X-style arch bridge on high-speed railways(HSR)is one kind of complicated long-span structure,and the track-bridge interaction is essential to ensure the safety and smoothness of HSR.Taking an X-style steel-box arch b...X-style arch bridge on high-speed railways(HSR)is one kind of complicated long-span structure,and the track-bridge interaction is essential to ensure the safety and smoothness of HSR.Taking an X-style steel-box arch bridge with a main span of450 m on HSR under construction for example,a new integrative mechanic model of rail-stringer-cross beam-suspenderpier-foundation coupling system was established,adopting the nonlinear spring element simulating the longitudinal resistance between track and bridge.The transmission law of continuous welded rail(CWR)on the X-style arch bridge was researched,and comparative study was carried out to discuss the influence of several sensitive factors,such as the temperature load case,the longitudinal resistance model,the scheme of longitudinal restraint conditions,the introverted inclination of arch rib,the stiffness of pier and abutment and the location of the rail expansion device.Calculating results indicate that the longitudinal resistance has a significant impact upon the longitudinal forces of CWR on this kind of bridge,while the arch rib’s inclination has little effect.Besides,temperature variation of arch ribs and suspenders should be taken into account in the calculation.Selecting the restraint system without longitudinally-fixed bearing and setting the rail expansion devices on both ends are more reasonable.展开更多
Flaviviruses are positive-sense RNA viruses, and many are important human pathogens. Nonstructural protein 2B and 3 of the flaviviruses(NS2BNS3) form an endoplasmic reticulum(ER) membrane-associated hetero-dimeric com...Flaviviruses are positive-sense RNA viruses, and many are important human pathogens. Nonstructural protein 2B and 3 of the flaviviruses(NS2BNS3) form an endoplasmic reticulum(ER) membrane-associated hetero-dimeric complex through the NS2B transmembrane region. The NS2BNS3 complex is multifunctional. The N-terminal region of NS3, and its cofactor NS2B fold into a protease that is responsible for viral polyprotein processing, and the C-terminal domain of NS3 possesses NTPase/RNA helicase activities and is involved in viral RNA replication and virus particle formation. In addition, NS2BNS3 complex has also been shown to modulate viral pathogenesis and the host immune response. Because of the essential functions that the NS2BNS3 complex plays in the flavivirus life cycle, it is an attractive target for antiviral development. This review focuses on the recent biochemical and structural advances of NS2BNS3 and provides a brief update on the current status of drug development targeting this viral protein complex.展开更多
A three-part comb decimator is presented in this paper, for the applications with severe requirements of circuit performance and frequency response. Based on the modified prime factorization method and multistage poly...A three-part comb decimator is presented in this paper, for the applications with severe requirements of circuit performance and frequency response. Based on the modified prime factorization method and multistage polyphase decomposition, an efficient non-recursive structure for the cascaded integrator-comb （CIC） decimation filter is derived. Utilizing this structure as the core part, the proposed comb decimator can not only loosen the decimation ratio＇s limitation, but also balance the tradeoff among the overall power consumption, circuit area and maximum speed. Further, to improve the frequency response of the comb decimator, a cos-prefilter is introduced as the preprocessing part for increasing the aliasing rejection, and an optimum sin-based filter is used as the compensation part for decreasing the passband droop.展开更多
The topological expression of the reduced quantum trajectory is given by using C-mapping topological current theory. The topological expression is used in study of the coherence and the decoherence. We find the expres...The topological expression of the reduced quantum trajectory is given by using C-mapping topological current theory. The topological expression is used in study of the coherence and the decoherence. We find the expression of vorticity for decoherence has a similar form as that for coherence. A topological reason leading to the decoherence is given and a new parameter is defined to indicate the coherence degree. The parameter is different from the damping factor because it relates to the topological structure of the reduced quantum trajectory.展开更多
Relative permeability is an indispensable property for characterizing the unsaturated flow and induced deformation in soils. The widely used Mualem model is inadequate for deformable soils because of its assumption of...Relative permeability is an indispensable property for characterizing the unsaturated flow and induced deformation in soils. The widely used Mualem model is inadequate for deformable soils because of its assumption of a rigid pore structure and the resultant unique dependence of the tortuosity factor on the volumetric water content. In this study, a unified relationship between the relative permeability and the effective degree of saturation was proposed for deformable soils by incorporating our newly developed water retention curve model into the original Mualem model, in which a new tortuosity factor was defined using the fractal dimension of flow paths and the mean radius of water-filled pores for representing the effect of pore structure variation. The modified deformation-dependent relative permeability model was verified using test data on five types of soils; the verification revealed a much better performance of the proposed model than the original model, which commonly overestimates the relative permeability of deformable soils. Finally, the proposed model was implemented in a coupled numerical model for examining the unsaturated flow and elastoplastic deformation processes in a soil slope induced by rain infiltration. The numerical results showed that the deformation-dependent nature of relative permeability has a remarkable effect on the elastoplastic deformation in the slope and that neglect of the deformation-dependent behavior of relative permeability causes overestimation of the depth of failure.展开更多
Motivated by the recent experimental achievements in using the Bragg spectroscopy to measure the excitation spectrum of an ultra-cold atomic system with long-range interactions, we investigate the dynamic structure fa...Motivated by the recent experimental achievements in using the Bragg spectroscopy to measure the excitation spectrum of an ultra-cold atomic system with long-range interactions, we investigate the dynamic structure factor of a cigar-shaped dipolar Bose condensate trapped in a one-dimensional optical lattices. Our results show that the Bogoliubov bands of the system, particularly the lowest one, can be significantly influenced when one tunes the dipole orientation. Consequently, the calculated static structure factor of an optically trapped dipolar Bose gas shows marked difference from the non-dipolar one. Moreover, we show that the effects of dipole-dipole interaction on the dynamic structure factor is also strongly affected by the strength of the optical confinement.展开更多
基金Projects(51378503,51178471) supported by the National Natural Science Foundation of China
文摘X-style arch bridge on high-speed railways(HSR)is one kind of complicated long-span structure,and the track-bridge interaction is essential to ensure the safety and smoothness of HSR.Taking an X-style steel-box arch bridge with a main span of450 m on HSR under construction for example,a new integrative mechanic model of rail-stringer-cross beam-suspenderpier-foundation coupling system was established,adopting the nonlinear spring element simulating the longitudinal resistance between track and bridge.The transmission law of continuous welded rail(CWR)on the X-style arch bridge was researched,and comparative study was carried out to discuss the influence of several sensitive factors,such as the temperature load case,the longitudinal resistance model,the scheme of longitudinal restraint conditions,the introverted inclination of arch rib,the stiffness of pier and abutment and the location of the rail expansion device.Calculating results indicate that the longitudinal resistance has a significant impact upon the longitudinal forces of CWR on this kind of bridge,while the arch rib’s inclination has little effect.Besides,temperature variation of arch ribs and suspenders should be taken into account in the calculation.Selecting the restraint system without longitudinally-fixed bearing and setting the rail expansion devices on both ends are more reasonable.
