The authors describe the use of photodynamic therapy with verteporfin for subfoveal choroidal neovascular membrane secondary to optic nerve drusen. A 28- year-old woman had a peripapillary choroidal neovascular membra...The authors describe the use of photodynamic therapy with verteporfin for subfoveal choroidal neovascular membrane secondary to optic nerve drusen. A 28- year-old woman had a peripapillary choroidal neovascular membrane secondary to optic nerve drusen with significant metamorphopsia. Photodynamic therapy using verteporfin was performed. Visual acuity improved to 20/20 with resolution of metamorphopsia and absence of leakage on fluorescein angiography a few weeks after verteporfin therapy. The patient’ s condition remained stable for 16 months with 20/20 vision. Photodynamic therapy with verteporfin may be a useful treatment option in patients with choroidal neovascularmembranes secondary to optic nerve drusen.展开更多
Purpose: To investigate the frequency and clinical features of polypoidal chor oidal vasculopathy (PCV) in a consecutive series of elderly Chinese patients. Me thods: A restrospective analysis of 166 consecutive patie...Purpose: To investigate the frequency and clinical features of polypoidal chor oidal vasculopathy (PCV) in a consecutive series of elderly Chinese patients. Me thods: A restrospective analysis of 166 consecutive patients 50 years or older w ith diagnosis of exudative age-related macular degeneration (AMD) was conducted . Color fundus photographs were taken and fluorescein and indocyanine green (ICG ) angiography were performed in all patients. Results: Of the 166 patients, 37 p atients (22.3%) initially suspected of having exudative AMD were ultimately dia gnosed as having PCV. Twenty-seven men (73.0%) were affected, 32 patients (86. 5%) were unilaterally involved. Of 42 eyes with PCV, 27 eyes (64.3%) demonstra ted polypoidal dilations with branching vascular network, and the other 15 eyes (35.7%) showed scattered polypoidal dilations without identifiable continuous b ranching vascular network on ICG angiography. The predominant location for these lesions was at the macular region in 26 eyes (61.9%), the temporal vascular ar cade in 9 eyes (21.4%), the peripapillary area in 6 eyes (14.3%), and the midp eriphery in 1 eye (2.4%). Conclusions: PCV is a common disease in elderly Chine se patients. In our study group PCV mainly affected men and was mostly unilatera l. Most of the lesions were located in the macular region and temporal vascular arcade.展开更多
Background and Purpose Cerebral autosomal dominant arteriopathy with subcort ical infarcts and leukoencephalopathy (CADASIL) is a progressive systemic nonath erosclerotic angiopathy which causes ischemic strokes and v...Background and Purpose Cerebral autosomal dominant arteriopathy with subcort ical infarcts and leukoencephalopathy (CADASIL) is a progressive systemic nonath erosclerotic angiopathy which causes ischemic strokes and vascular subcortical d ementia. A cross sectional study was performed to examine the retinal vascular caliber and blood flow in CADASIL. Methods Scanning laser Doppler flowmetry wa s used in a case control study (11 patients and controls) of peripapillary reti nal circulation. Automated full field perfusion image analysis was used to anal yze the flow data. Retinal vessel calibers were measured from retinal images acq uired with scanning laser ophthalmoscopy. The caliber of the superior and inferi or temporal retinal artery and vein were measured 1 and 2 mm from the disc rim, and the mean values were used for analysis. Results Retinal capillary peak sys tolic flow (mean, 249 versus 311 arbitrary unit [AU]; P=0.072) was lower, and mean capillary flow (mean, 184 versus 224 AU; P= 0.12) and minimum diastolic flow (mean, 105 versus 132 AU; P=0.16) tended to be lower in patients than in controls. No significant difference in the calibers of proximal retinal arteries (mean, 104 versus108 μm) and veins (mean, 150 versus 145 μm) was found between the patients and controls. Conclusions -Retinal cap illary blood flow is mild to moderately reduced in CADASIL but that does not app ear to cause major ischemic injury. Such reduction is analogous to that in the c erebral cortex in CADASIL patients with which retina appears to share its relati ve sparing from severe arterial ischemic tissue damage.展开更多
文摘The authors describe the use of photodynamic therapy with verteporfin for subfoveal choroidal neovascular membrane secondary to optic nerve drusen. A 28- year-old woman had a peripapillary choroidal neovascular membrane secondary to optic nerve drusen with significant metamorphopsia. Photodynamic therapy using verteporfin was performed. Visual acuity improved to 20/20 with resolution of metamorphopsia and absence of leakage on fluorescein angiography a few weeks after verteporfin therapy. The patient’ s condition remained stable for 16 months with 20/20 vision. Photodynamic therapy with verteporfin may be a useful treatment option in patients with choroidal neovascularmembranes secondary to optic nerve drusen.
文摘Purpose: To investigate the frequency and clinical features of polypoidal chor oidal vasculopathy (PCV) in a consecutive series of elderly Chinese patients. Me thods: A restrospective analysis of 166 consecutive patients 50 years or older w ith diagnosis of exudative age-related macular degeneration (AMD) was conducted . Color fundus photographs were taken and fluorescein and indocyanine green (ICG ) angiography were performed in all patients. Results: Of the 166 patients, 37 p atients (22.3%) initially suspected of having exudative AMD were ultimately dia gnosed as having PCV. Twenty-seven men (73.0%) were affected, 32 patients (86. 5%) were unilaterally involved. Of 42 eyes with PCV, 27 eyes (64.3%) demonstra ted polypoidal dilations with branching vascular network, and the other 15 eyes (35.7%) showed scattered polypoidal dilations without identifiable continuous b ranching vascular network on ICG angiography. The predominant location for these lesions was at the macular region in 26 eyes (61.9%), the temporal vascular ar cade in 9 eyes (21.4%), the peripapillary area in 6 eyes (14.3%), and the midp eriphery in 1 eye (2.4%). Conclusions: PCV is a common disease in elderly Chine se patients. In our study group PCV mainly affected men and was mostly unilatera l. Most of the lesions were located in the macular region and temporal vascular arcade.
文摘Background and Purpose Cerebral autosomal dominant arteriopathy with subcort ical infarcts and leukoencephalopathy (CADASIL) is a progressive systemic nonath erosclerotic angiopathy which causes ischemic strokes and vascular subcortical d ementia. A cross sectional study was performed to examine the retinal vascular caliber and blood flow in CADASIL. Methods Scanning laser Doppler flowmetry wa s used in a case control study (11 patients and controls) of peripapillary reti nal circulation. Automated full field perfusion image analysis was used to anal yze the flow data. Retinal vessel calibers were measured from retinal images acq uired with scanning laser ophthalmoscopy. The caliber of the superior and inferi or temporal retinal artery and vein were measured 1 and 2 mm from the disc rim, and the mean values were used for analysis. Results Retinal capillary peak sys tolic flow (mean, 249 versus 311 arbitrary unit [AU]; P=0.072) was lower, and mean capillary flow (mean, 184 versus 224 AU; P= 0.12) and minimum diastolic flow (mean, 105 versus 132 AU; P=0.16) tended to be lower in patients than in controls. No significant difference in the calibers of proximal retinal arteries (mean, 104 versus108 μm) and veins (mean, 150 versus 145 μm) was found between the patients and controls. Conclusions -Retinal cap illary blood flow is mild to moderately reduced in CADASIL but that does not app ear to cause major ischemic injury. Such reduction is analogous to that in the c erebral cortex in CADASIL patients with which retina appears to share its relati ve sparing from severe arterial ischemic tissue damage.
