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硬脂酸镁功能性参数对尼群地平片溶出行为影响的研究 被引量:8
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作者 龙海燕 刘雁鸣 +2 位作者 粟贵 彭念涔 谭必琴 《中南药学》 CAS 2016年第12期1298-1302,共5页
目的研究硬脂酸镁不同功能性参数对尼群地平片溶出度的影响。方法采用批准的工艺,用功能性参数不同的硬脂酸镁,其余原辅料完全一致,制备A、B、C 3批尼群地平片;分别按照Ch P2010、《日本橙皮书》、《仿制药质量一致性评价——普通口服... 目的研究硬脂酸镁不同功能性参数对尼群地平片溶出度的影响。方法采用批准的工艺,用功能性参数不同的硬脂酸镁,其余原辅料完全一致,制备A、B、C 3批尼群地平片;分别按照Ch P2010、《日本橙皮书》、《仿制药质量一致性评价——普通口服固体制剂溶出曲线测定与比较指导原则》等资料中的9种溶剂进行溶出曲线的比较和相似度评价。结果按照Ch P2010条件下,A、B、C在45 min时累积溶出度达到100%,3种片剂溶出行为相似;在日本橙皮书条件下,A、B、C在45 min时累积溶出只达到约30%,3种片剂溶出行为相似,但与橙皮书中所附曲线明显不相似;在《仿制药质量一致性评价——普通口服固体制剂溶出曲线测定与比较指导原则》规定的4种溶剂条件下,在pH=1.2、pH=4.0溶剂中A片与C片溶出行为不相似。结论硬脂酸镁的粒径分布等功能性参数对尼群地平片的溶出有一定影响。 展开更多
关键词 硬脂酸镁 尼群地平片 粒径分布 功能性参数 溶出度
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A dual⁃parameter method for seismic resilience assessment of buildings
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作者 LI Shuang HU Binbin +1 位作者 LIU Wen ZHAI Changhai 《Journal of Southeast University(English Edition)》 2025年第1期1-11,共11页
To quantify the seismic resilience of buildings,a method for evaluating functional loss from the component level to the overall building is proposed,and the dual-parameter seismic resilience assessment method based on... To quantify the seismic resilience of buildings,a method for evaluating functional loss from the component level to the overall building is proposed,and the dual-parameter seismic resilience assessment method based on postearthquake loss and recovery time is improved.A threelevel function tree model is established,which can consider the dynamic changes in weight coefficients of different category of components relative to their functional losses.Bayesian networks are utilized to quantify the impact of weather conditions,construction technology levels,and worker skill levels on component repair time.A method for determining the real-time functional recovery curve of buildings based on the component repair process is proposed.Taking a three-story teaching building as an example,the seismic resilience indices under basic earthquakes and rare earthquakes are calculated.The results show that the seismic resilience grade of the teaching building is comprehensively judged as GradeⅢ,and its resilience grade is more significantly affected by postearthquake loss.The proposed method can be used to predict the seismic resilience of buildings prior to earthquakes,identify weak components within buildings,and provide guidance for taking measures to enhance the seismic resilience of buildings. 展开更多
关键词 seismic resilience assessment dual-parameter method functional loss recovery time Bayesian networks
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Generalized Morrey spaces and trace operator 被引量:8
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作者 NAKAMURA Shohei NOI Takahiro SAWANO Yoshihiro 《Science China Mathematics》 SCIE CSCD 2016年第2期281-336,共56页
The theory of generalized Besov-Morrey spaces and generalized Triebel-Lizorkin-Morrey spaces is developed. Generalized Morrey spaces, which Mizuhara and Nakai proposed, are equipped with a parameter and a function. Th... The theory of generalized Besov-Morrey spaces and generalized Triebel-Lizorkin-Morrey spaces is developed. Generalized Morrey spaces, which Mizuhara and Nakai proposed, are equipped with a parameter and a function. The trace property is one of the main focuses of the present paper, which will clarify the role of the parameter of generalized Morrey spaces. The quarkonial decomposition is obtained as an application of the atomic decomposition. In the end, the relation between the function spaces dealt in the present paper and the foregoing researches is discussed. 展开更多
关键词 Morrey space trace operator DECOMPOSITION
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Efficient Quantile Estimation for Functional-Coefficient Partially Linear Regression Models
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作者 Zhangong ZHOU Rong JIANG Weimin QIAN 《Chinese Annals of Mathematics,Series B》 SCIE CSCD 2011年第5期729-740,共12页
The quantile estimation methods are proposed for functional-coefficient partially linear regression (FCPLR) model by combining nonparametric and functional-coefficient regression (FCR) model. The local linear sche... The quantile estimation methods are proposed for functional-coefficient partially linear regression (FCPLR) model by combining nonparametric and functional-coefficient regression (FCR) model. The local linear scheme and the integrated method are used to obtain Focal quantile estimators of all unknown functions in the FCPLR model. These resulting estimators are asymptotically normal, but each of them has big variance. To reduce variances of these quantile estimators, the one-step backfitting technique is used to obtain the efficient quantile estimators of all unknown functions, and their asymptotic normalities are derived. Two simulated examples are carried out to illustrate the proposed estimation methodology. 展开更多
关键词 Functional-coefficient model Quantile regression Local linear method Backfitting technique Asymptotic normality
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