The expression of phosphatase and tensin homolog (PTEN ), a tumor suppressor gene, is frequently downregulated in gastric carcinomas due to mutation, loss of heterozygosity, and promoter hypermethylation. However, it ...The expression of phosphatase and tensin homolog (PTEN ), a tumor suppressor gene, is frequently downregulated in gastric carcinomas due to mutation, loss of heterozygosity, and promoter hypermethylation. However, it is unknown if additional mechanisms may account for the down-regulation of PTEN expression. While neuronal precursor cell-expressed developmentally down-regulated 4-1 (NEDD4-1) is believed to be a potential dual regulator of PTEN, there are conflicting reports regarding their interaction. To gain further insight into the role of NEDD4-1 and its association with PTEN in gastric carcinoma development, we measured the protein expression of NEDD4-1 and PTEN in gastric mucosae with various pathological lesions and found that NEDD4-1 increased from normal gastric mucosa to intestinal metaplasia and decreased from dysplasia to gastric carcinoma. These changes did not correlate with PTEN expression changes during gastric carcinogenesis. Moreover, we found similar results in protein levels in the primary tumors and adjacent non-tumorous tissues. These results differ from a previous report showing that expression of NEDD4-1 is up-regulated in gastric carcinomas, and show a more complex pattern of NEDD4-1 gene expression during gastric carcinogenesis.展开更多
This paper proposes a novel dynamic control approach for a cable-driven robot with high redundant actuation and cable tension limitations to perform tracking task while interacting with environment. In order for a cab...This paper proposes a novel dynamic control approach for a cable-driven robot with high redundant actuation and cable tension limitations to perform tracking task while interacting with environment. In order for a cable-driven exoskeleton robot to execute the task smoothly and safely, it is necessary to consider the tracking motion performance as well as passivity when interacting with the environment under the conditions of the actuation cables＇ redundancy and the pulling limitation. With the additional consideration of the maximum limitation of the cable tension, cable-driven robot actually can only apply a certain range of feasible wrench on the external environment, which makes the task executed by robot be restricted. In order to make designed wrench be feasible and keep the desired trajectory tracking ability, we present a new control method by extending PVFC （passive velocity field control） method considering tracking stability and passivity. The approach augmented a higher dimensional virtual flywheel dynamics in a specific orthogonal complement space of the cable＇s actuation space. After the final adjustment of the designed wrench with respect to the cable＇s constraint, this method is capable of driving the cable robot to complete the trajectory tracking task and realize the passivity.展开更多
The in-orbit verification of a refueling test system has been completed successfully.The test system based on a surface tension tank was developed by the Beijing Institute of Control Engineering（BICE）,CAST and launc...The in-orbit verification of a refueling test system has been completed successfully.The test system based on a surface tension tank was developed by the Beijing Institute of Control Engineering（BICE）,CAST and launched into spacewith the Tianyuan 1 satellite aboard a LM-7 carrier rocket on June 25.The lifetime of any spacecraft is constrained by fuel it carried.展开更多
Automatic splicing of interrupted yarns in ring spinning has always been a problem in the industry.Factors such as low yarn strengths and environmental influence on yarn tensions make it difficult to control the yarn ...Automatic splicing of interrupted yarns in ring spinning has always been a problem in the industry.Factors such as low yarn strengths and environmental influence on yarn tensions make it difficult to control the yarn tension during the robotic splicing process.The purpose of this research is to design active disturbance rejection control(ADRC)for a third-order nonlinear tension system subject to external disturbances.Firstly,a third-order extended state observer(ESO)is designed to achieve the suppression and the compensation of the internal modeling error and the external disturbances of the system.Secondly,the adaptive gain error feedback control and the filtering process are designed to reduce the influence of sensor noise on the disturbance observation.Finally,the tension control during the splicing process is simulated and experimented,and the experiments show that the method has good robustness in the tension tracking task under a dynamic environment,which verifies the effectiveness of the method.展开更多
To weaken the nonlinear coupling influence among the variables in the speed and tension system of reversible cold strip mill, a compound control(CC) strategy based on invariance principle was proposed. Firstly, invari...To weaken the nonlinear coupling influence among the variables in the speed and tension system of reversible cold strip mill, a compound control(CC) strategy based on invariance principle was proposed. Firstly, invariance principle was used to realize static decoupling between the speed and tension of reversible cold strip mill. Then, considering the influence caused by the time variation of steel coil radius and rotational inertia of the left and right coilers, as well as the uncertainties, a CC strategy that is composed of extended state observer(ESO) and global sliding mode control(GSMC) with backstepping adaptive was proposed,which further realized dynamic decoupling and coordination control for the speed and tension system. Theoretical analysis shows that the resulting closed-loop system is global bounded stable. Finally, the simulation was carried out on the speed and tension system of a 1422 mm reversible cold strip mill by using the actual data, and through the comparison of the other control strategies, validity of the proposed CC strategy was shown by the results.展开更多
