硒化卡拉胶是一个新的含硒有机化合物。本文主要观察它对环磷酰胺引致免疫抑制小鼠的淋巴细胞增殖及抗体形成细胞(PFC)的影响。研究结果表明,环磷酰胺可明显抑制小鼠淋巴细胞增殖及抗体形成细胞数。硒化卡拉胶2或12 mg/kg po qd×20...硒化卡拉胶是一个新的含硒有机化合物。本文主要观察它对环磷酰胺引致免疫抑制小鼠的淋巴细胞增殖及抗体形成细胞(PFC)的影响。研究结果表明,环磷酰胺可明显抑制小鼠淋巴细胞增殖及抗体形成细胞数。硒化卡拉胶2或12 mg/kg po qd×20～40可明显刺激免疫抑制小鼠的淋巴细胞增殖或抗体形成细胞,但大剂量硒化卡拉胶(72 mg/kg)不能显示稳定的刺激作用,在某些条件下反而转向抑制作用。展开更多
Objective.To study the effect of HLA DQ2,dietary history and development of coeliac disease(CD) on the induction of antibody response to wheat gliadin and cow’s milk,beta-lactoglobulin between 1 and 2.5 years of age ...Objective.To study the effect of HLA DQ2,dietary history and development of coeliac disease(CD) on the induction of antibody response to wheat gliadin and cow’s milk,beta-lactoglobulin between 1 and 2.5 years of age in children who developed CD and in healthy children.Material and methods.Infants participating in a birth cohort study(the ABIS study) in Sweden were studied.Thirty-nine children developed CD(cases) ,confirmed through biopsy,during follow-up until 2.5-5 years of age.A total of 181 healthy control children were matched for duration of exclusive breast-feeding,birth-weight,gender,maternal smoking and season of birth.IgG and IgA antigliadin and anti-beta-lactoglobulin antibodies were measured using enzyme immunoassay(EIA) .The effects of HLA-risk genotypes,DQ2 and DQ8,on CD were also considered.Results.Children who developed CD had higher IgG and IgA antigliadin and anti-beta-lactoglobulin antibody levels at 1 year of age than controls(all comparisons:p < 0.001) .Similar differences were seen between cases with as yet undiagnosed CD by 1 year of age and controls,and also when cases were compared with HLA-matched controls.Higher levels of IgG and IgA antibodies to beta-lactoglobu-lin(p = 0.003;p = 0.001) ,but not to gliadin,were found in treated cases versus controls at 2.5 years of age.HLA-DQ2-positive healthy children had lower levels of IgG and IgA antigliadin antibodies than HLADQ2 negative controls at 1 year of age(p = 0.004;p = 0.012) .Conc-lusions.Enhanced humoral response emerging not only to gliadin,but also to other food antigens seems to be primarily associated with CD.Poor induction of antibody response to wheat gliadin in healthy children with the HLA-DQ2 risk molecule could at least partly explain the genetic predisposition to gluten intolerance and CD.展开更多
Objective: To assess whether the maternal consumption of milk and milk product s affects development of cow’s milk (CM) antibodies in infants. Design: A rando mized pilot trial using food frequency questionnaires (mo...Objective: To assess whether the maternal consumption of milk and milk product s affects development of cow’s milk (CM) antibodies in infants. Design: A rando mized pilot trial using food frequency questionnaires (mothers) and food records (infants). Setting: Families with a newborn infant with increased HLA-DQB1-co nferred risk of type 1 diabetes and at least one first-degree relative affected by type 1 diabetes from 16 hospitals in Finland between April 1995 and November 1997. Subjects and intervention: Infants randomized to receive a hydrolysed for mula when breast milk was not available during their first 6-8 mo (n = 112). Of these, 13 dropped out by the age of 3 mo and two were excluded due to incomplet e CM antibody data. Results: Maternal milk protein intake from cheese during pre gnancy was inversely related to IgA-class antibody titres to beta-lactoglobuli n (BLG) and casein (CAS) at 3 mo, and to IgA antibody titres to BLG at 6 mo. Mat ernal consumption of raw milk products during lactation was positively related t o the development of IgA antibody titres to CAS at 6 mo, and inversely correlate d to IgG antibody titres to bovine serum albumin (BSA) and IgA antibody titres t o CAS at 2 y. Maternal cheese consumption was inversely related to the IgG antib ody titres to CM formula and CAS and to the IgA antibody titres to CAS in early infancy. Conclusions: Few associations were established between maternal CM prot ein intake and CM protein antibody levels in the infants. The milk and milk prod ucts taken by the mother differed in their impact on the emerging CM antibody re sponse in the offspring.展开更多
