背景:既往研究表明,中老年人体内组织蛋白酶K水平可通过影响骨密度来干预骨质疏松的发生和发展,但组织蛋白酶家族与其他人群骨密度之间是否存在因果关系仍未知。目的:探讨组织蛋白酶与骨密度的因果关系。方法:从IEU Open GWAS数据库提取...背景:既往研究表明,中老年人体内组织蛋白酶K水平可通过影响骨密度来干预骨质疏松的发生和发展,但组织蛋白酶家族与其他人群骨密度之间是否存在因果关系仍未知。目的:探讨组织蛋白酶与骨密度的因果关系。方法:从IEU Open GWAS数据库提取与8种组织蛋白酶相关的遗传位点作为工具变量,以5个年龄段人群的骨密度作为结局。通过双向孟德尔随机化分析,评估组织蛋白酶与骨密度的因果关系。使用Cochran’s Q检验评估遗传工具变量的异质性,使用MR-Egger截距检验评估多效性,使用留一法评估作为工具变量的单核苷酸多态性对暴露和结局因果关系影响的敏感性。结果与结论:①正向孟德尔随机化的逆方差加权法结果显示,组织蛋白酶H与>45岁且≤60岁人群的骨密度呈负相关[OR(95%CI)=0.965(0.94-0.99),P=0.04],组织蛋白酶Z与>30岁且≤45岁人群的骨密度呈负相关[OR(95%CI)=1.06(1.00-1.11),P=0.03];②敏感性分析结果显示因果关系稳定,MR-Egger截距分析未检测到潜在的水平多效性;③反向孟德尔随机化结果显示,骨密度对组织蛋白酶无显著反向作用;④上述结果证实,组织蛋白酶对部分年龄段人群骨密度会造成影响,可能会增加骨质疏松症的发病风险,应给予更多关注。展开更多
目的:本研究旨在探讨未接受抗骨质疏松治疗的绝经后女性中,瘦体重(Lean Mass, LM)和脂肪量(Fat Mass, FM)对腰椎体积骨密度(Lumbar Spine vBMD)的相对贡献,以期为骨质疏松症的早期诊断和干预提供科学依据。方法:本研究纳入113名绝经后女...目的:本研究旨在探讨未接受抗骨质疏松治疗的绝经后女性中,瘦体重(Lean Mass, LM)和脂肪量(Fat Mass, FM)对腰椎体积骨密度(Lumbar Spine vBMD)的相对贡献,以期为骨质疏松症的早期诊断和干预提供科学依据。方法:本研究纳入113名绝经后女性(平均年龄63.81 ± 7.34岁),通过双能X线吸收测定法(DXA)评估身体成分(包括LM、FM及其指数),并通过定量CT (QCT)测定腰椎L1~L3的平均骨密度。采用Pearson相关性分析和多重线性回归分析,探讨身体成分参数与腰椎体积骨密度之间的关系。结果:研究发现腰椎体积骨密度与年龄、绝经年限呈显著负相关(p 0.05)。此外,随着骨密度的降低,LM和LMI均显著下降,而FM及其相关指数在三组(正常组、骨质减少组和骨质疏松组)之间无显著差异。结论:瘦体重(LM)是绝经后女性腰椎体积骨密度的重要预测指标。鼓励包括体育活动在内的有利于增强骨骼健康和LM的生活方式,对预防骨质疏松症或肌肉减少症等疾病是十分必要的。Objective: This study aimed to investigate the relative contributions of lean mass (LM) and fat mass (FM) to lumbar spine volumetric bone mineral density (vBMD) in postmenopausal women without anti-osteoporotic treatment, providing scientific evidence for the early diagnosis and intervention of osteoporosis. Methods: A total of 113 postmenopausal women (mean age: 63.81 ± 7.34 years) were included in the study. Body composition parameters, including LM, FM, and their respective indices, were assessed using dual-energy X-ray absorptiometry (DXA). Additionally, the average bone mineral density of the lumbar spine (L1-L3) was measured using quantitative computed tomography (QCT). Pearson correlation analysis and multiple regression analysis were performed to explore the relationships between body composition parameters and lumbar spine vBMD. Results: Lumbar spine vBMD was significantly negatively correlated with age and years since menopause (p 0.05). Additionally, LM and LMI decreased significantly with lower vBMD, while FM and its related indices did not differ significantly among the three groups (normal, osteopenia, and osteoporosis). Conclusion: Lean mass (LM) is a crucial predictor of lumbar spine vBMD in postmenopausal women. It is necessary to encourage lifestyles, including sports activities, which are beneficial for enhancing bone health and lean mass, in order to prevent diseases such as osteoporosis or sarcopenia.展开更多
