目的:外周血中白细胞的成分和计数不仅可以反映肿瘤微环境的炎症反应,还被认为是潜在有意义的肿瘤预后指标。本研究旨在评估晩期非小细胞肺癌患者胸部放疗对外周血淋巴细胞计数的影响,并分析放疗后中性粒细胞与淋巴细胞比值变化对近期...目的:外周血中白细胞的成分和计数不仅可以反映肿瘤微环境的炎症反应,还被认为是潜在有意义的肿瘤预后指标。本研究旨在评估晩期非小细胞肺癌患者胸部放疗对外周血淋巴细胞计数的影响,并分析放疗后中性粒细胞与淋巴细胞比值变化对近期疗效的预测价值。方法:回顾性分析了自2017年1月1日〜2018年9月1日在山东第一医科大学第三附属医院放疗中心放疗的非小细胞肺癌患者在放疗前、放疗中、放疗结束时、放疗后1月的血常规,记录各时间点的淋巴细胞计数值(lymphocyte,L值),并计算相应中性粒细胞与淋巴细胞比值(neutrophil to lymphocyte ratio,NLR),按照CTCAE 4.03标准对淋巴细胞计数降低进行分级,分析有效和无效两组放疗后的L值及NLR值有无统计学差异。结果:入组患者在放疗过程中和放疗后均发生不同程度的淋巴细胞计数降低,56.76%发生3-4级淋巴细胞计数降低。统计分析显示,有效组和无效组的放疗后L值、放疗后NLR值,放疗后1月L值、放疗后1月NLR值均无统计学差异。结论:放疗后淋巴细胞计数降低及NLR值与近期疗效无相关性,仍需前瞻性大样本研究证实。展开更多
目的:近年来研究发现中性粒细胞与淋巴细胞比值可以预测急性缺血性卒中(AIS)患者的短期和长期预后。但其变化量(ΔNLR)与患者溶栓后24 h的出血转化(HT)及早期神经功能改善(ENI)的关系仍缺乏研究。本次研究旨在探讨ΔNLR与溶栓后24 h的HT...目的:近年来研究发现中性粒细胞与淋巴细胞比值可以预测急性缺血性卒中(AIS)患者的短期和长期预后。但其变化量(ΔNLR)与患者溶栓后24 h的出血转化(HT)及早期神经功能改善(ENI)的关系仍缺乏研究。本次研究旨在探讨ΔNLR与溶栓后24 h的HT和ENI的关系,及ΔNLR与不同TOAST分型的患者溶栓后早期结局的关系。方法:纳入接受静脉溶栓治疗的AIS患者234例。对患者进行TOAST分型。根据HT和ENI的有无将患者进行分组。结果:发生HT的患者溶栓后NLR升高更明显,出现ENI的患者溶栓后NLR降低更明显。动脉粥样硬化型与心源性栓塞型患者的ΔNLR无明显差异,但小动脉闭塞型患者与大动脉粥样硬化型轻型患者相比,ΔNLR有统计学差异。结论:ΔNLR是AIS患者溶栓后HT和ENI的独立影响因素,且小动脉闭塞型脑卒中患者的ΔNLR大于轻型大动脉粥样硬化型脑卒中患者的ΔNLR。Objective: Recent studies have shown that the neutrophil-to-lymphocyte ratio can predict the short- and long-term prognosis of patients with acute ischemic stroke (AIS). However, the association between the variation of neutrophil-to- lymphocyte ratio(ΔNLR) and the bleeding transformation (HT) as well as early neurological improvement (ENI) at 24 h after thrombolysis is still lacking. The purpose of the study was to investigate the correlation between ΔNLR and HT as well as ENI 24 h after thrombolytic therapy, and the relationship between ΔNLR and early outcomes after thrombolytic therapy in patients with different TOAST classifications. Methods: 234 patients with AIS who received intravenous thrombolysis were included. The patients were classified by TOAST classifications. Patients were grouped according to the presence or absence of HT and ENI. Results: The increase of NLR after thrombolysis was more obvious in patients with HT while the decrease of NLR was more obvious in patients with ENI. There was no significant difference in ΔNLR between patients with atherosclerotic type and those with cardiogenic embolization type, but there was a statistical difference in ΔNLR between patients with small artery occlusion type and those with large artery atherosclerosis mild type. Conclusion: ΔNLR was an independent influencing factor for HT and ENI in AIS patients after thrombolysis, and ΔNLR in small artery occlusive stroke patients was greater than that in patients of minor stroke of LAA group.展开更多
