目的:研究早期结直肠癌患者幽门螺杆菌感染情况及血液炎症指标的变化情况,探讨幽门螺杆菌感染、炎症指标与早期结直肠癌的相关性。方法:回顾性分析2020年9月至2023年9月就诊于青岛市市立医院的早期结直肠癌患者及同期住院的健康体检者,...目的:研究早期结直肠癌患者幽门螺杆菌感染情况及血液炎症指标的变化情况,探讨幽门螺杆菌感染、炎症指标与早期结直肠癌的相关性。方法:回顾性分析2020年9月至2023年9月就诊于青岛市市立医院的早期结直肠癌患者及同期住院的健康体检者,对两组研究对象的一般情况、幽门螺杆菌感染情况和血液炎症指标情况进行统计学比较分析,构建早期结直肠癌预测模型。结果:早期结直肠癌组幽门螺杆菌感染率和炎症指标水平均高于健康体检组,幽门螺杆菌感染和系统免疫炎症指数是影响早期结直肠癌发生的重要因素。幽门螺杆菌和系统免疫炎症指数参与构建的早期结直肠癌预测模型的曲线下面积为0.803,预测概率的灵敏度和特异度分别为80.40%和67.90%。结论:幽门螺杆菌感染、炎症指标均与早期结直肠癌具有相关性,对早期结直肠癌的诊断具有积极意义。幽门螺杆菌和系统免疫炎症指数参与构建的早期结直肠癌预测模型对早期结直肠癌具有一定的诊断价值,对初步筛查早期结直肠癌高风险人群有一定的参考价值。Objective: To study the changes in Helicobacter pylori infection and blood inflammatory indexes in patients with early colorectal cancer, and to explore the correlation between Helicobacter pylori infection, inflammatory indexes and early colorectal cancer. Methods: Early colorectal cancer patients attending Qingdao Municipal Hospital from September 2020 to September 2023 and health checkups hospitalized during the same period were retrospectively analyzed, and the general conditions, Helicobacter pylori infection and blood inflammation indexes of the two groups of study subjects were statistically compared and analyzed to construct a prediction model for early colorectal cancer. Results: The infection rate of Helicobacter pylori and the level of inflammatory indexes in the early colorectal cancer group were higher than those in the healthy medical checkup group, and Helicobacter pylori infection and systemic immune-inflammation indexes were important factors affecting the development of early colorectal cancer. The area under the curve of the early colorectal cancer prediction model constructed with the participation of Helicobacter pylori and the systemic immune-inflammation indexes was 0.803, and the sensitivity and specificity of the prediction probability were respectively 80.40% and 67.90%. Conclusion: Helicobacter pylori infection and inflammation indexes all correlate with early colorectal cancer, and have positive significance for the diagnosis of early colorectal cancer. The prediction model of early colorectal cancer constructed with the participation of Helicobacter pylori and systemic immune-inflammation indexes has a certain diagnostic value for early colorectal cancer, and has a certain reference value for the preliminary screening of high-risk groups of early colorectal cancer.展开更多
目的:探讨妊娠期糖尿病(GDM)患者外周血炎症指标[全身免疫炎症指数(SII)、中性粒细胞/淋巴细胞比率(NLR)、衍生中性粒细胞/淋巴细胞比率(d-NLR)、血小板/淋巴细胞比率(PLR)、淋巴细胞/单核细胞比值(LMR)]与胰岛素抵抗的相关性,分析其在...目的:探讨妊娠期糖尿病(GDM)患者外周血炎症指标[全身免疫炎症指数(SII)、中性粒细胞/淋巴细胞比率(NLR)、衍生中性粒细胞/淋巴细胞比率(d-NLR)、血小板/淋巴细胞比率(PLR)、淋巴细胞/单核细胞比值(LMR)]与胰岛素抵抗的相关性,分析其在GDM临床诊治中的价值,为临床GDM的早期诊断治疗提供依据。方法:回顾性分析2023年1月-2023年12月就诊的136例孕24~28周孕妇的临床资料,根据行口服75 g葡萄糖耐量试验(75 g OGTT)结果是否符合GDM诊断标准,将其分为妊娠糖尿病组(观察组)和正常妊娠组(对照组),每组68例。检测两组孕妇的血常规分析(CBC)并计算SII,NLR,d-NLR,PLR,LMR和空腹血糖(FPG)、餐后1 h血糖(1 h PG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbAlc)、空腹胰岛素(FINS)水平。应用稳态模型计算胰岛素抵抗指数(HOMA-IR)、胰岛β细胞功能指数(HOMA-β)、空腹β细胞功能指数(FBCI)、胰岛素敏感指数(ISI)水平,并进行统计学分析。结果:观察组孕妇外周血炎症指标(SII,NLR,d-NLR,PLR,LMR)、血糖代谢指标(FPG,1 h PG,2 h PG,FINS)、胰岛素抵抗性和β细胞功能指标(HOMA-IR,HOMA-β,FBCI)水平与对照组比较,差异均有统计学意义(P<0.05);观察组孕妇HbA1c,ISI水平与对照组比较,差异无统计学意义(P>0.05)。观察组孕妇SII,d-NLR,NLR水平与HOMA-IR,FBCI呈正相关(P<0.05),与HOMA-β,ISI呈负相关(P<0.05);PLR水平与HOMA-IR呈正相关(P<0.05),与HOMA-β呈负相关(P<0.05),与FBCI,ISI无相关性(P>0.05);LMR与FBCI呈正相关(P<0.05),与ISI呈负相关(P<0.05),与HOMA-IR,HOMA-β无相关性(P>0.05)。结论:GDM患者的新型外周血炎症指标(SII,NLR,d-NLR,PLR和LMR)水平与胰岛素抵抗存在相关性,提示外周血炎症指标的监测对GDM的预防和诊治具有一定的参考价值。展开更多
