This article summarized the studies of Chinese Herbal Medicine transderm delivery system(CTDS)in recent years, including traditional and modern preparation,the methods of enhancement transdermal,Meanwhile,the author i...This article summarized the studies of Chinese Herbal Medicine transderm delivery system(CTDS)in recent years, including traditional and modern preparation,the methods of enhancement transdermal,Meanwhile,the author introduced the comdition of CTDS in vico and in citro’s study.展开更多
The skin is the largest organ of the body and is a potential route of exposure to sunscreens and cosmetics containing nanoparticles; however, the permeability of the skin to these nanoparticles is currently unknown. I...The skin is the largest organ of the body and is a potential route of exposure to sunscreens and cosmetics containing nanoparticles; however, the permeability of the skin to these nanoparticles is currently unknown. In this paper, we studied the transderreal delivery capacity through mouse skin of water-soluble CdSeS quantum dots （QDs） and the deposition of these QDs in the body. QD solution was coated onto the dorsal hairless skin of male ICR mice. Fluorescence microscopy and transmission electron microscopy （TEM） were used to observe the distribution of QDs in the skin and organs, and inductively coupled plasma-mass spectrometry （ICP-MS） was used to measure the 111Cd content to indicate the concentration of QDs in plasma and organs. Experimental results indicate that QDs can penetrate into the dermal layer and are limited to the uppermost stratum corneum layers and the hair follicles. Through blood circulation, QDs deposit mostly in liver and kidney and are difficult to clear, 111Cd concentration was greater than 14 ng g-1 in kidney after 120 h after 0.32 nmol QDs was applied to a mouse. These results suggest that QDs have in vivo transdermal delivery capacity through mouse skin and are harmful to the liver and kidney.展开更多
文摘This article summarized the studies of Chinese Herbal Medicine transderm delivery system(CTDS)in recent years, including traditional and modern preparation,the methods of enhancement transdermal,Meanwhile,the author introduced the comdition of CTDS in vico and in citro’s study.
基金supported by the Medical College of Chinese People’s Armed Police Force in 2010 (WYZ201003)
文摘The skin is the largest organ of the body and is a potential route of exposure to sunscreens and cosmetics containing nanoparticles; however, the permeability of the skin to these nanoparticles is currently unknown. In this paper, we studied the transderreal delivery capacity through mouse skin of water-soluble CdSeS quantum dots （QDs） and the deposition of these QDs in the body. QD solution was coated onto the dorsal hairless skin of male ICR mice. Fluorescence microscopy and transmission electron microscopy （TEM） were used to observe the distribution of QDs in the skin and organs, and inductively coupled plasma-mass spectrometry （ICP-MS） was used to measure the 111Cd content to indicate the concentration of QDs in plasma and organs. Experimental results indicate that QDs can penetrate into the dermal layer and are limited to the uppermost stratum corneum layers and the hair follicles. Through blood circulation, QDs deposit mostly in liver and kidney and are difficult to clear, 111Cd concentration was greater than 14 ng g-1 in kidney after 120 h after 0.32 nmol QDs was applied to a mouse. These results suggest that QDs have in vivo transdermal delivery capacity through mouse skin and are harmful to the liver and kidney.
