目的随机对照试验(RCT)通常具有严格的实施标准,纳入的研究对象特征以及干预实施条件与真实临床环境具有较大差异,这会导致干预措施在实际临床应用中的风险-效益与RCT中表现出的风险-效益存在差异,结果的外推性受到很大限制。因此需要...目的随机对照试验(RCT)通常具有严格的实施标准,纳入的研究对象特征以及干预实施条件与真实临床环境具有较大差异,这会导致干预措施在实际临床应用中的风险-效益与RCT中表现出的风险-效益存在差异,结果的外推性受到很大限制。因此需要一些方法增强RCT结果的外推性,以评估药物在真实人群和真实临床实践环境中的真实效果。方法检索PubMed、Embase、Web of Science、万方数据知识服务平台、维普数据库、中国知网6个数据库从建库至2022年12月31日的中英文文献。采用概括性综述的方法,对纳入文献进行归纳整合和定性描述。结果共纳入12篇文献。纳入文献中增强效力外推性的方法可以归纳为3类:①改善传统RCT设计,增强人群代表性;②将RCT数据与真实世界数据(RWD)结合分析;③根据真实世界患者特征,校准RCT结果。结论改进RCT设计,增强人群代表性,可提高RCT结果的外推性;将RCT数据与RWD结合分析,可发挥不同来源数据的优势;根据真实世界人群特征校准RCT结果,可预估干预措施在真实世界患者群体中的效果。展开更多
A one-step band-limited extrapolation procedure is systematically developed under an a priori assumption of bandwidth. The rationale of the proposed scheme is to expand the known signal segment based on a band-limited...A one-step band-limited extrapolation procedure is systematically developed under an a priori assumption of bandwidth. The rationale of the proposed scheme is to expand the known signal segment based on a band-limited basis function set and then to generate a set of Empirical Orthogonal Functions (EOF’s) adaptively from the sample values of the band-limited function set. Simulation results indicate that, in addi- tion to the attractive adaptive feature, this scheme also appears to guarantee a smooth result for inexact data, thus suggesting the robustness of the proposed procedure.展开更多
On the basis of the actual steel deck structure of Taizhou Bridge, this paper carries out hot-spot stress analysis on some key spots by using the finite element model which simulates local structure of orthotropic ste...On the basis of the actual steel deck structure of Taizhou Bridge, this paper carries out hot-spot stress analysis on some key spots by using the finite element model which simulates local structure of orthotropic steel bridge decks. A finite element model is established for local structure of orthotropic steel bridge decks, and in the analysis of linear elasticity of the structure, face load is employed to simulate the loads from vehicle wheels. Analysis results show that main stresses are relatively heavy at the joints between diaphragm plates, top plates and U-shaped ribs and the joints between diaphragm plates and U-shaped ribs. These joints shall be regarded as key points for hot-spot stress analysis. Different mesh densities are adopted in the finite element model and the main stresses at different hot spots are contrasted and linear extrapolation is carried out using extrapolation formulae. Results show that different mesh densities have different influences on the hot-spot stresses at the welded seams of U-shaped ribs. These influences shall be considered in calculation and analysis.展开更多
To explore the precise dynamic response of the levitation system with active controller, a maglev guide way-electromagnet-air spring-cabin coupled model is derived firstly. Based on the mathematical model, it shows th...To explore the precise dynamic response of the levitation system with active controller, a maglev guide way-electromagnet-air spring-cabin coupled model is derived firstly. Based on the mathematical model, it shows that the inherent nonlinearity, inner coupling, misalignments between the sensors and actuators, load uncertainties and external disturbances are the main issues that should be solved in engineering. Under the assumptions that the loads and external disturbance are measurable, the backstepping module controller developed in this work can tackle the above problems effectively. In reality, the load is uncertain due to the additions of luggage and passengers, which will degrade the dynamic performance. A load estimation algorithm is introduced to track the actual load asymptotically and eliminate its influence by tuning the parameters of controller online. Furthermore,considering the external disturbances generated by crosswind, pulling motor and air springs, the extended state observer is employed to estimate and suppress the external disturbance. Finally, results of numerical simulations illustrating closed-loop performance are provided.展开更多
