目的:探讨外周血平均血小板体积/淋巴细胞计数(MPVLR)联合APACHE II评分对脓毒症患者预后的预测价值。方法:采用回顾性队列研究方法,选择该院2020年8月至2023年8月收治的符合脓毒症3.0诊断标准的患者。根据脓毒症患者的28 d预后情况分...目的:探讨外周血平均血小板体积/淋巴细胞计数(MPVLR)联合APACHE II评分对脓毒症患者预后的预测价值。方法:采用回顾性队列研究方法,选择该院2020年8月至2023年8月收治的符合脓毒症3.0诊断标准的患者。根据脓毒症患者的28 d预后情况分为生存组及死亡组。收集患者的临床资料及确诊脓毒症后24 h内血小板体积(MPV)、淋巴细胞(LYM)计数的最差值,并计算平均血小板体积/淋巴细胞计数(MPVLR)、APACHE II评分及SOFA评分。随后使用多因素Logistic回归分析,确定脓毒症患者预后的影响因素,再构建受试者工作特征曲线,评估各项指标对脓毒症患者预后的预测价值。结果:共纳入患者127例,生存组患者76例,死亡组患者51例。死亡组患者更易合并慢性阻塞性肺疾病,且平均血小板体积(MPV)、平均血小板体积/淋巴细胞计数(MPVLR)、APACHE II评分、SOFA评分、及年龄均高于生存组,且差异具有统计学意义(P Objective: To investigate the prognostic value of the mean platelet volume (MPV)-to-lymphocyte ratio (MPVLR) combined with the APACHE II score in predicting the outcomes of patients with sepsis. Methods: This retrospective study screened patients with sepsis who were hospitalized in our hospital, from August 2020 to August 2023 were included and categorized into the survival group and the non-survival group based on 28-day outcomes of sepsis patients. Clinical date and the worst of mean platelet volume (MPV), lymphocyte (LYM) count values within 24 hours of sepsis diagnosis were collected, MPVLR and APACHE II scores were calculated. Multifactorial logistic regression analysis was used to identify risk factors affecting the prognosis of sepsis patients, and then a subject operating characteristic curve (ROC) was constructed to assess the predictive value of each indicator on the prognosis of sepsis patients. Results: A total of 127 patients were included, with 76 in the survival group and 51 in the non-survival group. Patients in the non-survival group were more likely to have chronic obstructive pulmonary disease, and had significantly higher MPV, MPVLR, APACHE II scores, SOFA scores and age compared to the survival group (P < 0.05). In contrast, peripheral blood lymphocyte counts in the survival group were significantly higher than that in the non-survival group (P < 0.05). Multivariate logistic regression analysis showed that MPVLR and APACHE II scores were independent risk factors for 28-day mortality in sepsis patients (P < 0.05). Receiver operating characteristic curve (ROC) curve analysis showed that the area under the curve (AUC) values for MPVLR, APACHE II scores, and their combination were 0.840, 0.800, and 0.885, respectively. Notably, the MPVLR combined with the APACHE II score showed the best predictive value, with an AUC of 0.824. It demonstrated excellent predictive performance, achieving a sensitivity of 94.6% and a specificity of 82.4%. Conclusion: APACHE II scores and MPVLR are independent risk factors for 28-day mortality in sepsis patients, and their combined use provides higher predictive value.展开更多
目的:探讨血小板平均体积(MPV)和血小板分布宽度(PDW)对颈动脉狭窄程度的预测。方法:选择2023年1月至2023年12月青岛大学附属医院收治的265例颈动脉狭窄患者进行回顾分析。根据患者头颈部血管CT显像结果和北美症状性颈动脉内膜切除术试...目的:探讨血小板平均体积(MPV)和血小板分布宽度(PDW)对颈动脉狭窄程度的预测。方法:选择2023年1月至2023年12月青岛大学附属医院收治的265例颈动脉狭窄患者进行回顾分析。根据患者头颈部血管CT显像结果和北美症状性颈动脉内膜切除术试验协作组(NASCET)标准,将患者分为轻度狭窄组(狭窄 Objective: To investigate the predictive value of mean platelet volume (MPV) and platelet distribution width (PDW) on the degree of carotid artery stenosis. Methods: A retrospective analysis was conducted on 265 patients diagnosed with carotid artery stenosis who were admitted to the Affiliated Hospital of Qingdao University between January and December of 2023. The patients’ head and neck vascular CT imaging results were then categorized into three groups according to the criteria established by the North American Symptomatic Carotid Endarterectomy Trial Collaborative Group (NASCET): mild stenosis (stenosis < 30%), moderate stenosis (30% ≤ stenosis < 85%), and severe stenosis (stenosis ≥ 85%). The clinical data and related laboratory indicators of the study participants were meticulously collected. Patients’ general data were systematically enumerated, laboratory data were objectively compared between groups, and the correlation with the degree of carotid artery stenosis was systematically analyzed. Results: The study revealed a positive correlation between PDW and the degree of carotid artery stenosis. Concurrently, HDL demonstrated a negative correlation with the severity of carotid artery stenosis. The findings further indicated that both PDW and HDL independently influenced carotid artery stenosis. However, no significant correlation was observed between MPV and carotid artery stenosis, indicating that other factors might be involved in the etiopathogenesis of this condition. Conclusions: Increased PDW exhibits a direct correlation with the severity of carotid artery stenosis and can serve as a predictive index to evaluate the severity of carotid artery stenosis.展开更多
