信号素4A (Sema4A)是信号蛋白家族的成员,被广泛认为参与免疫应答的所有阶段,是调节T细胞稳态、活化和Th1/2/17分化的关键分子,在T细胞介导的自身免疫性疾病的发病机制中具有重要作用。本文就Sema4A在部分T细胞介导的自身免疫性疾病,如...信号素4A (Sema4A)是信号蛋白家族的成员,被广泛认为参与免疫应答的所有阶段,是调节T细胞稳态、活化和Th1/2/17分化的关键分子,在T细胞介导的自身免疫性疾病的发病机制中具有重要作用。本文就Sema4A在部分T细胞介导的自身免疫性疾病,如类风湿性关节炎(RA)、多发性硬化(MS)、系统性红斑狼疮(SLE)、系统性硬化(SSc)中的研究进展展开介绍,可有助于寻找此类疾病新的可行性治疗靶标,并为其他自身免疫性疾病发病机制提供新的研究思路。Semaphorin 4A (Sema4A), a member of the semaphorin family, is widely recognized to be involved in all phases of the immune response. It is a key molecule that regulates T cell homeostasis, activation, and Th1/2/17 differentiation, and it plays an important role in the pathogenesis of T cell-mediated autoimmune diseases. This article introduces the research progress of Sema4A in some T cell-mediated autoimmune diseases, such as rheumatoid arthritis (RA), multiple sclerosis (MS), systemic lupus erythematosus (SLE), and systemic sclerosis (SSc), which can help to find new feasible therapeutic targets and provide new research ideas for the pathogenesis of autoimmune diseases.展开更多
文摘信号素4A (Sema4A)是信号蛋白家族的成员,被广泛认为参与免疫应答的所有阶段,是调节T细胞稳态、活化和Th1/2/17分化的关键分子,在T细胞介导的自身免疫性疾病的发病机制中具有重要作用。本文就Sema4A在部分T细胞介导的自身免疫性疾病,如类风湿性关节炎(RA)、多发性硬化(MS)、系统性红斑狼疮(SLE)、系统性硬化(SSc)中的研究进展展开介绍,可有助于寻找此类疾病新的可行性治疗靶标,并为其他自身免疫性疾病发病机制提供新的研究思路。Semaphorin 4A (Sema4A), a member of the semaphorin family, is widely recognized to be involved in all phases of the immune response. It is a key molecule that regulates T cell homeostasis, activation, and Th1/2/17 differentiation, and it plays an important role in the pathogenesis of T cell-mediated autoimmune diseases. This article introduces the research progress of Sema4A in some T cell-mediated autoimmune diseases, such as rheumatoid arthritis (RA), multiple sclerosis (MS), systemic lupus erythematosus (SLE), and systemic sclerosis (SSc), which can help to find new feasible therapeutic targets and provide new research ideas for the pathogenesis of autoimmune diseases.
