AIM:To estimate the cost-benefit of endoscopic screening strategies of esophageal cancer(EC)in high-risk areas of China. METHODS:Markov model-based analyses were conducted to compare the net present values(NPVs)and th...AIM:To estimate the cost-benefit of endoscopic screening strategies of esophageal cancer(EC)in high-risk areas of China. METHODS:Markov model-based analyses were conducted to compare the net present values(NPVs)and the benefit-cost ratios(BCRs)of 12 EC endoscopic screening strategies.Strategies varied according to the targeted screening age,screening frequencies,and follow-up intervals.Model parameters were collected from population-based studies in China,published literatures,and surveillance data. RESULTS:Compared with non-screening outcomes,all strategies with hypothetical 100 000 subjects saved life years.Among five dominant strategies determined by the incremental cost-effectiveness analysis,screening once at age 50 years incurred the lowest NPV(international dollar-I$55 million)and BCR(2.52).Screening six times between 40-70 years at a 5-year interval[i.e., six times(40)f-strategy]yielded the highest NPV(I$99 million)and BCR(3.06).Compared with six times(40)fstrategy,screening thrice between 40-70 years at a 10-year interval resulted in relatively lower NPV,but the same BCR. CONCLUSION:EC endoscopic screening is cost-beneficial in high-risk areas of China.Policy-makers should consider the cost-benefit,population acceptance,and local economic status when choosing suitable screening strategies.展开更多
AIM:To compare the costs and effectiveness of no screening and no eradication therapy, the population- based Helicobacter pylori (H pylori) serology screening with eradication therapy and 13C-Urea breath test (UBT) wi...AIM:To compare the costs and effectiveness of no screening and no eradication therapy, the population- based Helicobacter pylori (H pylori) serology screening with eradication therapy and 13C-Urea breath test (UBT) with eradication therapy. METHODS:A Markov model simulation was carried out in all 237 900 Chinese males with age between 35 and 44 from the perspective of the public healthcare provider in Singapore. The main outcome measures were the costs, number of gastric cancer cases prevented, life years saved, and quality-adjusted life years (QALYs) gained from screening age to death. The uncertainty surrounding the cost-effectiveness ratio was addressed by one-way sensitivity analyses. RESULTS:Compared to no screening, the incremental cost-effectiveness ratio (ICER) was $16 166 per life year saved or $13 571 per QALY gained for the serology screening, and $38 792 per life year saved and $32 525 per QALY gained for the UBT. The ICER was $477 079 per life year saved or $390 337 per QALY gained for the UBT compared to the serology screening. The cost- effectiveness of serology screening over the UBT was robust to most parameters in the model. CONCLUSION:The population-based serologyscreening for H pylori was more cost-effective than the UBT in prevention of gastric cancer in Singapore Chinese males.展开更多
Determining the optimal timing is the core of preventive maintenance. Highway agencies always face with the challenge of determining optimal timing for preventive maintenance, particularly in China where there are no ...Determining the optimal timing is the core of preventive maintenance. Highway agencies always face with the challenge of determining optimal timing for preventive maintenance, particularly in China where there are no condition indicators designed for determining adequate timing for applying preventive maintenance and little literature relating to the development of pavement performance. This work presented the indicators, including crack ratio （Rc）, rutting depth （DR）, international roughness index （IIR） and sideway force coefficient （CsF） to determine the adequate timing for preventive maintenance in China. The proper ranges of each indicator to apply to preventive maintenance were then recommended. They are 0.28%-1.4% for Rc, 10-15 mm for DR, 1.97-3.5 for lrR, 40--50 for CSF. Based on pavement condition survey data collected on the test roads in Hebei Province, China, on the application of slurry seal at different timings, the pavement performance was established and the adequate timings for applying slurry seal was studied. Based on benefit-cost analysis, it is suggested that the fourth year is the optimal timing for applying slurry seal based on the condition in China. A framework is established to determine the adequate timings of applying other preventive maintenance methods.展开更多
