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TWEAK、KIM-1及RPR与系统性红斑狼疮患儿疾病活动程度、肾损伤的相关性分析
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作者 赵申 李俊杰 《中国免疫学杂志》 北大核心 2025年第3期675-679,共5页
目的:探讨肿瘤坏死因素样凋亡微弱诱导剂(TWEAK)、肾损伤因子1(KIM-1)及红细胞分布宽度/血小板比值(RPR)与系统性红斑狼疮(SLE)患儿疾病活动度、肾损伤的关系。方法:收集2020年2月至2022年2月襄阳市中心医院42例初诊SLE患儿(SLE组),另... 目的:探讨肿瘤坏死因素样凋亡微弱诱导剂(TWEAK)、肾损伤因子1(KIM-1)及红细胞分布宽度/血小板比值(RPR)与系统性红斑狼疮(SLE)患儿疾病活动度、肾损伤的关系。方法:收集2020年2月至2022年2月襄阳市中心医院42例初诊SLE患儿(SLE组),另收集同期40例健康体检新生儿作为对照组;将SLE患儿根据系统性红斑狼疮疾病活动指数(SLEDAI)评分分为(≤9分)24例和高疾病活动度组(>9分)18例,根据是否伴有肾脏损害分为LN组31例和非LN组11例。检测所有受试对象红细胞分布宽度(RDW)和血小板计数(PLT),并计算RPR;ELISA法检测血清TWEAK、KIM-1水平。结果:SLE组血清TWEAK、KIM-1及RPR水平均显著高于对照组(P<0.05);高疾病活动度组SLE患儿血清TWEAK、KIM-1及RPR水平均显著高于低疾病活动度组(P<0.05);LN组患儿血清TWEAK、KIM-1及RPR水平均显著高于非LN组(P<0.05)。相关性分析显示,RPR与SLEDAI评分呈显著正相关(P<0.05),TWEAK、KIM-1与24 h尿蛋白呈显著正相关(P<0.05)。RPR评估SLE高疾病活动度的AUC为0.744(95%CI 0.657~0.818),显著大于TWEAK、KIM-1评估的AUC分别为0.678(95%CI:0.588~0.760)和0.598(95%CI:0.505~0.686,P<0.05);TWEAK和KIM-1预测LN的AUC分别为0.847(95%CI:0.773~0.905)和0.773(95%CI:0.690~0.842),显著大于RPR预测的AUC为0.645(95%CI:0.555~0.727,P<0.05)。结论:SLE患儿存在TWEAK、KIM-1及RPR水平变化,其中RPR对SLE疾病活动度具有较高的诊断效能,而TWEAK和KIM-1对LN预测价值较高。 展开更多
关键词 系统性红斑狼疮 肿瘤坏死因素样凋亡微弱诱导剂 肾损伤因子1 红细胞分布宽度/血小板比值 疾病活动度 狼疮性肾炎
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腹直肌TWEAK表达水平及其与胃癌患者生理指标的关系研究
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作者 和青森 钱国武 +2 位作者 张虎 孙晓林 史娟 《实用癌症杂志》 2025年第4期551-554,共4页
目的探讨胃癌患者腹直肌肿瘤坏死因子样弱凋亡诱导因子(TWEAK)的表达水平,及其与患者多项生理指标的相关性。方法选择80例胃癌患者设为观察组,选择80例行手术治疗的腹腔良性疾病患者设为对照组,术中均取0.1 g腹直肌的肌肉组织采用Wester... 目的探讨胃癌患者腹直肌肿瘤坏死因子样弱凋亡诱导因子(TWEAK)的表达水平,及其与患者多项生理指标的相关性。方法选择80例胃癌患者设为观察组,选择80例行手术治疗的腹腔良性疾病患者设为对照组,术中均取0.1 g腹直肌的肌肉组织采用Western blot法测定TWEAK表达水平。比较两组TWEAK表达水平,分析不同营养指标的胃癌患者腹直肌TWEAK表达差异及其相关性。结果观察组腹直肌TWEAK相对表达量为(0.20±0.06),高于对照组的(0.07±0.01),有统计学差异(t=19.116,P<0.001);以胃癌患者腹直肌TWEAK相对表达量中位数0.20为界,表达量高于0.20的52例患者纳入高表达组,≤0.20的28例患者纳入低表达组。腹直肌TWEAK表达升高与胃癌患者体质量指数、近半年体质量下降比例、预后营养指数(PNI)、血清血清白蛋白(ALB)、前白蛋白(PAB)、转铁蛋白和营养风险筛查2002(NRS 2002)评分有关(χ^(2)=8.137、4.216、20.247、24.759、13.410、32.919、3.970,P<0.05);Pearson分析显示,体质量指数、ALB、PAB、转铁蛋白与胃癌患者腹直肌TWEAK表达呈负相关(γ=-0.319、-0.556、-0.409、-0.641,P<0.05),近半年体质量下降比例、PNI、NRS 2002评分与胃癌患者腹直肌TWEAK表达呈正相关(γ=0.149、0.503、0.223,P<0.05)。结论胃癌患者腹直肌内TWEAK呈高表达,其表达高低与患者营养状况指标关系密切,可作为检测患者营养状况的重要指标,以指导临床治疗。 展开更多
关键词 胃癌 肿瘤坏死因子样弱凋亡诱导因子 腹直肌 营养状况
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Assessment for shallow and large tunnel construction in weak ground conditions:Application of tunnel boring machines
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作者 Servet Karahan Candan Gokceoglu 《Deep Underground Science and Engineering》 2025年第1期132-148,共17页
With recent technological advancements,tunnel boring machines(TBM)have developed and exhibited high performance in large diameters and weak ground conditions.Tunnels are crucial structures that significantly influence... With recent technological advancements,tunnel boring machines(TBM)have developed and exhibited high performance in large diameters and weak ground conditions.Tunnels are crucial structures that significantly influence the timelines of highway and railway projects.Therefore,the construction of tunnels with TBMs becomes a preferred option.In this study,a comparative analysis between TBM and the New Austrian Tunneling Method(NATM)for tunnel construction is performed in the construction of the T1 tunnel with a diameter of 13 m,which is the longest tunnel in the E?me-Salihli section of Ankara-izmir High-Speed Railway Project(Türkiye).The selection of TBM type,measures taken in problematic