间充质干细胞(Mesenchymal stem cells, MSCs)因其多向分化、自我更新、免疫调控等功能,可治疗多种疾病。尽管MSCs疗法在一定程度上已被证明是安全有效的,但在临床应用中,其疗效和安全性仍存在局限性,主要体现在MSCs靶向性不足、分化能...间充质干细胞(Mesenchymal stem cells, MSCs)因其多向分化、自我更新、免疫调控等功能,可治疗多种疾病。尽管MSCs疗法在一定程度上已被证明是安全有效的,但在临床应用中,其疗效和安全性仍存在局限性,主要体现在MSCs靶向性不足、分化能力受限、体内存活率低及药物递送效率不足等方面。为解决这些问题,目前出现多种工程化修饰技术,包括基因工程、表面修饰、物理化学修饰和组织工程等,以提高MSCs疗法的治疗效果和安全性。本文详细介绍了不同工程化修饰策略,并重点阐述各工程化修饰下MSCs功能化的实现和临床应用前景。Mesenchymal stem cells (MSCs) hold significant promise for the treatment of a wide range of diseases, owing to their multi-lineage differentiation potential, self-renewal capabilities, and immune regulatory properties. Although MSCs-based therapies have demonstrated safety and efficacy to some extent, their clinical application remains limited. These limitations are primarily due to challenges such as insufficient targeting of MSCs, restricted differentiation capacity, low in vivo survival rates, and poor drug delivery efficiency. To address these issues, a variety of engineering strategies, including genetic modification, surface functionalization, physicochemical modification, and tissue engineering, have been developed to enhance the therapeutic efficacy and safety of MSCs therapies. This paper provides a comprehensive overview of these engineering approaches and discusses their potential for future clinical application in MSCs-based therapies.展开更多
急性肺损伤(ALI)是一种具有高发病率和高死亡率的严重疾病,目前缺乏有效的治疗手段。近年来,干细胞治疗因其多能性和再生能力受到广泛关注。本综述总结了不同类型干细胞(如间充质干细胞、上皮祖细胞、内皮祖细胞等)在急性肺损伤中的治...急性肺损伤(ALI)是一种具有高发病率和高死亡率的严重疾病,目前缺乏有效的治疗手段。近年来,干细胞治疗因其多能性和再生能力受到广泛关注。本综述总结了不同类型干细胞(如间充质干细胞、上皮祖细胞、内皮祖细胞等)在急性肺损伤中的治疗潜力,重点阐述了其作用机制、实验研究进展以及临床应用的挑战和未来方向。Acute lung injury (ALI) is a severe clinical condition with high morbidity and mortality rates, for which effective treatment options remain elusive. In recent years, stem cell therapy has emerged as a promising approach due to the pluripotency and regenerative capabilities of stem cells. This review explores the therapeutic potential of various stem cell types, including mesenchymal stem cells (MSCs), epithelial progenitor cells, and endothelial progenitor cells, in the context of ALI. It highlights their mechanisms of action, recent advances in experimental studies, and the challenges associated with clinical translation, while providing insights into future research directions.展开更多
股骨头坏死（osteonecrosis of the femoral head,ONFH）是一种呈进行性发展的难治性疾病,为患者带来极大的痛苦。该病是由多种病因造成的股骨头内骨松质及骨细胞血液供应缺乏而坏死,进而导致股骨头关节软骨下骨变性、坏死、塌陷,最终...股骨头坏死（osteonecrosis of the femoral head,ONFH）是一种呈进行性发展的难治性疾病,为患者带来极大的痛苦。该病是由多种病因造成的股骨头内骨松质及骨细胞血液供应缺乏而坏死,进而导致股骨头关节软骨下骨变性、坏死、塌陷,最终形成骨性关节炎。展开更多
文摘间充质干细胞(Mesenchymal stem cells, MSCs)因其多向分化、自我更新、免疫调控等功能,可治疗多种疾病。尽管MSCs疗法在一定程度上已被证明是安全有效的,但在临床应用中,其疗效和安全性仍存在局限性,主要体现在MSCs靶向性不足、分化能力受限、体内存活率低及药物递送效率不足等方面。为解决这些问题,目前出现多种工程化修饰技术,包括基因工程、表面修饰、物理化学修饰和组织工程等,以提高MSCs疗法的治疗效果和安全性。本文详细介绍了不同工程化修饰策略,并重点阐述各工程化修饰下MSCs功能化的实现和临床应用前景。Mesenchymal stem cells (MSCs) hold significant promise for the treatment of a wide range of diseases, owing to their multi-lineage differentiation potential, self-renewal capabilities, and immune regulatory properties. Although MSCs-based therapies have demonstrated safety and efficacy to some extent, their clinical application remains limited. These limitations are primarily due to challenges such as insufficient targeting of MSCs, restricted differentiation capacity, low in vivo survival rates, and poor drug delivery efficiency. To address these issues, a variety of engineering strategies, including genetic modification, surface functionalization, physicochemical modification, and tissue engineering, have been developed to enhance the therapeutic efficacy and safety of MSCs therapies. This paper provides a comprehensive overview of these engineering approaches and discusses their potential for future clinical application in MSCs-based therapies.
文摘急性肺损伤(ALI)是一种具有高发病率和高死亡率的严重疾病,目前缺乏有效的治疗手段。近年来,干细胞治疗因其多能性和再生能力受到广泛关注。本综述总结了不同类型干细胞(如间充质干细胞、上皮祖细胞、内皮祖细胞等)在急性肺损伤中的治疗潜力,重点阐述了其作用机制、实验研究进展以及临床应用的挑战和未来方向。Acute lung injury (ALI) is a severe clinical condition with high morbidity and mortality rates, for which effective treatment options remain elusive. In recent years, stem cell therapy has emerged as a promising approach due to the pluripotency and regenerative capabilities of stem cells. This review explores the therapeutic potential of various stem cell types, including mesenchymal stem cells (MSCs), epithelial progenitor cells, and endothelial progenitor cells, in the context of ALI. It highlights their mechanisms of action, recent advances in experimental studies, and the challenges associated with clinical translation, while providing insights into future research directions.
