Mathematical models of propellers were created that investigate the influence of periodic boundary conditions on predictions of a propeller's performance.Thrust and torque coefficients corresponding to different a...Mathematical models of propellers were created that investigate the influence of periodic boundary conditions on predictions of a propeller's performance.Thrust and torque coefficients corresponding to different advance coefficients of DTMB 4119, 4382, and 4384 propellers were calculated.The pressure coefficient distribution of the DTMB 4119 propeller at different sections was also physically tested.Comparisons indicated good agreement between the results of experiments and the simulation.It showed that the periodic boundary condition can be used to rationally predict the open water performance of a propeller.By analyzing the three established modes for the computation, it was shown that using the spline curve method to divide the grids can meet the calculation's demands for precision better than using the rake cutting method.展开更多
CIN85 （Cbl-interacting protein of 85 kDa） is an important molecule involved in receptor tyrosine kinase endocytosis. Here we report that through its positively charged C-terminus, CIN85 associates with a fusogenic l...CIN85 （Cbl-interacting protein of 85 kDa） is an important molecule involved in receptor tyrosine kinase endocytosis. Here we report that through its positively charged C-terminus, CIN85 associates with a fusogenic lipid - phosphatidic acid. Its coiled-coil domain plays an important role in mediating this protein-lipid interaction. Deletion of the coiled-coil domain results in loss of membrane association, and reduced interaction with c-cbl, finally causing the blockage of epidermal growth factor receptor downregulation. In addition, a significant portion of CIN85 is located on the endosomal compartment and is related to endocytic cargo sorting, characterized by CIN85＇s localization on the ＂E class＂ compartment and EGF degradation blockage in CIN85 knockdown cells. Taken together, our results suggest that CIN85 may function as a scaffold molecule in both the internalization and endocytic cargo sorting processes through its association with the endosomal membrane.展开更多
In this paper, an efficient multigrid fictitious boundary method （MFBM） coupled with the FEM solver package FEATFLOW was used for the detailed simulation of incompressible viscous flows around one or more moving NAC...In this paper, an efficient multigrid fictitious boundary method （MFBM） coupled with the FEM solver package FEATFLOW was used for the detailed simulation of incompressible viscous flows around one or more moving NACA0012 airfoils. The calculations were carded on a fixed multigrid finite element mesh on which fluid equations were satisfied everywhere, and the airfoils were allowed to move freely through the mesh. The MFBM was employed to treat interactions between the fluid and the airfoils The motion of the airfoils was modeled by Newton-Euler equations. Numerical results of experiments verify that this method provides an efficient way to simulate incompressible viscous flows around moving airfoils.展开更多
Microstructure and hydrological profiles were collected along two cross-shelf sections from the deep slope to the shallow water in the north of Taiwan Island in the summer of 2006.While the tidal currents on the shelf...Microstructure and hydrological profiles were collected along two cross-shelf sections from the deep slope to the shallow water in the north of Taiwan Island in the summer of 2006.While the tidal currents on the shelf were dominated by the barotropic tide with the current ellipse stretched across the shelf,significant internal tides were observed on the slope.The depth-mean turbulent kinetic energy(TKE)dissipation rate on the shelf was 10^-6W kg^-1,corresponding to a diapycnal diffusivity of 10^-2 m^2s^-1.The depth-mean TKE dissipation rate on the slope was 1×10^-7 Wkg^-1,with diapycnal diffusivity of 3×10^-4m^2s^-1.The shear instability associated with internal tides largely contributed to the TKE dissipation rate on the slope from the surface to 150 m,while the enhanced turbulence on the shelf was dominated by tidal or residual current dissipations caused by friction in the thick bottom boundary layer(BBL).In the BBL,the Ekman currents associated with the northeastward Taiwan Warm Current were identified,showing a near-bottom velocity spiral,which agreed well with the analytical bottom Ekman solution.展开更多
A new version of the scalar transverse electric(TE) wave equation in the bent waveguide is introduced. Then, TE polarized field in curved single-mode waveguides is analyzed by using the finite-difference beam propagat...A new version of the scalar transverse electric(TE) wave equation in the bent waveguide is introduced. Then, TE polarized field in curved single-mode waveguides is analyzed by using the finite-difference beam propagation method(FD-BPM). The bending loss in bent waveguides is gotten for the optical fields obtained from BPM and comparisons are made among losses of the waveguides with various curvature radiuses, refractive index differences and cross sections. Based on the results, the design of spiral bent waveguide configuration is proposed as follows: refractive index difference being of 0.007, both width and thickness of waveguides being of 6 μm, the curvature radius in the spiral centre being of 4 mm, and the bending loss coefficient of the designed spiral bent waveguide being of 0.302 3 dB/cm.展开更多
基金supported by National Nature Science Foundation of China under Grant(10671128)the Key Project of Chinese Ministry of Education(211059)+1 种基金Innovation Program of Shanghai Municipal Education Commission(11zz123)National Education Foundation of China Grand(2009312711004)
基金Supported by the National Natural Science Foundation of China under Grant No.10702016
文摘Mathematical models of propellers were created that investigate the influence of periodic boundary conditions on predictions of a propeller's performance.Thrust and torque coefficients corresponding to different advance coefficients of DTMB 4119, 4382, and 4384 propellers were calculated.The pressure coefficient distribution of the DTMB 4119 propeller at different sections was also physically tested.Comparisons indicated good agreement between the results of experiments and the simulation.It showed that the periodic boundary condition can be used to rationally predict the open water performance of a propeller.By analyzing the three established modes for the computation, it was shown that using the spline curve method to divide the grids can meet the calculation's demands for precision better than using the rake cutting method.
