AIM:To prospectively confirm whether a small amount of polyethylene glycol(PEG)ingested after swallowing endoscopy capsule improves image quality and completion rate.METHODS:Forty-four consecutive patients referred to...AIM:To prospectively confirm whether a small amount of polyethylene glycol(PEG)ingested after swallowing endoscopy capsule improves image quality and completion rate.METHODS:Forty-four consecutive patients referred to us for capsule endoscopy(CE)were randomized to two groups.All patients were restricted to clear fluids for 12 h before the examination.Patients in group A(22 cases)received no additional preparation,while those in group B(20 cases)ingested 500 mL of PEG within a 2 h period starting 30 min after swallowing the capsule.Clear fluids and meals were allowed 2 h and 4 h after capsule ingestion,respectively.Image quality was assessed as the percentage of visualized bowel surface area as follows:1:<25%;2:25%-49%;3:50%-74%;4:75%-89%;5:>90%.The small bowel record was divided into five segments by time,and the score for each segment was evaluated.All CE examinations were performed with the Pillcam SB capsule endoscopy sys-tem(Given Imaging Co.Ltd.,Yoqnem).RESULTS:This study ended in December 2009,because sample size was considered large enough.A total of 44 patients were enrolled.Two patients in group B were excluded from the analysis because small bowel images could not be obtained from these patients;one had a full stomach,while the other presented with a massive gastric bleed.Thus,22 patients from group A and 20 patients from group B completed the study.There was no significant difference in age(P=0.22),sex(P=0.31),and indication for CE.No significant adverse events occurred in any of the study patients.In group A,image quality deteriorated as the capsule progressed distally.However,in group B,image quality was maintained to the distal small bowel.In each of the five segments,the visibility score was significantly higher in group B than in group A(segment 1:4.3± 0.7vs 4.7±0.5,P=0.03;segment 2:4.2±0.9vs 4.8 ±0.4,P=0.01;segment 3:4.0±1.0 vs 4.6±0.7,P =0.04;segment 4:3.6±1.1 vs 4.5±0.6,P=0.003;segment 5:2.7±1.0vs 4.4±0.8,P=0.00004).Thus,the use of PEG during CE examination significantly improved image quality in all time segments,and this effect was more pronounced in the distal ileum.The completion rate to the cecum was not significantly different between groups A and B(81.8%vs 85.0%,P =0.89).There was no difference in the gastric transit time between groups(36.2±35.0 min vs 54.0±56.6 min,P=0.23),but the small bowel transit time was significantly longer in group A than in group B(246.0± 107.0 minvs 171.0±104.0 min,P=0.04).CONCLUSION:The ingestion of a small amount of PEG after the swallowing of an endoscopy capsule significantly improved CE image quality,but did not enhance the completion rate to the cecum.展开更多
This paper considers the problem of estimating the finite population total in two-phase sampling when some information on auxiliary variable is available. The authors employ an informationtheoretic approach which make...This paper considers the problem of estimating the finite population total in two-phase sampling when some information on auxiliary variable is available. The authors employ an informationtheoretic approach which makes use of effective distance between the estimated probabilities and the empirical frequencies. It is shown that the proposed cross-entropy minimization estimator is more efficient than the usual estimator and has some desirable large sample properties. With some necessary modifications, the method can be applied to two-phase sampling for stratification and non-response. A simulation study is presented to assess the finite sample performance of the proposed estimator.展开更多
Consider the following heteroscedastic semiparametric regression model：where {Xi, 1 〈 i 〈 n} are random design points, errors {ei, 1 〈 i 〈 n} are negatively associated （NA） random variables, （r2 = h（ui）, and...Consider the following heteroscedastic semiparametric regression model：where {Xi, 1 〈 i 〈 n} are random design points, errors {ei, 1 〈 i 〈 n} are negatively associated （NA） random variables, （r2 = h（ui）, and {ui} and {ti} are two nonrandom sequences on [0, 1]. Some wavelet estimators of the parametric component β, the non- parametric component g（t） and the variance function h（u） are given. Under some general conditions, the strong convergence rate of these wavelet estimators is O（n- 1 log n）. Hence our results are extensions of those re, sults on independent random error settings.展开更多
This paper proposes the corrected likelihood ratio test （LRT） and large-dimensional trace criterion to test the independence of two large sets of multivariate variables of dimensions P1 and P2 when the dimensions P ...This paper proposes the corrected likelihood ratio test （LRT） and large-dimensional trace criterion to test the independence of two large sets of multivariate variables of dimensions P1 and P2 when the dimensions P = P1 ＋ P2 and the sample size n tend to infinity simultaneously and proportionally. Both theoretical and simulation results demonstrate that the traditional X2 approximation of the LRT performs poorly when the dimension p is large relative to the sample size n, while the corrected LRT and large-dimensional trace criterion behave well when the dimension is either small or large relative to the sample size. Moreover, the trace criterion can be used in the case of p 〉 n, while the corrected LRT is unfeasible due to the loss of definition.展开更多