文摘目的:研究早期结直肠癌患者幽门螺杆菌感染情况及血液炎症指标的变化情况,探讨幽门螺杆菌感染、炎症指标与早期结直肠癌的相关性。方法:回顾性分析2020年9月至2023年9月就诊于青岛市市立医院的早期结直肠癌患者及同期住院的健康体检者,对两组研究对象的一般情况、幽门螺杆菌感染情况和血液炎症指标情况进行统计学比较分析,构建早期结直肠癌预测模型。结果:早期结直肠癌组幽门螺杆菌感染率和炎症指标水平均高于健康体检组,幽门螺杆菌感染和系统免疫炎症指数是影响早期结直肠癌发生的重要因素。幽门螺杆菌和系统免疫炎症指数参与构建的早期结直肠癌预测模型的曲线下面积为0.803,预测概率的灵敏度和特异度分别为80.40%和67.90%。结论:幽门螺杆菌感染、炎症指标均与早期结直肠癌具有相关性,对早期结直肠癌的诊断具有积极意义。幽门螺杆菌和系统免疫炎症指数参与构建的早期结直肠癌预测模型对早期结直肠癌具有一定的诊断价值,对初步筛查早期结直肠癌高风险人群有一定的参考价值。Objective: To study the changes in Helicobacter pylori infection and blood inflammatory indexes in patients with early colorectal cancer, and to explore the correlation between Helicobacter pylori infection, inflammatory indexes and early colorectal cancer. Methods: Early colorectal cancer patients attending Qingdao Municipal Hospital from September 2020 to September 2023 and health checkups hospitalized during the same period were retrospectively analyzed, and the general conditions, Helicobacter pylori infection and blood inflammation indexes of the two groups of study subjects were statistically compared and analyzed to construct a prediction model for early colorectal cancer. Results: The infection rate of Helicobacter pylori and the level of inflammatory indexes in the early colorectal cancer group were higher than those in the healthy medical checkup group, and Helicobacter pylori infection and systemic immune-inflammation indexes were important factors affecting the development of early colorectal cancer. The area under the curve of the early colorectal cancer prediction model constructed with the participation of Helicobacter pylori and the systemic immune-inflammation indexes was 0.803, and the sensitivity and specificity of the prediction probability were respectively 80.40% and 67.90%. Conclusion: Helicobacter pylori infection and inflammation indexes all correlate with early colorectal cancer, and have positive significance for the diagnosis of early colorectal cancer. The prediction model of early colorectal cancer constructed with the participation of Helicobacter pylori and systemic immune-inflammation indexes has a certain diagnostic value for early colorectal cancer, and has a certain reference value for the preliminary screening of high-risk groups of early colorectal cancer.
文摘目的:探讨妊娠期糖尿病(GDM)患者外周血炎症指标[全身免疫炎症指数(SII)、中性粒细胞/淋巴细胞比率(NLR)、衍生中性粒细胞/淋巴细胞比率(d-NLR)、血小板/淋巴细胞比率(PLR)、淋巴细胞/单核细胞比值(LMR)]与胰岛素抵抗的相关性,分析其在GDM临床诊治中的价值,为临床GDM的早期诊断治疗提供依据。方法:回顾性分析2023年1月-2023年12月就诊的136例孕24~28周孕妇的临床资料,根据行口服75 g葡萄糖耐量试验(75 g OGTT)结果是否符合GDM诊断标准,将其分为妊娠糖尿病组(观察组)和正常妊娠组(对照组),每组68例。检测两组孕妇的血常规分析(CBC)并计算SII,NLR,d-NLR,PLR,LMR和空腹血糖(FPG)、餐后1 h血糖(1 h PG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbAlc)、空腹胰岛素(FINS)水平。应用稳态模型计算胰岛素抵抗指数(HOMA-IR)、胰岛β细胞功能指数(HOMA-β)、空腹β细胞功能指数(FBCI)、胰岛素敏感指数(ISI)水平,并进行统计学分析。结果:观察组孕妇外周血炎症指标(SII,NLR,d-NLR,PLR,LMR)、血糖代谢指标(FPG,1 h PG,2 h PG,FINS)、胰岛素抵抗性和β细胞功能指标(HOMA-IR,HOMA-β,FBCI)水平与对照组比较,差异均有统计学意义(P<0.05);观察组孕妇HbA1c,ISI水平与对照组比较,差异无统计学意义(P>0.05)。观察组孕妇SII,d-NLR,NLR水平与HOMA-IR,FBCI呈正相关(P<0.05),与HOMA-β,ISI呈负相关(P<0.05);PLR水平与HOMA-IR呈正相关(P<0.05),与HOMA-β呈负相关(P<0.05),与FBCI,ISI无相关性(P>0.05);LMR与FBCI呈正相关(P<0.05),与ISI呈负相关(P<0.05),与HOMA-IR,HOMA-β无相关性(P>0.05)。结论:GDM患者的新型外周血炎症指标(SII,NLR,d-NLR,PLR和LMR)水平与胰岛素抵抗存在相关性,提示外周血炎症指标的监测对GDM的预防和诊治具有一定的参考价值。