sections,and application issues of TBM are discussed.The impact of correct description of geological and geotechnical conditions on both selection and performance of TBM is presented.An earth pressure balanced type TBM is chosen for the construction of the T1 tunnel.Because of the additional engineering measures taken before excavation in problematic areas,the tunnel was completed with great success within the initially planned timeframe.From this point of view,this study is an important case and may contribute to worldwide tunneling literature. 展开更多
关键词 face pressure NATM railway tunnel TBM weak ground
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Selective flotation of ilmenite from titanaugite under weakly acidic pH conditions using 2-amino-1-propanol as novel depressant
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作者 Chuan DAI Pan CHEN +2 位作者 Yao-hui YANG Wei SUN Hong-bin WANG 《Transactions of Nonferrous Metals Society of China》 2025年第4期1325-1337,共13页
The potential of 2-amino-1-propanol(AP)as a novel depressant in selectively floating ilmenite from titanaugite under weakly acidic conditions was investigated.Micro-flotation results show that AP significantly reduces... The potential of 2-amino-1-propanol(AP)as a novel depressant in selectively floating ilmenite from titanaugite under weakly acidic conditions was investigated.Micro-flotation results show that AP significantly reduces the recovery of titanaugite while having no evident impact on ilmenite flotation.Subsequent bench-scale flotation tests further confirm a remarkable improvement in separation efficiency upon the introduction of AP.Contact angle and adsorption tests reveal a stronger affinity of AP towards the titanaugite surface in comparison to ilmenite.Zeta potential measurements and X-ray photoelectron spectroscopy(XPS)analyses exhibit favorable adsorption characteristics of AP on titanaugite,resulting from a synergy of electrostatic attraction and chemical interaction.In contrast,electrostatic repulsion hinders any significant interaction between AP and the ilmenite surface.These findings highlight the potential of AP as a highly efficient depressant for ilmenite flotation,paving the way for reduced reliance on sulfuric acid in the industry. 展开更多
关键词 ILMENITE titanaugite selective flotation weakly acidic condition depressant
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Cotorsion dimensions and FP-projective dimensions of weak Hopf actions
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作者 Xiaoyuan CHEN 《Frontiers of Mathematics in China》 2025年第1期17-24,共8页
Let H be a finite dimensional weak Hopf algebra and A be an Hmodule algebra.In this paper,we mainly discuss the relations of cotorsion dimension and FP-projective dimension between A#H and A.As applications,sufficient... Let H be a finite dimensional weak Hopf algebra and A be an Hmodule algebra.In this paper,we mainly discuss the relations of cotorsion dimension and FP-projective dimension between A#H and A.As applications,sufficient conditions are given for LCD(A#H)=LCD(A)and LFPD(A#H)=LFPD(A). 展开更多
关键词 Cotorsion dimension FP-projective dimension weak Hopf algebra
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Shadow and gravitational weak lensing around a quantum-corrected black hole surrounded by plasma
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作者 Mirzabek Alloqulov Yokubjon Isaqjonov +1 位作者 Sanjar Shaymatov Abdul Jawad 《Chinese Physics C》 2025年第4期230-240,共11页
