BACKGROUND At present,China has become the country with the largest number of individuals with diabetes mellitus(DM)in the world,with a total of approximately 140 million patients,the majority of whom have type 2 DM(T...BACKGROUND At present,China has become the country with the largest number of individuals with diabetes mellitus(DM)in the world,with a total of approximately 140 million patients,the majority of whom have type 2 DM(T2DM).Based on conven-tional nursing methods,community home care has important clinical significance in controlling blood sugar and disease progression.AIM To explore the impact of community public health nursing on treatment effect,health cognition,and self-management in patients with T2DM.METHODS One hundred patients with T2DM were selected as the research subjects.The patients were divided into either a conventional nursing group or community nursing(CN)group using the random number table method.The conventional nursing group(50 cases)received routine care,while the CN group(50 cases)received community public health care in addition to routine care as that for the conventional nursing group.The rate of excellent and good blood glucose control,fasting blood glucose before and after care,2-h postprandial blood glucose,health cognition,and self-management ability,and patient satisfaction were compared between the two groups.RESULTS The CN group had a higher rate of excellent blood sugar control than the conventional nursing group(88%vs 70%,P<0.05).Before care,there was no significant difference in fasting blood glucose or 2-h postprandial blood glucose between the two groups of patients(P>0.05).After nursing,fasting blood glucose and 2-h postprandial blood glucose were reduced to varying degrees in both groups,and both blood glucose levels in the CN group were lower than those of the conventional nursing group(P<0.05).Compared with the scores before care,the cognitive level score for diabetes and self-management ability score improved after care in both groups.The cognitive level and self-management ability of patients in the CN group were higher than those of the conventional nursing group(P<0.05).The overall satisfaction of the CN group was better than that of the conventional nursing group(98%vs 86%,P<0.05).CONCLUSION Community public health care based on conventional care of T2DM can achieve better blood sugar control,and improve patients’health cognitive level and self-management ability.展开更多
BACKGROUND Cognitive impairment is one of the common clinical manifestations of depression,causing negative distress to patients.Elevated homocysteine(Hcy)concentrations and gut microbiome dysfunction may be observed ...BACKGROUND Cognitive impairment is one of the common clinical manifestations of depression,causing negative distress to patients.Elevated homocysteine(Hcy)concentrations and gut microbiome dysfunction may be observed in patients with depression.AIM To investigate the relationship between Hcy,microbiome,and cognition in depressive patients.METHODS We recruited 67 patients with major depressive disorder(MDD)(MDD group)and 94 healthy controls(HCs)individuals(HCs group).Serum Hcy levels were determined using the enzyme circulation method.16s rRNA sequencing was used to classify and identify the fecal bacteria.17 Hamilton depression rating scale and MATRICS consensus cognitive battery were used to evaluate mood states and cognition in patients with MDD. Correlation analysis was performed to explore the correlation between fecal flora,Hcy, and depressive cognitive function.RESULTSElevated serum levels of Hcy were seen in patients with MDD compared to healthy individuals. Patients withMDD indicated significant decreases in cognitive scores (P < 0.001) in six modules: Speed of processing, workingmemory, visual learning, reasoning and problem-solving, social cognition, and total scores. Hcy levels showed anegative correlation with processing speed, social cognition, and total MDD scores (P < 0.05). Hcy was alsosignificantly negatively correlated with Alistipes, Ruminococcae, Tenericides, and Porphyromonas (P < 0.05).CONCLUSIONOur results highlight that Hcy was correlated with cognition and gut microbiome in MDD. This interaction may berelated to the physiological and pathological mechanisms underlying cognitive deficits in depression.展开更多
In patients with Alzheimer’s disease,gamma-glutamyl transferase 5(GGT5)expression has been observed to be downregulated in cerebrovascular endothelial cells.However,the functional role of GGT5 in the development of A...In patients with Alzheimer’s disease,gamma-glutamyl transferase 5(GGT5)expression has been observed to be downregulated in cerebrovascular endothelial cells.However,the functional role of GGT5 in the development of Alzheimer’s disease remains unclear.This study aimed to explore the effect of GGT5 on cognitive function and brain pathology in an APP/PS1 mouse model of Alzheimer’s disease,as well as the underlying mechanism.We observed a significant reduction in GGT5 expression in two in vitro models of Alzheimer’s disease(Aβ_(1-42)-treated hCMEC/D3 and bEnd.3 cells),as well as in the APP/PS1 mouse model.Additionally,injection of APP/PS1 mice with an adeno-associated virus encoding GGT5 enhanced hippocampal synaptic plasticity and mitigated cognitive deficits.Interestingly,increasing GGT5 expression in cerebrovascular endothelial cells reduced levels of both soluble and insoluble amyloid-βin the brains of APP/PS1 mice.This effect may be attributable to inhibition of the expression ofβ-site APP cleaving enzyme 1,which is mediated by nuclear factor-kappa B.Our findings demonstrate that GGT5 expression in cerebrovascular endothelial cells is inversely associated with Alzheimer’s disease pathogenesis,and that GGT5 upregulation mitigates cognitive deficits in APP/PS1 mice.These findings suggest that GGT5 expression in cerebrovascular endothelial cells is a potential therapeutic target and biomarker for Alzheimer’s disease.展开更多
The utilization of millimeter-wave frequencies and cognitive radio(CR)are promising ways to increase the spectral efficiency of wireless communication systems.However,conventional CR spectrum sensing techniques entail...The utilization of millimeter-wave frequencies and cognitive radio(CR)are promising ways to increase the spectral efficiency of wireless communication systems.However,conventional CR spectrum sensing techniques entail sampling the received signal at a Nyquist rate,and they are not viable for wideband signals due to their high cost.This paper expounds on how sub-Nyquist sampling in conjunction with deep learning can be leveraged to remove this limitation.To this end,we propose a multi-task learning(MTL)framework using convolutional neural networks for the joint inference of the underlying narrowband signal number,their modulation scheme,and their location in a wideband spectrum.We demonstrate the effectiveness of the proposed framework for real-world millimeter-wave wideband signals collected by physical devices,exhibiting a 91.7% accuracy in the joint inference task when considering up to two narrowband signals over a wideband spectrum.Ultimately,the proposed data-driven approach enables on-the-fly wideband spectrum sensing,combining accuracy,and computational efficiency,which are indispensable for CR and opportunistic networking.展开更多