文摘目的:探讨外周血平均血小板体积/淋巴细胞计数(MPVLR)联合APACHE II评分对脓毒症患者预后的预测价值。方法:采用回顾性队列研究方法,选择该院2020年8月至2023年8月收治的符合脓毒症3.0诊断标准的患者。根据脓毒症患者的28 d预后情况分为生存组及死亡组。收集患者的临床资料及确诊脓毒症后24 h内血小板体积(MPV)、淋巴细胞(LYM)计数的最差值,并计算平均血小板体积/淋巴细胞计数(MPVLR)、APACHE II评分及SOFA评分。随后使用多因素Logistic回归分析,确定脓毒症患者预后的影响因素,再构建受试者工作特征曲线,评估各项指标对脓毒症患者预后的预测价值。结果:共纳入患者127例,生存组患者76例,死亡组患者51例。死亡组患者更易合并慢性阻塞性肺疾病,且平均血小板体积(MPV)、平均血小板体积/淋巴细胞计数(MPVLR)、APACHE II评分、SOFA评分、及年龄均高于生存组,且差异具有统计学意义(P Objective: To investigate the prognostic value of the mean platelet volume (MPV)-to-lymphocyte ratio (MPVLR) combined with the APACHE II score in predicting the outcomes of patients with sepsis. Methods: This retrospective study screened patients with sepsis who were hospitalized in our hospital, from August 2020 to August 2023 were included and categorized into the survival group and the non-survival group based on 28-day outcomes of sepsis patients. Clinical date and the worst of mean platelet volume (MPV), lymphocyte (LYM) count values within 24 hours of sepsis diagnosis were collected, MPVLR and APACHE II scores were calculated. Multifactorial logistic regression analysis was used to identify risk factors affecting the prognosis of sepsis patients, and then a subject operating characteristic curve (ROC) was constructed to assess the predictive value of each indicator on the prognosis of sepsis patients. Results: A total of 127 patients were included, with 76 in the survival group and 51 in the non-survival group. Patients in the non-survival group were more likely to have chronic obstructive pulmonary disease, and had significantly higher MPV, MPVLR, APACHE II scores, SOFA scores and age compared to the survival group (P < 0.05). In contrast, peripheral blood lymphocyte counts in the survival group were significantly higher than that in the non-survival group (P < 0.05). Multivariate logistic regression analysis showed that MPVLR and APACHE II scores were independent risk factors for 28-day mortality in sepsis patients (P < 0.05). Receiver operating characteristic curve (ROC) curve analysis showed that the area under the curve (AUC) values for MPVLR, APACHE II scores, and their combination were 0.840, 0.800, and 0.885, respectively. Notably, the MPVLR combined with the APACHE II score showed the best predictive value, with an AUC of 0.824. It demonstrated excellent predictive performance, achieving a sensitivity of 94.6% and a specificity of 82.4%. Conclusion: APACHE II scores and MPVLR are independent risk factors for 28-day mortality in sepsis patients, and their combined use provides higher predictive value.
文摘目的:探讨血小板平均体积(MPV)和血小板分布宽度(PDW)对颈动脉狭窄程度的预测。方法:选择2023年1月至2023年12月青岛大学附属医院收治的265例颈动脉狭窄患者进行回顾分析。根据患者头颈部血管CT显像结果和北美症状性颈动脉内膜切除术试验协作组(NASCET)标准,将患者分为轻度狭窄组(狭窄 Objective: To investigate the predictive value of mean platelet volume (MPV) and platelet distribution width (PDW) on the degree of carotid artery stenosis. Methods: A retrospective analysis was conducted on 265 patients diagnosed with carotid artery stenosis who were admitted to the Affiliated Hospital of Qingdao University between January and December of 2023. The patients’ head and neck vascular CT imaging results were then categorized into three groups according to the criteria established by the North American Symptomatic Carotid Endarterectomy Trial Collaborative Group (NASCET): mild stenosis (stenosis < 30%), moderate stenosis (30% ≤ stenosis < 85%), and severe stenosis (stenosis ≥ 85%). The clinical data and related laboratory indicators of the study participants were meticulously collected. Patients’ general data were systematically enumerated, laboratory data were objectively compared between groups, and the correlation with the degree of carotid artery stenosis was systematically analyzed. Results: The study revealed a positive correlation between PDW and the degree of carotid artery stenosis. Concurrently, HDL demonstrated a negative correlation with the severity of carotid artery stenosis. The findings further indicated that both PDW and HDL independently influenced carotid artery stenosis. However, no significant correlation was observed between MPV and carotid artery stenosis, indicating that other factors might be involved in the etiopathogenesis of this condition. Conclusions: Increased PDW exhibits a direct correlation with the severity of carotid artery stenosis and can serve as a predictive index to evaluate the severity of carotid artery stenosis.
