慢性萎缩性胃炎(chronic atrophic gastritis, CAG)是一种十分常见的消化系统疾病,其发病率高,具有癌变风险。CAG的发病机制复杂,尚未十分明确,以根除Hp、抑酸护胃为主要方式的西医治疗对于改善症状有一定疗效,但难以逆转病理进程。近年...慢性萎缩性胃炎(chronic atrophic gastritis, CAG)是一种十分常见的消化系统疾病,其发病率高,具有癌变风险。CAG的发病机制复杂,尚未十分明确,以根除Hp、抑酸护胃为主要方式的西医治疗对于改善症状有一定疗效,但难以逆转病理进程。近年来,大量研究表明,中医药治疗以辨证论治为基础,可通过多途径、多靶点调控细胞凋亡、抑制胃黏膜异常增生、减轻炎症等,从而延缓或逆转CAG病理进程,表现出其独特的优势。磷脂酰肌醇3-激酶/蛋白激酶B (phosphatidylinositol 3-kinase/protein kinase B, PI3K/AKT)信号通路与CAG的发生发展密切相关,中医药可通过调控PI3K/AKT信号通路减轻胃黏膜炎症、调节细胞凋亡等,促进胃黏膜修复,阻断癌变。目前缺乏对中医药调控PI3K/AKT信号通路干预CAG的系统性阐述,因此,本文就近年来中医药调控PI3K/AKT信号通路干预CAG的相关研究进行综述,以期为CAG的基础研究与新药研发提供理论依据。Chronic atrophic gastritis (CAG) is a very common digestive system disease with a high incidence and a risk of canceration. The pathogenesis of CAG is complex and not very clear. Western medicine treatment with Hp eradication, acid suppression and stomach protection as the main methods has a certain effect on improving symptoms, but it is difficult to reverse the pathological process. In recent years, a large number of studies have shown that traditional Chinese medicine treatment is based on syndrome differentiation and treatment. It can regulate apoptosis, inhibit abnormal hyperplasia of gastric mucosa and reduce inflammation through multiple pathways and multiple targets, thus delaying or reversing the pathological process of CAG, showing its unique advantages. Phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) signaling pathway is closely related to the occurrence and development of CAG. Traditional Chinese medicine can reduce gastric mucosal inflammation and regulate apoptosis by regulating PI3K/AKT signaling pathway, promote gastric mucosal repair and block carcinogenesis. At present, there is a lack of systematic elaboration on the intervention of CAG by TCM regulating PI3K/AKT signaling pathway. Therefore, this paper reviews the related research on the intervention of CAG by TCM regulating PI3K/AKT signaling pathway in recent years, in order to provide theoretical basis for the basic research and new drug development of CAG.展开更多
文摘慢性萎缩性胃炎(chronic atrophic gastritis, CAG)是一种十分常见的消化系统疾病,其发病率高,具有癌变风险。CAG的发病机制复杂,尚未十分明确,以根除Hp、抑酸护胃为主要方式的西医治疗对于改善症状有一定疗效,但难以逆转病理进程。近年来,大量研究表明,中医药治疗以辨证论治为基础,可通过多途径、多靶点调控细胞凋亡、抑制胃黏膜异常增生、减轻炎症等,从而延缓或逆转CAG病理进程,表现出其独特的优势。磷脂酰肌醇3-激酶/蛋白激酶B (phosphatidylinositol 3-kinase/protein kinase B, PI3K/AKT)信号通路与CAG的发生发展密切相关,中医药可通过调控PI3K/AKT信号通路减轻胃黏膜炎症、调节细胞凋亡等,促进胃黏膜修复,阻断癌变。目前缺乏对中医药调控PI3K/AKT信号通路干预CAG的系统性阐述,因此,本文就近年来中医药调控PI3K/AKT信号通路干预CAG的相关研究进行综述,以期为CAG的基础研究与新药研发提供理论依据。Chronic atrophic gastritis (CAG) is a very common digestive system disease with a high incidence and a risk of canceration. The pathogenesis of CAG is complex and not very clear. Western medicine treatment with Hp eradication, acid suppression and stomach protection as the main methods has a certain effect on improving symptoms, but it is difficult to reverse the pathological process. In recent years, a large number of studies have shown that traditional Chinese medicine treatment is based on syndrome differentiation and treatment. It can regulate apoptosis, inhibit abnormal hyperplasia of gastric mucosa and reduce inflammation through multiple pathways and multiple targets, thus delaying or reversing the pathological process of CAG, showing its unique advantages. Phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) signaling pathway is closely related to the occurrence and development of CAG. Traditional Chinese medicine can reduce gastric mucosal inflammation and regulate apoptosis by regulating PI3K/AKT signaling pathway, promote gastric mucosal repair and block carcinogenesis. At present, there is a lack of systematic elaboration on the intervention of CAG by TCM regulating PI3K/AKT signaling pathway. Therefore, this paper reviews the related research on the intervention of CAG by TCM regulating PI3K/AKT signaling pathway in recent years, in order to provide theoretical basis for the basic research and new drug development of CAG.
