目的:水飞蓟种子中含有大量的黄酮类化合物,主要为水飞蓟素。本文对水飞蓟素防治代谢综合征的作用机制以及研究进展进行综述。为研发以防治代谢综合征为主要作用的药品或保健药食提供科学依据。方法:查阅有关水飞蓟素防治代谢综合征的...目的:水飞蓟种子中含有大量的黄酮类化合物,主要为水飞蓟素。本文对水飞蓟素防治代谢综合征的作用机制以及研究进展进行综述。为研发以防治代谢综合征为主要作用的药品或保健药食提供科学依据。方法:查阅有关水飞蓟素防治代谢综合征的相关文献,并系统总结与梳理。结果:水飞蓟素具有调节血脂、降低血糖、抗炎、抗肿瘤、抗氧化、抗凝血、抗动脉粥样硬化等药理作用,可以改善氧化应激、改善胰岛素抵抗(IR)、肥胖、保护血管内皮、改善肠道菌群、抑制血小板聚集、抑制炎症因子表达。结论:水飞蓟素作为无肝脏不良反应的保肝降脂药,具有抗氧化、抗炎、防治代谢综合征等功能,有望成为新型有效的保健食品。Objective: The seeds of silymarin contain a large amount of flavonoids, mainly silymarin. This article reviews the mechanism of action and research progress of silymarin in the prevention and treatment of metabolic syndrome to provide a scientific basis for the development of drugs or health supplements with the main function of preventing and treating metabolic syndrome. Method: We review relevant literature on the prevention and treatment of metabolic syndrome with silymarin, and systematically summarize and sort it out. Results: Silymarin has the pharmacological effects of regulating blood lipids, lowering blood sugar, anti-inflammatory, anti-tumor, antioxidant, anticoagulant, anti atherosclerosis, etc. It can improve oxidative stress, improve insulin resistance (IR), obesity, regulate lipid metabolism, protect vascular endothelium, improve intestinal flora, inhibit platelet aggregation, and inhibit the expression of inflammatory factors. Conclusion: Silymarin, as a liver protective and lipid-lowering drug without adverse liver reactions, has functions such as antioxidant, anti-inflammatory, and prevention and treatment of metabolic syndrome, and is expected to become a new and effective health food.展开更多
目的探究水飞蓟素在创伤性颅脑损伤发生中的作用机制。方法选取24只SPF级昆明小鼠作为研究对象,采用随机数字表法分为假手术组(未建模)、水飞蓟素组(未建模给予水飞蓟素)、颅脑损伤组(建颅脑损伤模型,不干预)、颅脑损伤+水飞蓟素组(建...目的探究水飞蓟素在创伤性颅脑损伤发生中的作用机制。方法选取24只SPF级昆明小鼠作为研究对象,采用随机数字表法分为假手术组(未建模)、水飞蓟素组(未建模给予水飞蓟素)、颅脑损伤组(建颅脑损伤模型,不干预)、颅脑损伤+水飞蓟素组(建颅脑损伤模型,给予水飞蓟素),每组6只。比较各组氧化应激反应、炎症反应指标、NLR家族Pyrin域蛋白3(NLRP3)炎症小体相关蛋白表达水平和神经功能。结果假手术组、水飞蓟素组超氧化物歧化酶(SOD)高于颅脑损伤+水飞蓟素组、颅脑损伤组,颅脑损伤+水飞蓟素组SOD高于颅脑损伤组,差异有统计学意义(P<0.05);假手术组、水飞蓟素组丙二醛(MDA)、肿瘤坏死因子-α(TNF-α)、白介素-1β(IL-1β)、白介素-6(IL-6)、NLRP3蛋白、Caspase-1-p20蛋白相对表达量低于颅脑损伤+水飞蓟素组、颅脑损伤组,颅脑损伤+水飞蓟素组各项指标低于颅脑损伤组,差异有统计学意义(P<0.05)。假手术组、水飞蓟素组小鼠颅脑创伤后3、7 d NSS评分低于颅脑损伤+水飞蓟素组、颅脑损伤组,颅脑损伤+水飞蓟素组低于颅脑损伤组,差异有统计学意义(P<0.05)。结论水飞蓟素在创伤性颅脑损伤治疗中可有效保护神经功能,可能与抑制氧化应激反应、炎症反应及NLRP3炎症小体活化有关。展开更多