In this study,we investigate the optical properties of a quantum-corrected black hole(BH)in loop quantum gravity surrounded by a plasma medium.First,we determine the photon and shadow radii resulting from quantum corr... In this study,we investigate the optical properties of a quantum-corrected black hole(BH)in loop quantum gravity surrounded by a plasma medium.First,we determine the photon and shadow radii resulting from quantum corrections and the plasma medium in the environment surrounding a quantum-corrected BH.Our findings indicate that the photon sphere and BH shadow radii decrease owing to the quantum correction parameterα,which acts as a repulsive gravitational charge.Further,we investigate the gravitational weak lensing by applying the general formalism used to model the deflection angle of the light traveling around the quantum-corrected BH within the plasma medium.We show,in conjunction with the fact that the combined effects of the quantum correction and non-uniform plasma frequency parameter can decrease the deflection angle,that the light traveling through the uniform plasma can be strongly deflected than the non-uniform plasma environment surrounding the quantum-corrected BH.Finally,we examine the magnification of the lensed image brightness under the effect of the quantum correction parameterα,including the uniform and non-uniform plasma effects. 展开更多
关键词 quantum-corrected black hole gravitational weak lensing photon motion SHADOW
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OPTIMAL DECAY RATES FOR THE WEAK SOLUTIONS OF THE FLOCKING PARTICLES COUPLED WITH INCOMPRESSIBLE VISCOUS FLUID MODELS
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作者 Houzhi TANG Shuxing ZHANG Weiyuan ZOU 《Acta Mathematica Scientia》 2025年第2期659-683,共25页
This paper studies the global existence and large-time behaviors of weak solutions to the kinetic particle model coupled with the incompressible Navier-Stokes equations in IR3.First,we obtain the global weak solution ... This paper studies the global existence and large-time behaviors of weak solutions to the kinetic particle model coupled with the incompressible Navier-Stokes equations in IR3.First,we obtain the global weak solution using the characteristic and energy methods.Then,under the small assumption of the mass of the particle,we show that the solutions decay at the algebraic time-decay rate.Finally,it is also proved that the above rate is optimal.It should be remarked that if the particle in the coupled system vanishes(i.e.f=O),our works coincide with the classical results by Schonbek[32](J Amer Math Soc,1991,4:423-449),which can be regarded as a generalization from a single fuid model to the two-phase fluid one. 展开更多
关键词 Cucker-Smale model incompressible Navier-Stokes equations weak solution large-time behavior optimal decay rates
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ICA-Net:improving class activation for weakly supervised semantic segmentation via joint contrastive and simulation learning
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作者 YE Zhuang LIU Ruyu SUN Bo 《Optoelectronics Letters》 2025年第3期188-192,共5页
In the field of optoelectronics,certain types of data may be difficult to accurately annotate,such as high-resolution optoelectronic imaging or imaging in certain special spectral ranges.Weakly supervised learning can... In the field of optoelectronics,certain types of data may be difficult to accurately annotate,such as high-resolution optoelectronic imaging or imaging in certain special spectral ranges.Weakly supervised learning can provide a more reliable approach in these situations.Current popular approaches mainly adopt the classification-based class activation maps(CAM)as initial pseudo labels to solve the task. 展开更多
