Environmental endocrine disrupting chemicals （EDCs）, commonly found in the environment, come from industry and agriculture, including pesticides, fungicides, insecticides, herbicides, and other chemicals. Nowadays, ...Environmental endocrine disrupting chemicals （EDCs）, commonly found in the environment, come from industry and agriculture, including pesticides, fungicides, insecticides, herbicides, and other chemicals. Nowadays, more and more EDCs were released into the environment. EDCs go into water body via atmosphere sedi-mentation, surface runoff, soil eluviation, etc., so water body becomes the main place for existing. In order to attract scientific and public attention worldwide and to prevent EDCs pol ution, in this study we reviewed the classification of EDCs and their concentrations in natural water bodies, drinking water sources and water plants, and the reproductive toxicity of EDCs to fish were reviewed. EDCs could disturb the endocrine system and make reproductive organs and reproduction abnor-mal, resulting in fertility descending, reproduction function damage, community quan-tity decrease and even species extinction. In addition, EDCs could disrupt the homeostasis maintained by hormones, which would result in defects of neural de-velopment and abnormalities of the endocrine and reproductive systems. The exact molecular mechanisms have not been completely reported, but researches have suggested that multiple mechanisms were involved in the action of EDCs. Although there have been researches on the biohazard of EDCs, there stil exist problems of weakness in fundamental researches, difficulties in recognizing and identifying EDCs and high cost, which restraint the knowledge on them.展开更多
Here reproduction and death toxicity data were selected for 4-nonylphenol based on endocrine disrupting properties of the re- productive system. Assessment factor （AF） and species sensitivity distribution （SSD） cu...Here reproduction and death toxicity data were selected for 4-nonylphenol based on endocrine disrupting properties of the re- productive system. Assessment factor （AF） and species sensitivity distribution （SSD） curve were employed to derive criteria maximum concentration （CMC） and criteria continuous concentration （CCC） of three different 4-nonylphenols for protection of aquatic life. The results showed that the CMC and CCC based on SSD method and death toxicity data for three different 4-nonylphenols （CAS No： 104405, 25154523, 84852163） were 26.7, 13.6, 3.84μg L-1 and 8.86, 2.21, 0.97 μg L-1, respectively. Based on SSD and reproductive toxicity data, the CCC values of different 4-nonylphenols （CAS No： 104405, 25154523） were 1.59 and 1.34μg L-l, respectively. The CCC values obtained by the AF for three different 4-nonylphenol （CAS No： 104405, 25154523, 84852163） were 0.165, 1.03, 0.74 μg L -1 and 0.5, 0.5, 0.1μg L-1, respectively, based on death toxicity data and re- productive toxicity data. The CCC values obtained by AF were all lower than the corresponding criteria values obtained by SSD, and the CCC values based on reproductive toxicity data were less than those based on the death toxicity data. This study provides a useful method for deriving water quality criteria for endocrine disruptors.展开更多
基金Supported by the China Agriculture Research System(CARS49)~~
文摘Environmental endocrine disrupting chemicals （EDCs）, commonly found in the environment, come from industry and agriculture, including pesticides, fungicides, insecticides, herbicides, and other chemicals. Nowadays, more and more EDCs were released into the environment. EDCs go into water body via atmosphere sedi-mentation, surface runoff, soil eluviation, etc., so water body becomes the main place for existing. In order to attract scientific and public attention worldwide and to prevent EDCs pol ution, in this study we reviewed the classification of EDCs and their concentrations in natural water bodies, drinking water sources and water plants, and the reproductive toxicity of EDCs to fish were reviewed. EDCs could disturb the endocrine system and make reproductive organs and reproduction abnor-mal, resulting in fertility descending, reproduction function damage, community quan-tity decrease and even species extinction. In addition, EDCs could disrupt the homeostasis maintained by hormones, which would result in defects of neural de-velopment and abnormalities of the endocrine and reproductive systems. The exact molecular mechanisms have not been completely reported, but researches have suggested that multiple mechanisms were involved in the action of EDCs. Although there have been researches on the biohazard of EDCs, there stil exist problems of weakness in fundamental researches, difficulties in recognizing and identifying EDCs and high cost, which restraint the knowledge on them.
基金supported by National Key Basic Research Development Program (Grant No. 2008CB418205)Major Project of Water Pollution Control and Management (Grant No. 2009ZX07528-002-04)+1 种基金Outstanding Young Teacher Research and Special Projects (Grant No. Shu10040)Shanghai Leading Academic Discipline (Grant No. S30109)
文摘Here reproduction and death toxicity data were selected for 4-nonylphenol based on endocrine disrupting properties of the re- productive system. Assessment factor （AF） and species sensitivity distribution （SSD） curve were employed to derive criteria maximum concentration （CMC） and criteria continuous concentration （CCC） of three different 4-nonylphenols for protection of aquatic life. The results showed that the CMC and CCC based on SSD method and death toxicity data for three different 4-nonylphenols （CAS No： 104405, 25154523, 84852163） were 26.7, 13.6, 3.84μg L-1 and 8.86, 2.21, 0.97 μg L-1, respectively. Based on SSD and reproductive toxicity data, the CCC values of different 4-nonylphenols （CAS No： 104405, 25154523） were 1.59 and 1.34μg L-l, respectively. The CCC values obtained by the AF for three different 4-nonylphenol （CAS No： 104405, 25154523, 84852163） were 0.165, 1.03, 0.74 μg L -1 and 0.5, 0.5, 0.1μg L-1, respectively, based on death toxicity data and re- productive toxicity data. The CCC values obtained by AF were all lower than the corresponding criteria values obtained by SSD, and the CCC values based on reproductive toxicity data were less than those based on the death toxicity data. This study provides a useful method for deriving water quality criteria for endocrine disruptors.