Objective:The aim of our study was to estimate the cost of colorectal cancer screening and to provide evidence for the cost control of colorectal cancer screening among general population in rural area of China.Method...Objective:The aim of our study was to estimate the cost of colorectal cancer screening and to provide evidence for the cost control of colorectal cancer screening among general population in rural area of China.Methods:We determined the net cost for colorectal cancer mass-screening in Jiashan County,and evaluated the cost-benefit and cost effectiveness.Results:The compliance rate of primary screening and intensive screening were 84.6% and 78.7%,respectively.In primary screening,the average cost for each individual was 27.2 yuan,and the average cost for identifying one high-risk individual was 180.5 yuan.The mean cost to diagnose one colorectal cancer patient was 42963.3 yuan.As for identification of adenoma,the average cost for each case was 4384.0 yuan.Based on the calculation,the average cost of reducing one colorectal cancer patient was 12768 yuan by conducting the mass-screening protocol.Conclusion:It was beneficial to do the cost-benefit analysis of colorectal cancer screening in area of high incidence.Based on the results of cost-benefit analysis,more efforts should be made to reduce the cost and to improve the efficiency of the colorectal cancer screening.展开更多
Trade and economic relations between China and Africa have a protracted history and have developed incrementally over the course of time. Consequently, increasing numbers of Chinese businesses and entrepreneurs have s...Trade and economic relations between China and Africa have a protracted history and have developed incrementally over the course of time. Consequently, increasing numbers of Chinese businesses and entrepreneurs have sought partnerships with African companies with the aim of establishing strategic partnerships, collaborations, and joint ventures. In recent years, these Sino-African trading relations have been the subject of consistent debate and scrutiny, attracting positive and negative analyses from scholars and practitioners across disciplines. Some studies questioned China＇s motives in Africa＇s markets, and others viewed with suspicion the structure of Sino-Africa＇s bilateral trading engagements. Conducting an extensive literature survey of related sources and employing content analysis of recent and current data （2000-2009）, the paper examined institutional and academic publications pertaining to Sino-African relationship. It determines imbalance in the structure of Sino-African bilateral trade, negative impact on domestic economic development, and competitive disadvantage in African marketplaces. Policy implications of these findings were provided as well as recommendations for mutual trade benefits and global strategic investments展开更多
Considering the additional electric energy generated after the full operation of the underground hydropower station, the electric energy accommodation of the Three Gorges Project （TGP） is reviewed. It is .focused on...Considering the additional electric energy generated after the full operation of the underground hydropower station, the electric energy accommodation of the Three Gorges Project （TGP） is reviewed. It is .focused on the additional electricity accommodation, based on the research at the earl）, stage. The electric energ）, accommodation solutions ate recommended as that. based on the cost-benefit analysis of the power distribution area, the additional electric energy of the Three Gorges should be given ptqority to meet the needs at the supply end of Hubei and Chongqing. The results of this research has a reference value on the implementation of the Three Gorges electric power accommodation, after the further optimization of the transmission curves in both wet and dry seasons.展开更多
The present research is based upon a comprehensive survey which discusses the slightly tolerable water level of Balaton between 2000 and 2003. The low water level of the extreme period caused considerable problems in ...The present research is based upon a comprehensive survey which discusses the slightly tolerable water level of Balaton between 2000 and 2003. The low water level of the extreme period caused considerable problems in recreation. Our goal was to investigate the possible water transfer policies and the water level regulation policy of Lake Balaton by applying the dynamic programming of Markov chains. This iteration supports the cost-benefit analysis of different scenarios and also provides information about the best water governing policy. As a basis of our scientific analysis, Markov chains were created by ARMA （autoregressive moving average） synthetic data generator. Profit was joined to each transition-probability for the economic analysis. In our case the profit was negative, because the harmful effects of the low water level should be estimated, which is based on the calculated willingness-to-pay for improving the water quality of Lake Balaton. In addition, the profit includes the cost of different water supplement scenarios. After computer programming, the method proved to be an efficient tool to buttress the cost-benefit analysis of water supplement scenarios. The result highlights the importance of further climate change monitoring. Calculation confirmed water transfer to be cost-effective, yet scenarios with less ecological risk are also effective, thus preferable.展开更多
