Objective. To determine whether malariotherapy (an old therapy for treatment of neurosyphilis) improves some clinical and laboratory parameters of HIV positive patients without iatrogenic compl...Objective. To determine whether malariotherapy (an old therapy for treatment of neurosyphilis) improves some clinical and laboratory parameters of HIV positive patients without iatrogenic complications. Methods. Total 8 asymptomatic HIV 1 positive subjects whose CD4 cell counts were over 250×10 6 cells/L were selected for the phase 1 studies of malariotherapy and were intravenously injected Plasmodia vivax to induce artificial malaria. Malaria was terminated with chloroquine after 10～20 malarial fever episodes. Cell bound CD4 levels were measured by APAAP (a solid phase enzyme essay) and levels of neopterin (NPT), beta 2 microglobulin (B2M), soluble tumor necrosis factor receptor 2(sTNF RII), interleukin 2(IL 2) and HIV P24 antigen were measured by ELISA. Patients were followed up to 24～30 months. Results.CD4 levels increased in 5, NPT decreased in 7 of 8 patients; IL 2 increased in 5 of 6 patients after malariotherapy. The total trends of B2M and sTNF RII basically remained stable. HIV P24 antigen remained undetectable in 6, remained detectably low level in 1 and experienced increase in 1 of 8 patients after malariotherapy. No any severe complications occurred in all 8 patients. Conclusions. The results indicate that malariotherapy basically is safe for HIV infection and it seems that the therapy improves some immunological parameters of HIV patients.展开更多
文摘Objective. To determine whether malariotherapy (an old therapy for treatment of neurosyphilis) improves some clinical and laboratory parameters of HIV positive patients without iatrogenic complications. Methods. Total 8 asymptomatic HIV 1 positive subjects whose CD4 cell counts were over 250×10 6 cells/L were selected for the phase 1 studies of malariotherapy and were intravenously injected Plasmodia vivax to induce artificial malaria. Malaria was terminated with chloroquine after 10～20 malarial fever episodes. Cell bound CD4 levels were measured by APAAP (a solid phase enzyme essay) and levels of neopterin (NPT), beta 2 microglobulin (B2M), soluble tumor necrosis factor receptor 2(sTNF RII), interleukin 2(IL 2) and HIV P24 antigen were measured by ELISA. Patients were followed up to 24～30 months. Results.CD4 levels increased in 5, NPT decreased in 7 of 8 patients; IL 2 increased in 5 of 6 patients after malariotherapy. The total trends of B2M and sTNF RII basically remained stable. HIV P24 antigen remained undetectable in 6, remained detectably low level in 1 and experienced increase in 1 of 8 patients after malariotherapy. No any severe complications occurred in all 8 patients. Conclusions. The results indicate that malariotherapy basically is safe for HIV infection and it seems that the therapy improves some immunological parameters of HIV patients.
