骨原发性非霍奇金淋巴瘤（primary non—Hodgkin’s lymphoma of bone）是一类发生于骨髓而无区域淋巴结及内脏受侵的少见骨肿瘤，其发病率仅占全部恶性淋巴瘤的1％～2％，占全部淋巴结以外淋巴瘤的3％-5％，好发部位依次为下肢长骨及...骨原发性非霍奇金淋巴瘤（primary non—Hodgkin’s lymphoma of bone）是一类发生于骨髓而无区域淋巴结及内脏受侵的少见骨肿瘤，其发病率仅占全部恶性淋巴瘤的1％～2％，占全部淋巴结以外淋巴瘤的3％-5％，好发部位依次为下肢长骨及骨盆（50％）、上肢长骨（20％）、脊柱、肋骨等。颅骨作为首发部位的病例非常罕见，1983年国外学者报道了第一例颅骨原发性非霍奇金淋巴瘤。展开更多
An association between chronic hepatitis C virus （HCV） infection and essential mixed cryoglobulinaemia and non-Hodgkin lymphoma （NHL） has been suggested. However, a causative role of HCV in these conditions has no...An association between chronic hepatitis C virus （HCV） infection and essential mixed cryoglobulinaemia and non-Hodgkin lymphoma （NHL） has been suggested. However, a causative role of HCV in these conditions has not been established. The authors report a case of a 50 year-old woman with chronic hepatitis C （CHC） who has been fol- lowed up since 1998 due to a high viral load, genotype lb and moderately elevated liver function tests （LFTs）. Laboratory data and liver biopsy revealed moderate activity （grade： 5/18, stage： 1/6）. In April 1999, one-year interferon therapy was started. HCV-RNA became negative with normalization of LFTs. However, the patient relapsed during treatment. In September 2002, the patient was admitted for chronic back pain. ACT examination demonstrated degenerative changes. In March 2003, multiple myeloma was diagnosed （IgG-kappa, bone marrow biopsy： 50% plasma cell infiltration）. MRI revealed a compression fracture of the 5^th lumbar vertebral body and an abdominal mass in the right lower quadrant, infiltrating the canalis spinalis. Treatment with vincristine, adriamycin and dexamethasone （VAD） was started and bisphosphonate was administered regularly. In January 2004, after six cycles of VAD therapy, the multiple myeloma regressed. Thalidomide, as a second line treatment of refractory multiple myeloma （MM） was initiated, and followed by peginterferon-α2b and ribavirin against the HCV infection in June. In June 2005, LFTs returned to normal, while HCV-RNA was negative, demonstrating an end of treatment response. Although a pathogenic role of HCV infection in malignant lymphoproliferative disorders has not been established, NHL and possibly MM may develop in CHC patients, supporting a role of a complex follow-up in these patients.展开更多
文摘骨原发性非霍奇金淋巴瘤（primary non—Hodgkin’s lymphoma of bone）是一类发生于骨髓而无区域淋巴结及内脏受侵的少见骨肿瘤，其发病率仅占全部恶性淋巴瘤的1％～2％，占全部淋巴结以外淋巴瘤的3％-5％，好发部位依次为下肢长骨及骨盆（50％）、上肢长骨（20％）、脊柱、肋骨等。颅骨作为首发部位的病例非常罕见，1983年国外学者报道了第一例颅骨原发性非霍奇金淋巴瘤。
文摘An association between chronic hepatitis C virus （HCV） infection and essential mixed cryoglobulinaemia and non-Hodgkin lymphoma （NHL） has been suggested. However, a causative role of HCV in these conditions has not been established. The authors report a case of a 50 year-old woman with chronic hepatitis C （CHC） who has been fol- lowed up since 1998 due to a high viral load, genotype lb and moderately elevated liver function tests （LFTs）. Laboratory data and liver biopsy revealed moderate activity （grade： 5/18, stage： 1/6）. In April 1999, one-year interferon therapy was started. HCV-RNA became negative with normalization of LFTs. However, the patient relapsed during treatment. In September 2002, the patient was admitted for chronic back pain. ACT examination demonstrated degenerative changes. In March 2003, multiple myeloma was diagnosed （IgG-kappa, bone marrow biopsy： 50% plasma cell infiltration）. MRI revealed a compression fracture of the 5^th lumbar vertebral body and an abdominal mass in the right lower quadrant, infiltrating the canalis spinalis. Treatment with vincristine, adriamycin and dexamethasone （VAD） was started and bisphosphonate was administered regularly. In January 2004, after six cycles of VAD therapy, the multiple myeloma regressed. Thalidomide, as a second line treatment of refractory multiple myeloma （MM） was initiated, and followed by peginterferon-α2b and ribavirin against the HCV infection in June. In June 2005, LFTs returned to normal, while HCV-RNA was negative, demonstrating an end of treatment response. Although a pathogenic role of HCV infection in malignant lymphoproliferative disorders has not been established, NHL and possibly MM may develop in CHC patients, supporting a role of a complex follow-up in these patients.
