AIM： To describe the prevalence of transfusiontransmitted virus （TTV） infection in association with hepatitis A-E viral infections in different forms of liver diseases in North India. METHODS： Sera from a total nu...AIM： To describe the prevalence of transfusiontransmitted virus （TTV） infection in association with hepatitis A-E viral infections in different forms of liver diseases in North India. METHODS： Sera from a total number of 137 patients, including 37 patients with acute viral hepatitis （AVH）, 37 patients with chronic viral hepatitis （CVH）, 31 patients with cirrhosis of liver and 32 patients with fulminant hepatic failure （FHF）, were analyzed both for TTV-DNA and hepatitis A-E viral markers. Presence of hepatitis B virus （HBV）, hepatitis C virus （HCV） and hepatitis E virus （HEV） infections was detected in different proportions in different groups. Moreover, rrV-DNA was simultaneously tested in 100 healthy blood donors also. RESULTS： None of the patients had hepatitis A virus （HAV） and hepatitis D virus （HDV） infections. Overall prevalence of TTV-DNA was detected in 27.1% cases with AVH, 18.9% cases with CVH, 48.4% cases with cirrhosis and 9.4% cases with FHF. TTV-DNA simultaneously tested in 100 healthy blood donors showed 27% positivity. On establishing a relation between TTV infection with other hepatitis viral infections, TTV demonstrated co-infection with HBV, HCV and HEV in these disease groups. Correlation of TTV with ALT level in sera did not demonstrate high ALT level in TTV-infected patients, suggesting that TI-V does not cause severe liver damage. CONCLUSION： TTV infection is prevalent both in patients and healthy individuals in India. However, it does not have any significant correlation with other hepatitis viral infections, nor does it produce an evidence of severe liver damage in patients with liver diseases.展开更多
AIM:To investigate the current seroprevalence of hepatitis A virus(HAV) antibodies in patients with chronic viral liver disease in Korea.We also tried to identify the factors affecting the prevalence of HAV antibodies...AIM:To investigate the current seroprevalence of hepatitis A virus(HAV) antibodies in patients with chronic viral liver disease in Korea.We also tried to identify the factors affecting the prevalence of HAV antibodies. METHODS:We performed an analysis of the clinical records of 986 patients(mean age:49±9 years,714 males/272 females) with chronic hepatitis B virus(HBV) or hepatitis C virus(HCV) infection who had undergone HAV antibody testing between January 2008 and December 2009.RESULTS:The overall prevalence of IgG anti-HAV was 86.61%(854/986) in patients with chronic liver disease and was 88.13%(869/986) in age-and gendermatched patients from the Center for Health Promotion.The anti-HAV prevalence was 80.04%(405/506) in patients with chronic hepatitis B,86.96%(20/23) in patients with chronic hepatitis C,93.78%(422/450) in patients with HBV related liver cirrhosis,and 100%(7/7) in patients with HCV related liver cirrhosis.The anti-HAV prevalence according to the decade of age was as follows:20s(6.67%) ,30s(50.86%) ,40s(92.29%) ,50s(97.77%) ,and 60s(100%) .The antiHAV prevalence was significantly higher in patients older than 40 years compared with that in patients younger than 40 years of age.Multivariable analysis showed that age≥40 years,female gender and metropolitan cities as the place of residence were independent risk factors for IgG anti-HAV seropositivity. CONCLUSION:Most Korean patients with chronic liver disease and who are above 40 years of age have already been exposed to hepatitis A virus.展开更多
基金Supported by financial grant from ICMR, New Delhi 110049
文摘AIM： To describe the prevalence of transfusiontransmitted virus （TTV） infection in association with hepatitis A-E viral infections in different forms of liver diseases in North India. METHODS： Sera from a total number of 137 patients, including 37 patients with acute viral hepatitis （AVH）, 37 patients with chronic viral hepatitis （CVH）, 31 patients with cirrhosis of liver and 32 patients with fulminant hepatic failure （FHF）, were analyzed both for TTV-DNA and hepatitis A-E viral markers. Presence of hepatitis B virus （HBV）, hepatitis C virus （HCV） and hepatitis E virus （HEV） infections was detected in different proportions in different groups. Moreover, rrV-DNA was simultaneously tested in 100 healthy blood donors also. RESULTS： None of the patients had hepatitis A virus （HAV） and hepatitis D virus （HDV） infections. Overall prevalence of TTV-DNA was detected in 27.1% cases with AVH, 18.9% cases with CVH, 48.4% cases with cirrhosis and 9.4% cases with FHF. TTV-DNA simultaneously tested in 100 healthy blood donors showed 27% positivity. On establishing a relation between TTV infection with other hepatitis viral infections, TTV demonstrated co-infection with HBV, HCV and HEV in these disease groups. Correlation of TTV with ALT level in sera did not demonstrate high ALT level in TTV-infected patients, suggesting that TI-V does not cause severe liver damage. CONCLUSION： TTV infection is prevalent both in patients and healthy individuals in India. However, it does not have any significant correlation with other hepatitis viral infections, nor does it produce an evidence of severe liver damage in patients with liver diseases.
文摘AIM:To investigate the current seroprevalence of hepatitis A virus(HAV) antibodies in patients with chronic viral liver disease in Korea.We also tried to identify the factors affecting the prevalence of HAV antibodies. METHODS:We performed an analysis of the clinical records of 986 patients(mean age:49±9 years,714 males/272 females) with chronic hepatitis B virus(HBV) or hepatitis C virus(HCV) infection who had undergone HAV antibody testing between January 2008 and December 2009.RESULTS:The overall prevalence of IgG anti-HAV was 86.61%(854/986) in patients with chronic liver disease and was 88.13%(869/986) in age-and gendermatched patients from the Center for Health Promotion.The anti-HAV prevalence was 80.04%(405/506) in patients with chronic hepatitis B,86.96%(20/23) in patients with chronic hepatitis C,93.78%(422/450) in patients with HBV related liver cirrhosis,and 100%(7/7) in patients with HCV related liver cirrhosis.The anti-HAV prevalence according to the decade of age was as follows:20s(6.67%) ,30s(50.86%) ,40s(92.29%) ,50s(97.77%) ,and 60s(100%) .The antiHAV prevalence was significantly higher in patients older than 40 years compared with that in patients younger than 40 years of age.Multivariable analysis showed that age≥40 years,female gender and metropolitan cities as the place of residence were independent risk factors for IgG anti-HAV seropositivity. CONCLUSION:Most Korean patients with chronic liver disease and who are above 40 years of age have already been exposed to hepatitis A virus.