对中性粒细胞与淋巴细胞比值(Neutrophil to Lymphocyte Rate,NLR)联合红细胞分布宽度(Red blood cell distribution width,RDW)对于急诊老年脓毒症患者的诊疗价值进行分析与探讨。方法 2023年2月至2024年7月期间,招募180名老年脓毒症患...对中性粒细胞与淋巴细胞比值(Neutrophil to Lymphocyte Rate,NLR)联合红细胞分布宽度(Red blood cell distribution width,RDW)对于急诊老年脓毒症患者的诊疗价值进行分析与探讨。方法 2023年2月至2024年7月期间,招募180名老年脓毒症患者,依据其在急救过程中的休克状态,将其划分为非休克组(112名)与休克组(68名)。入院后随访观察30d,根据患者预后情况分为生存组(n=130)和死亡组(n=50)。对比不同组别患者NLR(中性粒细胞与淋巴细胞比值)、RDW(红细胞分布宽度)值以及NLR、RDW值与急性生理与慢性健康状况评估(Acute Physiology And Chronic Health Evaluation,APACHE Ⅱ)的相关性。结果 急诊时,NLR、RDW以及APACHEⅡ评分比较,休克组较非休克组明显更高(P<0.05);预后死亡组较生存组明显更高(P<0.05)。NLR、RDW单独预测患者死亡风险时,AUC、95%CI显著低于APACHEⅡ评分(P<0.05),二者联合应用时AUC、95%CI与APACHEⅡ评分相当(P>0.05)。结论 NLR、RDW能够较好的评估急诊老年脓毒症患者病情,能够较为准确的预测患者预后情况,二者联合应用的预后评估准确性与APACHEⅡ评分相近。展开更多
目的:旨在探讨中性粒细胞/淋巴细胞比值(neutrophil to lymphocyte ratio, NLR)对心房颤动患者射频消融术后复发的预测价值。方法:回顾性选取2018年1月至2022年12月期间在江苏省扬州大学附属医院接受射频导管消融术的心房颤动患者为研...目的:旨在探讨中性粒细胞/淋巴细胞比值(neutrophil to lymphocyte ratio, NLR)对心房颤动患者射频消融术后复发的预测价值。方法:回顾性选取2018年1月至2022年12月期间在江苏省扬州大学附属医院接受射频导管消融术的心房颤动患者为研究对象。所有患者均在术后随访1年,根据术后是否发生持续时间 ≥ 30 s的房颤、房扑、房速将患者分为复发组和未复发组。结果:本研究共纳入接受射频导管消融术的心房颤动患者164例,其中男性101例,女性63例,复发组29例,未复发组135例。两组间比较,复发组术前中性粒细胞计数、淋巴细胞计数、NLR、左房内径(left atrial diameter, LAD)高于未复发组,复发组术前高密度脂蛋白胆固醇(HDL-c)低于未复发组,差异有统计学意义(P 0.05)。二元logistic回归分析显示,消融前HDL-c (OR = 0.046, 95%CI = 0.003~0.718, P = 0.028)、NLR (OR = 4.830, 95%CI = 2.118~11.010, P Objective: The purpose of this study was to explore the value of neutrophil to lymphocyte ratio in predicting recurrence after radiofrequency ablation in patients with atrial fibrillation. Methods: Patients with atrial fibrillation who underwent radiofrequency catheter ablation in the Affiliated Hospital of Yangzhou University in Jiangsu Province from January 2018 to December 2022 were retrospectively selected. All patients were followed up for 1 year. According to the occurrence of atrial fibrillation, atrial flutter and atrial tachycardia with duration ≥ 30 s after the operation, the patients were divided into a recurrent group and a non-recurrent group. Result: A total of 164 patients with atrial fibrillation who underwent radiofrequency catheter ablation were included in this study, including 101 males and 63 females, 29 patients with recurrence and 135 patients without recurrence. The preoperative neutrophil count, lymphoid