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非NMDA受体的细胞内调控及其机制
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作者 王婧 伍龙军 徐天乐 《生命科学》 CSCD 2002年第5期257-260,共4页
非NMDA受体是AMPA受体和KA受体的统称,其亚基上的胞内C末端上有很多磷酸化脱磷酸化及胞内蛋白的结合位点,这些作用位点与非NMDA受体的调控密切相关。如PKA、PKC、PKG、CaMKⅡ和PTK等蛋白激酶均可调节受体的活性。另外,胞内的一些骨架蛋... 非NMDA受体是AMPA受体和KA受体的统称,其亚基上的胞内C末端上有很多磷酸化脱磷酸化及胞内蛋白的结合位点,这些作用位点与非NMDA受体的调控密切相关。如PKA、PKC、PKG、CaMKⅡ和PTK等蛋白激酶均可调节受体的活性。另外,胞内的一些骨架蛋白和信号蛋白也可与非NMDA受体结合而影响其功能。本文着重综述非NMDA受体的细胞内调控及其机制。 展开更多
关键词 磷酸化 胞内蛋白 非NMDA受体 细胞内调控 机制
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胆汁酸盐输出泵转录调控及细胞内运输的分子机制 被引量:4
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作者 刘彬彬 孔静 +1 位作者 吴硕东 王玉 《世界华人消化杂志》 CAS 北大核心 2014年第6期788-794,共7页
胆汁酸盐输出泵(bile salt export pump,BSEP)是ATP结合盒超家族蛋白(ATP binding cassette,ABC)的一员,负责转运胆汁酸盐,并定位于肝细胞胆小管侧膜.在人类,BSEP缺陷可导致多种不同的胆汁淤积性疾病,包括遗传性肝病或获得性肝病.同时,B... 胆汁酸盐输出泵(bile salt export pump,BSEP)是ATP结合盒超家族蛋白(ATP binding cassette,ABC)的一员,负责转运胆汁酸盐,并定位于肝细胞胆小管侧膜.在人类,BSEP缺陷可导致多种不同的胆汁淤积性疾病,包括遗传性肝病或获得性肝病.同时,BSEP也是Lith1致石基因的最可能的候选基因.由于胆汁酸盐在许多生理及病理生理过程中均有重要作用科学界对BSEP表达的调节机制的研究非常重视.本文对BSEP的转录调节及细胞内运输改变所致BSEP在胆小管侧膜的表达功能改变包括细胞内内质网以及细胞膜泛素化-蛋白酶介导的蛋白降解,BSEP的短期磷酸化、糖基化、泛素化及胆小管侧膜相关蛋白对BSEP的调节等相关研究进行综述. 展开更多
关键词 胆汁酸盐输出泵 法尼酯衍生物X受体 小窝蛋白 HAX-1 细胞内调控
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肝干细胞分化调控研究进展 被引量:2
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作者 涂玉亮 方驰华 《中华肝胆外科杂志》 CAS CSCD 2004年第3期214-216,共3页
关键词 肝干细胞 分化调控 研究进展 细胞调控 细胞内调控 白血病抑制因子
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The Involvement of Hydrogen Peroxide in the Regulation of Cell Content Redistribution in the Excised Garlic Scape of Allium sativum
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作者 赵林川 《Developmental and Reproductive Biology》 2002年第2期95-100,共6页
During long term storage at 25℃ in the dark,a large number of cell content were transferred from the senescing scape to the developing cloves,and the transfer from the basal part of scape was earlier than that from t... During long term storage at 25℃ in the dark,a large number of cell content were transferred from the senescing scape to the developing cloves,and the transfer from the basal part of scape was earlier than that from the apical part in the excised garlic scape ( Allium sativum var Taichang).Levels of H 2O 2 decreased in the cloves and significantly increased up to 10 folds and then declined quickly in the scape.Levels of H 2O 2 were enhanced early in the basal part of scape.In the treatment of GA 3 at the cloves,levels of H 2O 2 were strongly enhanced in the cloves and inhibited in the scape,coinciding with the distinct inhibition of cell content tansfer.The results indicated that H 2O 2 may be involved in cell content redistribution and its regulation.3-Amino-1,2,4-triazole (AT) is a specific inhibitor of catalase.Effects of AT on cell content redistribution and levels of H 2O 2 were almost similar to those of GA 3,It further proved the above concept.According to the changes of H 2O 2 leves and activities of peroxidase and catalase in the cloves and in the scape,we suggest that the accumulation of H 2O 2 in the scape was transducted from the cloves,and the decline of H 2O 2 level in the scape with GA 3 or AT at the cloves was mainly through the inhibition of H 2O 2 synthesis in the cloves. 展开更多
关键词 excised garlic scape cell content REDISTRIBUTION REGULATION hydrogen peroxide
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