A new descriptor,namely scores vector of zero dimension,one dimension,two dimension and three dimension(SZOTT),was derived from principle components analysis of a matrix of 1 369 structural variables including 0D,1D,2...A new descriptor,namely scores vector of zero dimension,one dimension,two dimension and three dimension(SZOTT),was derived from principle components analysis of a matrix of 1 369 structural variables including 0D,1D,2D and 3D information for 20 coded amino acids.SZOTT scales were then employed to express structures of 20 thromboplastin inhibitors and 34 bactericidal peptides.The correlation coefficients of both whole calibration(%R%2=%R%2cu)and of cross validation(%Q%2=%R%2cv)for the multiple-variable models by classical partial least squares(PLS)and orthogonal signal correction-partial least squares(OSC-PLS)of 20 thromboplastin inhibitors were 0.989 and 0.748,0.994 and 0.936,respectively.%R%2 and %Q%2 for the models by PLS and OSC-PLS of 34 bactericidal peptides were 0.619 and 0.406,0.910 and 0.503,respectively.Satisfactory results obtained showed that structural information related to biological activity in both data sets could be described by SZOTT which included plentiful information related to biological activity,and which was conveniently operated and easy interpreted.,also predictive capability of models were relative robust.There is a high prospect for SZOTT wide applications on quantitative sequence-activity modeling(QSAM)of peptides.展开更多
针对拓展的Web服务体系结构,利用概率时间自动机(probabilistic timed automata,PTA)对Web服务组合进行形式化建模,将Web服务组合的过程理解为一个实时系统的运行过程,进而对Web服务组合的整体服务质量(quality of service,QoS)进行定...针对拓展的Web服务体系结构,利用概率时间自动机(probabilistic timed automata,PTA)对Web服务组合进行形式化建模,将Web服务组合的过程理解为一个实时系统的运行过程,进而对Web服务组合的整体服务质量(quality of service,QoS)进行定量分析,从而克服了已有Web服务质量研究方式主要集中在对单个Web服务分析评估上的局限性,在整个分析过程中充分考虑Web服务组合执行过程所具有的随机性和不确定性,具有较高的可信度.通过实验说明了建模分析方法的可行性,并证明了采取相应的服务选择策略有助于提高Web服务组合的成功率.展开更多
文摘A new descriptor,namely scores vector of zero dimension,one dimension,two dimension and three dimension(SZOTT),was derived from principle components analysis of a matrix of 1 369 structural variables including 0D,1D,2D and 3D information for 20 coded amino acids.SZOTT scales were then employed to express structures of 20 thromboplastin inhibitors and 34 bactericidal peptides.The correlation coefficients of both whole calibration(%R%2=%R%2cu)and of cross validation(%Q%2=%R%2cv)for the multiple-variable models by classical partial least squares(PLS)and orthogonal signal correction-partial least squares(OSC-PLS)of 20 thromboplastin inhibitors were 0.989 and 0.748,0.994 and 0.936,respectively.%R%2 and %Q%2 for the models by PLS and OSC-PLS of 34 bactericidal peptides were 0.619 and 0.406,0.910 and 0.503,respectively.Satisfactory results obtained showed that structural information related to biological activity in both data sets could be described by SZOTT which included plentiful information related to biological activity,and which was conveniently operated and easy interpreted.,also predictive capability of models were relative robust.There is a high prospect for SZOTT wide applications on quantitative sequence-activity modeling(QSAM)of peptides.
文摘针对拓展的Web服务体系结构,利用概率时间自动机(probabilistic timed automata,PTA)对Web服务组合进行形式化建模,将Web服务组合的过程理解为一个实时系统的运行过程,进而对Web服务组合的整体服务质量(quality of service,QoS)进行定量分析,从而克服了已有Web服务质量研究方式主要集中在对单个Web服务分析评估上的局限性,在整个分析过程中充分考虑Web服务组合执行过程所具有的随机性和不确定性,具有较高的可信度.通过实验说明了建模分析方法的可行性,并证明了采取相应的服务选择策略有助于提高Web服务组合的成功率.