cell count, neutrophil to lymphocyte ratio and left atrial diameter in the recurrent group were higher than those in the non-recurrent group, while the preoperative high density lipoprotein cholesterol in the recurrent group was significantly lower than that in the non-recurrent group (P 0.05). Binary logistic regression analysis showed that HDL-c (OR = 0.046, 95%CI = 0.003~0.718, P = 0.028), NLR (OR = 4.830, 95%CI = 2.118~11.010, P < 0.001) and LAD (OR = 1.225, 95%CI = 1.082~1.386, P = 0.001) were independent risk factors for predicting recurrence of atrial fibrillation after radiofrequency ablation. ROC curve analysis showed that the areas under the curve of HDL-c, NLR and LAD were 0.713 (95%CI = 0.606~0.821, P < 0.001), 0.858 (95%CI = 0.782~0.934, P < 0.001) and 0.864 (95%CI = 0.806~0.921, P < 0.001). In addition, NLR ≥ 2.765 was significantly associated with an increased risk of recurrence of atrial fibrillation after radiofrequency ablation (P < 0.001). Conclusion: The increase of NLR before radiofrequency ablation is related to the increased risk of postoperative atrial fibrillation recurrence. Additionally, NLR is a better predictor of recurrence of atrial fibrillation after radiofrequency ablation.展开更多
文摘目的:外周血中白细胞的成分和计数不仅可以反映肿瘤微环境的炎症反应,还被认为是潜在有意义的肿瘤预后指标。本研究旨在评估晩期非小细胞肺癌患者胸部放疗对外周血淋巴细胞计数的影响,并分析放疗后中性粒细胞与淋巴细胞比值变化对近期疗效的预测价值。方法:回顾性分析了自2017年1月1日〜2018年9月1日在山东第一医科大学第三附属医院放疗中心放疗的非小细胞肺癌患者在放疗前、放疗中、放疗结束时、放疗后1月的血常规,记录各时间点的淋巴细胞计数值(lymphocyte,L值),并计算相应中性粒细胞与淋巴细胞比值(neutrophil to lymphocyte ratio,NLR),按照CTCAE 4.03标准对淋巴细胞计数降低进行分级,分析有效和无效两组放疗后的L值及NLR值有无统计学差异。结果:入组患者在放疗过程中和放疗后均发生不同程度的淋巴细胞计数降低,56.76%发生3-4级淋巴细胞计数降低。统计分析显示,有效组和无效组的放疗后L值、放疗后NLR值,放疗后1月L值、放疗后1月NLR值均无统计学差异。结论:放疗后淋巴细胞计数降低及NLR值与近期疗效无相关性,仍需前瞻性大样本研究证实。
文摘目的:近年来研究发现中性粒细胞与淋巴细胞比值可以预测急性缺血性卒中(AIS)患者的短期和长期预后。但其变化量(ΔNLR)与患者溶栓后24 h的出血转化(HT)及早期神经功能改善(ENI)的关系仍缺乏研究。本次研究旨在探讨ΔNLR与溶栓后24 h的HT和ENI的关系,及ΔNLR与不同TOAST分型的患者溶栓后早期结局的关系。方法:纳入接受静脉溶栓治疗的AIS患者234例。对患者进行TOAST分型。根据HT和ENI的有无将患者进行分组。结果:发生HT的患者溶栓后NLR升高更明显,出现ENI的患者溶栓后NLR降低更明显。动脉粥样硬化型与心源性栓塞型患者的ΔNLR无明显差异,但小动脉闭塞型患者与大动脉粥样硬化型轻型患者相比,ΔNLR有统计学差异。结论:ΔNLR是AIS患者溶栓后HT和ENI的独立影响因素,且小动脉闭塞型脑卒中患者的ΔNLR大于轻型大动脉粥样硬化型脑卒中患者的ΔNLR。