关键词 high resolution imaging supervised learning class activation maps joint contrastive simulation learning special spectral ranges weakly supervised learning OPTOELECTRONICS
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胃癌根治术病人术前血清sTWEAK、YKL-40水平对预后的影响
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作者 孙东跃 王旭青 《安徽医药》 2025年第4期729-732,共4页
目的探讨胃癌根治术病人术前血清可溶性肿瘤坏死因子样凋亡弱诱导因子(sTWEAK)、甲壳质酶蛋白40(YKL-40)表达水平及其对预后的影响。方法选取2017年10月至2019年12月在江苏大学附属医院接受诊治的122例胃癌根治术病人,并收集所有病人临... 目的探讨胃癌根治术病人术前血清可溶性肿瘤坏死因子样凋亡弱诱导因子(sTWEAK)、甲壳质酶蛋白40(YKL-40)表达水平及其对预后的影响。方法选取2017年10月至2019年12月在江苏大学附属医院接受诊治的122例胃癌根治术病人,并收集所有病人临床资料。采用酶联免疫吸附分析(ELISA)对胃癌根治术病人术前、术后血清sTWEAK、YKL-40水平进行检测;术后随访3年,根据术后生存状况分为预后良好组(n=70)和预后不良组(n=52)。比较各组间血清sTWEAK、YKL-40水平与基本资料;Cox回归分析胃癌根治术预后影响因素;受试者操作特征曲线(ROC曲线)分析sTWEAK、YKL-40对胃癌根治术预后的预测价值。结果胃癌根治术前病人血清sTWEAK(258.47±60.27)ng/L、YKL-40(106.41±30.47)μg/L水平显著高于术后(200.01±41.33)ng/L、(55.16±6.79)μg/L(P<0.05);与预后良好组相比,预后不良组术前血清sTWEAK、YKL-40水平显著升高(P<0.05);预后良好组与预后不良组在TNM分期、组织学类型上差异有统计学意义(P<0.05);TNM分期、组织学类型、sTWEAK、YKL-40为胃癌根治术预后的独立危险因素(P<0.05);ROC曲线结果显示术前sTWEAK、YKL-40单独评估胃癌根治术病人预后的AUC分别为0.74、0.74,灵敏度分别为64.0%、80.0%,特异度分别为36.2%、36.9%,两者联合评估的AUC为0.86,灵敏度、特异度分别为80.0%、60.6%。结论胃癌根治术后病人血清sTWEAK、YKL-40水平均显著降低,且术前血清sTWEAK、YKL-40是影响胃癌根治术病人预后的重要因素,因此sTWEAK、YKL-40在胃癌根治术病人血清中的表达水平可预测病人生存状况。 展开更多
关键词 胃肿瘤 胃切除术 肿瘤坏死因子样弱凋亡诱导物 甲壳质酶蛋白40(YKL-40) 预后
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Strengths,weaknesses,opportunities,and threats analysis of combination therapy for inflammatory bowel disease
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作者 Jia-Wang Yan Mei Nie +2 位作者 Hang Zhang Yan-Miao Liu Fu-Shan Tang 《World Journal of Gastroenterology》 2025年第9期176-182,共7页
Inflammatory bowel disease(IBD),encompassing Crohn’s disease and ulcerative colitis,manifests as a chronic,recurrent,and refractory intestinal inflammatory condition significantly impacting patients’quality of life.... Inflammatory bowel disease(IBD),encompassing Crohn’s disease and ulcerative colitis,manifests as a chronic,recurrent,and refractory intestinal inflammatory condition significantly impacting patients’quality of life.Despite ongoing research,its etiology and pathogenesis remain incompletely understood.Recent advancements in medical research highlight the critical role of drug combination therapies in managing IBD.This paper employs the strengths,weaknesses,opportunities,and threats framework to evaluate the four strategic elements(strengths,weaknesses,opportunities,and threats)pertaining to combination therapies for IBD.Among the strengths,the paper underscores the efficacy of multi-targeted strategies,the advancement of personalized medicine,and the mitigation of drug resistance.Nonetheless,the analysis identifies significant weaknesses,including the prohibitive cost of treatment,issues with patient compliance,and the necessity for comprehensive long-term safety data.The paper also delineates opportunities to augment therapeutic success through the incorporation of biomarkers,the application of artificial intelligence,and extensive international collaborative efforts.In contrast,the paper does not shy away from addressing the threats,which include the potential for therapeutic resistance and the logistical challenges inherent in global therapy deployment.These initiatives aim to refine future therapeutic practices,fostering safer,more effective,and personalized treatment paradigms for IBD patients. 展开更多
