Objective: to explore the application of life test and routine test in the diagnosis of diabetes. Methods: 100 patients suspected of diabetic diseases were selected for biochemical test and routine test, and the resul...Objective: to explore the application of life test and routine test in the diagnosis of diabetes. Methods: 100 patients suspected of diabetic diseases were selected for biochemical test and routine test, and the results were compared. Results: compared with routine test, biochemical test has higher sensitivity, specificity and accuracy with significant difference (P<0.05). Conclusion: biochemical test has more clinical value in the diagnosis of diabetes.展开更多
Objective: to compare and analyze the value of routine urine detection and biochemical detection in the diagnosis of clinical diabetes mellitus. Methods: from the patients with diabetes admitted to our hospital from J...Objective: to compare and analyze the value of routine urine detection and biochemical detection in the diagnosis of clinical diabetes mellitus. Methods: from the patients with diabetes admitted to our hospital from January 2021 to May 2021, 120 cases with complete data and relatively coordinated were selected for the study. Patients were randomly divided into 2 groups with 60 cases in each group according to blind selection method. Among them, patients receiving routine urine test were named as the control group, and patients receiving biochemical test were named as the observation group. Through the analysis of the indicators of the two groups of patients, with reference to the diagnosis results, to compare the diagnostic accuracy. Results: the diagnostic accuracy of observation group was significantly higher than control group, the difference was statistically significant (P < 0.05). Conclusion: in the clinical diagnosis of diabetes, biochemical detection is more accurate than routine urine detection, and can reflect the degree of pathological changes of patients through cholesterol, fasting blood glucose and other indicators, providing reliable basis for the development of follow-up treatment measures, and can be used as the first clinical choice.展开更多
Objective: to analyze the application value of routine blood test for iron deficiency anemia. Methods: 50 patients with iron deficiency anemia admitted from January 2020 to December 2020 were selected for routine bloo...Objective: to analyze the application value of routine blood test for iron deficiency anemia. Methods: 50 patients with iron deficiency anemia admitted from January 2020 to December 2020 were selected for routine blood test. The patient was judged based on the test results. At the same time, 50 normal patients who underwent physical examination in our hospital at the same time were selected as controls to take the same test to compare the routine blood test results of the two groups. Results: there were statistical differences between RBC, Hb, MCV, MCH, MCHC, RDW levels and the normal population in patients with iron deficiency anemia (P <0.05). Hb for iron deficiency anemia was (73.24 ± 10.12) (g / L), Hb (138.21 ± 9.41) (g / L) (P <0.05), RBC (3.01 ± 0.82) (1012 / L), RBC for healthy people (4.61 ± 0.35) (1012 / L) (P <0.05), MCV (64.12 ± 2.62) (fl) and MCV (89.12 ± 3.21) (fl) (P <0.05).RDW for iron deficiency anemia was (15.91 ± 1.31) (%), RDW was (12.21 ± 1.64) (%) (P <0.05), MCH was (21.21 ± 2.31) (pg), MCH was (32.21 ± 2.21) (pg) (P <0.05), MCHC was (297.12 ± 26.21) (g / L), and MCHC was (342.12 ± 16.21) (g / L) (P <0.05).Conclusion: routine blood test for patients with iron deficiency anemia can provide the basis for the disease judgment and facilitate the early diagnosis and treatment of the disease.展开更多
Objective: this study focuses on the main causes and solutions of the routine blood test. Methods: in this study, 120 patients with the error in the routine blood test results from March 2020 to March 2021 were random...Objective: this study focuses on the main causes and solutions of the routine blood test. Methods: in this study, 120 patients with the error in the routine blood test results from March 2020 to March 2021 were randomly selected as the study subjects, and the clinical data of all the study subjects were analyzed retrospectively. All patients received 2mL blood collection from peripheral blood and 14ml of venous blood. The venous blood samples were divided into 7 groups, among which group 1 was tested immediately after collection, groups 2 and 3 were stored in refrigerator (4℃) and room temperature, groups 4 and 4 hours respectively, group 6 and 7 were treated with 1.6 mg/ml and 2.8 mg/ml anticoagulant respectively. Peripheral blood needs to be tested immediately. The root causes of common errors are summarized, and the influence of different blood collection location, placement time and anticoagulant concentration on the routine blood test indicators is discussed, and the corresponding solutions are summarized. Results: the results of this study showed that platelet content in peripheral blood samples was significantly lower than venous blood, with significantly different data between groups (P <0.05). Blood samples were retained for 2 hours after collection, the hemoglobin concentration and platelet content were lower than the 4-hour retained samples, and the data differences between groups were significant (P <0.05).Blood samples were stored in the refrigerator, the hemoglobin concentration was lower than those stored at room