A cooperative model of multiple primary and secondary users coexisting cognitive network is presented. In this model, the control center is aware of all the users＇ locations in order to allocate the nearest secondary...A cooperative model of multiple primary and secondary users coexisting cognitive network is presented. In this model, the control center is aware of all the users＇ locations in order to allocate the nearest secondary user to the primary user. The control center is aware of the information of the unused spectral resources in terms of the feedback of the sensing results from the secondary users. It allocates idle frequency bands among the secondary users. The primary user accesses the base station （BS） in orthogonal subchannels, and it cooperatively transmits packets with the secondary user and exploits the free band assigned by the control center to amplify-and-forward what it receives immediately. Under this scenario, the outage probability of the cooperative transmission pair of the primary and secondary transmitters is derived. The numerical simulation of the outage probabilities as a function of primary transmission probability ps, power allocation ratio ξ between the primary and secondary users, and the numbers of the primary and secondary users are given respectively. The results show that the optimal system performance is achieved under the conditions of ξ=0.5 and the numbers of the primary and the secondary users being equal.展开更多
BACKGROUND Propofol and sevoflurane are commonly used anesthetic agents for maintenance anesthesia during radical resection of gastric cancer.However,there is a debate concerning their differential effects on cognitiv...BACKGROUND Propofol and sevoflurane are commonly used anesthetic agents for maintenance anesthesia during radical resection of gastric cancer.However,there is a debate concerning their differential effects on cognitive function,anxiety,and depression in patients undergoing this procedure.AIM To compare the effects of propofol and sevoflurane anesthesia on postoperative cognitive function,anxiety,depression,and organ function in patients undergoing radical resection of gastric cancer.METHODS A total of 80 patients were involved in this research.The subjects were divided into two groups:Propofol group and sevoflurane group.The evaluation scale for cognitive function was the Loewenstein occupational therapy cognitive assessment(LOTCA),and anxiety and depression were assessed with the aid of the self-rating anxiety scale(SAS)and self-rating depression scale(SDS).Hemodynamic indicators,oxidative stress levels,and pulmonary function were also measured.RESULTS The LOTCA score at 1 d after surgery was significantly lower in the propofol group than in the sevoflurane group.Additionally,the SAS and SDS scores of the sevoflurane group were significantly lower than those of the propofol group.The sevoflurane group showed greater stability in heart rate as well as the mean arterial pressure compared to the propofol group.Moreover,the sevoflurane group displayed better pulmonary function and less lung injury than the propofol group.CONCLUSION Both propofol and sevoflurane could be utilized as maintenance anesthesia during radical resection of gastric cancer.Propofol anesthesia has a minimal effect on patients'pulmonary function,consequently enhancing their postoperative recovery.Sevoflurane anesthesia causes less impairment on patients'cognitive function and mitigates negative emotions,leading to an improved postoperative mental state.Therefore,the selection of anesthetic agents should be based on the individual patient's specific circumstances.展开更多
According to the fact that the secondary users＇ delay requirements for data transmission are not unitary in cognitive radio networks, the secondary users are divided into two classes, denoted by SU1 and SU2, respecti...According to the fact that the secondary users＇ delay requirements for data transmission are not unitary in cognitive radio networks, the secondary users are divided into two classes, denoted by SU1 and SU2, respectively. It is assumed that SU1 has a higher priority to occupy the primary users＇ unutilized channels than SU2. A preemptive resume priority M/G/1 queuing network is used to model the multiple spectrum handoffs processing. By using a state transition probability matrix and a cost matrix, the average cumulative delays of SU1 and SU2 are calculated, respectively. Numerical results show that the more the primary user＇s traffic load, the more rapidly the SU2＇s cumulative handoff delay grows. Compared with the networks where secondary users are unitary, the lower the SUI＇s arrival rate, the more obviously both SUI＇s and SU2＇s handoff delays decrease. The admission access regions limited by the maximum tolerable delay can also facilitate the design of admission control rules for graded secondary users.展开更多
The interference alignment （IA） algorithm based on FDPM subspace tracking （FDPM-ST IA） is proposed for MIMO cognitive network （CRN） with multiple primary users in this paper. The feasibility conditions of FDPM-S...The interference alignment （IA） algorithm based on FDPM subspace tracking （FDPM-ST IA） is proposed for MIMO cognitive network （CRN） with multiple primary users in this paper. The feasibility conditions of FDPM-ST IA is also got. Futherly, IA scheme of secondary network and IA scheme of primary network are given respectively without assuming a priori knowledge of interference covariance matrices. Moreover, the paper analyses the computational complexity of FDPM-ST IA. Simulation results and theoretical calculations show that the proposed algorithm can achieve higher sum rate with lower computational complexity.展开更多
Introduction: The epidemiology of both hepatitis B virus (HBV) and hepatitis C virus (HCV) infections among drug users (DUs) is little known in West Africa. The study aimed to assess the prevalence of hepatitis B and ...Introduction: The epidemiology of both hepatitis B virus (HBV) and hepatitis C virus (HCV) infections among drug users (DUs) is little known in West Africa. The study aimed to assess the prevalence of hepatitis B and C viruses among drug users in Burkina Faso. Methodology: This was a cross-sectional biological and behavioral survey conducted between June and August 2022, among drug users in Ouagadougou and Bobo Dioulasso, the two main cities of Burkina Faso. A respondent-driven sampling (RDS) was used to recruit drug users. Hepatitis B surface antigen was determined using lateral flow rapid test kits and antibodies to hepatitis C virus in serum determined using an Enzyme-Linked Immunosorbent Assay. Data were entered and analyzed using Stata 17 software. Weighted binary logistic regression was used to identify the associated factors of hepatitis B and C infections and a p-value Results: A total of 323 drug users were recruited with 97.5% males. The mean age was 32.7 years old. The inhaled or smoked mode was the most used by drug users. The adjusted hepatitis B and hepatitis C prevalence among study participants were 11.1% and 2.3% respectively. The marital status (p = 0.001), and the nationality (p = 0.011) were significantly associated with hepatitis B infection. The type of drug used was not significantly associated with hepatitis B infection or hepatitis C infection. Conclusion: The prevalence of HBsAg and anti-HCV antibodies among DUs are comparable to those reported in the general population in Burkina Faso. This result suggests that the main routes of contamination by HBV and HCV among DUs are similar to those in the population, and could be explained by the low use of the injectable route by DUs in Burkina Faso.展开更多