For the Poisson equation with Robin boundary conditions,by using a few techniques such as orthogonal expansion(M-type),separation of the main part and the finite element projection,we prove for the first time that the...For the Poisson equation with Robin boundary conditions,by using a few techniques such as orthogonal expansion(M-type),separation of the main part and the finite element projection,we prove for the first time that the asymptotic error expansions of bilinear finite element have the accuracy of O(h3)for u∈H3.Based on the obtained asymptotic error expansions for linear finite elements,extrapolation cascadic multigrid method(EXCMG)can be used to solve Robin problems effectively.Furthermore,by virtue of Richardson not only the accuracy of the approximation is improved,but also a posteriori error estimation is obtained.Finally,some numerical experiments that confirm the theoretical analysis are presented.展开更多
A new model used to calculate the free energy change of protein unfolding is presented. In this model, proteins are considered to be composed of structural elements. The unfolding of a structural element obeys a two-s...A new model used to calculate the free energy change of protein unfolding is presented. In this model, proteins are considered to be composed of structural elements. The unfolding of a structural element obeys a two-state mechanism and the free energy change of the element can be obtained by a linear extrapolation method. If a protein consists of the same structural elements, its unfolding will displays a two-state process, and only the average structural element free energy change 〈△G0 element（H2O）〉 can be measured. If protein consists of completely different structural elements, its unfolding will show a multi-state behavior. When a protein consists of n structural elements its unfolding will shows a （n＋1）-state behavior. A least-squares fitting can be used to analyze the contribution of each structural element to the protein and the free energy change of each structural element can be obtained by using linear extrapolation to zero denaturant concentration, not to the start of each transition. The measured △Gn protein（H2O） is the sum of the free energy change for each structural element. Using this new model, we can not only analyze the stability of various proteins with similar structure and similar molecular weight, which undergo multi-state unfolding processes, but also compare the stability of proteins with different structures and molecular weights using the average structural element free energy change 〈△G0 element（H2O）〉. Although this method cannot completely provide the exact free energy of proteins, it is better than current methods.展开更多
The triangular linear finite elements on piecewise uniform grid for an elliptic problem in convex polygonal domain are discussed. Global superconvergence in discrete Hi-norm and global extrapolation in discrete L2-nor...The triangular linear finite elements on piecewise uniform grid for an elliptic problem in convex polygonal domain are discussed. Global superconvergence in discrete Hi-norm and global extrapolation in discrete L2-norm are proved. Based on these global estimates the conjugate gradient method （CG） is effective, which is applied to extrapolation cascadic multigrid method （EXCMG）. The numerical experiments show that EXCMG is of the global higher accuracy for both function and gradient.展开更多
文摘目的随机对照试验(RCT)通常具有严格的实施标准,纳入的研究对象特征以及干预实施条件与真实临床环境具有较大差异,这会导致干预措施在实际临床应用中的风险-效益与RCT中表现出的风险-效益存在差异,结果的外推性受到很大限制。因此需要一些方法增强RCT结果的外推性,以评估药物在真实人群和真实临床实践环境中的真实效果。方法检索PubMed、Embase、Web of Science、万方数据知识服务平台、维普数据库、中国知网6个数据库从建库至2022年12月31日的中英文文献。采用概括性综述的方法,对纳入文献进行归纳整合和定性描述。结果共纳入12篇文献。纳入文献中增强效力外推性的方法可以归纳为3类:①改善传统RCT设计,增强人群代表性;②将RCT数据与真实世界数据(RWD)结合分析;③根据真实世界患者特征,校准RCT结果。结论改进RCT设计,增强人群代表性,可提高RCT结果的外推性;将RCT数据与RWD结合分析,可发挥不同来源数据的优势;根据真实世界人群特征校准RCT结果,可预估干预措施在真实世界患者群体中的效果。
文摘A one-step band-limited extrapolation procedure is systematically developed under an a priori assumption of bandwidth. The rationale of the proposed scheme is to expand the known signal segment based on a band-limited basis function set and then to generate a set of Empirical Orthogonal Functions (EOF’s) adaptively from the sample values of the band-limited function set. Simulation results indicate that, in addi- tion to the attractive adaptive feature, this scheme also appears to guarantee a smooth result for inexact data, thus suggesting the robustness of the proposed procedure.