temperature, and there were significant differences between groups (P <0.05).After the blood samples were treated with 2.8 mg/ml anticoagulant concentration, the content of each index was significantly higher than that treated with 1.6 mg/ml, and the data between the two groups varied significantly (P <0.05).Among the routine blood tests, 120 subjects had the error in the routine blood test indicators, including the unreasonable anticoagulant concentration, long inspection time, unreasonable storage and personal factors of the subjects. Conclusion: in the routine blood test, many factors resulted in the test error. The hospital should clarify the main influencing factors, improve the efficiency and quality of routine blood test by strengthening the training of relevant personnel, actively communicating with the subjects, and making reasonable use of anticoagulant, reducing the probability of error, and provide reliable support for the clinical diagnosis and treatment of doctors.展开更多
Objective: to study and analyze the application effect of different blood collection methods in routine blood tests.Methods: the study subjects were mainly 130 patients receiving routine blood test between January and...Objective: to study and analyze the application effect of different blood collection methods in routine blood tests.Methods: the study subjects were mainly 130 patients receiving routine blood test between January and June 2021. All patients were randomly divided into two groups, 65 in each group. The specific test results of the two groups were analyzed.Results: the effect of venous blood collection is more accurate and can be considered.Conclusion: in clinical aspects, routine blood test adopts intravenous blood sampling, less possibility of cross-infection, small test error, test results and more accurate, which can provide more reliable test data. Such blood collection method can be considered in clinical aspects.展开更多
[Objectives]This study was conducted to analyze effects of antimicrobial peptides added to the diet of Tan sheep on their production, slaughter performance and blood composition. [Methods] Ninety two four-month-old Ta...[Objectives]This study was conducted to analyze effects of antimicrobial peptides added to the diet of Tan sheep on their production, slaughter performance and blood composition. [Methods] Ninety two four-month-old Tan sheep were randomly divided into two treatment groups according to their body weight, 46 in each group. The control check group(CK) was feed with conventional diet, and the experimental group was fed with the addition of antimicrobial peptide on the basis of the conventional diet, with the added amount of 2.5 g/sheep per day. The experimental period was 60 d. [Results] The incidence rate was 75.06% lower in the experimental group than in the CK. The average daily weight gain per sheep was 11.27% higher in the experimental group than in the CK(P<0.05). The feed conversion ratio was 8.45% lower in the experimental group than in the CK(P<0.05). The average daily gross profit per sheep was 12.12% higher in the experimental group than in the CK. For slaughter performance, the data difference of each item was not significant. The PH at 45 min and 24 h after slaughter was within the normal range of fresh mutton. The cooked meat percentage and water loss rate showed no significant differences(P>0.05). The marbling ranged from 2.45 to 2.50, indicating that the fat content was moderate, and the difference between groups was not significant(P>0.05). The flesh color ranged from 3.00 to 3.15, between light red and bright red, belonging to the normal color of mutton, and the difference between groups was not significant(P>0.05). The shear force was between 2.50 and 2.65, without a significant difference between groups(P>0.05). The white blood cells, lymphocytes and platelets in the experimental group were lower than those in the CK(P<0.01). The erythrocytes and hemoglobin in the erythrocyte group were higher than those in the CK(P<0.05). The neutrophils and monocytes in the experimental group were lower than those in the CK(P<0.05). [Conclusions] This study provides a technical basis for the rational use of antimicrobial peptides and their application in ruminants.展开更多
Objective: to discuss the clinical value of new hemolysin and traditional hemolysin in blood routine examination. Methods: a total of 89 blood routine test subjects were selected from our hospital. The average control...Objective: to discuss the clinical value of new hemolysin and traditional hemolysin in blood routine examination. Methods: a total of 89 blood routine test subjects were selected from our hospital. The average control group (45 cases, using traditional hemolysin) and the study group (44 cases, using new hemolysin) were compared. Results: there were no statistically significant differences in the levels of red blood cells, white blood cells and platelets between the two groups (P > 0.05). The level of hemoglobin and satisfaction score in the study group were significantly higher than those in the control group (P < 0.05). The test time and cost in the study group were significantly lower than those in the control group (P < 0.05). Conclusion: the new hemolysin has more application value in routine blood test.展开更多
