鼻咽癌(nasopharyngeal carcinoma, NPC)是一种起源于鼻咽黏膜上皮细胞的恶性肿瘤,通常被认为与EB病毒感染、遗传易感性及环境因素等相关。由于鼻咽解剖位置特殊,放射治疗(简称放疗)已成为当前NPC治疗的核心。然而,放疗完成后,仍有部分...鼻咽癌(nasopharyngeal carcinoma, NPC)是一种起源于鼻咽黏膜上皮细胞的恶性肿瘤,通常被认为与EB病毒感染、遗传易感性及环境因素等相关。由于鼻咽解剖位置特殊,放射治疗(简称放疗)已成为当前NPC治疗的核心。然而,放疗完成后,仍有部分NPC患者存在肿瘤局部残留。目前对于局部残留的治疗时机、治疗方式以及残留对预后的影响尚存在诸多争议。本文旨在综述NPC放疗后局部残留的当前治疗选择及其预后现状。Nasopharyngeal carcinoma (NPC) is a malignant tumor originating from the epithelial cells of the nasopharyngeal mucosa and is commonly associated with Epstein-Barr virus (EBV) infection, genetic susceptibility, and environmental factors. Due to the unique anatomical location of the nasopharynx, radiotherapy (RT) has become the cornerstone of NPC treatment. However, even after completing RT, a subset of NPC patients still exhibit residual local tumors. Currently, there is significant controversy surrounding the timing of treatment, therapeutic approaches, and the impact of residual tumors on prognosis. This article aims to review the current treatment options for local residual NPC after radiotherapy and their prognostic implications.展开更多
文摘鼻咽癌(nasopharyngeal carcinoma, NPC)是一种起源于鼻咽黏膜上皮细胞的恶性肿瘤,通常被认为与EB病毒感染、遗传易感性及环境因素等相关。由于鼻咽解剖位置特殊,放射治疗(简称放疗)已成为当前NPC治疗的核心。然而,放疗完成后,仍有部分NPC患者存在肿瘤局部残留。目前对于局部残留的治疗时机、治疗方式以及残留对预后的影响尚存在诸多争议。本文旨在综述NPC放疗后局部残留的当前治疗选择及其预后现状。Nasopharyngeal carcinoma (NPC) is a malignant tumor originating from the epithelial cells of the nasopharyngeal mucosa and is commonly associated with Epstein-Barr virus (EBV) infection, genetic susceptibility, and environmental factors. Due to the unique anatomical location of the nasopharynx, radiotherapy (RT) has become the cornerstone of NPC treatment. However, even after completing RT, a subset of NPC patients still exhibit residual local tumors. Currently, there is significant controversy surrounding the timing of treatment, therapeutic approaches, and the impact of residual tumors on prognosis. This article aims to review the current treatment options for local residual NPC after radiotherapy and their prognostic implications.