基金National Science and Technology Support Program of China(No.2009BAG15B02)Key Programs for Science and Technology Development of Chinese Transportation Industry(No.2008-353-332-180)+1 种基金"333 High-level Personnel Training Project"Special Funded Projects in Jiangsu ProvinceJiangsu Communications Science Research Program(No.08Y29-16)
文摘On the basis of the actual steel deck structure of Taizhou Bridge, this paper carries out hot-spot stress analysis on some key spots by using the finite element model which simulates local structure of orthotropic steel bridge decks. A finite element model is established for local structure of orthotropic steel bridge decks, and in the analysis of linear elasticity of the structure, face load is employed to simulate the loads from vehicle wheels. Analysis results show that main stresses are relatively heavy at the joints between diaphragm plates, top plates and U-shaped ribs and the joints between diaphragm plates and U-shaped ribs. These joints shall be regarded as key points for hot-spot stress analysis. Different mesh densities are adopted in the finite element model and the main stresses at different hot spots are contrasted and linear extrapolation is carried out using extrapolation formulae. Results show that different mesh densities have different influences on the hot-spot stresses at the welded seams of U-shaped ribs. These influences shall be considered in calculation and analysis.
基金Projects(60404003,11202230)supported by the National Natural Science Foundation of China
文摘To explore the precise dynamic response of the levitation system with active controller, a maglev guide way-electromagnet-air spring-cabin coupled model is derived firstly. Based on the mathematical model, it shows that the inherent nonlinearity, inner coupling, misalignments between the sensors and actuators, load uncertainties and external disturbances are the main issues that should be solved in engineering. Under the assumptions that the loads and external disturbance are measurable, the backstepping module controller developed in this work can tackle the above problems effectively. In reality, the load is uncertain due to the additions of luggage and passengers, which will degrade the dynamic performance. A load estimation algorithm is introduced to track the actual load asymptotically and eliminate its influence by tuning the parameters of controller online. Furthermore,considering the external disturbances generated by crosswind, pulling motor and air springs, the extended state observer is employed to estimate and suppress the external disturbance. Finally, results of numerical simulations illustrating closed-loop performance are provided.
基金supported by National Natural Science Foundation of China(Grant Nos.11226332,41204082 and 11071067)the China Postdoctoral Science Foundation(Grant No.2011M501295)+1 种基金the Research Fund for the Doctoral Program of Higher Education of China(Grant No.20120162120036)the Construct Program of the Key Discipline in Hunan Province
文摘For the Poisson equation with Robin boundary conditions,by using a few techniques such as orthogonal expansion(M-type),separation of the main part and the finite element projection,we prove for the first time that the asymptotic error expansions of bilinear finite element have the accuracy of O(h3)for u∈H3.Based on the obtained asymptotic error expansions for linear finite elements,extrapolation cascadic multigrid method(EXCMG)can be used to solve Robin problems effectively.Furthermore,by virtue of Richardson not only the accuracy of the approximation is improved,but also a posteriori error estimation is obtained.Finally,some numerical experiments that confirm the theoretical analysis are presented.
基金supported by the National Natural Science Foundation of China (20771068 and 20901048)the PhD Programs Foundation of the Ministry of Education of China (20091401110007)
文摘A new model used to calculate the free energy change of protein unfolding is presented. In this model, proteins are considered to be composed of structural elements. The unfolding of a structural element obeys a two-state mechanism and the free energy change of the element can be obtained by a linear extrapolation method. If a protein consists of the same structural elements, its unfolding will displays a two-state process, and only the average structural element free energy change 〈△G0 element（H2O）〉 can be measured. If protein consists of completely different structural elements, its unfolding will show a multi-state behavior. When a protein consists of n structural elements its unfolding will shows a （n＋1）-state behavior. A least-squares fitting can be used to analyze the contribution of each structural element to the protein and the free energy change of each structural element can be obtained by using linear extrapolation to zero denaturant concentration, not to the start of each transition. The measured △Gn protein（H2O） is the sum of the free energy change for each structural element. Using this new model, we can not only analyze the stability of various proteins with similar structure and similar molecular weight, which undergo multi-state unfolding processes, but also compare the stability of proteins with different structures and molecular weights using the average structural element free energy change 〈△G0 element（H2O）〉. Although this method cannot completely provide the exact free energy of proteins, it is better than current methods.
基金supported by National Natural Science Foundation of China(Grant Nos.1130117611071067 and 11226332)+1 种基金the Research Fund for the Doctoral Program of Higher Education of China(Grant No.20120162120036)the Construct Program of the Key Discipline in Hunan Province
文摘The triangular linear finite elements on piecewise uniform grid for an elliptic problem in convex polygonal domain are discussed. Global superconvergence in discrete Hi-norm and global extrapolation in discrete L2-norm are proved. Based on these global estimates the conjugate gradient method （CG） is effective, which is applied to extrapolation cascadic multigrid method （EXCMG）. The numerical experiments show that EXCMG is of the global higher accuracy for both function and gradient.