文摘硒化卡拉胶是一个新的含硒有机化合物。本文主要观察它对环磷酰胺引致免疫抑制小鼠的淋巴细胞增殖及抗体形成细胞(PFC)的影响。研究结果表明,环磷酰胺可明显抑制小鼠淋巴细胞增殖及抗体形成细胞数。硒化卡拉胶2或12 mg/kg po qd×20～40可明显刺激免疫抑制小鼠的淋巴细胞增殖或抗体形成细胞,但大剂量硒化卡拉胶(72 mg/kg)不能显示稳定的刺激作用,在某些条件下反而转向抑制作用。
文摘Objective.To study the effect of HLA DQ2,dietary history and development of coeliac disease(CD) on the induction of antibody response to wheat gliadin and cow’s milk,beta-lactoglobulin between 1 and 2.5 years of age in children who developed CD and in healthy children.Material and methods.Infants participating in a birth cohort study(the ABIS study) in Sweden were studied.Thirty-nine children developed CD(cases) ,confirmed through biopsy,during follow-up until 2.5-5 years of age.A total of 181 healthy control children were matched for duration of exclusive breast-feeding,birth-weight,gender,maternal smoking and season of birth.IgG and IgA antigliadin and anti-beta-lactoglobulin antibodies were measured using enzyme immunoassay(EIA) .The effects of HLA-risk genotypes,DQ2 and DQ8,on CD were also considered.Results.Children who developed CD had higher IgG and IgA antigliadin and anti-beta-lactoglobulin antibody levels at 1 year of age than controls(all comparisons:p < 0.001) .Similar differences were seen between cases with as yet undiagnosed CD by 1 year of age and controls,and also when cases were compared with HLA-matched controls.Higher levels of IgG and IgA antibodies to beta-lactoglobu-lin(p = 0.003;p = 0.001) ,but not to gliadin,were found in treated cases versus controls at 2.5 years of age.HLA-DQ2-positive healthy children had lower levels of IgG and IgA antigliadin antibodies than HLADQ2 negative controls at 1 year of age(p = 0.004;p = 0.012) .Conc-lusions.Enhanced humoral response emerging not only to gliadin,but also to other food antigens seems to be primarily associated with CD.Poor induction of antibody response to wheat gliadin in healthy children with the HLA-DQ2 risk molecule could at least partly explain the genetic predisposition to gluten intolerance and CD.
文摘Objective: To assess whether the maternal consumption of milk and milk product s affects development of cow’s milk (CM) antibodies in infants. Design: A rando mized pilot trial using food frequency questionnaires (mothers) and food records (infants). Setting: Families with a newborn infant with increased HLA-DQB1-co nferred risk of type 1 diabetes and at least one first-degree relative affected by type 1 diabetes from 16 hospitals in Finland between April 1995 and November 1997. Subjects and intervention: Infants randomized to receive a hydrolysed for mula when breast milk was not available during their first 6-8 mo (n = 112). Of these, 13 dropped out by the age of 3 mo and two were excluded due to incomplet e CM antibody data. Results: Maternal milk protein intake from cheese during pre gnancy was inversely related to IgA-class antibody titres to beta-lactoglobuli n (BLG) and casein (CAS) at 3 mo, and to IgA antibody titres to BLG at 6 mo. Mat ernal consumption of raw milk products during lactation was positively related t o the development of IgA antibody titres to CAS at 6 mo, and inversely correlate d to IgG antibody titres to bovine serum albumin (BSA) and IgA antibody titres t o CAS at 2 y. Maternal cheese consumption was inversely related to the IgG antib ody titres to CM formula and CAS and to the IgA antibody titres to CAS in early infancy. Conclusions: Few associations were established between maternal CM prot ein intake and CM protein antibody levels in the infants. The milk and milk prod ucts taken by the mother differed in their impact on the emerging CM antibody re sponse in the offspring.
