Objective: To investigate the relationship between neutrophil extracellular traps (NETs) and sepsis, which can help elucidate the specific molecular mechanisms of sepsis. The causal link between NETs and sepsis progre...Objective: To investigate the relationship between neutrophil extracellular traps (NETs) and sepsis, which can help elucidate the specific molecular mechanisms of sepsis. The causal link between NETs and sepsis progression has been extensively validated. However, few articles have utilized bibliometric methods to analyze research in this field. Therefore, this paper analyzes the research hotspots and trends in NETs and sepsis over the past two decades from a bibliometric perspective, aiming to provide new insights into the fundamentals and research in this field. Methods: We collected publications related to neutrophil extracellular traps (NETs) in the field of sepsis from 2004 to 2024 from the Web of Science Core Collection. Publications were limited to articles and reviews, and the language was restricted to English. VOSviewer and COOC software were used to conduct bibliometric and knowledge map analysis of research collaboration networks, journals, cited references, and keywords in this field. Results: From 2004 to 2024, the Web of Science Core Collection included 720 articles on NETs and sepsis research, including 452 articles and 226 reviews. Since 2022, the number of articles in this field has rapidly increased. The United States and China are the primary contributors in this field. Articles on this topic have been published in 294 academic journals. The author with the most publications is Liaw Patricia C., and Frontiers in Immunology is the most cited journal. In addition to “sepsis” and “neutrophil extracellular traps,” high-frequency terms in the keyword co-occurrence network analysis include inflammation, neutrophils, platelets, thrombosis, Covid-19, infection, innate immunity, and septic shock. An analysis of keyword trends using the burst test indicates that thrombosis and ARDS are currently at the forefront of research in this field. ARDS is currently a hot topic regarding the related roles and potential mechanisms of NETs and sepsis in this field. Conclusion: This study provides a bibliometric analysis and visualization of key research areas in sepsis and NETs over the past 20 years. The results indicate that thrombosis and ARDS are currently hot topics regarding the related roles and potential mechanisms of NETs and sepsis in this field.展开更多
中性粒细胞胞外陷阱(Neutrophil Extracellular Traps, NETs)由中性粒细胞活化后分泌并释放到细胞外,是一种由DNA、组蛋白和抗菌蛋白组成的网状结构,负责捕获和杀死细胞外病原体。中性粒细胞在细菌、真菌、炎症因子等刺激物的刺激下被...中性粒细胞胞外陷阱(Neutrophil Extracellular Traps, NETs)由中性粒细胞活化后分泌并释放到细胞外,是一种由DNA、组蛋白和抗菌蛋白组成的网状结构,负责捕获和杀死细胞外病原体。中性粒细胞在细菌、真菌、炎症因子等刺激物的刺激下被活化并持续释放NETs,可使周围血小板活化,组织细胞受损。一些研究已经证明了Nets的形成是促进炎症发生发展的方式之一,炎症因子如IL-8、IL-1β和TNF-α与NETs的形成关系密切。近年来,NETs在重症肺炎(Severe Pneumonia, SP)发生发展中的作用不断被揭示出来。因此,我们综述了目前对NETs与重症肺炎相关的作用机制的相关研究。旨在为评估重症肺炎病情的严重程度及寻找治疗重症肺炎的新靶点提供理论依据。Neutrophil Extracellular Traps (NETs) are secreted and released outside the cell by activated neutrophils and are a meshwork of DNA, histones and antimicrobial proteins responsible for trapping and killing extracellular pathogens. The activation and sustained release of NETs by neutrophils stimulated by stimuli such as bacteria, fungi and inflammatory factors can lead to activation of peripheral platelets and damage to tissue cells. Several studies have demonstrated that the formation of NETs is one of the ways to promote the occurrence and development of inflammation, and inflammatory factors such as IL-8, IL-1β, and TNF-α are closely related to the formation of NETs. In recent years, the role of NETs in the occurrence and development of Severe Pneumonia (SP) has been continuously revealed. Therefore, we reviewed the current studies related to the mechanism of action of NETs associated with severe pneumonia. The aim is to provide a theoretical basis for evaluating the severity of severe pneumonia and searching for new targets for the treatment of severe pneumonia.展开更多