关键词 Inflammatory bowel disease Ulcerative colitis Crohn’s disease Combination therapy Strengths weaknesses opportunities threats analysis
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Fiber optic high temperature sensor with weak strain sensitivity based on Mach-Zehnder interferometric structure
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作者 LIU Ming MA Chengju +3 位作者 ZHANG Yixin LIU Qianzhen HU Hui WU Jirui 《Optoelectronics Letters》 2025年第4期199-204,共6页
We proposed a fiber optic high temperature sensor based on the Mach-Zehnder interference(MZI)structure,which is composed of two lengths of multi-mode fibers(MMFs),a length of few-mode fiber(FMF)and two sections of sin... We proposed a fiber optic high temperature sensor based on the Mach-Zehnder interference(MZI)structure,which is composed of two lengths of multi-mode fibers(MMFs),a length of few-mode fiber(FMF)and two sections of single-mode fibers(SMFs).Firstly,the two sections of MMFs were spliced with two sections of SMFs.Then,the MMFs were fused to two ends of FMF to form a symmetrically structured fiber-optic MZI structure.In this structure,the MMF served as the optical mode field coupling element,and the cladding and core of the FMF are the interference arm and the reference arm of the MZI structure,respectively.We investigated the sensor's response characteristics of the temperature and strain.The experimental results indicate that the sensor is sensitive to temperature variation,and the temperature response sensitivity is up to 61.4 pm/℃ in the range of 40-250℃,while the sensor has weak strain sensitivity,its strain sensitivity is only-0.72 pm/μe in the strain range of 0-1400μe.Moreover,the sensor has good stability and repeatability.In brief,the proposed fiber optic high temperature sensor has good properties,such as high sensitivity,compact structure,good stability and repeatability,which can be used for monitoring the temperature of submerged oil electric pump units under oil wells. 展开更多
关键词 fiber optic sensor weak strain sensitivity optical mode field coupling elementand multi mode fiber Mach Zehnder interferometric structure temperature sensing single mode fiber few mode fiber
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Hcy与sTWEAK对前循环急性缺血性脑卒中患者脑白质病变的评估价值
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作者 宋庆云 吴文娟 +3 位作者 刘小娟 郭莹 刘春玲 王友明 《中国实用神经疾病杂志》 2025年第3期326-330,共5页
目的探究同型半胱氨酸(Hcy)及可溶性肿瘤坏死因子样弱凋亡诱导剂(sTWEAK)评估前循环急性缺血性脑卒中(AIS)患者脑白质病变(WML)的价值。方法回顾性分析2021-08—2023-08邯郸市人民医院收治的100例AIS患者资料,按是否并发WML将患者分为WM... 目的探究同型半胱氨酸(Hcy)及可溶性肿瘤坏死因子样弱凋亡诱导剂(sTWEAK)评估前循环急性缺血性脑卒中(AIS)患者脑白质病变(WML)的价值。方法回顾性分析2021-08—2023-08邯郸市人民医院收治的100例AIS患者资料,按是否并发WML将患者分为WML组(n=79)及非WML组(n=21),再按严重程度将WML患者分为轻度组(n=23)、中度组(n=30)及重度组(n=26)3个亚组。收集并比较WML组及非WML组基线资料及血清指标水平。采用Logistic回归分析AIS并发WML的危险因素。绘制ROC曲线分析血清Hcy及sTWEAK诊断AIS并发WML及评估WML严重程度的临床价值。结果WML组Hcy及sTWEAK水平高于非WML组(P<0.05)。三亚组Hcy及sTWEAK水平有统计学差异(P<0.05),血清Hcy及sTWEAK水平分布表现为轻度组<中度组<重度组(P<0.05)。高龄、合并高血压、高Hcy及高sTWEAK是AIS患者并发WML的独立危险因素(P<0.05)。Hcy联合sTWEAK诊断WML的AUC值(0.945)最大,高于Hcy(Z=2.989,P=0.003)及sTWEAK(Z=2.614,P=0.009)。Hcy联合sTWEAK诊断重度WML的AUC值最大(0.927),高于Hcy(Z=2.566,P=0.010)及sTWEAK(Z=1.537,P=0.124)。结论血清Hcy及sTWEAK能有效诊断AIS患者并发WML以及评估WML严重程度,血清Hcy及sTWEAK高表达是AIS患者并发WML的独立危险因素。 展开更多
关键词 急性缺血性脑卒中 前循环 脑白质病变 同型半胱氨酸 可溶性肿瘤坏死因子样弱凋亡诱导剂 血清 预测价值 危险因素
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血清sTWEAK、Netrin-1联合APACHEⅡ评分对重型颅脑损伤患者术后预后不良的预测价值 被引量:1
