AIM To evaluate the clinical and radiographic results of patients with complicated infectious spondylitis treated with single-stage anterior debridement and reconstruction using tantalum mesh cage(TaMC) followed by im...AIM To evaluate the clinical and radiographic results of patients with complicated infectious spondylitis treated with single-stage anterior debridement and reconstruction using tantalum mesh cage(TaMC) followed by immediate instrumentation.METHODS Single-stage radical debridement and subsequent reconstruction with TaMC instead of autograft or allograft were performed to treat 20 patients with spinal deformity or instability due to complicated infectious spondylitis. Clinical outcomes were assessed by careful physical examination and regular serological tests to determine the infection control. In addition, the visual analog score(VAS), neurologic status, length of vertebral body reconstruction, and the correction of sagittal Cobb angle on radiography were recorded and compared before and after surgery. The conditions of the patients were evaluated based on the modified Brodsky's criteria.RESULTS The average VAS score significantly decreased after the surgery(from 7.4 ± 0.8 to 3.3 ± 0.8, P < 0.001). The average Cobb angle correction was 14.9 degrees. The neurologic status was significantly improved after the surgery(P = 0.003). One patient experienced refractory infection and underwent additional debridement. Eighteen patients achieved good outcome based on the modified Brodsky's criteria and significant improvement after the surgery(P < 0.001). No implant breakage orTaMC dislodgement was found during at least 24 mo of follow-up.CONCLUSION Single-stage anterior debridement and reconstruction with TaMC followed by immediate instrumentation could be an alternative method to manage the patients with spinal deformity or instability due to complicated infectious spondylitis.展开更多
Objective To explore the application of scalp rotation flap in reconstruction of infectious scalp defect with titanium mesh exposure. Methods Twelve patients were treated in this group including 4 males and 8 female. ...Objective To explore the application of scalp rotation flap in reconstruction of infectious scalp defect with titanium mesh exposure. Methods Twelve patients were treated in this group including 4 males and 8 female. S The defective size ranged from 2. 0 cm × 5. 0 cm to 0.展开更多
In light of the rising evidence of the association between viral and bacterial infections and neurodegeneration,we aimed at revisiting the infectious hypothesis of Alzheimer’s disease and analyzing the possible impli...In light of the rising evidence of the association between viral and bacterial infections and neurodegeneration,we aimed at revisiting the infectious hypothesis of Alzheimer’s disease and analyzing the possible implications of COVID-19 neurological sequelae in long-term neurodegeneration.We wondered how SARS-CoV-2 could be related to the amyloid-βcascade and how it could lead to the pathological hallmarks of the disease.We also predict a paradigm change in clinical medicine,which now has a great opportunity to conduct prospective surveillance of cognitive sequelae and progression to dementia in people who suffered severe infections together with other risk factors for Alzheimer’s disease.展开更多
Neurological symptoms of COVID-19 infection can be lethal if optimum intervention is not provided at the right time.However,it is extremely important to distinguish the non-specific symptoms of COVID-19 according to i...Neurological symptoms of COVID-19 infection can be lethal if optimum intervention is not provided at the right time.However,it is extremely important to distinguish the non-specific symptoms of COVID-19 according to its severity directly or indirectly caused by the coronavirus.Here,we present five radiological case studies of COVID-19 to highlight the wide array of neurological manifestations associated with COVID-19.展开更多
高迁移率族蛋白B1(High mobility group protein box 1,HMGB1)是一种多功能核内蛋白,在所有哺乳动物细胞中广泛表达,可调节DNA复制和基因转录,参与细胞自噬反应。释放在胞外的HMGB1可参与炎症反应和免疫应答。研究发现,HMGB1与许多儿科...高迁移率族蛋白B1(High mobility group protein box 1,HMGB1)是一种多功能核内蛋白,在所有哺乳动物细胞中广泛表达,可调节DNA复制和基因转录,参与细胞自噬反应。释放在胞外的HMGB1可参与炎症反应和免疫应答。研究发现,HMGB1与许多儿科疾病的发生发展有关。本文将对近年来HMGB1在感染性疾病、恶性肿瘤、缺氧缺血性疾病、神经系统疾病、自身免疫性疾病等儿科疾病中的研究进展进行综述。展开更多
International Journal of Molecular Medical Science(IJMMS,ISSN 1927-6656)is an international,open access,peer reviewed journal,independently published by Editorial Team based the Bio Publisher Platform,committed to ser...International Journal of Molecular Medical Science(IJMMS,ISSN 1927-6656)is an international,open access,peer reviewed journal,independently published by Editorial Team based the Bio Publisher Platform,committed to serve for medical sciences and clinical practice research.IJMMS publishes scientific articles like original research articles,case reports,review articles,editorials,short communications and correspondence of the high quality pertinent to all aspects of human biology and pathophysiology.All papers chosen展开更多
International Journal of Molecular Medical Science(IJMMS,ISSN 1927-6656)is an international,open access,peer reviewed journal,independently published by Editorial Team based the Bio Publisher Platform,committed to ser...International Journal of Molecular Medical Science(IJMMS,ISSN 1927-6656)is an international,open access,peer reviewed journal,independently published by Editorial Team based the Bio Publisher Platform,committed to serve for medical sciences and clinical practice research.IJMMS publishes scientific articles like original research articles,case reports,review articles,editorials,short communications and correspondence of the展开更多