Objective: Recent studies have shown that the neutrophil-to-lymphocyte ratio can predict the short- and long-term prognosis of patients with acute ischemic stroke (AIS). However, the association between the variation of neutrophil-to- lymphocyte ratio(ΔNLR) and the bleeding transformation (HT) as well as early neurological improvement (ENI) at 24 h after thrombolysis is still lacking. The purpose of the study was to investigate the correlation between ΔNLR and HT as well as ENI 24 h after thrombolytic therapy, and the relationship between ΔNLR and early outcomes after thrombolytic therapy in patients with different TOAST classifications. Methods: 234 patients with AIS who received intravenous thrombolysis were included. The patients were classified by TOAST classifications. Patients were grouped according to the presence or absence of HT and ENI. Results: The increase of NLR after thrombolysis was more obvious in patients with HT while the decrease of NLR was more obvious in patients with ENI. There was no significant difference in ΔNLR between patients with atherosclerotic type and those with cardiogenic embolization type, but there was a statistical difference in ΔNLR between patients with small artery occlusion type and those with large artery atherosclerosis mild type. Conclusion: ΔNLR was an independent influencing factor for HT and ENI in AIS patients after thrombolysis, and ΔNLR in small artery occlusive stroke patients was greater than that in patients of minor stroke of LAA group.
文摘对中性粒细胞与淋巴细胞比值(Neutrophil to Lymphocyte Rate,NLR)联合红细胞分布宽度(Red blood cell distribution width,RDW)对于急诊老年脓毒症患者的诊疗价值进行分析与探讨。方法 2023年2月至2024年7月期间,招募180名老年脓毒症患者,依据其在急救过程中的休克状态,将其划分为非休克组(112名)与休克组(68名)。入院后随访观察30d,根据患者预后情况分为生存组(n=130)和死亡组(n=50)。对比不同组别患者NLR(中性粒细胞与淋巴细胞比值)、RDW(红细胞分布宽度)值以及NLR、RDW值与急性生理与慢性健康状况评估(Acute Physiology And Chronic Health Evaluation,APACHE Ⅱ)的相关性。结果 急诊时,NLR、RDW以及APACHEⅡ评分比较,休克组较非休克组明显更高(P<0.05);预后死亡组较生存组明显更高(P<0.05)。NLR、RDW单独预测患者死亡风险时,AUC、95%CI显著低于APACHEⅡ评分(P<0.05),二者联合应用时AUC、95%CI与APACHEⅡ评分相当(P>0.05)。结论 NLR、RDW能够较好的评估急诊老年脓毒症患者病情,能够较为准确的预测患者预后情况,二者联合应用的预后评估准确性与APACHEⅡ评分相近。
文摘目的:旨在探讨中性粒细胞/淋巴细胞比值(neutrophil to lymphocyte ratio, NLR)对心房颤动患者射频消融术后复发的预测价值。方法:回顾性选取2018年1月至2022年12月期间在江苏省扬州大学附属医院接受射频导管消融术的心房颤动患者为研究对象。所有患者均在术后随访1年,根据术后是否发生持续时间 ≥ 30 s的房颤、房扑、房速将患者分为复发组和未复发组。结果:本研究共纳入接受射频导管消融术的心房颤动患者164例,其中男性101例,女性63例,复发组29例,未复发组135例。两组间比较,复发组术前中性粒细胞计数、淋巴细胞计数、NLR、左房内径(left atrial diameter, LAD)高于未复发组,复发组术前高密度脂蛋白胆固醇(HDL-c)低于未复发组,差异有统计学意义(P 0.05)。