By analyzing the observed phenomena and the data collected in the study, a multi-compartment linear circulation model for targeting drug delivery system was developed and the function formulas of the drug concentratio...By analyzing the observed phenomena and the data collected in the study, a multi-compartment linear circulation model for targeting drug delivery system was developed and the function formulas of the drug concentration-time in blood and target organ by computing were figured out. The drug concentration-time curve for target organ can be plotted with reference to the data of drug concentration in blood according to the model. The pharmacokinetic parameters of the drug in target organ could also be obtained. The practicability of the model was further checked by the curves of drug concentration-time in blood and target organ(liver) of liver-targeting nanoparticles in animal tests. Based on the liver drug concentration-time curves calculated by the function formula of the drug in target organ, the pharmacokinetic behavior of the drug in target organ(liver) was analyzed by statistical moment, and its pharmacokinetic parameters in liver were obtained. It is suggested that the (relative targeting index( can be used for quantitative evaluation of the targeting drug delivery systems.展开更多
In order to solve the problem of efficiently assigning tasks in an ad-hoc mobile cloud( AMC),a task assignment algorithm based on the heuristic algorithm is proposed. The proposed task assignment algorithm based on pa...In order to solve the problem of efficiently assigning tasks in an ad-hoc mobile cloud( AMC),a task assignment algorithm based on the heuristic algorithm is proposed. The proposed task assignment algorithm based on particle swarm optimization and simulated annealing( PSO-SA) transforms the dependencies between tasks into a directed acyclic graph( DAG) model. The number in each node represents the computation workload of each task and the number on each edge represents the workload produced by the transmission. In order to simulate the environment of task assignment in AMC,mathematical models are developed to describe the dependencies between tasks and the costs of each task are defined. PSO-SA is used to make the decision for task assignment and for minimizing the cost of all devices,which includes the energy consumption and time delay of all devices.PSO-SA also takes the advantage of both particle swarm optimization and simulated annealing by selecting an optimal solution with a certain probability to avoid falling into local optimal solution and to guarantee the convergence speed. The simulation results show that compared with other existing algorithms,the PSO-SA has a smaller cost and the result of PSO-SA can be very close to the optimal solution.展开更多
In this paper,we intreduce the concept and discuss the properties of minimum cycle of row vector in a generalized circulant Fuzzy matrix. We present a new expression for circulant Fuzzy matrix,and discuss some propert...In this paper,we intreduce the concept and discuss the properties of minimum cycle of row vector in a generalized circulant Fuzzy matrix. We present a new expression for circulant Fuzzy matrix,and discuss some properties of the idempotent elements of the semigroup of generalized circulant Fuzzy matrixes in connection with minimum cycle of row vector.展开更多
The Southern Annular Mode(SAM)is the leading mode of atmospheric variability in the mid–high latitudes of the Southern Hemisphere,representing large-scale variations in pressure and the polar front jet(PFJ).In SAM ev...The Southern Annular Mode(SAM)is the leading mode of atmospheric variability in the mid–high latitudes of the Southern Hemisphere,representing large-scale variations in pressure and the polar front jet(PFJ).In SAM events,the combination of the SAM and other modes may result in different atmospheric patterns.In this study,a neural-network-based cluster technique,the self-organizing map,was applied to extract the distinct patterns of SAM events on the monthly time scale based on geopotential height anomalies at 500 hPa.Four pairs of distinguishable patterns of positive and negative SAM events were identified,representing the diversity in spatial distribution,especially the zonal symmetry of the center of action at high latitudes—that is,symmetric patterns,split-center patterns,West Antarctica patterns,and a tripole pattern.Although the SAM is well known to be beltshaped,within the selected SAM events,the occurrence frequency of symmetric patterns is only 23.8%—less than that of West Antarctica patterns.Diverse PFJ variations were found in the symmetric and asymmetric patterns of SAM events.The more asymmetric the spatial distribution of the pressure anomaly,the more localized the adjusted zonal wind anomaly.The adjusted PFJ varied in meridional displacement and strength in different patterns of SAM events.In addition,the entrance and exit of the jet changed in most of the patterns,especially in the asymmetric patterns,which might result in different climate impacts of the SAM.展开更多