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作者 沈晨 施巍 +2 位作者 张元杰 杨治荣 程华怡 《国际检验医学杂志》 CAS 2024年第4期404-409,415,共7页
目的探讨血清可溶性肿瘤坏死因子样凋亡弱诱导因子(sTWEAK)、神经轴突导向因子-1(Netrin-1)联合急性生理学与慢性健康状况评分系统Ⅱ(APACHEⅡ)评分对重型颅脑损伤患者术后预后不良的预测价值。方法选取2020年6月至2022年6月该院收治的... 目的探讨血清可溶性肿瘤坏死因子样凋亡弱诱导因子(sTWEAK)、神经轴突导向因子-1(Netrin-1)联合急性生理学与慢性健康状况评分系统Ⅱ(APACHEⅡ)评分对重型颅脑损伤患者术后预后不良的预测价值。方法选取2020年6月至2022年6月该院收治的120例重型颅脑损伤患者,根据术后30 d预后情况分为预后良好组和预后不良组。对比两组血清sTWEAK、Netrin-1水平及APACHEⅡ评分。采用单因素和多因素Logistic回归分析重型颅脑损伤患者术后预后不良的影响因素,并据以构建血清sTWEAK、Netrin-1及APACHEⅡ评分联合应用的预测模型,受试者工作特征(ROC)曲线分析血清sTWEAK、Netrin-1水平及APACHEⅡ评分对重型颅脑损伤患者术后预后不良的预测价值。结果预后不良组的重症监护室居住时间长于预后良好组,白蛋白水平、入院时格拉斯哥昏迷评分法评分和血清Netrin-1水平低于预后良好组,多发脑挫裂伤占比、机械通气占比、入院时APACHEⅡ评分和血清sTWEAK、血清肌酐、血尿素氮水平均高于预后良好组,差异有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,多发脑挫裂伤、Netrin-1水平降低、入院时APACHEⅡ评分升高、sTWEAK水平升高为重型颅脑损伤患者术后预后不良的危险因素(P<0.05)。ROC曲线分析结果显示,血清sTWEAK、Netrin-1及APACHEⅡ评分3个指标单独及联合应用时曲线下面积及其95%CI分别为0.742(0.552~0.925)、0.731(0.488~0.963)、0.714(0.502~0.911)、0.882(0.795~0.947)。结论血清sTWEAK、Netrin-1联合APACHEⅡ评分对重型颅脑损伤患者术后预后不良具有较好的预测价值,可为临床治疗方案的制订提供参考。 展开更多
关键词 重型颅脑损伤 可溶性肿瘤坏死因子样凋亡弱诱导因子 神经轴突导向因子-1 急性生理学与慢性健康状况评分系统Ⅱ 预后
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Unique Common Fixed Points for Two Weakly C~*-contractive Mappings on Partially Ordered 2-metric Spaces 被引量:1
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作者 Piao Yong-jie 《Communications in Mathematical Research》 CSCD 2018年第1期77-88,共12页
In this paper, we give existence theorems of common fixed points for two mappings with a weakly C*-contractive condition on partially ordered 2-metric spaces and give a sufficient condition under which there exists a ... In this paper, we give existence theorems of common fixed points for two mappings with a weakly C*-contractive condition on partially ordered 2-metric spaces and give a sufficient condition under which there exists a unique common fixed point. 展开更多
关键词 2-metric space weak C*-contraction common fixed point
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自发性急性脑出血患者血浆sCD163/sTWEAK比值与预后的关系
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作者 张文超 杨雪辉 +2 位作者 尹涛 王睿健 张盟盟 《天津医药》 CAS 2024年第3期297-301,共5页
目的探究自发性急性脑出血(ACH)患者血浆可溶性CD163(sCD163)/可溶性肿瘤坏死因子样凋亡弱诱导因子(sTWEAK)比值与预后的关系。方法纳入ACH患者90例作为病例组,根据格拉斯哥预后评分将病例组分为预后不良组(38例)和预后良好组(52例);另... 目的探究自发性急性脑出血(ACH)患者血浆可溶性CD163(sCD163)/可溶性肿瘤坏死因子样凋亡弱诱导因子(sTWEAK)比值与预后的关系。方法纳入ACH患者90例作为病例组,根据格拉斯哥预后评分将病例组分为预后不良组(38例)和预后良好组(52例);另选取同期体检健康者45例为对照组。酶联免疫吸附试验检测血浆sCD163、sTWEAK水平并计算sCD163/sTWEAK比值。分析血浆sCD163、sTWEAK水平及sCD163/sTWEAK比值与临床资料的相关性;Logistic回归分析ACH患者预后不良的影响因素;受试者工作特征(ROC)曲线分析sCD163/sTWEAK比值对ACH患者预后不良的预测价值。结果病例组血浆sCD163、sTWEAK水平及sCD163/sTWEAK比值均显著高于对照组;预后良好组上述指标均低于预后不良组(P<0.05)。预后良好组血肿体积、美国国立卫生研究院卒中量表(NIHSS)评分、高血压及幕下出血比例均低于预后不良组,低密度脂蛋白胆固醇(LDL-C)高于预后不良组(P<0.05)。相关性分析表明,血浆sCD163、sTWEAK水平及sCD163/sTWEAK比值与出血部位、血肿体积、NIHSS评分、白细胞计数、血小板计数、中性粒细胞/淋巴细胞比值(NLR)呈正相关(P<0.05)。Logistic回归分析显示,sCD163/sTWEAK比值、出血部位、血肿体积、NIHSS评分为ACH患者预后不良的影响因素(P<0.05)。ROC曲线结果表明,sCD163/sTWEAK比值评估ACH患者预后不良的AUC为0.850,敏感度和特异度分别为86.84%和69.23%。结论sCD163/sTWEAK比值在ACH患者血浆中水平较高,并与预后不良有关,该值对此类患者的预后有一定预测价值。 展开更多
关键词 脑出血 细胞因子Tweak 预后 可溶性血红蛋白清道夫受体163蛋白 可溶性肿瘤坏死因子样凋亡弱诱导因子
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注意缺陷多动障碍患儿血清ACE2,TWEAK和CCL5水平检测及诊断价值研究
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作者 王立宁 史亚楠 李宝广 《现代检验医学杂志》 CAS 2024年第5期152-156,167,共6页
