the presence of eosinophilic clonality. Chronic eosinophilic leukemia not otherwise specified (CEL-NOS) diagnosis is made when no fusion genes are detected by most modern molecular testing, particularly the most common fusion gene FIP1L-1/PDGFRA (Factor Interacting with PAP like-1/Platelet-Derived Growth Factor Receptor Alpha). This disease is very rare, and its description in the literature is not well characterized. We report a fetal case of severe CEL-NOS in a 19-year-old male who presented with a plethora of clinical features consists of constitutional symptoms, pancytopenia, intravascular thrombosis, acute stroke and endomyocardial infiltrates. The course of his disease was aggressive and resistant to conventional treatment. After a short period of improvement, an acute transformation into blast crisis (BC) had occurred. The diagnosis was confirmed by morphology and immunophenotyping of bone marrow biopsy. The patient eventually died of heart failure and sepsis. To our knowledge this is the first case report of fatal CEL-NOS transforming into severe blast crisis. 展开更多
关键词 Hypereosinophilic Syndrome (HES) Eosinophils Degranulation WHO World Health organization Classification Chronic Eosinophilic Leukemia Not Other-wise Specified (CEL-NOS) Fluorescent In Situ Hybridization (FISH) Tyrosine Kinase Inhibitor Imatinib Acute transformation into Blast Crisis
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多级特征交互Transformer的多器官图像分割
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作者 武书磊 张方红 +1 位作者 杨有 刘学文 《计算机系统应用》 2024年第6期232-241,共10页
多器官医学图像分割有助于医生做出临床诊断.针对CNN提取全局特征能力弱,Transformer提取局部特征能力弱,以及Transformer具有二次方计算复杂度的问题,提出了用于多器官医学图像分割的多级特征交互Transformer模型.所提模型采用CNN提取... 多器官医学图像分割有助于医生做出临床诊断.针对CNN提取全局特征能力弱,Transformer提取局部特征能力弱,以及Transformer具有二次方计算复杂度的问题,提出了用于多器官医学图像分割的多级特征交互Transformer模型.所提模型采用CNN提取局部特征,局部特征经Swin Transformer输出全局特征;通过下采样分别产生多级局部和全局特征,每级局部和全局特征经过交互并增强;每级增强后的特征经多级特征融合模块进行交叉融合;再次融合后的特征经过上采样和分割头输出分割掩码.所提模型在Synapse和ACDC数据集上进行实验,平均DSC和平均HD95系数值为80.16%和19.20 mm,均优于LGNet和RFE-UNet等代表性模型.该模型对多器官医学图像分割是有效的. 展开更多
关键词 多器官医学图像分割 多级特征交互 transformER 卷积神经网络(CNN) 语义分割 深度学习
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Biotechnological Transformation of Lignocellulosic Biomass in to Industrial Products: An Overview
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作者 Amit Kumar Archana Gautam Dharm Dutt 《Advances in Bioscience and Biotechnology》 2016年第3期149-168,共20页
Lignocellulose—a major component of biomass available on earth is a renewable and abundantly available with great potential for bioconversion to value-added bio-products. The review aims at physio-chemical features o... Lignocellulose—a major component of biomass available on earth is a renewable and abundantly available with great potential for bioconversion to value-added bio-products. The review aims at physio-chemical features of lignocellulosic biomass and composition of different lignocellulosic materials. This work is an overview about the conversion of lignocellulosic biomass into bio-energy products such as bio-ethanol, 1-butanol, bio-methane, bio-hydrogen, organic acids including citric acid, succinic acid and lactic acid, microbial polysaccharides, single cell protein and xylitol. The biotechnological aspect of bio-transformation of lignocelluloses research and its future prospects are also discussed. 展开更多
关键词 Lignocellulosic Biomass Bio-transformation BIO-ENERGY organic Acids Microbial Polysaccharides Single Cell Proteins
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技术治理视角下医保数字化转型的实践风险与应对
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作者 褚雷 王艺颖 《山东行政学院学报》 2025年第2期91-99,共9页
深入推进医保制度体系数字化转型是落实数字中国建设重大部署,是实现医保事业高质量发展战略目标的重要举措。从技术治理的视角出发,选取“技术—结构”“情境—关系”和“价值—目标”三个维度,探讨医保体系数字化转型实践过程中面临... 深入推进医保制度体系数字化转型是落实数字中国建设重大部署,是实现医保事业高质量发展战略目标的重要举措。从技术治理的视角出发,选取“技术—结构”“情境—关系”和“价值—目标”三个维度,探讨医保体系数字化转型实践过程中面临的组织调整适配不足风险、技术情境中协同功能发挥失灵风险以及工具理性下多元需求回应滞后风险。聚焦技术层面的精准应用与安全有效、组织层面的机制创新与包容协同以及价值层面的需求驱动与公平可及,坚持以人民为中心推进技术精准赋能和医保体系优化升级,才能平稳推进医保数字化转型,加快实现医保数字化建设目标。 展开更多
关键词 医保数字化转型 技术治理 组织 情境 风险应对
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舒兰教授基于“平衡脏腑、内外合治”思想论治性早熟
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作者 陶洪 舒兰 《湖南中医药大学学报》 2025年第1期164-168,共5页
性早熟是儿童常见的内分泌疾病之一,也是严重阻碍儿童健康成长及心理健康的疾病之一。目前,西医治疗本病使用促性腺激素释放激素类似物,但临床实际运用该类药物时有明显的局限性。国家级名中医舒兰教授认为,性早熟的基本病机为肾之阴阳... 性早熟是儿童常见的内分泌疾病之一,也是严重阻碍儿童健康成长及心理健康的疾病之一。目前,西医治疗本病使用促性腺激素释放激素类似物,但临床实际运用该类药物时有明显的局限性。国家级名中医舒兰教授认为,性早熟的基本病机为肾之阴阳失衡,“天癸”早至,并提出引起肾之阴阳失衡的原因不局限于肾脏本身,而在于脏腑之间生理功能联系失衡,以平衡脏腑功能、内外合治为基本治疗原则。内治以平衡脏腑为法,常用龙胆泻肝汤合知柏地黄汤、柴胡疏肝散合二陈汤、二陈汤合二至丸、黄连阿胶汤合两地汤等加减治疗;外治以消肿通络为法,常用玄明粉外敷或自制早熟贴治疗,并强调临证时需注重宣教开导、身心兼治。基于“平衡脏腑、内外合治”的思想为性早熟提供新的诊疗思路,并附临床验案一则。 展开更多
关键词 性早熟 平衡脏腑 内外合治 舒兰 乳疠 肝郁化火、肾阴不足证
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