International Journal of Molecular Medical Science(IJMMS,ISSN 1927-6656)is an international,open access,peer reviewed journal,independently published by Editorial Team based the Bio Publisher Platform,committed to ser...International Journal of Molecular Medical Science(IJMMS,ISSN 1927-6656)is an international,open access,peer reviewed journal,independently published by Editorial Team based the Bio Publisher Platform,committed to serve for medical sciences and clinical practice research.IJMMS publishes scientific articles like original research articles,case reports,review articles,editorials,short communications and correspondence of the high quality pertinent to all aspects of human biology and pathophysiology.All papers chosen展开更多
文摘AIM To evaluate the clinical and radiographic results of patients with complicated infectious spondylitis treated with single-stage anterior debridement and reconstruction using tantalum mesh cage(TaMC) followed by immediate instrumentation.METHODS Single-stage radical debridement and subsequent reconstruction with TaMC instead of autograft or allograft were performed to treat 20 patients with spinal deformity or instability due to complicated infectious spondylitis. Clinical outcomes were assessed by careful physical examination and regular serological tests to determine the infection control. In addition, the visual analog score(VAS), neurologic status, length of vertebral body reconstruction, and the correction of sagittal Cobb angle on radiography were recorded and compared before and after surgery. The conditions of the patients were evaluated based on the modified Brodsky's criteria.RESULTS The average VAS score significantly decreased after the surgery(from 7.4 ± 0.8 to 3.3 ± 0.8, P < 0.001). The average Cobb angle correction was 14.9 degrees. The neurologic status was significantly improved after the surgery(P = 0.003). One patient experienced refractory infection and underwent additional debridement. Eighteen patients achieved good outcome based on the modified Brodsky's criteria and significant improvement after the surgery(P < 0.001). No implant breakage orTaMC dislodgement was found during at least 24 mo of follow-up.CONCLUSION Single-stage anterior debridement and reconstruction with TaMC followed by immediate instrumentation could be an alternative method to manage the patients with spinal deformity or instability due to complicated infectious spondylitis.
文摘Objective To explore the application of scalp rotation flap in reconstruction of infectious scalp defect with titanium mesh exposure. Methods Twelve patients were treated in this group including 4 males and 8 female. S The defective size ranged from 2. 0 cm × 5. 0 cm to 0.
基金supported by grants to DD from Agencia Nacional de Promoción de la Investigación,el desarrollo tecnológico y la innovación(ANPCyT,PICT N°03893).
文摘In light of the rising evidence of the association between viral and bacterial infections and neurodegeneration,we aimed at revisiting the infectious hypothesis of Alzheimer’s disease and analyzing the possible implications of COVID-19 neurological sequelae in long-term neurodegeneration.We wondered how SARS-CoV-2 could be related to the amyloid-βcascade and how it could lead to the pathological hallmarks of the disease.We also predict a paradigm change in clinical medicine,which now has a great opportunity to conduct prospective surveillance of cognitive sequelae and progression to dementia in people who suffered severe infections together with other risk factors for Alzheimer’s disease.
文摘Neurological symptoms of COVID-19 infection can be lethal if optimum intervention is not provided at the right time.However,it is extremely important to distinguish the non-specific symptoms of COVID-19 according to its severity directly or indirectly caused by the coronavirus.Here,we present five radiological case studies of COVID-19 to highlight the wide array of neurological manifestations associated with COVID-19.
文摘高迁移率族蛋白B1(High mobility group protein box 1,HMGB1)是一种多功能核内蛋白,在所有哺乳动物细胞中广泛表达,可调节DNA复制和基因转录,参与细胞自噬反应。释放在胞外的HMGB1可参与炎症反应和免疫应答。研究发现,HMGB1与许多儿科疾病的发生发展有关。本文将对近年来HMGB1在感染性疾病、恶性肿瘤、缺氧缺血性疾病、神经系统疾病、自身免疫性疾病等儿科疾病中的研究进展进行综述。
文摘International Journal of Molecular Medical Science(IJMMS,ISSN 1927-6656)is an international,open access,peer reviewed journal,independently published by Editorial Team based the Bio Publisher Platform,committed to serve for medical sciences and clinical practice research.IJMMS publishes scientific articles like original research articles,case reports,review articles,editorials,short communications and correspondence of the high quality pertinent to all aspects of human biology and pathophysiology.All papers chosen
文摘International Journal of Molecular Medical Science(IJMMS,ISSN 1927-6656)is an international,open access,peer reviewed journal,independently published by Editorial Team based the Bio Publisher Platform,committed to serve for medical sciences and clinical practice research.IJMMS publishes scientific articles like original research articles,case reports,review articles,editorials,short communications and correspondence of the
文摘International Journal of Molecular Medical Science(IJMMS,ISSN 1927-6656)is an international,open access,peer reviewed journal,independently published by Editorial Team based the Bio Publisher Platform,committed to serve for medical sciences and clinical practice research.IJMMS publishes scientific articles like original research articles,case reports,review articles,editorials,short communications and correspondence of the high quality pertinent to all aspects of human biology and pathophysiology.All papers chosen