Recently,user recognitionmethods to authenticate personal identity has attracted significant attention especially with increased availability of various internet of things(IoT)services through fifth-generation technol...Recently,user recognitionmethods to authenticate personal identity has attracted significant attention especially with increased availability of various internet of things(IoT)services through fifth-generation technology(5G)based mobile devices.The EMG signals generated inside the body with unique individual characteristics are being studied as a part of nextgeneration user recognition methods.However,there is a limitation when applying EMG signals to user recognition systems as the same operation needs to be repeated while maintaining a constant strength of muscle over time.Hence,it is necessary to conduct research on multidimensional feature transformation that includes changes in frequency features over time.In this paper,we propose a user recognition system that applies EMG signals to the short-time fourier transform(STFT),and converts the signals into EMG spectrogram images while adjusting the time-frequency resolution to extract multidimensional features.The proposed system is composed of a data pre-processing and normalization process,spectrogram image conversion process,and final classification process.The experimental results revealed that the proposed EMG spectrogram image-based user recognition system has a 95.4%accuracy performance,which is 13%higher than the EMGsignal-based system.Such a user recognition accuracy improvement was achieved by using multidimensional features,in the time-frequency domain.展开更多
Autonomous vehicles (AVs) hold immense promises in revolutionizing transportation, and their potential benefits extend to individuals with impairments, particularly those with vision and hearing impairments. However, ...Autonomous vehicles (AVs) hold immense promises in revolutionizing transportation, and their potential benefits extend to individuals with impairments, particularly those with vision and hearing impairments. However, the accommodation of these individuals in AVs requires developing advanced user interfaces. This paper describes an explorative study of a multimodal user interface for autonomous vehicles, specifically developed for passengers with sensory (vision and/or hearing) impairments. In a driving simulator, 32 volunteers with simulated sensory impairments, were exposed to multiple drives in an autonomous vehicle while freely interacting with standard and inclusive variants of the infotainment and navigation system interface. The two user interfaces differed in graphical layout and voice messages, which adopted inclusive design principles for the inclusive variant. Questionnaires and structured interviews were conducted to collect participants’ impressions. The data analysis reports positive user experiences, but also identifies technical challenges. Verified guidelines are provided for further development of inclusive user interface solutions.展开更多
In traditional cognitive radio(CR) network,secondary users(SUs) are always assumed to obey the rule of"introducing no interference to the primary users(PUs) ".However,this assumption may be not realistic as ...In traditional cognitive radio(CR) network,secondary users(SUs) are always assumed to obey the rule of"introducing no interference to the primary users(PUs) ".However,this assumption may be not realistic as the CR devices becoming more and more intelligent nowadays.In this paper,with the concept of lighthanded CR,which is proposed to deal with the above mentioned problem by enforcing"punishment"to illegal CR transmissions,the action decisions of primary users(PUs) are modeled as a partially observable Markov decision process(POMDP),and the optimal spectrum allocation scheme with the objective of maximizing their reward is proposed,which is defined by the utility function.Furthermore,a reduced scheme with much smaller state space has been proposed in this paper for lower computational complexity.Extensive simulation results show that the proposed schemes improve the reward significantly compared to the existing scheme.展开更多
During the 1980s, as part of a policy of liberalization, following budgetary cuts linked to the implementation of structural adjustment programs, management responsibilities for AHAs were transferred from ONAHA to coo...During the 1980s, as part of a policy of liberalization, following budgetary cuts linked to the implementation of structural adjustment programs, management responsibilities for AHAs were transferred from ONAHA to cooperatives concerned. Due to lack of financial resources, but also because of poor management, everywhere in Niger we are witnessing an accelerated deterioration of the irrigation infrastructure of hydro-agricultural developments. Institutional studies carried out on this situation led the State of Niger to initiate a reform of the governance of hydro-agricultural developments, by streng-thening the status of ONAHA, by creating an Association of Irrigation Water Users (AUEI) and by restructuring the old cooperatives. Indeed, this research aims to analyze the creation of functional and sustainable Irrigation Water User Associations (AUEI) in Niger in a context of reform of the irrigation sector, and based on the experience of the Konni AHA. It is based on a methodological approach which takes into account documentary research and the collection of data from 115 farmers, selected by reasoned choice and directly concerned by the management of the irrigated area. The data collected was analyzed and the results were analyzed using the systemic approach and the diagnostic process. The results show that the main mission of the AUEI is to ensure better management of water, hydraulic equipment and infrastructure on the hydro-agricultural developments of Konni. The creation of the Konni AUEI was possible thanks to massive support from the populations and authorities in the implementation process. After its establishment, the AUEI experienced a certain lethargy for some time due to the rehabilitation work of the AHA but currently it is functional and operational in terms of associative life and governance. Thus, the constraints linked to the legal system, the delay in the completion of the work, the uncertainties of access to irrigation water but also the problems linked to the change in mentality of certain ONAHA agents constitute the challenges that must be resolved in the short term for the operationalization of the Konni AUEI.展开更多