目的探究脂质生物标志物与骨密度的相关性。方法利用2007—2010年NHANES数据库的横断面数据,通过筛选共纳入了3213名参与者,获取其全股骨、股骨颈和腰椎的骨密度(bone mineral density,BMD),以及脂质生物标志物,包括三酰甘油(triglyceri...目的探究脂质生物标志物与骨密度的相关性。方法利用2007—2010年NHANES数据库的横断面数据,通过筛选共纳入了3213名参与者,获取其全股骨、股骨颈和腰椎的骨密度(bone mineral density,BMD),以及脂质生物标志物,包括三酰甘油(triglycerides,TG)、总胆固醇(total cholesterol,TC)、高密度脂蛋白(high-density lipoprotein,HDL)和低密度脂蛋白(low-density lipoprotein,LDL)等数据。采用多元线性回归模型和平滑曲线拟合,校正年龄、性别、种族、体质指数、实验室指标和生活方式等混杂因素,探讨脂质生物标志物与BMD之间的相关性。此外,通过进行亚组分析以评估结果的稳健性。结果经完全调整协变量后,TG、HDL与总股骨、股骨颈、腰椎BMD均无明显相关性(P>0.05)。TC与股骨颈、腰椎BMD呈负相关[股骨颈:β=-0.0001,95%CI(-0.0002~-0.0000),P=0.030;腰椎:β=-0.0002,95%CI(-0.0004~-0.0001),P<0.001]。LDL与总股骨BMD无明显相关性,而与股骨颈、腰椎BMD呈负相关[股骨颈:β=-0.0001,95%CI(-0.0003~-0.0000),P=0.019;腰椎:β=-0.0003,95%CI(-0.0004~-0.0001),P<0.001]。亚组分析结果显示,经完全调整协变量后,在女性[β=-0.0002,95%CI(-0.0004~-0.0000),P=0.017]和非西班牙白人[β=-0.0003,95%CI(-0.0004~-0.0001),P=0.006]中,TC与腰椎BMD之间的负相关更为显著;而LDL与腰椎BMD的负相关关系在男性[β=-0.0003,95%CI(-0.0005~-0.0001),P=0.012]和非西班牙白人[β=-0.0003,95%CI(-0.0005~-0.0001),P=0.005]更为显著。采用平滑曲线拟合解决TC、LDL与腰椎BMD之间的非线性关系,结果显示TC、LDL与腰椎骨密度均呈线性负相关。在女性分组中,平滑曲线拟合结果提示TC与腰椎骨密度之间为非线性关系,存在1个拐点,使用二分段线性回归模型分析显示拐点是180 mg/dL。结论TC、LDL与股骨颈、腰椎BMD均呈负相关关系。相较于TG、HDL,TC、LDL可能是识别骨质疏松症的潜在脂质生物标志物。展开更多
文摘背景:既往研究表明,中老年人体内组织蛋白酶K水平可通过影响骨密度来干预骨质疏松的发生和发展,但组织蛋白酶家族与其他人群骨密度之间是否存在因果关系仍未知。目的:探讨组织蛋白酶与骨密度的因果关系。方法:从IEU Open GWAS数据库提取与8种组织蛋白酶相关的遗传位点作为工具变量,以5个年龄段人群的骨密度作为结局。通过双向孟德尔随机化分析,评估组织蛋白酶与骨密度的因果关系。使用Cochran’s Q检验评估遗传工具变量的异质性,使用MR-Egger截距检验评估多效性,使用留一法评估作为工具变量的单核苷酸多态性对暴露和结局因果关系影响的敏感性。结果与结论:①正向孟德尔随机化的逆方差加权法结果显示,组织蛋白酶H与>45岁且≤60岁人群的骨密度呈负相关[OR(95%CI)=0.965(0.94-0.99),P=0.04],组织蛋白酶Z与>30岁且≤45岁人群的骨密度呈负相关[OR(95%CI)=1.06(1.00-1.11),P=0.03];②敏感性分析结果显示因果关系稳定,MR-Egger截距分析未检测到潜在的水平多效性;③反向孟德尔随机化结果显示,骨密度对组织蛋白酶无显著反向作用;④上述结果证实,组织蛋白酶对部分年龄段人群骨密度会造成影响,可能会增加骨质疏松症的发病风险,应给予更多关注。
文摘目的:本研究旨在探讨未接受抗骨质疏松治疗的绝经后女性中,瘦体重(Lean Mass, LM)和脂肪量(Fat Mass, FM)对腰椎体积骨密度(Lumbar Spine vBMD)的相对贡献,以期为骨质疏松症的早期诊断和干预提供科学依据。方法:本研究纳入113名绝经后女性(平均年龄63.81 ± 7.34岁),通过双能X线吸收测定法(DXA)评估身体成分(包括LM、FM及其指数),并通过定量CT (QCT)测定腰椎L1~L3的平均骨密度。采用Pearson相关性分析和多重线性回归分析,探讨身体成分参数与腰椎体积骨密度之间的关系。结果:研究发现腰椎体积骨密度与年龄、绝经年限呈显著负相关(p 0.05)。此外,随着骨密度的降低,LM和LMI均显著下降,而FM及其相关指数在三组(正常组、骨质减少组和骨质疏松组)之间无显著差异。结论:瘦体重(LM)是绝经后女性腰椎体积骨密度的重要预测指标。鼓励包括体育活动在内的有利于增强骨骼健康和LM的生活方式,对预防骨质疏松症或肌肉减少症等疾病是十分必要的。Objective: This study aimed to investigate the relative contributions of lean mass (LM) and fat mass (FM) to lumbar spine volumetric bone mineral density (vBMD) in postmenopausal women without anti-osteoporotic treatment, providing scientific evidence for the early diagnosis and intervention of osteoporosis. Methods: A total of 113 postmenopausal women (mean age: 63.81 ± 7.34 years) were included in the study. Body composition parameters, including LM, FM, and their respective indices, were assessed using dual-energy X-ray absorptiometry (DXA). Additionally, the average bone mineral density of the lumbar spine (L1-L3) was measured using quantitative computed tomography (QCT). Pearson correlation analysis and multiple regression analysis were performed to explore the relationships between body composition parameters and lumbar spine vBMD. Results: Lumbar spine vBMD was significantly negatively correlated with age and years since menopause (p 0.05). Additionally, LM and LMI decreased significantly with lower vBMD, while FM and its related indices did not differ significantly among the three groups (normal, osteopenia, and osteoporosis). Conclusion: Lean mass (LM) is a crucial predictor of lumbar spine vBMD in postmenopausal women. It is necessary to encourage lifestyles, including sports activities, which are beneficial for enhancing bone health and lean mass, in order to prevent diseases such as osteoporosis or sarcopenia.
