Current treatment modalities provide limited improvement in the natural course of lung cancer, and prognosis remains poor. Lung cancer is a malignancy with great molecular heterogeneity. The complexity of the signalin...Current treatment modalities provide limited improvement in the natural course of lung cancer, and prognosis remains poor. Lung cancer is a malignancy with great molecular heterogeneity. The complexity of the signaling process leading to cancer cell proliferation and to the neoplastic phenotype supports the necessity of interfering at different stages to avoid cancer cell resistance to therapy. For this reason, new strategies for the simultaneous inhibition of multiple molecular targets are being pursued.展开更多
Present mobile communication system suffers from the exponentially increased mobile traffic and research on the fifth generation(5G) mobile network architectures is ongoing to solve this problem. We investigate the fe...Present mobile communication system suffers from the exponentially increased mobile traffic and research on the fifth generation(5G) mobile network architectures is ongoing to solve this problem. We investigate the feasibility of the proposals used for the network architecture evolution from 4G to 5G and first propose a compatible network architecture, which decouples the management plane, the control plane and the user plane based on NO Stack framework proposed in our previous study. We mainly design detail procedures including UE attachment, service request and dedicated bearer activation/deactivation for our proposal network architecture. Finally, we establish a clear analytical mode of the application and system states to evaluate the signaling loads of new architecture. Simulation results show that our proposal network architecture with elaborated signaling procedures has much impact on the total signaling loads of system and could obviously decrease the signaling overhead compared with LTE.展开更多
With rapid development of the railway traffic, the moving block signaling system （MBS） method has become more and more important for increasing the track capacity by allowing trains to run in a shorter time-headway ...With rapid development of the railway traffic, the moving block signaling system （MBS） method has become more and more important for increasing the track capacity by allowing trains to run in a shorter time-headway while maintaining the required safety margins. In this framework, the tracking target point of the following train is moving forward with its leading train. This paper focuses on the energy saving tracking control of two successive trains in MBS. Nonlinear programming method is used to optimize the energy-saving speed trajectory of the following train. The real-time location of the leading train could be integrated into the optimization process. Due to simplicity, it can be used for online implementation. The feasibility and effectiveness are verified through simulation. The results show that the new method is efficient on energy saving even when disturbances present.展开更多
Animal personalities have been a major focus of behavioral ecology over the past decade. Consistent individual dif ferences in behavior have been found across taxa, and have been shown to influence a range of ecologic...Animal personalities have been a major focus of behavioral ecology over the past decade. Consistent individual dif ferences in behavior have been found across taxa, and have been shown to influence a range of ecological processes. The role of personalities in sexual selection has been considered, and examples exist that show selection for personality traits with both assortative and disassortative mating patterns between personality types. One overlooked aspect of the personality and sexual se lection literature is the potential for personalitysignaling interactions, specifically with complex signaling. Complex signaling is a diverse topic in itself, and in short, consists of multiple signals within one or more modalities that interact to elicit a receiver response. Research into complex signaling has been thorough, although at times studies discover complex signaling systems that fail to fit into one of the existing hypotheses in the literature. Here, we argue that personalities may interact with complex signal ing, which should be considered by researchers of both personality and sexual selection and communication. We describe several ways in which personalitycomplex signaling interactions could affect both the signaler and receiver, and the way in which they may drive personalityspecific signals as well as receiver preferences. Finally, we discuss how considering personality in com plex signaling studies may inform theory as well as improve the ability of researchers to accurately describe its function.展开更多
文摘Current treatment modalities provide limited improvement in the natural course of lung cancer, and prognosis remains poor. Lung cancer is a malignancy with great molecular heterogeneity. The complexity of the signaling process leading to cancer cell proliferation and to the neoplastic phenotype supports the necessity of interfering at different stages to avoid cancer cell resistance to therapy. For this reason, new strategies for the simultaneous inhibition of multiple molecular targets are being pursued.
基金supported by the Chinas 863 Project (No.2015AA01A706)the National Science and Technology Major Project (No. 2016ZX03001017)+1 种基金the Science and Technology Program of Beijing (No. D161100001016002)the Science and Technology Cooperation Projects (No. 2015DFT10160B)
文摘Present mobile communication system suffers from the exponentially increased mobile traffic and research on the fifth generation(5G) mobile network architectures is ongoing to solve this problem. We investigate the feasibility of the proposals used for the network architecture evolution from 4G to 5G and first propose a compatible network architecture, which decouples the management plane, the control plane and the user plane based on NO Stack framework proposed in our previous study. We mainly design detail procedures including UE attachment, service request and dedicated bearer activation/deactivation for our proposal network architecture. Finally, we establish a clear analytical mode of the application and system states to evaluate the signaling loads of new architecture. Simulation results show that our proposal network architecture with elaborated signaling procedures has much impact on the total signaling loads of system and could obviously decrease the signaling overhead compared with LTE.
文摘With rapid development of the railway traffic, the moving block signaling system （MBS） method has become more and more important for increasing the track capacity by allowing trains to run in a shorter time-headway while maintaining the required safety margins. In this framework, the tracking target point of the following train is moving forward with its leading train. This paper focuses on the energy saving tracking control of two successive trains in MBS. Nonlinear programming method is used to optimize the energy-saving speed trajectory of the following train. The real-time location of the leading train could be integrated into the optimization process. Due to simplicity, it can be used for online implementation. The feasibility and effectiveness are verified through simulation. The results show that the new method is efficient on energy saving even when disturbances present.
文摘Animal personalities have been a major focus of behavioral ecology over the past decade. Consistent individual dif ferences in behavior have been found across taxa, and have been shown to influence a range of ecological processes. The role of personalities in sexual selection has been considered, and examples exist that show selection for personality traits with both assortative and disassortative mating patterns between personality types. One overlooked aspect of the personality and sexual se lection literature is the potential for personalitysignaling interactions, specifically with complex signaling. Complex signaling is a diverse topic in itself, and in short, consists of multiple signals within one or more modalities that interact to elicit a receiver response. Research into complex signaling has been thorough, although at times studies discover complex signaling systems that fail to fit into one of the existing hypotheses in the literature. Here, we argue that personalities may interact with complex signal ing, which should be considered by researchers of both personality and sexual selection and communication. We describe several ways in which personalitycomplex signaling interactions could affect both the signaler and receiver, and the way in which they may drive personalityspecific signals as well as receiver preferences. Finally, we discuss how considering personality in com plex signaling studies may inform theory as well as improve the ability of researchers to accurately describe its function.