In cognitive radio networks(CRNs), through recruiting secondary user(SU) as friendly jammer, the secrecy rate obtained by primary user(PU) can be improved. Previous work only considered a simple scenario with a single...In cognitive radio networks(CRNs), through recruiting secondary user(SU) as friendly jammer, the secrecy rate obtained by primary user(PU) can be improved. Previous work only considered a simple scenario with a single PU in their frameworks. In this paper, we will consider a more complicated scenario with multiple PUs and try to investigate the cooperative jamming between multiple PUs and a single SU. When there are multiple PUs in CRN, in order to obtain more spectrum for data transmission, SU will cooperate with multiple PUs at the same time. Considering that both PU and SU are rational and selfish individuals, the interaction between PUs and SU is formulated as a multi-leaders and single-follower Stackelberg game, wherein PU is the leader and SU is the follower. And the Stackelberg Equilibrium(SE) is considered as the final decisions accepted by all PUs and SU. Furthermore, we also prove that when a specific condition is satisfied, the existence of SE can be guaranteed. And a Gauss-Jacobi iterative algorithm is proposed to compute a SE. Finally, simulation results are given to verify the performance and demonstrate that both of the PUs' secrecy rate and the SU's transmission rate can be improved through cooperation.展开更多
In this paper,a cooperative spectrum sensing scheme,which is based on cooperation of a certain number of secondary users and cooperative diversity under multi-antenna scenario,is proposed.Under multi-antenna scenario,...In this paper,a cooperative spectrum sensing scheme,which is based on cooperation of a certain number of secondary users and cooperative diversity under multi-antenna scenario,is proposed.Under multi-antenna scenario,we set a targeted detection probability and optimize the false alarm probability of the network by choosing a certain number of secondary users with the highest primary user’s signal to noise ratio.The detection performance of the network is also evaluated when all the secondary users are cooperating to illustrate the benefits of the proposed scheme as a contrast.In addition,how to choose the detection threshold of the secondary user is analyzed for the purpose of decreasing the average risk.Theory analysis and simulation results show that the optimum false alarm probability can be derived by cooperating a certain number of secondary users rather than all the secondary users and the detection performance of the network can be further improved if secondary users are equipped with multiple antennas.Also,a minimum average risk can be obtained by optimizing the detection threshold.展开更多
The majority of existing papers about spectrum sensing have the assumption that secondary users(SUs) are stationary. However,mobility is an essential feature of mobile communications networks. In this paper,the detect...The majority of existing papers about spectrum sensing have the assumption that secondary users(SUs) are stationary. However,mobility is an essential feature of mobile communications networks. In this paper,the detection performance of spectrum sensing by mobile SUs was analyzed. Three performance metrics,i.e.,detection probability,miss detection probability and false alarm probability,were thoroughly investigated. In our analysis,a critical variable was the real-time received primary user signal power by a mobile SU. Its probability distribution and mathematical expectation were analytically derived. Moreover,the three performance metrics in single-node spectrum sensing and multi-node collaborative spectrum sensing systems were also derived. Extensive simulations were performed. The results are consistent with the theoretical analysis. And it is concluded that SU mobility has a significant impact on the detection probability and the miss detection probability,but not on the false alarm probability.展开更多
The cognitive multiple input multiple output( MIMO)network can utilize radio spectrum efficiently and satisfy the demand of high data rate. In order to decrease the interference during transmission,a new interference ...The cognitive multiple input multiple output( MIMO)network can utilize radio spectrum efficiently and satisfy the demand of high data rate. In order to decrease the interference during transmission,a new interference alignment( IA) algorithm based on cognitive MIMO networks is proposed in this paper. The algorithm is realized by designing two-level pre-coding, the first-level precoding aligns the interference generated by the cognitive users( CUs) to unused sub-channels of the primary user( PU),thereby eliminating the interference of CUs to PU; the second-level precoding is used to improve the throughput of CUs. Simulation shows that the proposed IA algorithm can eliminate the interference that the CUs produce on the PU and improve the throughput of CUs spontaneously.展开更多
In the era of network live broadcasting for everyone,the development of live broadcasting platforms is also more intelligent and diversified.However,in the face of a large group of elderly users,the interface interact...In the era of network live broadcasting for everyone,the development of live broadcasting platforms is also more intelligent and diversified.However,in the face of a large group of elderly users,the interface interaction design mode used is still mainly based on the interaction mode for young groups,and is not designed for elderly users.Therefore,a design method for optimizing the interaction interface of live broadcasting platform for elderly users was proposed in this study.Firstly,the case study method and Delphi expert survey method were used to determine the design needs of elderly users and the design mode was analysed.Secondly,the orthogonal design principle was used to design a test sample of the interactive interface of live broadcasting platform applicable for the elderly users,and then a user evaluation system was established to calculate the weights of the design elements using hierarchical analysis,and then the predictive relationship between the design mode of the interactive interface of live broadcasting platform and the elderly users was established by Quantitative Theory I.Finally,Genetic Algorithm was applied to generate the optimized design scheme.The results showed that the design method based on the Genetic Algorithm and the combination of Quantitative Theory can scientifically and effectively optimize the design of the interactive interface of the live broadcasting platform for the elderly users,and improve the experience of the elderly users.展开更多
In a cognitive radio network, the secondary users can use the spectrum holes when the primary users do not utilize the spectrum, but they must vacant the spectrum when the primary users need to transmit data on the sp...In a cognitive radio network, the secondary users can use the spectrum holes when the primary users do not utilize the spectrum, but they must vacant the spectrum when the primary users need to transmit data on the spectrum. In other words, the primary users have higher priority over the secondary users. In this paper, backlog and delay distribution bounds for both primary users and secondary users are obtained. The analysis is based on stochastic network calculus, for which, stochastic service curves are t-n-st derived for both primary users and secondary users, and the network calculus independent case analysis approach is used to find the distribution bounds. Numerical results and simulation results are also presented and discussed.展开更多