Conventional optical burst switching(OBS)technique adopts purely statistical multiplex mechanismso that the bursts collide with each other very easily.To address this problem,a novel proactive con-tention avoidance sc...Conventional optical burst switching(OBS)technique adopts purely statistical multiplex mechanismso that the bursts collide with each other very easily.To address this problem,a novel proactive con-tention avoidance scheme is proposed,which assigns dedicated wavelengths to each ingress node,then st-numbering algorithm is used to construct the traffic load balanced spanning trees .In this way,contentioncan be eliminated at ingress nodes,and the amount of bursts that could be accommodated by ingressnodes will be maximized.Further,those unused wavelengths left by traffic load balanced spanning treeare also organized as partial trees to carry bursts,thus the link utilization can be improved effectively.Simulation result shows that our scheme can improve the burst loss performance significantly without thewavelength converters or optical buffers comparing to other popular routing and wavelength assignment(RWA)algorithms.展开更多
In the BOPP （Biaxially Oriented Polypropylene） production line, the tension size and smooth film received change volume has a decisive effect on the rolling quality, casting machine is a complicated electromechanica...In the BOPP （Biaxially Oriented Polypropylene） production line, the tension size and smooth film received change volume has a decisive effect on the rolling quality, casting machine is a complicated electromechanical control system, tension control of casting machine are the main factors that influence the production quality. Analyzed the reason and the tension control mathematical model generation casting machine tension in the BOPP production line, for the constant tension control of casting machine, put forward a kind of improved PID control method based on RBF neural network. By the method of Jacobian information identification of RBF neural network, combined with the incremental PID algorithm to realize the self-tuning tension control parameters, control simulation and implementation of the model using Matlab software programming. The simulation results show that, the improved algorithm has better control effect than the general PID.展开更多
基金Supported by Grants from the National Natural Science Foundation of China, No. 81060038the Graduate Innovative Fund of Jiangxi Province, No. YC10A020
文摘The expression of phosphatase and tensin homolog (PTEN ), a tumor suppressor gene, is frequently downregulated in gastric carcinomas due to mutation, loss of heterozygosity, and promoter hypermethylation. However, it is unknown if additional mechanisms may account for the down-regulation of PTEN expression. While neuronal precursor cell-expressed developmentally down-regulated 4-1 (NEDD4-1) is believed to be a potential dual regulator of PTEN, there are conflicting reports regarding their interaction. To gain further insight into the role of NEDD4-1 and its association with PTEN in gastric carcinoma development, we measured the protein expression of NEDD4-1 and PTEN in gastric mucosae with various pathological lesions and found that NEDD4-1 increased from normal gastric mucosa to intestinal metaplasia and decreased from dysplasia to gastric carcinoma. These changes did not correlate with PTEN expression changes during gastric carcinogenesis. Moreover, we found similar results in protein levels in the primary tumors and adjacent non-tumorous tissues. These results differ from a previous report showing that expression of NEDD4-1 is up-regulated in gastric carcinomas, and show a more complex pattern of NEDD4-1 gene expression during gastric carcinogenesis.
基金This research has been partially supported by National Natural Science Foundation of China under Grant No. 61472117.
文摘This paper proposes a novel dynamic control approach for a cable-driven robot with high redundant actuation and cable tension limitations to perform tracking task while interacting with environment. In order for a cable-driven exoskeleton robot to execute the task smoothly and safely, it is necessary to consider the tracking motion performance as well as passivity when interacting with the environment under the conditions of the actuation cables＇ redundancy and the pulling limitation. With the additional consideration of the maximum limitation of the cable tension, cable-driven robot actually can only apply a certain range of feasible wrench on the external environment, which makes the task executed by robot be restricted. In order to make designed wrench be feasible and keep the desired trajectory tracking ability, we present a new control method by extending PVFC （passive velocity field control） method considering tracking stability and passivity. The approach augmented a higher dimensional virtual flywheel dynamics in a specific orthogonal complement space of the cable＇s actuation space. After the final adjustment of the designed wrench with respect to the cable＇s constraint, this method is capable of driving the cable robot to complete the trajectory tracking task and realize the passivity.