基金Supported by The National Science and Technology Pillar Program of the 11th National Five-Year Plan of China,No. 2006BAI02A15
文摘AIM:To estimate the cost-benefit of endoscopic screening strategies of esophageal cancer(EC)in high-risk areas of China. METHODS:Markov model-based analyses were conducted to compare the net present values(NPVs)and the benefit-cost ratios(BCRs)of 12 EC endoscopic screening strategies.Strategies varied according to the targeted screening age,screening frequencies,and follow-up intervals.Model parameters were collected from population-based studies in China,published literatures,and surveillance data. RESULTS:Compared with non-screening outcomes,all strategies with hypothetical 100 000 subjects saved life years.Among five dominant strategies determined by the incremental cost-effectiveness analysis,screening once at age 50 years incurred the lowest NPV(international dollar-I$55 million)and BCR(2.52).Screening six times between 40-70 years at a 5-year interval[i.e., six times(40)f-strategy]yielded the highest NPV(I$99 million)and BCR(3.06).Compared with six times(40)fstrategy,screening thrice between 40-70 years at a 10-year interval resulted in relatively lower NPV,but the same BCR. CONCLUSION:EC endoscopic screening is cost-beneficial in high-risk areas of China.Policy-makers should consider the cost-benefit,population acceptance,and local economic status when choosing suitable screening strategies.
文摘AIM:To compare the costs and effectiveness of no screening and no eradication therapy, the population- based Helicobacter pylori (H pylori) serology screening with eradication therapy and 13C-Urea breath test (UBT) with eradication therapy. METHODS:A Markov model simulation was carried out in all 237 900 Chinese males with age between 35 and 44 from the perspective of the public healthcare provider in Singapore. The main outcome measures were the costs, number of gastric cancer cases prevented, life years saved, and quality-adjusted life years (QALYs) gained from screening age to death. The uncertainty surrounding the cost-effectiveness ratio was addressed by one-way sensitivity analyses. RESULTS:Compared to no screening, the incremental cost-effectiveness ratio (ICER) was $16 166 per life year saved or $13 571 per QALY gained for the serology screening, and $38 792 per life year saved and $32 525 per QALY gained for the UBT. The ICER was $477 079 per life year saved or $390 337 per QALY gained for the UBT compared to the serology screening. The cost- effectiveness of serology screening over the UBT was robust to most parameters in the model. CONCLUSION:The population-based serologyscreening for H pylori was more cost-effective than the UBT in prevention of gastric cancer in Singapore Chinese males.
基金Project(IRT1050) supported by Program for Changjiang Scholars and Innovative Research Team in University, ChinaProject (2009318000027) supported by Ministry of Transport of ChinaProject(CHD2011TD002) supported by the Special Fund for Basic Scientific Research of Central Colleges, Chang’an University, China
文摘Determining the optimal timing is the core of preventive maintenance. Highway agencies always face with the challenge of determining optimal timing for preventive maintenance, particularly in China where there are no condition indicators designed for determining adequate timing for applying preventive maintenance and little literature relating to the development of pavement performance. This work presented the indicators, including crack ratio （Rc）, rutting depth （DR）, international roughness index （IIR） and sideway force coefficient （CsF） to determine the adequate timing for preventive maintenance in China. The proper ranges of each indicator to apply to preventive maintenance were then recommended. They are 0.28%-1.4% for Rc, 10-15 mm for DR, 1.97-3.5 for lrR, 40--50 for CSF. Based on pavement condition survey data collected on the test roads in Hebei Province, China, on the application of slurry seal at different timings, the pavement performance was established and the adequate timings for applying slurry seal was studied. Based on benefit-cost analysis, it is suggested that the fourth year is the optimal timing for applying slurry seal based on the condition in China. A framework is established to determine the adequate timings of applying other preventive maintenance methods.