Metaverse,once a concept confined to science fiction,has emerged as a transformative reality during the digital era.As this immersive virtual world gains prominence,the role of avatars and the digital representations ...Metaverse,once a concept confined to science fiction,has emerged as a transformative reality during the digital era.As this immersive virtual world gains prominence,the role of avatars and the digital representations of users in shaping educational experiences within a metaverse becomes increasingly crucial.This study examined the design of avatars and their effectiveness in virtual education.Using the cognitive walkthrough(CW)method,a well-established user-centric assessment approach,this study examined how users engage in avatar design in virtual educational settings,highlighting their cognitive processes.Through the CW approach,this study identified usability issues and learning challenges,providing valuable insights into the user experience.The investigation focuses on the VRoid platform for avatar design,selected for its user-friendly interface and robust customization features.Participants(n=12;six men and six women)from diverse educational backgrounds were carefully selected to offer a comprehensive range of perspectives.They performed avatar design tasks that closely mirrored the learning environment of the metaverse,followed by in-depth post-exercise interviews.The findings of this study highlight the essential role of avatar design in enhancing user engagement and improving the learning outcomes of virtual education.Furthermore,we provide practical recommendations for educators and designers to effectively leverage avatar innovation.In a continuously evolving era of metaverse,this research contributes significantly to the ongoing discourse on user-centered design in educational settings,thereby influencing the future trajectory of virtual education.展开更多
文摘BACKGROUND At present,China has become the country with the largest number of individuals with diabetes mellitus(DM)in the world,with a total of approximately 140 million patients,the majority of whom have type 2 DM(T2DM).Based on conven-tional nursing methods,community home care has important clinical significance in controlling blood sugar and disease progression.AIM To explore the impact of community public health nursing on treatment effect,health cognition,and self-management in patients with T2DM.METHODS One hundred patients with T2DM were selected as the research subjects.The patients were divided into either a conventional nursing group or community nursing(CN)group using the random number table method.The conventional nursing group(50 cases)received routine care,while the CN group(50 cases)received community public health care in addition to routine care as that for the conventional nursing group.The rate of excellent and good blood glucose control,fasting blood glucose before and after care,2-h postprandial blood glucose,health cognition,and self-management ability,and patient satisfaction were compared between the two groups.RESULTS The CN group had a higher rate of excellent blood sugar control than the conventional nursing group(88%vs 70%,P<0.05).Before care,there was no significant difference in fasting blood glucose or 2-h postprandial blood glucose between the two groups of patients(P>0.05).After nursing,fasting blood glucose and 2-h postprandial blood glucose were reduced to varying degrees in both groups,and both blood glucose levels in the CN group were lower than those of the conventional nursing group(P<0.05).Compared with the scores before care,the cognitive level score for diabetes and self-management ability score improved after care in both groups.The cognitive level and self-management ability of patients in the CN group were higher than those of the conventional nursing group(P<0.05).The overall satisfaction of the CN group was better than that of the conventional nursing group(98%vs 86%,P<0.05).CONCLUSION Community public health care based on conventional care of T2DM can achieve better blood sugar control,and improve patients’health cognitive level and self-management ability.
基金Supported by the Wuxi Municipal Health Commission Youth Fund Project,No.Q202268Wuxi Scientific and technological breakthrough of“Light of the Taihu Lake”(Basic Research),No.K20221039+4 种基金Jiangsu Shuangchuang Doctoral Program,No.JSSCBS20221991Beijing Municipal Administration of Hospital Incubating Program,No.PX2023070 and No.PX2024072Capital’s Funds for Health Improvement and Research,No.SF2024-4-2134Beijing Hospitals Authority Youth Program,No.QML20232003the Top Talent Support Program for young and middle-aged people of Wuxi Health Committee,No.HB2023089.
文摘BACKGROUND Cognitive impairment is one of the common clinical manifestations of depression,causing negative distress to patients.Elevated homocysteine(Hcy)concentrations and gut microbiome dysfunction may be observed in patients with depression.AIM To investigate the relationship between Hcy,microbiome,and cognition in depressive patients.METHODS We recruited 67 patients with major depressive disorder(MDD)(MDD group)and 94 healthy controls(HCs)individuals(HCs group).Serum Hcy levels were determined using the enzyme circulation method.16s rRNA sequencing was used to classify and identify the fecal bacteria.17 Hamilton depression rating scale and MATRICS consensus cognitive battery were used to evaluate mood states and cognition in patients with MDD. Correlation analysis was performed to explore the correlation between fecal flora,Hcy, and depressive cognitive function.RESULTSElevated serum levels of Hcy were seen in patients with MDD compared to healthy individuals. Patients withMDD indicated significant decreases in cognitive scores (P < 0.001) in six modules: Speed of processing, workingmemory, visual learning, reasoning and problem-solving, social cognition, and total scores. Hcy levels showed anegative correlation with processing speed, social cognition, and total MDD scores (P < 0.05). Hcy was alsosignificantly negatively correlated with Alistipes, Ruminococcae, Tenericides, and Porphyromonas (P < 0.05).CONCLUSIONOur results highlight that Hcy was correlated with cognition and gut microbiome in MDD. This interaction may berelated to the physiological and pathological mechanisms underlying cognitive deficits in depression.
基金supported by STI2030-Major Projects,No.2021ZD 0201801(to JG)Shanxi Province Basic Research Program,No.20210302123429(to QS).
文摘In patients with Alzheimer’s disease,gamma-glutamyl transferase 5(GGT5)expression has been observed to be downregulated in cerebrovascular endothelial cells.However,the functional role of GGT5 in the development of Alzheimer’s disease remains unclear.This study aimed to explore the effect of GGT5 on cognitive function and brain pathology in an APP/PS1 mouse model of Alzheimer’s disease,as well as the underlying mechanism.We observed a significant reduction in GGT5 expression in two in vitro models of Alzheimer’s disease(Aβ_(1-42)-treated hCMEC/D3 and bEnd.3 cells),as well as in the APP/PS1 mouse model.Additionally,injection of APP/PS1 mice with an adeno-associated virus encoding GGT5 enhanced hippocampal synaptic plasticity and mitigated cognitive deficits.Interestingly,increasing GGT5 expression in cerebrovascular endothelial cells reduced levels of both soluble and insoluble amyloid-βin the brains of APP/PS1 mice.This effect may be attributable to inhibition of the expression ofβ-site APP cleaving enzyme 1,which is mediated by nuclear factor-kappa B.Our findings demonstrate that GGT5 expression in cerebrovascular endothelial cells is inversely associated with Alzheimer’s disease pathogenesis,and that GGT5 upregulation mitigates cognitive deficits in APP/PS1 mice.These findings suggest that GGT5 expression in cerebrovascular endothelial cells is a potential therapeutic target and biomarker for Alzheimer’s disease.
