新生儿Fc受体(neonatal Fc receptor,FcRn)通过与免疫球蛋G(immunoglobulin G,IgG)结合,延长其半衰期并促进再循环,是维持血清IgG稳态的重要受体。然而,致病性IgG的异常积累与多种神经免疫性疾病的发生密切相关。FcRn拮抗剂通过阻断FcRn...新生儿Fc受体(neonatal Fc receptor,FcRn)通过与免疫球蛋G(immunoglobulin G,IgG)结合,延长其半衰期并促进再循环,是维持血清IgG稳态的重要受体。然而,致病性IgG的异常积累与多种神经免疫性疾病的发生密切相关。FcRn拮抗剂通过阻断FcRn与IgG的结合,可显著降低致病性IgG水平,从而有效地缓解相关疾病的临床症状。FcRn拮抗剂作为一种新兴的靶向治疗药物,展示了其治疗IgG介导的神经免疫性疾病的潜力。本文对FcRn拮抗剂的作用机制、种类和临床研究进展进行总结,以期为IgG介导的神经免疫性疾病的精准治疗提供新思路。未来的研究应重点关注药物的长期安全性、适应证拓展及个体化治疗策略,以进一步提升其临床应用价值。展开更多
Based on the minimum settling time （MST） theory and step-response analysis of the second order system in active switched capacitor （SC） networks, a novel clock feedthrough frequency compensation （CFFC） method fo...Based on the minimum settling time （MST） theory and step-response analysis of the second order system in active switched capacitor （SC） networks, a novel clock feedthrough frequency compensation （CFFC） method for a folded-cascode OTA is proposed. The damping factor r/is adjusted by using MOS capacitors to introduce clock feedthrough so that the OTA can obtain the MST state and thus achieve fast settling. Research results indicate that the settling time of the compensated OTA is reduced by 22.7% ;as the capacitor load varies from 0.5 to 2.5pF,the improved settling time increases approximately linearly from 3.62 to 4.46ns： for VGA application, fast settling can also be achieved by modifying the MOS capacitor value accordingly when the closed loop gain of the compensated OTA varies.展开更多
A new configuration of Bulk-Driven Folded-Cascode (BDFC) amplifier is presented in this paper. Due to this modifying, significant improvement in differential DC-Gain (more than 11 dB) is achieved in compare to the con...A new configuration of Bulk-Driven Folded-Cascode (BDFC) amplifier is presented in this paper. Due to this modifying, significant improvement in differential DC-Gain (more than 11 dB) is achieved in compare to the conventional structure. Settling behavior of proposed amplifier is also improved and accuracy more than 8 bit for 500 mV voltage swing is obtained. Simulation results using HSPICE Environment are included which validate the theoretical analysis. The amplifier is designed using standard 0.18 μm CMOS triple-well (level 49) process with supply voltage of 1.2 V. The correct functionality of this configuration is verified from –50℃ to 100℃.展开更多
文摘新生儿Fc受体(neonatal Fc receptor,FcRn)通过与免疫球蛋G(immunoglobulin G,IgG)结合,延长其半衰期并促进再循环,是维持血清IgG稳态的重要受体。然而,致病性IgG的异常积累与多种神经免疫性疾病的发生密切相关。FcRn拮抗剂通过阻断FcRn与IgG的结合,可显著降低致病性IgG水平,从而有效地缓解相关疾病的临床症状。FcRn拮抗剂作为一种新兴的靶向治疗药物,展示了其治疗IgG介导的神经免疫性疾病的潜力。本文对FcRn拮抗剂的作用机制、种类和临床研究进展进行总结,以期为IgG介导的神经免疫性疾病的精准治疗提供新思路。未来的研究应重点关注药物的长期安全性、适应证拓展及个体化治疗策略,以进一步提升其临床应用价值。
文摘Based on the minimum settling time （MST） theory and step-response analysis of the second order system in active switched capacitor （SC） networks, a novel clock feedthrough frequency compensation （CFFC） method for a folded-cascode OTA is proposed. The damping factor r/is adjusted by using MOS capacitors to introduce clock feedthrough so that the OTA can obtain the MST state and thus achieve fast settling. Research results indicate that the settling time of the compensated OTA is reduced by 22.7% ;as the capacitor load varies from 0.5 to 2.5pF,the improved settling time increases approximately linearly from 3.62 to 4.46ns： for VGA application, fast settling can also be achieved by modifying the MOS capacitor value accordingly when the closed loop gain of the compensated OTA varies.
文摘A new configuration of Bulk-Driven Folded-Cascode (BDFC) amplifier is presented in this paper. Due to this modifying, significant improvement in differential DC-Gain (more than 11 dB) is achieved in compare to the conventional structure. Settling behavior of proposed amplifier is also improved and accuracy more than 8 bit for 500 mV voltage swing is obtained. Simulation results using HSPICE Environment are included which validate the theoretical analysis. The amplifier is designed using standard 0.18 μm CMOS triple-well (level 49) process with supply voltage of 1.2 V. The correct functionality of this configuration is verified from –50℃ to 100℃.
