目的:可注射水凝胶再生修复退变髓核的研究进展进行综述。方法:广泛查阅近年来国内外相关研究文献,对不同类型可注射水凝胶用于髓核再生修复研究进展进行总结。结果:可注射水凝胶在机械性能、组织相容性、微创置入及负载生物活性物质等...目的:可注射水凝胶再生修复退变髓核的研究进展进行综述。方法:广泛查阅近年来国内外相关研究文献,对不同类型可注射水凝胶用于髓核再生修复研究进展进行总结。结果:可注射水凝胶在机械性能、组织相容性、微创置入及负载生物活性物质等方面具有优势,目前关于可注射水凝胶在髓核再生修复的临床研究也取得了较好的结果,但其临床转化还需解决机械强度匹配、水凝胶泄露移位的问题。结论:可注射水凝胶的特性可以实现水凝胶的微创化置入,在成分和结构上模拟原生髓核组织,恢复髓核微环境和生物力学功能,同时可以作为生物活性物质的载体促进髓核再生,在髓核修复领域具有广阔的应用场景。Objective: To review the research progress of injectable hydrogel for regeneration and repair of degenerated nucleus pulposus. Methods: The related research literature at home and abroad in recent years was extensively reviewed, and the research progress of different types of injectable hydrogels for nucleus pulposus regeneration and repair was summarized. Results: Injectable hydrogel has advantages in mechanical properties, histocompatibility, minimally invasive implantation and loading of bioactive substances. At present, the clinical research of injectable hydrogel in the regeneration and repair of nucleus pulposus has also achieved good results, but its clinical transformation still needs to solve the problems of mechanical strength matching, hydrogel leakage and displacement. Conclusion: The characteristics of injectable hydrogel can realize the minimally invasive implantation of hydrogel, simulate the original nucleus pulposus tissue in composition and structure, restore the microenvironment and biomechanical function of nucleus pulposus, and can be used as a carrier of bioactive substances to promote the regeneration of nucleus pulposus, which has a broad application scenario in the field of nucleus pulposus repair.展开更多
文摘目的:可注射水凝胶再生修复退变髓核的研究进展进行综述。方法:广泛查阅近年来国内外相关研究文献,对不同类型可注射水凝胶用于髓核再生修复研究进展进行总结。结果:可注射水凝胶在机械性能、组织相容性、微创置入及负载生物活性物质等方面具有优势,目前关于可注射水凝胶在髓核再生修复的临床研究也取得了较好的结果,但其临床转化还需解决机械强度匹配、水凝胶泄露移位的问题。结论:可注射水凝胶的特性可以实现水凝胶的微创化置入,在成分和结构上模拟原生髓核组织,恢复髓核微环境和生物力学功能,同时可以作为生物活性物质的载体促进髓核再生,在髓核修复领域具有广阔的应用场景。Objective: To review the research progress of injectable hydrogel for regeneration and repair of degenerated nucleus pulposus. Methods: The related research literature at home and abroad in recent years was extensively reviewed, and the research progress of different types of injectable hydrogels for nucleus pulposus regeneration and repair was summarized. Results: Injectable hydrogel has advantages in mechanical properties, histocompatibility, minimally invasive implantation and loading of bioactive substances. At present, the clinical research of injectable hydrogel in the regeneration and repair of nucleus pulposus has also achieved good results, but its clinical transformation still needs to solve the problems of mechanical strength matching, hydrogel leakage and displacement. Conclusion: The characteristics of injectable hydrogel can realize the minimally invasive implantation of hydrogel, simulate the original nucleus pulposus tissue in composition and structure, restore the microenvironment and biomechanical function of nucleus pulposus, and can be used as a carrier of bioactive substances to promote the regeneration of nucleus pulposus, which has a broad application scenario in the field of nucleus pulposus repair.