文摘The utilization of millimeter-wave frequencies and cognitive radio(CR)are promising ways to increase the spectral efficiency of wireless communication systems.However,conventional CR spectrum sensing techniques entail sampling the received signal at a Nyquist rate,and they are not viable for wideband signals due to their high cost.This paper expounds on how sub-Nyquist sampling in conjunction with deep learning can be leveraged to remove this limitation.To this end,we propose a multi-task learning(MTL)framework using convolutional neural networks for the joint inference of the underlying narrowband signal number,their modulation scheme,and their location in a wideband spectrum.We demonstrate the effectiveness of the proposed framework for real-world millimeter-wave wideband signals collected by physical devices,exhibiting a 91.7% accuracy in the joint inference task when considering up to two narrowband signals over a wideband spectrum.Ultimately,the proposed data-driven approach enables on-the-fly wideband spectrum sensing,combining accuracy,and computational efficiency,which are indispensable for CR and opportunistic networking.
基金The National Natural Science Foundation of China (No.60972026)the Natural Science Foundation of Jiangsu Province (No.BK2008289)Specialized Research Fund for the Doctoral Program ofHigher Education (No.20090092110009)
文摘A cooperative model of multiple primary and secondary users coexisting cognitive network is presented. In this model, the control center is aware of all the users＇ locations in order to allocate the nearest secondary user to the primary user. The control center is aware of the information of the unused spectral resources in terms of the feedback of the sensing results from the secondary users. It allocates idle frequency bands among the secondary users. The primary user accesses the base station （BS） in orthogonal subchannels, and it cooperatively transmits packets with the secondary user and exploits the free band assigned by the control center to amplify-and-forward what it receives immediately. Under this scenario, the outage probability of the cooperative transmission pair of the primary and secondary transmitters is derived. The numerical simulation of the outage probabilities as a function of primary transmission probability ps, power allocation ratio ξ between the primary and secondary users, and the numbers of the primary and secondary users are given respectively. The results show that the optimal system performance is achieved under the conditions of ξ=0.5 and the numbers of the primary and the secondary users being equal.
文摘BACKGROUND Propofol and sevoflurane are commonly used anesthetic agents for maintenance anesthesia during radical resection of gastric cancer.However,there is a debate concerning their differential effects on cognitive function,anxiety,and depression in patients undergoing this procedure.AIM To compare the effects of propofol and sevoflurane anesthesia on postoperative cognitive function,anxiety,depression,and organ function in patients undergoing radical resection of gastric cancer.METHODS A total of 80 patients were involved in this research.The subjects were divided into two groups:Propofol group and sevoflurane group.The evaluation scale for cognitive function was the Loewenstein occupational therapy cognitive assessment(LOTCA),and anxiety and depression were assessed with the aid of the self-rating anxiety scale(SAS)and self-rating depression scale(SDS).Hemodynamic indicators,oxidative stress levels,and pulmonary function were also measured.RESULTS The LOTCA score at 1 d after surgery was significantly lower in the propofol group than in the sevoflurane group.Additionally,the SAS and SDS scores of the sevoflurane group were significantly lower than those of the propofol group.The sevoflurane group showed greater stability in heart rate as well as the mean arterial pressure compared to the propofol group.Moreover,the sevoflurane group displayed better pulmonary function and less lung injury than the propofol group.CONCLUSION Both propofol and sevoflurane could be utilized as maintenance anesthesia during radical resection of gastric cancer.Propofol anesthesia has a minimal effect on patients'pulmonary function,consequently enhancing their postoperative recovery.Sevoflurane anesthesia causes less impairment on patients'cognitive function and mitigates negative emotions,leading to an improved postoperative mental state.Therefore,the selection of anesthetic agents should be based on the individual patient's specific circumstances.
基金The National Natural Science Foundation of China(No.60972026,61271207)the National Science and Technology Major Project(No.2010ZX03006-002-01)+1 种基金the Specialized Research Fund for the Doctoral Program of Higher Education(No.20090092110009)the Specialized Development Foundation for the Achievement Transformation of Jiangsu Province(No.BA2010023)
文摘According to the fact that the secondary users＇ delay requirements for data transmission are not unitary in cognitive radio networks, the secondary users are divided into two classes, denoted by SU1 and SU2, respectively. It is assumed that SU1 has a higher priority to occupy the primary users＇ unutilized channels than SU2. A preemptive resume priority M/G/1 queuing network is used to model the multiple spectrum handoffs processing. By using a state transition probability matrix and a cost matrix, the average cumulative delays of SU1 and SU2 are calculated, respectively. Numerical results show that the more the primary user＇s traffic load, the more rapidly the SU2＇s cumulative handoff delay grows. Compared with the networks where secondary users are unitary, the lower the SUI＇s arrival rate, the more obviously both SUI＇s and SU2＇s handoff delays decrease. The admission access regions limited by the maximum tolerable delay can also facilitate the design of admission control rules for graded secondary users.
基金the National Nature Science Foundation of China under Grant No.61271259 and 61301123,the Chongqing Nature Science Foundation under Grant No.CTSC2011jjA40006,and the Research Project of Chongqing Education Commission under Grant No.KJ120501 and KJ120502
文摘The interference alignment （IA） algorithm based on FDPM subspace tracking （FDPM-ST IA） is proposed for MIMO cognitive network （CRN） with multiple primary users in this paper. The feasibility conditions of FDPM-ST IA is also got. Futherly, IA scheme of secondary network and IA scheme of primary network are given respectively without assuming a priori knowledge of interference covariance matrices. Moreover, the paper analyses the computational complexity of FDPM-ST IA. Simulation results and theoretical calculations show that the proposed algorithm can achieve higher sum rate with lower computational complexity.