目的 探究血清血管紧张素转换酶2(angiotensin-converting enzyme 2,ACE2),细胞因子肿瘤坏死因子样细胞凋亡弱诱导因子(tumor necrosis factor-like weak inducer of apoptosis,TWEAK)和CC趋化因子配体5(CC motif chemokine ligand 5,CC... 目的 探究血清血管紧张素转换酶2(angiotensin-converting enzyme 2,ACE2),细胞因子肿瘤坏死因子样细胞凋亡弱诱导因子(tumor necrosis factor-like weak inducer of apoptosis,TWEAK)和CC趋化因子配体5(CC motif chemokine ligand 5,CCL5)水平在注意缺陷多动障碍(attention deficit hyperactivity disorder,ADHD)患儿诊断、病情严重程度评估中的价值。方法 选取2022年10月~2023年10月在河北省儿童医院就诊的125例ADHD患儿记为ADHD组,另选105例在河北省妇幼保健中心体检的健康儿童为对照组,根据临床总体印象严重程度量表(CGI-S)将患儿分为轻中度组(n=83)和重度组(n=42)。ELISA方法检测血清ACE2,TWEAK,CCL5,促黄体生成素(LH)和催乳素(PRL)水平,联合型瑞文测验(CRT)和Conners父母症状问卷(PSQ)对患儿认知和行为状况进行评分。Spearman相关性分析重度组血清ACE2,TWEAK,CCL5与CGI-S,CRT,PSQ评分的相关性;受试者工作特征(ROC)曲线分析ACE2,TWEAK,CCL5对ADHD及严重程度的诊断价值。结果 ADHD患儿血清ACE2(284.35±92.34 pg/ml),TWEAK(2.56±0.76 pg/ml)水平低于对照组(379.23±106.28 pg/ml,3.52±1.12 pg/ml),CCL5水平(7.36±2.37ng/ml)高于对照组(5.24±1.63 ng/ml),差异具有统计学意义(t=7.244,7.703,7.753,均P<0.05);重度组患儿CRT,血清ACE2,TWEAK水平低于轻中度组(t=5.318,6.686,6.490),而PSQ,CCL5水平较高于轻中度组(t=5.220,6.134),差异具有统计学意义(均P<0.05);Spearman相关性分析结果显示,重度组患儿血清ACE2,TWEAK水平与CGI-S,PSQ评分负相关(r=-0.432,-0.453;-0.421,-0.426,均P<0.001),与CRT评分呈正相关(r=0.427,0.418,均P<0.001);CCL5与CGI-S,PSQ评分呈正相关(r=0.421,0.433,均P<0.001),与CRT评分呈负相关(r=-0.446,P<0.001)。血清ACE2,TWEAK和CCL5诊断ADHD发生的AUC分别为0.814,0.803和0.807,三者联合诊断的AUC为0.945,优于各自单独诊断(Z=5.439,4.258,5.576,均P<0.001);血清ACE2,TWEAK,CCL5诊断重度ADHD的AUC分别为0.853,0.796和0.805,三者联合诊断的AUC为0.930,优于各自单独诊断(Z=2.604,3.851,3.567,均P<0.001)。结论 血清ACE2,TWEAK在ADHD患儿血清中低表达,而CCL5高表达,三者表达水平具有相关性,并且诊断ADHD发生和严重程度具有较高的价值。 展开更多
关键词 注意缺陷多动障碍 血管紧张素转换酶2 细胞因子肿瘤坏死因子样细胞凋亡弱诱导因子 CC趋化因子配体5
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Significant risk factors for intensive care unit-acquired weakness:A processing strategy based on repeated machine learning 被引量:11
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作者 Ling Wang Deng-Yan Long 《World Journal of Clinical Cases》 SCIE 2024年第7期1235-1242,共8页
BACKGROUND Intensive care unit-acquired weakness(ICU-AW)is a common complication that significantly impacts the patient's recovery process,even leading to adverse outcomes.Currently,there is a lack of effective pr... BACKGROUND Intensive care unit-acquired weakness(ICU-AW)is a common complication that significantly impacts the patient's recovery process,even leading to adverse outcomes.Currently,there is a lack of effective preventive measures.AIM To identify significant risk factors for ICU-AW through iterative machine learning techniques and offer recommendations for its prevention and treatment.METHODS Patients were categorized into ICU-AW and non-ICU-AW groups on the 14th day post-ICU admission.Relevant data from the initial 14 d of ICU stay,such as age,comorbidities,sedative dosage,vasopressor dosage,duration of mechanical ventilation,length of ICU stay,and rehabilitation therapy,were gathered.The relationships between these variables and ICU-AW were examined.Utilizing iterative machine learning techniques,a multilayer perceptron neural network model was developed,and its predictive performance for ICU-AW was assessed using the receiver operating characteristic curve.RESULTS Within the ICU-AW group,age,duration of mechanical ventilation,lorazepam dosage,adrenaline dosage,and length of ICU stay were significantly higher than in the non-ICU-AW group.Additionally,sepsis,multiple organ dysfunction syndrome,hypoalbuminemia,acute heart failure,respiratory failure,acute kidney injury,anemia,stress-related gastrointestinal bleeding,shock,hypertension,coronary artery disease,malignant tumors,and rehabilitation therapy ratios were significantly higher in the ICU-AW group,demonstrating statistical significance.The most influential factors contributing to ICU-AW were identified as the length of ICU stay(100.0%)and the duration of mechanical ventilation(54.9%).The neural network model predicted ICU-AW with an area under the curve of 0.941,sensitivity of 92.2%,and specificity of 82.7%.CONCLUSION The main factors influencing ICU-AW are the length of ICU stay and the duration of mechanical ventilation.A primary preventive strategy,when feasible,involves minimizing both ICU stay and mechanical ventilation duration. 展开更多
