目的:旨在探讨中性粒细胞/淋巴细胞比值(neutrophil to lymphocyte ratio, NLR)对心房颤动患者射频消融术后复发的预测价值。方法:回顾性选取2018年1月至2022年12月期间在江苏省扬州大学附属医院接受射频导管消融术的心房颤动患者为研...目的:旨在探讨中性粒细胞/淋巴细胞比值(neutrophil to lymphocyte ratio, NLR)对心房颤动患者射频消融术后复发的预测价值。方法:回顾性选取2018年1月至2022年12月期间在江苏省扬州大学附属医院接受射频导管消融术的心房颤动患者为研究对象。所有患者均在术后随访1年,根据术后是否发生持续时间 ≥ 30 s的房颤、房扑、房速将患者分为复发组和未复发组。结果:本研究共纳入接受射频导管消融术的心房颤动患者164例,其中男性101例,女性63例,复发组29例,未复发组135例。两组间比较,复发组术前中性粒细胞计数、淋巴细胞计数、NLR、左房内径(left atrial diameter, LAD)高于未复发组,复发组术前高密度脂蛋白胆固醇(HDL-c)低于未复发组,差异有统计学意义(P 0.05)。二元logistic回归分析显示,消融前HDL-c (OR = 0.046, 95%CI = 0.003~0.718, P = 0.028)、NLR (OR = 4.830, 95%CI = 2.118~11.010, P Objective: The purpose of this study was to explore the value of neutrophil to lymphocyte ratio in predicting recurrence after radiofrequency ablation in patients with atrial fibrillation. Methods: Patients with atrial fibrillation who underwent radiofrequency catheter ablation in the Affiliated Hospital of Yangzhou University in Jiangsu Province from January 2018 to December 2022 were retrospectively selected. All patients were followed up for 1 year. According to the occurrence of atrial fibrillation, atrial flutter and atrial tachycardia with duration ≥ 30 s after the operation, the patients were divided into a recurrent group and a non-recurrent group. Result: A total of 164 patients with atrial fibrillation who underwent radiofrequency catheter ablation were included in this study, including 101 males and 63 females, 29 patients with recurrence and 135 patients without recurrence. The preoperative neutrophil count, lymphoid cell count, neutrophil to lymphocyte ratio and left atrial diameter in the recurrent group were higher than those in the non-recurrent group, while the preoperative high density lipoprotein cholesterol in the recurrent group was significantly lower than that in the non-recurrent group (P 0.05). Binary logistic regression analysis showed that HDL-c (OR = 0.046, 95%CI = 0.003~0.718, P = 0.028), NLR (OR = 4.830, 95%CI = 2.118~11.010, P < 0.001) and LAD (OR = 1.225, 95%CI = 1.082~1.386, P = 0.001) were independent risk factors for predicting recurrence of atrial fibrillation after radiofrequency ablation. ROC curve analysis showed that the areas under the curve of HDL-c, NLR and LAD were 0.713 (95%CI = 0.606~0.821, P < 0.001), 0.858 (95%CI = 0.782~0.934, P < 0.001) and 0.864 (95%CI = 0.806~0.921, P < 0.001). In addition, NLR ≥ 2.765 was significantly associated with an increased risk of recurrence of atrial fibrillation after radiofrequency ablation (P < 0.001). Conclusion: The increase of NLR before radiofrequency ablation is related to the increased risk of postoperative atrial fibrillation recurrence. Additionally, NLR is a better predictor of recurrence of atrial fibrillation after radiofrequency ablation.展开更多