文摘Flaviviruses are positive-sense RNA viruses, and many are important human pathogens. Nonstructural protein 2B and 3 of the flaviviruses(NS2BNS3) form an endoplasmic reticulum(ER) membrane-associated hetero-dimeric complex through the NS2B transmembrane region. The NS2BNS3 complex is multifunctional. The N-terminal region of NS3, and its cofactor NS2B fold into a protease that is responsible for viral polyprotein processing, and the C-terminal domain of NS3 possesses NTPase/RNA helicase activities and is involved in viral RNA replication and virus particle formation. In addition, NS2BNS3 complex has also been shown to modulate viral pathogenesis and the host immune response. Because of the essential functions that the NS2BNS3 complex plays in the flavivirus life cycle, it is an attractive target for antiviral development. This review focuses on the recent biochemical and structural advances of NS2BNS3 and provides a brief update on the current status of drug development targeting this viral protein complex.
基金Supported by the China Postdoctoral Science Foundation （20080431379）.
文摘A three-part comb decimator is presented in this paper, for the applications with severe requirements of circuit performance and frequency response. Based on the modified prime factorization method and multistage polyphase decomposition, an efficient non-recursive structure for the cascaded integrator-comb （CIC） decimation filter is derived. Utilizing this structure as the core part, the proposed comb decimator can not only loosen the decimation ratio＇s limitation, but also balance the tradeoff among the overall power consumption, circuit area and maximum speed. Further, to improve the frequency response of the comb decimator, a cos-prefilter is introduced as the preprocessing part for increasing the aliasing rejection, and an optimum sin-based filter is used as the compensation part for decreasing the passband droop.
基金Supported by the Fundamental Research Fonds for the Central Universities
文摘The topological expression of the reduced quantum trajectory is given by using C-mapping topological current theory. The topological expression is used in study of the coherence and the decoherence. We find the expression of vorticity for decoherence has a similar form as that for coherence. A topological reason leading to the decoherence is given and a new parameter is defined to indicate the coherence degree. The parameter is different from the damping factor because it relates to the topological structure of the reduced quantum trajectory.
基金supported by the CRSRI Open Research Program(Grant No.CKWV2015209/KY)the National Natural Science Foundation of China(Grant Nos.51409198,51179136&51222903)
文摘Relative permeability is an indispensable property for characterizing the unsaturated flow and induced deformation in soils. The widely used Mualem model is inadequate for deformable soils because of its assumption of a rigid pore structure and the resultant unique dependence of the tortuosity factor on the volumetric water content. In this study, a unified relationship between the relative permeability and the effective degree of saturation was proposed for deformable soils by incorporating our newly developed water retention curve model into the original Mualem model, in which a new tortuosity factor was defined using the fractal dimension of flow paths and the mean radius of water-filled pores for representing the effect of pore structure variation. The modified deformation-dependent relative permeability model was verified using test data on five types of soils; the verification revealed a much better performance of the proposed model than the original model, which commonly overestimates the relative permeability of deformable soils. Finally, the proposed model was implemented in a coupled numerical model for examining the unsaturated flow and elastoplastic deformation processes in a soil slope induced by rain infiltration. The numerical results showed that the deformation-dependent nature of relative permeability has a remarkable effect on the elastoplastic deformation in the slope and that neglect of the deformation-dependent behavior of relative permeability causes overestimation of the depth of failure.
基金Supported by the National Natural Science Foundation of China under Grant Nos.11004200 and 11274315
文摘Motivated by the recent experimental achievements in using the Bragg spectroscopy to measure the excitation spectrum of an ultra-cold atomic system with long-range interactions, we investigate the dynamic structure factor of a cigar-shaped dipolar Bose condensate trapped in a one-dimensional optical lattices. Our results show that the Bogoliubov bands of the system, particularly the lowest one, can be significantly influenced when one tunes the dipole orientation. Consequently, the calculated static structure factor of an optically trapped dipolar Bose gas shows marked difference from the non-dipolar one. Moreover, we show that the effects of dipole-dipole interaction on the dynamic structure factor is also strongly affected by the strength of the optical confinement.