By modifying the salicylic-acid moiety with electron-withdrawing or –donating groups, three new terbium complexes（LⅠ·Tb, LⅡ·Tb, L·（Ⅲ）Tb） based on tripodal carboxylate ligands were synthesized. D...By modifying the salicylic-acid moiety with electron-withdrawing or –donating groups, three new terbium complexes（LⅠ·Tb, LⅡ·Tb, L·（Ⅲ）Tb） based on tripodal carboxylate ligands were synthesized. Due to different pull-push electronic effects of ligands, the fluorescence intensities of these terbium complexes significantly varied, that is： LⅡ·Tb 〉L（Ⅲ）·Tb〉 LⅠ·Tb. Meanwhile, the characteristic peaks at 492 nm（5D4→7F6） and 547 nm（5 D4→7F5） showed ＂Off–On–Off＂ fluorescence response to various p H conditions,which indicated that all of them can be used as the highly sensitive pH fluorescent probes. Notably, using LⅡ·Tb with the best fluorescence performance as a probe, some patients＇ urine samples can be easily monitored through the response triggered by pH value. Therefore, LⅡ·Tb has the potential to auxiliarily diagnose some diseases in clinical practice through p H detection of routine urine test.展开更多
Hypercoagulation is not detected in clinical practice with routinely performed blood coagulation tests. More advanced laboratory analyses to detect or monitor hypercoagulation have not yet been introduced into routine...Hypercoagulation is not detected in clinical practice with routinely performed blood coagulation tests. More advanced laboratory analyses to detect or monitor hypercoagulation have not yet been introduced into routine clinical management. Thromboelastography assesses the influence of plasma factors and platelets during all phases of haemostasis, thus permits evaluation of hypo- and hyper- coagulation status. This prospective study included assessment of 35 patients with thrombotic complications （II-nd group）, compared with 34 healthy controls （I-st group）. Haemostasis was analyzed with routine clotting tests： protrombin time （PT）, activated partial thromboplastin time （APTT）, fibrinogen, platelets and rotation thromboelastography （ROTEM~） with measuring time to 20 min. All data are presented as mean and standard deviation （SD）. Statistical comparisons of samples were performed by student＇s t-test. The sensitivity, specificity, positive and negative predictive value of the parameters was calculated by using the receiver operator characteristic （ROC） curves for two groups. There was significant difference （P 〈 0.05） observed in the parameters of ROTEM： clot formation time （CFT）, a-angle, maximum clot firmness （MCF） and thrombodynamic potential index （TPI） in the patient＇s population compared to the healthy controls. No significant difference was observed in CT （ROTEM） and routine coagulation tests when the two groups were compared. Rotation thromboelastography analysis demonstrated to be a reliable method for diagnosis of hypercoagulable state.展开更多
We present in this work how to use the dura palm kernel shell powders as loads for the elaboration by extrusion of PVC tubes. The transformation of dura palm kernel shells into micronized shell powder as well as its c...We present in this work how to use the dura palm kernel shell powders as loads for the elaboration by extrusion of PVC tubes. The transformation of dura palm kernel shells into micronized shell powder as well as its characterization was the subject of recent work. We carried out, the formulations by using the industrial scales of precision, the mixtures of the instrants with an industrial machine of mark HENSHLLE N˚2 MAIN 570762, the routine tests by ATG/DSC then by IRTF, the extrusion of the tubes with an extruder twin-screw with 9 rooms of transformation finally the tests of conformity by the observations and the analyses. We obtained for the formulations the dosage of 0%, 4.01%, 12.54%, 23.03%, 32.01%, 38.01%, 51.02% representing the percentage of hull powder in the mixture, the machine mixing gave perfectly homogeneous powders, the routine tests showed that the hull powder keeps all its properties until the end of the shaping whatever the percentage of hulls contained in the PVC, the extrusion gave tubes for each formulation and the conformity tests gave perfectly round tubes of diameter 90 × 82 mm, a coloration going from white grey at 0% to dark black at 51.02% showing the influence of the carbon black and the color of the shell powder according to its proportion. The infrared of the tubes obtained shows for each formulation a variation of the CH<sub>2</sub> and CH bonds and a decrease of the −OH bonds. The thermogravimetric analyses and the differential calorimetric analyses of the tubes of each formulation, show each time that the quantity of shell powders in the mixture influences the PVC tubes obtained. Thus, we obtain a variation of the phase temperatures according to the dosage, giving from 108.72<span style="white-space:normal;">˚</span>C to 76.56<span style="white-space:normal;">˚</span>C for the glass transition temperature and from 494.71<span style="white-space:normal;">˚</span>C to 414.56<span style="white-space:normal;">˚</span>C for the melting temperature, at the DSC and a progressive decrease of the mass following the heat absorption with each time 4 phases instead of 5 for the unloaded PVC tubes at the ATG according to the dosage.展开更多