文摘目的探讨中性粒细胞/淋巴细胞比值(neutrophil-to-lymphocyte ratio,NLR)、血糖变异度(glycemic variability,GV)对脓毒症患者预后的预测价值。方法选取2023年1月至2024年1月在金华市中心医院住院的121例脓毒症患者,根据患者确诊脓毒症28d内是否死亡分为存活组(n=68)和死亡组(n=53)。记录患者确诊脓毒症后第1~3天的血糖水平,计算GV。对脓毒症患者预后的危险因素进行二元Logistic回归分析。评估相关指标对脓毒症患者预后的预测价值采用受试者操作特征曲线(receiver operating characteristic curve,ROC曲线)。结果与存活组比较,死亡组患者的嗜中性粒细胞计数、急性生理学与慢性健康状况评分Ⅱ、降钙素原、NLR、GV水平升高(P<0.05),而淋巴细胞计数降低(P<0.05)。Logistic回归分析结果表明,NLR与GV是影响脓毒症患者预后的独立危险因素。ROC曲线分析结果显示,NLR的曲线下面积(area under the curve,AUC)为0.814,GV的AUC为0.805。结论NLR和GV可能是影响脓毒症患者预后的独立危险因素,对脓毒症患者的预后有一定预测价值。
文摘目的:旨在探讨中性粒细胞/淋巴细胞比值(neutrophil to lymphocyte ratio, NLR)对心房颤动患者射频消融术后复发的预测价值。方法:回顾性选取2018年1月至2022年12月期间在江苏省扬州大学附属医院接受射频导管消融术的心房颤动患者为研究对象。所有患者均在术后随访1年,根据术后是否发生持续时间 ≥ 30 s的房颤、房扑、房速将患者分为复发组和未复发组。结果:本研究共纳入接受射频导管消融术的心房颤动患者164例,其中男性101例,女性63例,复发组29例,未复发组135例。两组间比较,复发组术前中性粒细胞计数、淋巴细胞计数、NLR、左房内径(left atrial diameter, LAD)高于未复发组,复发组术前高密度脂蛋白胆固醇(HDL-c)低于未复发组,差异有统计学意义(P 0.05)。二元logistic回归分析显示,消融前HDL-c (OR = 0.046, 95%CI = 0.003~0.718, P = 0.028)、NLR (OR = 4.830, 95%CI = 2.118~11.010, P Objective: The purpose of this study was to explore the value of neutrophil to lymphocyte ratio in predicting recurrence after radiofrequency ablation in patients with atrial fibrillation. Methods: Patients with atrial fibrillation who underwent radiofrequency catheter ablation in the Affiliated Hospital of Yangzhou University in Jiangsu Province from January 2018 to December 2022 were retrospectively selected. All patients were followed up for 1 year. According to the occurrence of atrial fibrillation, atrial flutter and atrial tachycardia with duration ≥ 30 s after the operation, the patients were divided into a recurrent group and a non-recurrent group. Result: A total of 164 patients with atrial fibrillation who underwent radiofrequency catheter ablation were included in this study, including 101 males and 63 females, 29 patients with recurrence and 135 patients without recurrence. The preoperative neutrophil count, lymphoid cell count, neutrophil to lymphocyte ratio and left atrial diameter in the recurrent group were higher than those in the non-recurrent group, while the preoperative high density lipoprotein cholesterol in the recurrent group was significantly lower than that in the non-recurrent group (P 0.05). Binary logistic regression analysis showed that HDL-c (OR = 0.046, 95%CI = 0.003~0.718, P = 0.028), NLR (OR = 4.830, 95%CI = 2.118~11.010, P < 0.001) and LAD (OR = 1.225, 95%CI = 1.082~1.386, P = 0.001) were independent risk factors for predicting recurrence of atrial fibrillation after radiofrequency ablation. ROC curve analysis showed that the areas under the curve of HDL-c, NLR and LAD were 0.713 (95%CI = 0.606~0.821, P < 0.001), 0.858 (95%CI = 0.782~0.934, P < 0.001) and 0.864 (95%CI = 0.806~0.921, P < 0.001). In addition, NLR ≥ 2.765 was significantly associated with an increased risk of recurrence of atrial fibrillation after radiofrequency ablation (P < 0.001). Conclusion: The increase of NLR before radiofrequency ablation is related to the increased risk of postoperative atrial fibrillation recurrence. Additionally, NLR is a better predictor of recurrence of atrial fibrillation after radiofrequency ablation.