A direction related polarizer (DRP) was used in a laser cavity to eliminate spatial hole burning of gain medium in a bidirectional Er-doped fiber ring laser. A stable operation of single longitudinal mode was achieved...A direction related polarizer (DRP) was used in a laser cavity to eliminate spatial hole burning of gain medium in a bidirectional Er-doped fiber ring laser. A stable operation of single longitudinal mode was achieved with comparable intensities for both clockwise and counterclockwise direction. A beat signal of 30 dB over noise was observed. This laser used as a gyroscope was demonstrated and a good linear relation between the beat frequency shift and the cavity rotation rate was acquired.展开更多
The economic development bring serious environmental problems to China, the quality of atmospheric environment has an important bearing on the forecast. Be aimed at the complexity and non-linear of the quality of atmo...The economic development bring serious environmental problems to China, the quality of atmospheric environment has an important bearing on the forecast. Be aimed at the complexity and non-linear of the quality of atmospheric environment, chaos theory has been put forward which takes full advantage of using date information. Based on the reconstruction of time-series phase space of the quality of atmospheric environment with the use of least squares support vector machine theory, the atmospheric environment prediction model was built up, and 25 years of historical data viewed as the raw data of the quality of the environment in Benxi City, giving a practical example, it shows that the results forecasted by the least squares support vector machine and the actual results match the better the forecast accuracy also meet the engineering application.展开更多
The transmission shaft of the underground screw drill fractured when milling-shoe and grinding bridge plug was applied to the coiled tubes in a horizontal well of Sichuan province, but the position of this transmissio...The transmission shaft of the underground screw drill fractured when milling-shoe and grinding bridge plug was applied to the coiled tubes in a horizontal well of Sichuan province, but the position of this transmission shaft fracture did not occur at the minor-diameter retracting position and reducing position that were easy to fracture. An analysis of the transverse planes of the fracture found that the cause of the transmission shaft fracture surface was that the defects of the initial surface were propagating to cracks and gave rise to the fracture under torque load. To specifically know well the strength of the transmission shaft under damaging fracture, a statics analysis was conducted on the transmission shaft through ANSYS finite element simulation software, and the finite element models under no cracks, different-depth circumferential cracks, and similar situation of the transverse planes of fracture were established respectively. An analysis of the crack-free finite element model found that the fracture of the transmission shaft was really not caused by the self-structure of the transmission shaft; an analysis of circumferential crack finite element model found that strong stress concentration would appear in the tip of cracks, and the value of the stress would increase along with the increase of the circumferential crack depth, the stress of the entire crack top tended to fluctuate like waves, and also the strength of the transmission shaft was greatly impacted by the presence of cracks; an analysis of the similar crack finite element model found that stress concentration would appear in the tip of cracks, and the initial cracks always started to propagate from the tip of the external surface of the transmission shaft and would propagate inward until the propagating areas of two cracks overlapped, and finally reached the position of transient interruption, and then the transmission shaft fractured completely and the fracture strength was onlv 1/5 of that under no cracks.展开更多
How would typhoon activity over the western North Pacific change for various scenarios of future global warming?Using the model projections of the Coupled Model Intercomparison Project phase 3(CMIP 3)under the SRES A1...How would typhoon activity over the western North Pacific change for various scenarios of future global warming?Using the model projections of the Coupled Model Intercomparison Project phase 3(CMIP 3)under the SRES A1B scenario,we generated summer(September)ice-free Arctic conditions,also referred to as Blue Arctic conditions,and then used the corresponding monthly sea surface temperature(SST)and a set of CO2concentrations to drive an AGCM model to simulate the resulting changes in background conditions affecting typhoon activity over the western North Pacific.Our results show that,during typhoon season(June to October),atmospheric and ocean circulations over the western North Pacific would be significantly different from the present circulations.Changes in the vertical shear of zonal wind and outgoing longwave radiation(OLR)in the western North Pacific are favorable for westward and northward shift,respectively,of the location of typhoon genesis.Moreover,changes in the above fields over the key area may be conducive to less frequent typhoons.In addition,the tropical cyclone genesis potential index(GPI)over the western North Pacific would decrease(increase)east(west)of 150°E(140°E).展开更多