文摘Introduction: The epidemiology of both hepatitis B virus (HBV) and hepatitis C virus (HCV) infections among drug users (DUs) is little known in West Africa. The study aimed to assess the prevalence of hepatitis B and C viruses among drug users in Burkina Faso. Methodology: This was a cross-sectional biological and behavioral survey conducted between June and August 2022, among drug users in Ouagadougou and Bobo Dioulasso, the two main cities of Burkina Faso. A respondent-driven sampling (RDS) was used to recruit drug users. Hepatitis B surface antigen was determined using lateral flow rapid test kits and antibodies to hepatitis C virus in serum determined using an Enzyme-Linked Immunosorbent Assay. Data were entered and analyzed using Stata 17 software. Weighted binary logistic regression was used to identify the associated factors of hepatitis B and C infections and a p-value Results: A total of 323 drug users were recruited with 97.5% males. The mean age was 32.7 years old. The inhaled or smoked mode was the most used by drug users. The adjusted hepatitis B and hepatitis C prevalence among study participants were 11.1% and 2.3% respectively. The marital status (p = 0.001), and the nationality (p = 0.011) were significantly associated with hepatitis B infection. The type of drug used was not significantly associated with hepatitis B infection or hepatitis C infection. Conclusion: The prevalence of HBsAg and anti-HCV antibodies among DUs are comparable to those reported in the general population in Burkina Faso. This result suggests that the main routes of contamination by HBV and HCV among DUs are similar to those in the population, and could be explained by the low use of the injectable route by DUs in Burkina Faso.
基金supported by Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education(No.2017R1A6A1A03015496)the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIT)(No.NRF-2021R1A2C1014033).
文摘Recently,user recognitionmethods to authenticate personal identity has attracted significant attention especially with increased availability of various internet of things(IoT)services through fifth-generation technology(5G)based mobile devices.The EMG signals generated inside the body with unique individual characteristics are being studied as a part of nextgeneration user recognition methods.However,there is a limitation when applying EMG signals to user recognition systems as the same operation needs to be repeated while maintaining a constant strength of muscle over time.Hence,it is necessary to conduct research on multidimensional feature transformation that includes changes in frequency features over time.In this paper,we propose a user recognition system that applies EMG signals to the short-time fourier transform(STFT),and converts the signals into EMG spectrogram images while adjusting the time-frequency resolution to extract multidimensional features.The proposed system is composed of a data pre-processing and normalization process,spectrogram image conversion process,and final classification process.The experimental results revealed that the proposed EMG spectrogram image-based user recognition system has a 95.4%accuracy performance,which is 13%higher than the EMGsignal-based system.Such a user recognition accuracy improvement was achieved by using multidimensional features,in the time-frequency domain.
文摘Autonomous vehicles (AVs) hold immense promises in revolutionizing transportation, and their potential benefits extend to individuals with impairments, particularly those with vision and hearing impairments. However, the accommodation of these individuals in AVs requires developing advanced user interfaces. This paper describes an explorative study of a multimodal user interface for autonomous vehicles, specifically developed for passengers with sensory (vision and/or hearing) impairments. In a driving simulator, 32 volunteers with simulated sensory impairments, were exposed to multiple drives in an autonomous vehicle while freely interacting with standard and inclusive variants of the infotainment and navigation system interface. The two user interfaces differed in graphical layout and voice messages, which adopted inclusive design principles for the inclusive variant. Questionnaires and structured interviews were conducted to collect participants’ impressions. The data analysis reports positive user experiences, but also identifies technical challenges. Verified guidelines are provided for further development of inclusive user interface solutions.
基金Sponsored by the National Natural Science Foundation of China(Grant No. 61101113,61072088)the Doctoral Research Initiation Foundation Project of Beijing University of Technology(Grant No. X0002012201104)
文摘In traditional cognitive radio(CR) network,secondary users(SUs) are always assumed to obey the rule of"introducing no interference to the primary users(PUs) ".However,this assumption may be not realistic as the CR devices becoming more and more intelligent nowadays.In this paper,with the concept of lighthanded CR,which is proposed to deal with the above mentioned problem by enforcing"punishment"to illegal CR transmissions,the action decisions of primary users(PUs) are modeled as a partially observable Markov decision process(POMDP),and the optimal spectrum allocation scheme with the objective of maximizing their reward is proposed,which is defined by the utility function.Furthermore,a reduced scheme with much smaller state space has been proposed in this paper for lower computational complexity.Extensive simulation results show that the proposed schemes improve the reward significantly compared to the existing scheme.
文摘During the 1980s, as part of a policy of liberalization, following budgetary cuts linked to the implementation of structural adjustment programs, management responsibilities for AHAs were transferred from ONAHA to cooperatives concerned. Due to lack of financial resources, but also because of poor management, everywhere in Niger we are witnessing an accelerated deterioration of the irrigation infrastructure of hydro-agricultural developments. Institutional studies carried out on this situation led the State of Niger to initiate a reform of the governance of hydro-agricultural developments, by streng-thening the status of ONAHA, by creating an Association of Irrigation Water Users (AUEI) and by restructuring the old cooperatives. Indeed, this research aims to analyze the creation of functional and sustainable Irrigation Water User Associations (AUEI) in Niger in a context of reform of the irrigation sector, and based on the experience of the Konni AHA. It is based on a methodological approach which takes into account documentary research and the collection of data from 115 farmers, selected by reasoned choice and directly concerned by the management of the irrigated area. The data collected was analyzed and the results were analyzed using the systemic approach and the diagnostic process. The results show that the main mission of the AUEI is to ensure better management of water, hydraulic equipment and infrastructure on the hydro-agricultural developments of Konni. The creation of the Konni AUEI was possible thanks to massive support from the populations and authorities in the implementation process. After its establishment, the AUEI experienced a certain lethargy for some time due to the rehabilitation work of the AHA but currently it is functional and operational in terms of associative life and governance. Thus, the constraints linked to the legal system, the delay in the completion of the work, the uncertainties of access to irrigation water but also the problems linked to the change in mentality of certain ONAHA agents constitute the challenges that must be resolved in the short term for the operationalization of the Konni AUEI.