关键词 Intensive care unit-acquired weakness Risk factors Machine learning PREVENTION Strategies
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THE LERAY-SCHAUDER CONDITION FOR 1-SET WEAKLY-CONTRACTIVE AND(ws)-COMPACT OPERATORS
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作者 Afif BEN AMAR 《Acta Mathematica Scientia》 SCIE CSCD 2014年第2期263-273,共11页
Abstract The main purpose of this article is to prove a collection of new nxea point theorems for (ws)-compact and so-called 1-set weakly contractive operators under Leray- Schauder boundary condition. We also intro... Abstract The main purpose of this article is to prove a collection of new nxea point theorems for (ws)-compact and so-called 1-set weakly contractive operators under Leray- Schauder boundary condition. We also introduce the concept of semi-closed operator at the origin and obtain a series of new fixed point theorems for such class of operators. As consequences, we get new fixed point existence for (ws)-compact (in particular nonexpansive) self mappings unbounded closed convex subset of Banach spaces. The main condition in our results is formulated in terms of axiomatic measures of weak noncompactness. Later on, we give an application to generalized Hammerstein type integral equations. 展开更多
关键词 Measure of weak noncompactness weakly condensing and weakly nonexpan-sire (ws)-compact operator fixed point theorems semi-closed at the origin
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A Note on the Paper “Generalized -Contraction for a Pair of Mappings on Cone Metric Spaces”
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作者 Mohamed Abd El-Rahman Ahmed 《Advances in Pure Mathematics》 2012年第1期6-7,共2页
We note that Theorem 2.3 [1] is a consequence of the same theorem for one map.
关键词 Generalized φ-contraction weakLY Compatible Solid CONE
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血清sTWEAK、sLOX-1与H型高血压合并HFpEF患者颈动脉粥样硬化的关系
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作者 姜金钟 郭华 +2 位作者 苗维 田守森 田雯艳 《广东医学》 CAS 2024年第10期1226-1230,共5页
目的研究血清可溶性肿瘤坏死因子样凋亡弱诱导因子(sTWEAK)、可溶性凝集素样氧化型低密度脂蛋白受体-1(sLOX-1)与H型高血压合并射血分数保留的心力衰竭(HFpEF)患者颈动脉粥样硬化的关系。方法选取2021年2月至2023年3月沧州中西医结合医... 目的研究血清可溶性肿瘤坏死因子样凋亡弱诱导因子(sTWEAK)、可溶性凝集素样氧化型低密度脂蛋白受体-1(sLOX-1)与H型高血压合并射血分数保留的心力衰竭(HFpEF)患者颈动脉粥样硬化的关系。方法选取2021年2月至2023年3月沧州中西医结合医院收治的161例H型高血压合并HFpEF患者,按是否发生颈动脉粥样硬化分为硬化组与非硬化组。同期选取80例于我院体检的健康的志愿者作为对照组。收集受试者的临床资料,采用酶联免疫吸附法检测血清sTWEAK、sLOX-1水平,比较H型高血压合并HFpEF患者与对照组血清sTWEAK、sLOX-1水平,采用多因素logistic回归分析患者发生颈动脉粥样硬化的影响因素,受试者工作特征(ROC)曲线分析血清sTWEAK、sLOX-1对患者发生颈动脉粥样硬化的预测价值。结果161例患者中65例发生颈动脉粥样硬化,发生率为40.37%(65/161),未发生颈动脉粥样硬化者96例。两组在年龄、吸烟、血脂四项等方面比较,差异有统计学意义(P<0.05)。硬化组与非硬化组血清sTWEAK水平低于对照组,sLOX-1水平高于对照组(P<0.05);且硬化组sTWEAK水平低于非硬化组,sLOX-1水平高于非硬化组(P<0.05)。多因素logistic回归分析显示,HDL-C、sTWEAK、年龄、LDL-C、sLOX-1水平是患者发生颈动脉粥样硬化的影响因素(P<0.05)。ROC曲线显示,血清sTWEAK、sLOX-1联合检测对发生颈动脉粥样硬化的预测曲线下面积(AUC)为0.842,预测效能高于两指标单独检测。结论H型高血压合并HFpEF患者的血清sTWEAK水平下降、sLOX-1水平上升,与颈动脉粥样硬化发生有关,两者联合检测对颈动脉粥样硬化的发生具有一定预测价值。 展开更多
关键词 H型高血压 射血分数保留心力衰竭 颈动脉粥样硬化 可溶性肿瘤坏死因子样凋亡弱诱导因子 可溶性凝集素样氧化型低密度脂蛋白受体-1
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