【据Journal of Hepatology 2021年12月报道】题:调节性T淋巴细胞和中性粒细胞胞外陷阱相互作用促进非酒精性脂肪性肝炎向肝细胞癌的转化(作者Wang H等)非酒精性脂肪性肝病(NAFLD)困扰着很大一部分西方人口,并在发展中国家迅速蔓延。非...【据Journal of Hepatology 2021年12月报道】题:调节性T淋巴细胞和中性粒细胞胞外陷阱相互作用促进非酒精性脂肪性肝炎向肝细胞癌的转化(作者Wang H等)非酒精性脂肪性肝病(NAFLD)困扰着很大一部分西方人口,并在发展中国家迅速蔓延。非酒精性脂肪性肝炎(NASH)是NAFLD的一种侵袭性形式。在美国,10%~20%的NASH患者会发展成为终末期肝病,如肝硬化,并在5~10年内进一步发展为肝细胞癌(HCC)。迄今为止,尚无能够阻止或者逆转NASH及其并发症的有效干预手段。展开更多
文摘Objective: To investigate the relationship between neutrophil extracellular traps (NETs) and sepsis, which can help elucidate the specific molecular mechanisms of sepsis. The causal link between NETs and sepsis progression has been extensively validated. However, few articles have utilized bibliometric methods to analyze research in this field. Therefore, this paper analyzes the research hotspots and trends in NETs and sepsis over the past two decades from a bibliometric perspective, aiming to provide new insights into the fundamentals and research in this field. Methods: We collected publications related to neutrophil extracellular traps (NETs) in the field of sepsis from 2004 to 2024 from the Web of Science Core Collection. Publications were limited to articles and reviews, and the language was restricted to English. VOSviewer and COOC software were used to conduct bibliometric and knowledge map analysis of research collaboration networks, journals, cited references, and keywords in this field. Results: From 2004 to 2024, the Web of Science Core Collection included 720 articles on NETs and sepsis research, including 452 articles and 226 reviews. Since 2022, the number of articles in this field has rapidly increased. The United States and China are the primary contributors in this field. Articles on this topic have been published in 294 academic journals. The author with the most publications is Liaw Patricia C., and Frontiers in Immunology is the most cited journal. In addition to “sepsis” and “neutrophil extracellular traps,” high-frequency terms in the keyword co-occurrence network analysis include inflammation, neutrophils, platelets, thrombosis, Covid-19, infection, innate immunity, and septic shock. An analysis of keyword trends using the burst test indicates that thrombosis and ARDS are currently at the forefront of research in this field. ARDS is currently a hot topic regarding the related roles and potential mechanisms of NETs and sepsis in this field. Conclusion: This study provides a bibliometric analysis and visualization of key research areas in sepsis and NETs over the past 20 years. The results indicate that thrombosis and ARDS are currently hot topics regarding the related roles and potential mechanisms of NETs and sepsis in this field.
文摘中性粒细胞胞外陷阱(Neutrophil Extracellular Traps, NETs)由中性粒细胞活化后分泌并释放到细胞外,是一种由DNA、组蛋白和抗菌蛋白组成的网状结构,负责捕获和杀死细胞外病原体。中性粒细胞在细菌、真菌、炎症因子等刺激物的刺激下被活化并持续释放NETs,可使周围血小板活化,组织细胞受损。一些研究已经证明了Nets的形成是促进炎症发生发展的方式之一,炎症因子如IL-8、IL-1β和TNF-α与NETs的形成关系密切。近年来,NETs在重症肺炎(Severe Pneumonia, SP)发生发展中的作用不断被揭示出来。因此,我们综述了目前对NETs与重症肺炎相关的作用机制的相关研究。旨在为评估重症肺炎病情的严重程度及寻找治疗重症肺炎的新靶点提供理论依据。Neutrophil Extracellular Traps (NETs) are secreted and released outside the cell by activated neutrophils and are a meshwork of DNA, histones and antimicrobial proteins responsible for trapping and killing extracellular pathogens. The activation and sustained release of NETs by neutrophils stimulated by stimuli such as bacteria, fungi and inflammatory factors can lead to activation of peripheral platelets and damage to tissue cells. Several studies have demonstrated that the formation of NETs is one of the ways to promote the occurrence and development of inflammation, and inflammatory factors such as IL-8, IL-1β, and TNF-α are closely related to the formation of NETs. In recent years, the role of NETs in the occurrence and development of Severe Pneumonia (SP) has been continuously revealed. Therefore, we reviewed the current studies related to the mechanism of action of NETs associated with severe pneumonia. The aim is to provide a theoretical basis for evaluating the severity of severe pneumonia and searching for new targets for the treatment of severe pneumonia.
文摘【据Journal of Hepatology 2021年12月报道】题:调节性T淋巴细胞和中性粒细胞胞外陷阱相互作用促进非酒精性脂肪性肝炎向肝细胞癌的转化(作者Wang H等)非酒精性脂肪性肝病(NAFLD)困扰着很大一部分西方人口,并在发展中国家迅速蔓延。非酒精性脂肪性肝炎(NASH)是NAFLD的一种侵袭性形式。在美国,10%~20%的NASH患者会发展成为终末期肝病,如肝硬化,并在5~10年内进一步发展为肝细胞癌(HCC)。迄今为止,尚无能够阻止或者逆转NASH及其并发症的有效干预手段。
