非侵入式负荷监测(non-intrusive load monitoring,NILM)是一种无需进入每个用电器内部系统,仅在用户总线入口处安装监测设备的技术.在开展NILM技术研究时,往往需要收集大规模的用户负荷数据来证明所提出方法的普适性,此需求不可避免地...非侵入式负荷监测(non-intrusive load monitoring,NILM)是一种无需进入每个用电器内部系统,仅在用户总线入口处安装监测设备的技术.在开展NILM技术研究时,往往需要收集大规模的用户负荷数据来证明所提出方法的普适性,此需求不可避免地带来了繁重的数据收集与整理负担.为克服该挑战,设计了一种结合周期信号频率不变变换(frequency invariant transformation for periodic signals,FIT-PS)原理与时间序列生成对抗网络(time series generative adversarial networks,TimeGAN)的混合模型,记为FIT-PSTimeGAN.针对全球家庭与工业瞬态能量数据集(worldwide household and industry transient energy dataset,WHITED)中的空调、微波炉、吸尘器、冰箱和热水壶5种电器,运用FIT-PS对负荷数据集进行切割和拼接,构建TimeGAN不同状态下的训练集和测试集.评估测试集的效果发现,生成的波形数据与真实数据表现出高度一致性.进一步采用FIT-PS对训练得到的生成数据进行截取和拼接,生成满足测试需求的完整的单负荷波形和多负荷波形.对这些生成的波形与相同状态下的真实数据进行对比,结果显示两者吻合度很高.与自回归模型和生成对抗网络(generative adversarial network,GAN)模型相比,FIT-PS-TimeGAN模型在生成数据的性能方面表现更优.研究结果表明,FIT-PS-TimeGAN混合模型能够有效生成符合标准电器运行规律的波形和场景数据.展开更多
Studies on rodents and humans demonstrate an inherited predisposition to hepatocellular carcinoma （HCC）. Analysis of the molecular alterations involved in the acquisition of a phenotype resistant or susceptible to h...Studies on rodents and humans demonstrate an inherited predisposition to hepatocellular carcinoma （HCC）. Analysis of the molecular alterations involved in the acquisition of a phenotype resistant or susceptible to hepatocarcinogenesis showed a deregulation of G1 and S phases in HCC of genetically susceptible F344 rats and a G1-S block in lesions of resistant Brown norway （BN） rats. Unrestrained extracellular signal-regulated kinase （ERK） activity linked to proteasomal degradation of dual-specificity phosphatase 1 （DUSP1）, a specific ERK inhibitor, by the CKS1-SKP2 ubiquitin ligase complex occurs in more aggressive HCC of F344 rats and humans. This mechanism is less active in HCC of BN rats and human HCC with better prognosis. Upregulation of iNos cross-talk with IKK/NF-KB and RAS/ERK pathways occurs in rodent liver lesions at higher levels in the most aggressive models represented by HCC of F344 rats and c-Myc-TGF-α transgenic mice. iNOS, IKK/NF-κB, and RAS/ERK upregulation is highest in human HCC with a poorer prognosis and positively correlates with tumor proliferation, genomic instability and microvascularization, and negatively with apoptosis. Thus, cell cycle regulation and the activity of signal transduction pathways seem to be modulated by HCC modifier genes, and differences in their efficiency influence the susceptibility to hepatocarcinogenesis and probably the prognosis of human HCC.展开更多
文摘非侵入式负荷监测(non-intrusive load monitoring,NILM)是一种无需进入每个用电器内部系统,仅在用户总线入口处安装监测设备的技术.在开展NILM技术研究时,往往需要收集大规模的用户负荷数据来证明所提出方法的普适性,此需求不可避免地带来了繁重的数据收集与整理负担.为克服该挑战,设计了一种结合周期信号频率不变变换(frequency invariant transformation for periodic signals,FIT-PS)原理与时间序列生成对抗网络(time series generative adversarial networks,TimeGAN)的混合模型,记为FIT-PSTimeGAN.针对全球家庭与工业瞬态能量数据集(worldwide household and industry transient energy dataset,WHITED)中的空调、微波炉、吸尘器、冰箱和热水壶5种电器,运用FIT-PS对负荷数据集进行切割和拼接,构建TimeGAN不同状态下的训练集和测试集.评估测试集的效果发现,生成的波形数据与真实数据表现出高度一致性.进一步采用FIT-PS对训练得到的生成数据进行截取和拼接,生成满足测试需求的完整的单负荷波形和多负荷波形.对这些生成的波形与相同状态下的真实数据进行对比,结果显示两者吻合度很高.与自回归模型和生成对抗网络(generative adversarial network,GAN)模型相比,FIT-PS-TimeGAN模型在生成数据的性能方面表现更优.研究结果表明,FIT-PS-TimeGAN混合模型能够有效生成符合标准电器运行规律的波形和场景数据.
基金Supported by Grants from the"Associazione Italiana Ricerche sul Cancro"
文摘Studies on rodents and humans demonstrate an inherited predisposition to hepatocellular carcinoma （HCC）. Analysis of the molecular alterations involved in the acquisition of a phenotype resistant or susceptible to hepatocarcinogenesis showed a deregulation of G1 and S phases in HCC of genetically susceptible F344 rats and a G1-S block in lesions of resistant Brown norway （BN） rats. Unrestrained extracellular signal-regulated kinase （ERK） activity linked to proteasomal degradation of dual-specificity phosphatase 1 （DUSP1）, a specific ERK inhibitor, by the CKS1-SKP2 ubiquitin ligase complex occurs in more aggressive HCC of F344 rats and humans. This mechanism is less active in HCC of BN rats and human HCC with better prognosis. Upregulation of iNos cross-talk with IKK/NF-KB and RAS/ERK pathways occurs in rodent liver lesions at higher levels in the most aggressive models represented by HCC of F344 rats and c-Myc-TGF-α transgenic mice. iNOS, IKK/NF-κB, and RAS/ERK upregulation is highest in human HCC with a poorer prognosis and positively correlates with tumor proliferation, genomic instability and microvascularization, and negatively with apoptosis. Thus, cell cycle regulation and the activity of signal transduction pathways seem to be modulated by HCC modifier genes, and differences in their efficiency influence the susceptibility to hepatocarcinogenesis and probably the prognosis of human HCC.