文摘By analyzing the observed phenomena and the data collected in the study, a multi-compartment linear circulation model for targeting drug delivery system was developed and the function formulas of the drug concentration-time in blood and target organ by computing were figured out. The drug concentration-time curve for target organ can be plotted with reference to the data of drug concentration in blood according to the model. The pharmacokinetic parameters of the drug in target organ could also be obtained. The practicability of the model was further checked by the curves of drug concentration-time in blood and target organ(liver) of liver-targeting nanoparticles in animal tests. Based on the liver drug concentration-time curves calculated by the function formula of the drug in target organ, the pharmacokinetic behavior of the drug in target organ(liver) was analyzed by statistical moment, and its pharmacokinetic parameters in liver were obtained. It is suggested that the (relative targeting index( can be used for quantitative evaluation of the targeting drug delivery systems.
基金The National Natural Science Foundation of China(No.61741102,61471164,61601122)the Fundamental Research Funds for the Central Universities(No.SJLX_160040)
文摘In order to solve the problem of efficiently assigning tasks in an ad-hoc mobile cloud( AMC),a task assignment algorithm based on the heuristic algorithm is proposed. The proposed task assignment algorithm based on particle swarm optimization and simulated annealing( PSO-SA) transforms the dependencies between tasks into a directed acyclic graph( DAG) model. The number in each node represents the computation workload of each task and the number on each edge represents the workload produced by the transmission. In order to simulate the environment of task assignment in AMC,mathematical models are developed to describe the dependencies between tasks and the costs of each task are defined. PSO-SA is used to make the decision for task assignment and for minimizing the cost of all devices,which includes the energy consumption and time delay of all devices.PSO-SA also takes the advantage of both particle swarm optimization and simulated annealing by selecting an optimal solution with a certain probability to avoid falling into local optimal solution and to guarantee the convergence speed. The simulation results show that compared with other existing algorithms,the PSO-SA has a smaller cost and the result of PSO-SA can be very close to the optimal solution.
文摘In this paper,we intreduce the concept and discuss the properties of minimum cycle of row vector in a generalized circulant Fuzzy matrix. We present a new expression for circulant Fuzzy matrix,and discuss some properties of the idempotent elements of the semigroup of generalized circulant Fuzzy matrixes in connection with minimum cycle of row vector.
基金This work was jointly supported by the National Natural Science Foundation of China[grant numbers 42088101 and 42175019]Guangdong Province Key Laboratory for Climate Change and Natural Disaster Studies[grant number 2020B1212060025].
文摘The Southern Annular Mode(SAM)is the leading mode of atmospheric variability in the mid–high latitudes of the Southern Hemisphere,representing large-scale variations in pressure and the polar front jet(PFJ).In SAM events,the combination of the SAM and other modes may result in different atmospheric patterns.In this study,a neural-network-based cluster technique,the self-organizing map,was applied to extract the distinct patterns of SAM events on the monthly time scale based on geopotential height anomalies at 500 hPa.Four pairs of distinguishable patterns of positive and negative SAM events were identified,representing the diversity in spatial distribution,especially the zonal symmetry of the center of action at high latitudes—that is,symmetric patterns,split-center patterns,West Antarctica patterns,and a tripole pattern.Although the SAM is well known to be beltshaped,within the selected SAM events,the occurrence frequency of symmetric patterns is only 23.8%—less than that of West Antarctica patterns.Diverse PFJ variations were found in the symmetric and asymmetric patterns of SAM events.The more asymmetric the spatial distribution of the pressure anomaly,the more localized the adjusted zonal wind anomaly.The adjusted PFJ varied in meridional displacement and strength in different patterns of SAM events.In addition,the entrance and exit of the jet changed in most of the patterns,especially in the asymmetric patterns,which might result in different climate impacts of the SAM.