文摘CIN85 （Cbl-interacting protein of 85 kDa） is an important molecule involved in receptor tyrosine kinase endocytosis. Here we report that through its positively charged C-terminus, CIN85 associates with a fusogenic lipid - phosphatidic acid. Its coiled-coil domain plays an important role in mediating this protein-lipid interaction. Deletion of the coiled-coil domain results in loss of membrane association, and reduced interaction with c-cbl, finally causing the blockage of epidermal growth factor receptor downregulation. In addition, a significant portion of CIN85 is located on the endosomal compartment and is related to endocytic cargo sorting, characterized by CIN85＇s localization on the ＂E class＂ compartment and EGF degradation blockage in CIN85 knockdown cells. Taken together, our results suggest that CIN85 may function as a scaffold molecule in both the internalization and endocytic cargo sorting processes through its association with the endosomal membrane.
基金Supported by National 863 Plan Project of Ministry of Science and Technology of China under Grant No. 2006AA09Z354National Natural Science Foundation of China under Grant No. 10672101.
文摘In this paper, an efficient multigrid fictitious boundary method （MFBM） coupled with the FEM solver package FEATFLOW was used for the detailed simulation of incompressible viscous flows around one or more moving NACA0012 airfoils. The calculations were carded on a fixed multigrid finite element mesh on which fluid equations were satisfied everywhere, and the airfoils were allowed to move freely through the mesh. The MFBM was employed to treat interactions between the fluid and the airfoils The motion of the airfoils was modeled by Newton-Euler equations. Numerical results of experiments verify that this method provides an efficient way to simulate incompressible viscous flows around moving airfoils.
基金sponsored by the National Basic Research Program of China (Ministry of Science and Technology)granted by the National Natural Science Foundation of China (Grant Nos. 41306003 and 41430963)+2 种基金the Fundamental Research Funds for the Central Universities (Grant Nos. 0905-841313038, 1100841262028 and 0905-201462003)the China Postdoctoral Science Foundation (Grant No. 2013M531647)the Natural Science Foundation of Shandong (Grant No. BS2013HZ015)
文摘Microstructure and hydrological profiles were collected along two cross-shelf sections from the deep slope to the shallow water in the north of Taiwan Island in the summer of 2006.While the tidal currents on the shelf were dominated by the barotropic tide with the current ellipse stretched across the shelf,significant internal tides were observed on the slope.The depth-mean turbulent kinetic energy(TKE)dissipation rate on the shelf was 10^-6W kg^-1,corresponding to a diapycnal diffusivity of 10^-2 m^2s^-1.The depth-mean TKE dissipation rate on the slope was 1×10^-7 Wkg^-1,with diapycnal diffusivity of 3×10^-4m^2s^-1.The shear instability associated with internal tides largely contributed to the TKE dissipation rate on the slope from the surface to 150 m,while the enhanced turbulence on the shelf was dominated by tidal or residual current dissipations caused by friction in the thick bottom boundary layer(BBL).In the BBL,the Ekman currents associated with the northeastward Taiwan Warm Current were identified,showing a near-bottom velocity spiral,which agreed well with the analytical bottom Ekman solution.
文摘A new version of the scalar transverse electric(TE) wave equation in the bent waveguide is introduced. Then, TE polarized field in curved single-mode waveguides is analyzed by using the finite-difference beam propagation method(FD-BPM). The bending loss in bent waveguides is gotten for the optical fields obtained from BPM and comparisons are made among losses of the waveguides with various curvature radiuses, refractive index differences and cross sections. Based on the results, the design of spiral bent waveguide configuration is proposed as follows: refractive index difference being of 0.007, both width and thickness of waveguides being of 6 μm, the curvature radius in the spiral centre being of 4 mm, and the bending loss coefficient of the designed spiral bent waveguide being of 0.302 3 dB/cm.