二元logistic回归分析显示,消融前HDL-c (OR = 0.046, 95%CI = 0.003~0.718, P = 0.028)、NLR (OR = 4.830, 95%CI = 2.118~11.010, P Objective: The purpose of this study was to explore the value of neutrophil to lymphocyte ratio in predicting recurrence after radiofrequency ablation in patients with atrial fibrillation. Methods: Patients with atrial fibrillation who underwent radiofrequency catheter ablation in the Affiliated Hospital of Yangzhou University in Jiangsu Province from January 2018 to December 2022 were retrospectively selected. All patients were followed up for 1 year. According to the occurrence of atrial fibrillation, atrial flutter and atrial tachycardia with duration ≥ 30 s after the operation, the patients were divided into a recurrent group and a non-recurrent group. Result: A total of 164 patients with atrial fibrillation who underwent radiofrequency catheter ablation were included in this study, including 101 males and 63 females, 29 patients with recurrence and 135 patients without recurrence. The preoperative neutrophil count, lymphoid cell count, neutrophil to lymphocyte ratio and left atrial diameter in the recurrent group were higher than those in the non-recurrent group, while the preoperative high density lipoprotein cholesterol in the recurrent group was significantly lower than that in the non-recurrent group (P 0.05). Binary logistic regression analysis showed that HDL-c (OR = 0.046, 95%CI = 0.003~0.718, P = 0.028), NLR (OR = 4.830, 95%CI = 2.118~11.010, P < 0.001) and LAD (OR = 1.225, 95%CI = 1.082~1.386, P = 0.001) were independent risk factors for predicting recurrence of atrial fibrillation after radiofrequency ablation. ROC curve analysis showed that the areas under the curve of HDL-c, NLR and LAD were 0.713 (95%CI = 0.606~0.821, P < 0.001), 0.858 (95%CI = 0.782~0.934, P < 0.001) and 0.864 (95%CI = 0.806~0.921, P < 0.001). In addition, NLR ≥ 2.765 was significantly associated with an increased risk of recurrence of atrial fibrillation after radiofrequency ablation (P < 0.001). Conclusion: The increase of NLR before radiofrequency ablation is related to the increased risk of postoperative atrial fibrillation recurrence. Additionally, NLR is a better predictor of recurrence of atrial fibrillation after radiofrequency ablation.
文摘目的探讨中性粒细胞/淋巴细胞比值(neutrophil-to-lymphocyte ratio,NLR)、血糖变异度(glycemic variability,GV)对脓毒症患者预后的预测价值。方法选取2023年1月至2024年1月在金华市中心医院住院的121例脓毒症患者,根据患者确诊脓毒症28d内是否死亡分为存活组(n=68)和死亡组(n=53)。记录患者确诊脓毒症后第1~3天的血糖水平,计算GV。对脓毒症患者预后的危险因素进行二元Logistic回归分析。评估相关指标对脓毒症患者预后的预测价值采用受试者操作特征曲线(receiver operating characteristic curve,ROC曲线)。结果与存活组比较,死亡组患者的嗜中性粒细胞计数、急性生理学与慢性健康状况评分Ⅱ、降钙素原、NLR、GV水平升高(P<0.05),而淋巴细胞计数降低(P<0.05)。Logistic回归分析结果表明,NLR与GV是影响脓毒症患者预后的独立危险因素。ROC曲线分析结果显示,NLR的曲线下面积(area under the curve,AUC)为0.814,GV的AUC为0.805。结论NLR和GV可能是影响脓毒症患者预后的独立危险因素,对脓毒症患者的预后有一定预测价值。