文摘AIM:To prospectively confirm whether a small amount of polyethylene glycol(PEG)ingested after swallowing endoscopy capsule improves image quality and completion rate.METHODS:Forty-four consecutive patients referred to us for capsule endoscopy(CE)were randomized to two groups.All patients were restricted to clear fluids for 12 h before the examination.Patients in group A(22 cases)received no additional preparation,while those in group B(20 cases)ingested 500 mL of PEG within a 2 h period starting 30 min after swallowing the capsule.Clear fluids and meals were allowed 2 h and 4 h after capsule ingestion,respectively.Image quality was assessed as the percentage of visualized bowel surface area as follows:1:<25%;2:25%-49%;3:50%-74%;4:75%-89%;5:>90%.The small bowel record was divided into five segments by time,and the score for each segment was evaluated.All CE examinations were performed with the Pillcam SB capsule endoscopy sys-tem(Given Imaging Co.Ltd.,Yoqnem).RESULTS:This study ended in December 2009,because sample size was considered large enough.A total of 44 patients were enrolled.Two patients in group B were excluded from the analysis because small bowel images could not be obtained from these patients;one had a full stomach,while the other presented with a massive gastric bleed.Thus,22 patients from group A and 20 patients from group B completed the study.There was no significant difference in age(P=0.22),sex(P=0.31),and indication for CE.No significant adverse events occurred in any of the study patients.In group A,image quality deteriorated as the capsule progressed distally.However,in group B,image quality was maintained to the distal small bowel.In each of the five segments,the visibility score was significantly higher in group B than in group A(segment 1:4.3± 0.7vs 4.7±0.5,P=0.03;segment 2:4.2±0.9vs 4.8 ±0.4,P=0.01;segment 3:4.0±1.0 vs 4.6±0.7,P =0.04;segment 4:3.6±1.1 vs 4.5±0.6,P=0.003;segment 5:2.7±1.0vs 4.4±0.8,P=0.00004).Thus,the use of PEG during CE examination significantly improved image quality in all time segments,and this effect was more pronounced in the distal ileum.The completion rate to the cecum was not significantly different between groups A and B(81.8%vs 85.0%,P =0.89).There was no difference in the gastric transit time between groups(36.2±35.0 min vs 54.0±56.6 min,P=0.23),but the small bowel transit time was significantly longer in group A than in group B(246.0± 107.0 minvs 171.0±104.0 min,P=0.04).CONCLUSION:The ingestion of a small amount of PEG after the swallowing of an endoscopy capsule significantly improved CE image quality,but did not enhance the completion rate to the cecum.
基金supported by the National Natural Science Foundation of China under Grant No.61070236
文摘This paper considers the problem of estimating the finite population total in two-phase sampling when some information on auxiliary variable is available. The authors employ an informationtheoretic approach which makes use of effective distance between the estimated probabilities and the empirical frequencies. It is shown that the proposed cross-entropy minimization estimator is more efficient than the usual estimator and has some desirable large sample properties. With some necessary modifications, the method can be applied to two-phase sampling for stratification and non-response. A simulation study is presented to assess the finite sample performance of the proposed estimator.
基金supported by the National Natural Science Foundation of China (No. 11071022)the Key Project of the Ministry of Education of China (No. 209078)the Youth Project of Hubei Provincial Department of Education of China (No. Q20122202)
文摘Consider the following heteroscedastic semiparametric regression model：where {Xi, 1 〈 i 〈 n} are random design points, errors {ei, 1 〈 i 〈 n} are negatively associated （NA） random variables, （r2 = h（ui）, and {ui} and {ti} are two nonrandom sequences on [0, 1]. Some wavelet estimators of the parametric component β, the non- parametric component g（t） and the variance function h（u） are given. Under some general conditions, the strong convergence rate of these wavelet estimators is O（n- 1 log n）. Hence our results are extensions of those re, sults on independent random error settings.
基金supported by National Natural Science Foundation of China(Grant Nos.11101181,11171057,11171058 and 11071035)Research Fund for the Doctoral Program of Higher Education of China(Grant No.20110061120005)+1 种基金NECT-11-0616,PCSIRTthe Fundamental Research Funds for the Central Universities
文摘This paper proposes the corrected likelihood ratio test （LRT） and large-dimensional trace criterion to test the independence of two large sets of multivariate variables of dimensions P1 and P2 when the dimensions P = P1 ＋ P2 and the sample size n tend to infinity simultaneously and proportionally. Both theoretical and simulation results demonstrate that the traditional X2 approximation of the LRT performs poorly when the dimension p is large relative to the sample size n, while the corrected LRT and large-dimensional trace criterion behave well when the dimension is either small or large relative to the sample size. Moreover, the trace criterion can be used in the case of p 〉 n, while the corrected LRT is unfeasible due to the loss of definition.
