树突状细胞(dendritic cells, DCs)是免疫系统专业的抗原呈递细胞(APC),标志性功能是启动T细胞激活抗原特异性免疫反应。DCs作为宿主免疫应答的关键细胞,在连接先天免疫和适应性免疫之间发挥关键的免疫调控作用。在肿瘤微环境(tumor mic...树突状细胞(dendritic cells, DCs)是免疫系统专业的抗原呈递细胞(APC),标志性功能是启动T细胞激活抗原特异性免疫反应。DCs作为宿主免疫应答的关键细胞,在连接先天免疫和适应性免疫之间发挥关键的免疫调控作用。在肿瘤微环境(tumor microenviroment, TME)中,DCs识别肿瘤相关抗原(tumor associated antigen, TAA)是启动和维持有效T细胞介导的抗肿瘤应答的关键起始步骤。大量对肿瘤DCs生物学的研究揭示,由于TME的免疫抑制性及DCs亚群的可塑性,TME中DCs往往功能障碍,并且已经证明这些DCs在抗肿瘤免疫应答中协助肿瘤逃脱免疫监视,促进肿瘤生长。本文介绍DCs的个体生物学、亚群功能及其在TME中功能障碍的机制和可能的治疗靶点。Dendritic cells (DCs) are specialized antigen-presenting cells (APCs) of the immune system, with the characteristic function of initiating T cell activation of antigen-specific immune responses. DCs, as key cells in host immune response, play a crucial role in immune regulation by connecting innate and adaptive immunity. In the tumor microenvironment (TME), DCs recognize tumor-associated antigen (TAA), which is a key initiating step in initiating and maintaining effective T cell-mediated anti-tumor responses. A large amount of research on the biology of tumor DCs has revealed that due to the immunosuppressive properties of TME and the plasticity of DC subpopulations, DCs in TME often function abnormally, and it has been proven that these DCs assist tumors in escaping immune surveillance and promoting tumor growth in anti-tumor immune responses. This article introduces the individual biology, subpopulation functions, and mechanisms of functional impairment of DCs in TME, as well as possible therapeutic targets.展开更多
文摘树突状细胞(dendritic cells, DCs)是免疫系统专业的抗原呈递细胞(APC),标志性功能是启动T细胞激活抗原特异性免疫反应。DCs作为宿主免疫应答的关键细胞,在连接先天免疫和适应性免疫之间发挥关键的免疫调控作用。在肿瘤微环境(tumor microenviroment, TME)中,DCs识别肿瘤相关抗原(tumor associated antigen, TAA)是启动和维持有效T细胞介导的抗肿瘤应答的关键起始步骤。大量对肿瘤DCs生物学的研究揭示,由于TME的免疫抑制性及DCs亚群的可塑性,TME中DCs往往功能障碍,并且已经证明这些DCs在抗肿瘤免疫应答中协助肿瘤逃脱免疫监视,促进肿瘤生长。本文介绍DCs的个体生物学、亚群功能及其在TME中功能障碍的机制和可能的治疗靶点。Dendritic cells (DCs) are specialized antigen-presenting cells (APCs) of the immune system, with the characteristic function of initiating T cell activation of antigen-specific immune responses. DCs, as key cells in host immune response, play a crucial role in immune regulation by connecting innate and adaptive immunity. In the tumor microenvironment (TME), DCs recognize tumor-associated antigen (TAA), which is a key initiating step in initiating and maintaining effective T cell-mediated anti-tumor responses. A large amount of research on the biology of tumor DCs has revealed that due to the immunosuppressive properties of TME and the plasticity of DC subpopulations, DCs in TME often function abnormally, and it has been proven that these DCs assist tumors in escaping immune surveillance and promoting tumor growth in anti-tumor immune responses. This article introduces the individual biology, subpopulation functions, and mechanisms of functional impairment of DCs in TME, as well as possible therapeutic targets.