文摘Objective:The aim of our study was to estimate the cost of colorectal cancer screening and to provide evidence for the cost control of colorectal cancer screening among general population in rural area of China.Methods:We determined the net cost for colorectal cancer mass-screening in Jiashan County,and evaluated the cost-benefit and cost effectiveness.Results:The compliance rate of primary screening and intensive screening were 84.6% and 78.7%,respectively.In primary screening,the average cost for each individual was 27.2 yuan,and the average cost for identifying one high-risk individual was 180.5 yuan.The mean cost to diagnose one colorectal cancer patient was 42963.3 yuan.As for identification of adenoma,the average cost for each case was 4384.0 yuan.Based on the calculation,the average cost of reducing one colorectal cancer patient was 12768 yuan by conducting the mass-screening protocol.Conclusion:It was beneficial to do the cost-benefit analysis of colorectal cancer screening in area of high incidence.Based on the results of cost-benefit analysis,more efforts should be made to reduce the cost and to improve the efficiency of the colorectal cancer screening.
文摘Trade and economic relations between China and Africa have a protracted history and have developed incrementally over the course of time. Consequently, increasing numbers of Chinese businesses and entrepreneurs have sought partnerships with African companies with the aim of establishing strategic partnerships, collaborations, and joint ventures. In recent years, these Sino-African trading relations have been the subject of consistent debate and scrutiny, attracting positive and negative analyses from scholars and practitioners across disciplines. Some studies questioned China＇s motives in Africa＇s markets, and others viewed with suspicion the structure of Sino-Africa＇s bilateral trading engagements. Conducting an extensive literature survey of related sources and employing content analysis of recent and current data （2000-2009）, the paper examined institutional and academic publications pertaining to Sino-African relationship. It determines imbalance in the structure of Sino-African bilateral trade, negative impact on domestic economic development, and competitive disadvantage in African marketplaces. Policy implications of these findings were provided as well as recommendations for mutual trade benefits and global strategic investments
文摘Considering the additional electric energy generated after the full operation of the underground hydropower station, the electric energy accommodation of the Three Gorges Project （TGP） is reviewed. It is .focused on the additional electricity accommodation, based on the research at the earl）, stage. The electric energ）, accommodation solutions ate recommended as that. based on the cost-benefit analysis of the power distribution area, the additional electric energy of the Three Gorges should be given ptqority to meet the needs at the supply end of Hubei and Chongqing. The results of this research has a reference value on the implementation of the Three Gorges electric power accommodation, after the further optimization of the transmission curves in both wet and dry seasons.
文摘The present research is based upon a comprehensive survey which discusses the slightly tolerable water level of Balaton between 2000 and 2003. The low water level of the extreme period caused considerable problems in recreation. Our goal was to investigate the possible water transfer policies and the water level regulation policy of Lake Balaton by applying the dynamic programming of Markov chains. This iteration supports the cost-benefit analysis of different scenarios and also provides information about the best water governing policy. As a basis of our scientific analysis, Markov chains were created by ARMA （autoregressive moving average） synthetic data generator. Profit was joined to each transition-probability for the economic analysis. In our case the profit was negative, because the harmful effects of the low water level should be estimated, which is based on the calculated willingness-to-pay for improving the water quality of Lake Balaton. In addition, the profit includes the cost of different water supplement scenarios. After computer programming, the method proved to be an efficient tool to buttress the cost-benefit analysis of water supplement scenarios. The result highlights the importance of further climate change monitoring. Calculation confirmed water transfer to be cost-effective, yet scenarios with less ecological risk are also effective, thus preferable.