文摘A direction related polarizer (DRP) was used in a laser cavity to eliminate spatial hole burning of gain medium in a bidirectional Er-doped fiber ring laser. A stable operation of single longitudinal mode was achieved with comparable intensities for both clockwise and counterclockwise direction. A beat signal of 30 dB over noise was observed. This laser used as a gyroscope was demonstrated and a good linear relation between the beat frequency shift and the cavity rotation rate was acquired.
文摘The economic development bring serious environmental problems to China, the quality of atmospheric environment has an important bearing on the forecast. Be aimed at the complexity and non-linear of the quality of atmospheric environment, chaos theory has been put forward which takes full advantage of using date information. Based on the reconstruction of time-series phase space of the quality of atmospheric environment with the use of least squares support vector machine theory, the atmospheric environment prediction model was built up, and 25 years of historical data viewed as the raw data of the quality of the environment in Benxi City, giving a practical example, it shows that the results forecasted by the least squares support vector machine and the actual results match the better the forecast accuracy also meet the engineering application.
文摘The transmission shaft of the underground screw drill fractured when milling-shoe and grinding bridge plug was applied to the coiled tubes in a horizontal well of Sichuan province, but the position of this transmission shaft fracture did not occur at the minor-diameter retracting position and reducing position that were easy to fracture. An analysis of the transverse planes of the fracture found that the cause of the transmission shaft fracture surface was that the defects of the initial surface were propagating to cracks and gave rise to the fracture under torque load. To specifically know well the strength of the transmission shaft under damaging fracture, a statics analysis was conducted on the transmission shaft through ANSYS finite element simulation software, and the finite element models under no cracks, different-depth circumferential cracks, and similar situation of the transverse planes of fracture were established respectively. An analysis of the crack-free finite element model found that the fracture of the transmission shaft was really not caused by the self-structure of the transmission shaft; an analysis of circumferential crack finite element model found that strong stress concentration would appear in the tip of cracks, and the value of the stress would increase along with the increase of the circumferential crack depth, the stress of the entire crack top tended to fluctuate like waves, and also the strength of the transmission shaft was greatly impacted by the presence of cracks; an analysis of the similar crack finite element model found that stress concentration would appear in the tip of cracks, and the initial cracks always started to propagate from the tip of the external surface of the transmission shaft and would propagate inward until the propagating areas of two cracks overlapped, and finally reached the position of transient interruption, and then the transmission shaft fractured completely and the fracture strength was onlv 1/5 of that under no cracks.
基金supported by the National Basic Research Program of China (Grant No. 2012CB955401)the National Natural Science Foundation of China (Grant No. 41130103)Norwegian Research Council project "East-Asia DecCen"
文摘How would typhoon activity over the western North Pacific change for various scenarios of future global warming?Using the model projections of the Coupled Model Intercomparison Project phase 3(CMIP 3)under the SRES A1B scenario,we generated summer(September)ice-free Arctic conditions,also referred to as Blue Arctic conditions,and then used the corresponding monthly sea surface temperature(SST)and a set of CO2concentrations to drive an AGCM model to simulate the resulting changes in background conditions affecting typhoon activity over the western North Pacific.Our results show that,during typhoon season(June to October),atmospheric and ocean circulations over the western North Pacific would be significantly different from the present circulations.Changes in the vertical shear of zonal wind and outgoing longwave radiation(OLR)in the western North Pacific are favorable for westward and northward shift,respectively,of the location of typhoon genesis.Moreover,changes in the above fields over the key area may be conducive to less frequent typhoons.In addition,the tropical cyclone genesis potential index(GPI)over the western North Pacific would decrease(increase)east(west)of 150°E(140°E).