文摘The in-orbit verification of a refueling test system has been completed successfully.The test system based on a surface tension tank was developed by the Beijing Institute of Control Engineering（BICE）,CAST and launched into spacewith the Tianyuan 1 satellite aboard a LM-7 carrier rocket on June 25.The lifetime of any spacecraft is constrained by fuel it carried.
基金National Natural Science Foundation of China(No.52275478)Fundamental Research Funds for the Central Universities,China(No.2232024Y-01)DHU Distinguished Young Professor Program,China(No.LZB2023001)。
文摘Automatic splicing of interrupted yarns in ring spinning has always been a problem in the industry.Factors such as low yarn strengths and environmental influence on yarn tensions make it difficult to control the yarn tension during the robotic splicing process.The purpose of this research is to design active disturbance rejection control(ADRC)for a third-order nonlinear tension system subject to external disturbances.Firstly,a third-order extended state observer(ESO)is designed to achieve the suppression and the compensation of the internal modeling error and the external disturbances of the system.Secondly,the adaptive gain error feedback control and the filtering process are designed to reduce the influence of sensor noise on the disturbance observation.Finally,the tension control during the splicing process is simulated and experimented,and the experiments show that the method has good robustness in the tension tracking task under a dynamic environment,which verifies the effectiveness of the method.
基金Project(61074099)supported by the National Natural Science Foundation of ChinaProject(LJRC013)supported by Cultivation Program for Leading Talent of Innovation Team in Colleges and Universities of Hebei Province,ChinaProject(B705)supported by Doctor Foundation of Yanshan University,China
文摘To weaken the nonlinear coupling influence among the variables in the speed and tension system of reversible cold strip mill, a compound control(CC) strategy based on invariance principle was proposed. Firstly, invariance principle was used to realize static decoupling between the speed and tension of reversible cold strip mill. Then, considering the influence caused by the time variation of steel coil radius and rotational inertia of the left and right coilers, as well as the uncertainties, a CC strategy that is composed of extended state observer(ESO) and global sliding mode control(GSMC) with backstepping adaptive was proposed,which further realized dynamic decoupling and coordination control for the speed and tension system. Theoretical analysis shows that the resulting closed-loop system is global bounded stable. Finally, the simulation was carried out on the speed and tension system of a 1422 mm reversible cold strip mill by using the actual data, and through the comparison of the other control strategies, validity of the proposed CC strategy was shown by the results.
基金supported by the National Natural Science Foundation of China(No.60572050)the National High Technology Research and Development Programme of China(No.2008AA01Z211)
文摘Conventional optical burst switching(OBS)technique adopts purely statistical multiplex mechanismso that the bursts collide with each other very easily.To address this problem,a novel proactive con-tention avoidance scheme is proposed,which assigns dedicated wavelengths to each ingress node,then st-numbering algorithm is used to construct the traffic load balanced spanning trees .In this way,contentioncan be eliminated at ingress nodes,and the amount of bursts that could be accommodated by ingressnodes will be maximized.Further,those unused wavelengths left by traffic load balanced spanning treeare also organized as partial trees to carry bursts,thus the link utilization can be improved effectively.Simulation result shows that our scheme can improve the burst loss performance significantly without thewavelength converters or optical buffers comparing to other popular routing and wavelength assignment(RWA)algorithms.
文摘In the BOPP （Biaxially Oriented Polypropylene） production line, the tension size and smooth film received change volume has a decisive effect on the rolling quality, casting machine is a complicated electromechanical control system, tension control of casting machine are the main factors that influence the production quality. Analyzed the reason and the tension control mathematical model generation casting machine tension in the BOPP production line, for the constant tension control of casting machine, put forward a kind of improved PID control method based on RBF neural network. By the method of Jacobian information identification of RBF neural network, combined with the incremental PID algorithm to realize the self-tuning tension control parameters, control simulation and implementation of the model using Matlab software programming. The simulation results show that, the improved algorithm has better control effect than the general PID.
