膝骨关节炎(knee osteoarthritis, KOA)是一种多病因的、累及全关节的慢性致残性疾病,伴有关节软骨、软骨下骨、韧带、滑膜、关节囊和关节周围肌肉结构的病变。年龄、体重、性别、关节结构改变及职业均是KOA的危险因素。而其中绝经后女...膝骨关节炎(knee osteoarthritis, KOA)是一种多病因的、累及全关节的慢性致残性疾病,伴有关节软骨、软骨下骨、韧带、滑膜、关节囊和关节周围肌肉结构的病变。年龄、体重、性别、关节结构改变及职业均是KOA的危险因素。而其中绝经后女性KOA患病率显著增加。目前认为,是与其体内雌激素与卵泡刺激素(follicle-stimulatinghormone, FSH)的合成与分泌水平密切相关。而中医药疗法作为我国传统优势疗法可显著改善KOA患者的临床症状,在KOA防治过程中具有独特优势,中药在疾病治疗过程中的科学性也逐渐被全世界认可。本文基于国内外防治KOA的研究成果,将传统中医理论与现代医学理论相结合,对“补肝益肾”“祛风寒湿”“活血化瘀”等中医理论指导下的中药防治KOA的研究进行了归纳和总结,并为中药防治KOA研究提供新的思路与方法。Knee osteoarthritis (KOA) is a chronic disabling condition with multiple etiologies, affecting the entire joint. It is characterized by pathological alterations in articular cartilage, subchondral bone, ligaments, synovium, joint capsule, and surrounding muscles. Various risk factors contribute to KOA, including age, weight, gender, structural changes in joints, and occupational hazards. Notably, the prevalence of KOA rises significantly among post-menopausal women. It is currently believed that a phenomenon closely linked to fluctuations in estrogen and follicle-stimulating hormone (FSH) levels. Traditional Chinese Medicine (TCM) offers a unique therapeutic approach that shows promise in alleviating clinical symptoms for patients suffering from KOA. Its effectiveness in the prevention and treatment of KOA is increasingly acknowledged both within China and internationally, highlighting the scientific basis of TCM in managing diseases. This article synthesizes findings from domestic and global research on KOA prevention and treatment, integrating TCM principles such as “nourishing the liver and kidneys,” “dispersing wind, cold, and dampness,” and “enhancing blood circulation to eliminate stagnation” with contemporary medical theories. The objective is to provide innovative perspectives and strategies for advancing research on the prevention and treatment of KOA through TCM methodologies.展开更多
文摘膝骨关节炎(knee osteoarthritis, KOA)是一种多病因的、累及全关节的慢性致残性疾病,伴有关节软骨、软骨下骨、韧带、滑膜、关节囊和关节周围肌肉结构的病变。年龄、体重、性别、关节结构改变及职业均是KOA的危险因素。而其中绝经后女性KOA患病率显著增加。目前认为,是与其体内雌激素与卵泡刺激素(follicle-stimulatinghormone, FSH)的合成与分泌水平密切相关。而中医药疗法作为我国传统优势疗法可显著改善KOA患者的临床症状,在KOA防治过程中具有独特优势,中药在疾病治疗过程中的科学性也逐渐被全世界认可。本文基于国内外防治KOA的研究成果,将传统中医理论与现代医学理论相结合,对“补肝益肾”“祛风寒湿”“活血化瘀”等中医理论指导下的中药防治KOA的研究进行了归纳和总结,并为中药防治KOA研究提供新的思路与方法。Knee osteoarthritis (KOA) is a chronic disabling condition with multiple etiologies, affecting the entire joint. It is characterized by pathological alterations in articular cartilage, subchondral bone, ligaments, synovium, joint capsule, and surrounding muscles. Various risk factors contribute to KOA, including age, weight, gender, structural changes in joints, and occupational hazards. Notably, the prevalence of KOA rises significantly among post-menopausal women. It is currently believed that a phenomenon closely linked to fluctuations in estrogen and follicle-stimulating hormone (FSH) levels. Traditional Chinese Medicine (TCM) offers a unique therapeutic approach that shows promise in alleviating clinical symptoms for patients suffering from KOA. Its effectiveness in the prevention and treatment of KOA is increasingly acknowledged both within China and internationally, highlighting the scientific basis of TCM in managing diseases. This article synthesizes findings from domestic and global research on KOA prevention and treatment, integrating TCM principles such as “nourishing the liver and kidneys,” “dispersing wind, cold, and dampness,” and “enhancing blood circulation to eliminate stagnation” with contemporary medical theories. The objective is to provide innovative perspectives and strategies for advancing research on the prevention and treatment of KOA through TCM methodologies.