基金supported in part by the National Key Research and Development Program of China under Grant 2016QY01W0204in part by Key Industrial Innovation Chain in Industrial Domain under Grant 2016KTZDGY-02in part by National High-Level TalentsSpecial Support Program of China under Grant CS31117200001
文摘In cognitive radio networks(CRNs), through recruiting secondary user(SU) as friendly jammer, the secrecy rate obtained by primary user(PU) can be improved. Previous work only considered a simple scenario with a single PU in their frameworks. In this paper, we will consider a more complicated scenario with multiple PUs and try to investigate the cooperative jamming between multiple PUs and a single SU. When there are multiple PUs in CRN, in order to obtain more spectrum for data transmission, SU will cooperate with multiple PUs at the same time. Considering that both PU and SU are rational and selfish individuals, the interaction between PUs and SU is formulated as a multi-leaders and single-follower Stackelberg game, wherein PU is the leader and SU is the follower. And the Stackelberg Equilibrium(SE) is considered as the final decisions accepted by all PUs and SU. Furthermore, we also prove that when a specific condition is satisfied, the existence of SE can be guaranteed. And a Gauss-Jacobi iterative algorithm is proposed to compute a SE. Finally, simulation results are given to verify the performance and demonstrate that both of the PUs' secrecy rate and the SU's transmission rate can be improved through cooperation.
基金Acknowledgments The authors are supported by The National 863 Program under Grants 2009AA01Z247 and by National Nature Science Foundation of China （NSFC） under Grants 60972076, 61072052.
文摘In this paper,a cooperative spectrum sensing scheme,which is based on cooperation of a certain number of secondary users and cooperative diversity under multi-antenna scenario,is proposed.Under multi-antenna scenario,we set a targeted detection probability and optimize the false alarm probability of the network by choosing a certain number of secondary users with the highest primary user’s signal to noise ratio.The detection performance of the network is also evaluated when all the secondary users are cooperating to illustrate the benefits of the proposed scheme as a contrast.In addition,how to choose the detection threshold of the secondary user is analyzed for the purpose of decreasing the average risk.Theory analysis and simulation results show that the optimum false alarm probability can be derived by cooperating a certain number of secondary users rather than all the secondary users and the detection performance of the network can be further improved if secondary users are equipped with multiple antennas.Also,a minimum average risk can be obtained by optimizing the detection threshold.
基金supported by National Natural Science Foundation of China under Grand No.61671183
文摘The majority of existing papers about spectrum sensing have the assumption that secondary users(SUs) are stationary. However,mobility is an essential feature of mobile communications networks. In this paper,the detection performance of spectrum sensing by mobile SUs was analyzed. Three performance metrics,i.e.,detection probability,miss detection probability and false alarm probability,were thoroughly investigated. In our analysis,a critical variable was the real-time received primary user signal power by a mobile SU. Its probability distribution and mathematical expectation were analytically derived. Moreover,the three performance metrics in single-node spectrum sensing and multi-node collaborative spectrum sensing systems were also derived. Extensive simulations were performed. The results are consistent with the theoretical analysis. And it is concluded that SU mobility has a significant impact on the detection probability and the miss detection probability,but not on the false alarm probability.
基金Innovation Program of Shanghai Municipal Education Commission,China(No.12ZZ126)the Program of Shanghai Normal University,China(No.DZL126)
文摘The cognitive multiple input multiple output( MIMO)network can utilize radio spectrum efficiently and satisfy the demand of high data rate. In order to decrease the interference during transmission,a new interference alignment( IA) algorithm based on cognitive MIMO networks is proposed in this paper. The algorithm is realized by designing two-level pre-coding, the first-level precoding aligns the interference generated by the cognitive users( CUs) to unused sub-channels of the primary user( PU),thereby eliminating the interference of CUs to PU; the second-level precoding is used to improve the throughput of CUs. Simulation shows that the proposed IA algorithm can eliminate the interference that the CUs produce on the PU and improve the throughput of CUs spontaneously.
文摘In the era of network live broadcasting for everyone,the development of live broadcasting platforms is also more intelligent and diversified.However,in the face of a large group of elderly users,the interface interaction design mode used is still mainly based on the interaction mode for young groups,and is not designed for elderly users.Therefore,a design method for optimizing the interaction interface of live broadcasting platform for elderly users was proposed in this study.Firstly,the case study method and Delphi expert survey method were used to determine the design needs of elderly users and the design mode was analysed.Secondly,the orthogonal design principle was used to design a test sample of the interactive interface of live broadcasting platform applicable for the elderly users,and then a user evaluation system was established to calculate the weights of the design elements using hierarchical analysis,and then the predictive relationship between the design mode of the interactive interface of live broadcasting platform and the elderly users was established by Quantitative Theory I.Finally,Genetic Algorithm was applied to generate the optimized design scheme.The results showed that the design method based on the Genetic Algorithm and the combination of Quantitative Theory can scientifically and effectively optimize the design of the interactive interface of the live broadcasting platform for the elderly users,and improve the experience of the elderly users.
文摘In a cognitive radio network, the secondary users can use the spectrum holes when the primary users do not utilize the spectrum, but they must vacant the spectrum when the primary users need to transmit data on the spectrum. In other words, the primary users have higher priority over the secondary users. In this paper, backlog and delay distribution bounds for both primary users and secondary users are obtained. The analysis is based on stochastic network calculus, for which, stochastic service curves are t-n-st derived for both primary users and secondary users, and the network calculus independent case analysis approach is used to find the distribution bounds. Numerical results and simulation results are also presented and discussed.
文摘Metaverse,once a concept confined to science fiction,has emerged as a transformative reality during the digital era.As this immersive virtual world gains prominence,the role of avatars and the digital representations of users in shaping educational experiences within a metaverse becomes increasingly crucial.This study examined the design of avatars and their effectiveness in virtual education.Using the cognitive walkthrough(CW)method,a well-established user-centric assessment approach,this study examined how users engage in avatar design in virtual educational settings,highlighting their cognitive processes.Through the CW approach,this study identified usability issues and learning challenges,providing valuable insights into the user experience.The investigation focuses on the VRoid platform for avatar design,selected for its user-friendly interface and robust customization features.Participants(n=12;six men and six women)from diverse educational backgrounds were carefully selected to offer a comprehensive range of perspectives.They performed avatar design tasks that closely mirrored the learning environment of the metaverse,followed by in-depth post-exercise interviews.The findings of this study highlight the essential role of avatar design in enhancing user engagement and improving the learning outcomes of virtual education.Furthermore,we provide practical recommendations for educators and designers to effectively leverage avatar innovation.In a continuously evolving era of metaverse,this research contributes significantly to the ongoing discourse on user-centered design in educational settings,thereby influencing the future trajectory of virtual education.