文摘目的:水飞蓟种子中含有大量的黄酮类化合物,主要为水飞蓟素。本文对水飞蓟素防治代谢综合征的作用机制以及研究进展进行综述。为研发以防治代谢综合征为主要作用的药品或保健药食提供科学依据。方法:查阅有关水飞蓟素防治代谢综合征的相关文献,并系统总结与梳理。结果:水飞蓟素具有调节血脂、降低血糖、抗炎、抗肿瘤、抗氧化、抗凝血、抗动脉粥样硬化等药理作用,可以改善氧化应激、改善胰岛素抵抗(IR)、肥胖、保护血管内皮、改善肠道菌群、抑制血小板聚集、抑制炎症因子表达。结论:水飞蓟素作为无肝脏不良反应的保肝降脂药,具有抗氧化、抗炎、防治代谢综合征等功能,有望成为新型有效的保健食品。Objective: The seeds of silymarin contain a large amount of flavonoids, mainly silymarin. This article reviews the mechanism of action and research progress of silymarin in the prevention and treatment of metabolic syndrome to provide a scientific basis for the development of drugs or health supplements with the main function of preventing and treating metabolic syndrome. Method: We review relevant literature on the prevention and treatment of metabolic syndrome with silymarin, and systematically summarize and sort it out. Results: Silymarin has the pharmacological effects of regulating blood lipids, lowering blood sugar, anti-inflammatory, anti-tumor, antioxidant, anticoagulant, anti atherosclerosis, etc. It can improve oxidative stress, improve insulin resistance (IR), obesity, regulate lipid metabolism, protect vascular endothelium, improve intestinal flora, inhibit platelet aggregation, and inhibit the expression of inflammatory factors. Conclusion: Silymarin, as a liver protective and lipid-lowering drug without adverse liver reactions, has functions such as antioxidant, anti-inflammatory, and prevention and treatment of metabolic syndrome, and is expected to become a new and effective health food.
文摘目的探究水飞蓟素在创伤性颅脑损伤发生中的作用机制。方法选取24只SPF级昆明小鼠作为研究对象,采用随机数字表法分为假手术组(未建模)、水飞蓟素组(未建模给予水飞蓟素)、颅脑损伤组(建颅脑损伤模型,不干预)、颅脑损伤+水飞蓟素组(建颅脑损伤模型,给予水飞蓟素),每组6只。比较各组氧化应激反应、炎症反应指标、NLR家族Pyrin域蛋白3(NLRP3)炎症小体相关蛋白表达水平和神经功能。结果假手术组、水飞蓟素组超氧化物歧化酶(SOD)高于颅脑损伤+水飞蓟素组、颅脑损伤组,颅脑损伤+水飞蓟素组SOD高于颅脑损伤组,差异有统计学意义(P<0.05);假手术组、水飞蓟素组丙二醛(MDA)、肿瘤坏死因子-α(TNF-α)、白介素-1β(IL-1β)、白介素-6(IL-6)、NLRP3蛋白、Caspase-1-p20蛋白相对表达量低于颅脑损伤+水飞蓟素组、颅脑损伤组,颅脑损伤+水飞蓟素组各项指标低于颅脑损伤组,差异有统计学意义(P<0.05)。假手术组、水飞蓟素组小鼠颅脑创伤后3、7 d NSS评分低于颅脑损伤+水飞蓟素组、颅脑损伤组,颅脑损伤+水飞蓟素组低于颅脑损伤组,差异有统计学意义(P<0.05)。结论水飞蓟素在创伤性颅脑损伤治疗中可有效保护神经功能,可能与抑制氧化应激反应、炎症反应及NLRP3炎症小体活化有关。