OBJECTIVE:To reach consensus on the diagnostic criteria of syndrome of dampness obstruction in idiopathic membranous nephropathy(IMN)patients by literature research and expert investigation(interviews and a Delphi met...OBJECTIVE:To reach consensus on the diagnostic criteria of syndrome of dampness obstruction in idiopathic membranous nephropathy(IMN)patients by literature research and expert investigation(interviews and a Delphi method).METHODS:Our study was consistent with T/CACM 1336-2020.We searched the monographs and references published in the past 40 years(1983-2022),and established the diagnostic criteria pool of waterdampness syndrome and dampness-turbidity syndrome in Traditional Chinese Medicine(TCM)based on literature by using frequency statistics and correlation analysis.Expert investigation(interview method and two rounds of Delphi method)was used to form the diagnostic criteria of water-dampness syndrome and dampnessturbidity syndrome of idiopathic membranous nephropathy.Clinical diagnostic test research was carried out,and compared with“Diagnostic Criteria for dampness syndrome”(T/CACM 1454-2023)to evaluate the authenticity,reliability and clinical application value of the standard.RESULTS:A total of 122 relevant guides,standards,monographs and documents were included through searching books and Chinese databases.Four experts were interviewed and two rounds of delphi method(75 experts nationwide)were carried out.The experts'opinions are relatively concentrated and the differences are small.Based on the weight of each index,the diagnostic criteria indexes of water-dampness syndrome and dampness-turbidity syndrome were selected.After discussion by the core group members,the diagnostic model of"necessary symptoms and optional symptoms"was established,and the final diagnostic criteria of waterdampness syndrome and dampness-turbidity syndrome were established.One hundred and ninety-one inpatients and outpatients of Guangdong Provincial Hospital of Chinese Medicine from January 2021 to February 2023 were included in Diagnostic test study.There was no statistical difference in gender,age and course of disease(P>0.05).The sensitivity and specificity of the trial standard were 90.34%and 73.33%respectively,while the sensitivity and specificity of T/CACM 1454-2023 were 99.43%and 6.67%,respectively.CONCLUSIONS:The consensus-based diagnostic criteria for IMN can be widely incorporated in TCM.A further clinical study will be conducted to analyze the diagnosis value and cut-off score of our IMN criteria.展开更多
文摘Objective: to explore the application of life test and routine test in the diagnosis of diabetes. Methods: 100 patients suspected of diabetic diseases were selected for biochemical test and routine test, and the results were compared. Results: compared with routine test, biochemical test has higher sensitivity, specificity and accuracy with significant difference (P<0.05). Conclusion: biochemical test has more clinical value in the diagnosis of diabetes.
文摘Objective: to compare and analyze the value of routine urine detection and biochemical detection in the diagnosis of clinical diabetes mellitus. Methods: from the patients with diabetes admitted to our hospital from January 2021 to May 2021, 120 cases with complete data and relatively coordinated were selected for the study. Patients were randomly divided into 2 groups with 60 cases in each group according to blind selection method. Among them, patients receiving routine urine test were named as the control group, and patients receiving biochemical test were named as the observation group. Through the analysis of the indicators of the two groups of patients, with reference to the diagnosis results, to compare the diagnostic accuracy. Results: the diagnostic accuracy of observation group was significantly higher than control group, the difference was statistically significant (P < 0.05). Conclusion: in the clinical diagnosis of diabetes, biochemical detection is more accurate than routine urine detection, and can reflect the degree of pathological changes of patients through cholesterol, fasting blood glucose and other indicators, providing reliable basis for the development of follow-up treatment measures, and can be used as the first clinical choice.
文摘Objective: to analyze the application value of routine blood test for iron deficiency anemia. Methods: 50 patients with iron deficiency anemia admitted from January 2020 to December 2020 were selected for routine blood test. The patient was judged based on the test results. At the same time, 50 normal patients who underwent physical examination in our hospital at the same time were selected as controls to take the same test to compare the routine blood test results of the two groups. Results: there were statistical differences between RBC, Hb, MCV, MCH, MCHC, RDW levels and the normal population in patients with iron deficiency anemia (P <0.05). Hb for iron deficiency anemia was (73.24 ± 10.12) (g / L), Hb (138.21 ± 9.41) (g / L) (P <0.05), RBC (3.01 ± 0.82) (1012 / L), RBC for healthy people (4.61 ± 0.35) (1012 / L) (P <0.05), MCV (64.12 ± 2.62) (fl) and MCV (89.12 ± 3.21) (fl) (P <0.05).RDW for iron deficiency anemia was (15.91 ± 1.31) (%), RDW was (12.21 ± 1.64) (%) (P <0.05), MCH was (21.21 ± 2.31) (pg), MCH was (32.21 ± 2.21) (pg) (P <0.05), MCHC was (297.12 ± 26.21) (g / L), and MCHC was (342.12 ± 16.21) (g / L) (P <0.05).Conclusion: routine blood test for patients with iron deficiency anemia can provide the basis for the disease judgment and facilitate the early diagnosis and treatment of the disease.
文摘Objective: this study focuses on the main causes and solutions of the routine blood test. Methods: in this study, 120 patients with the error in the routine blood test results from March 2020 to March 2021 were randomly selected as the study subjects, and the clinical data of all the study subjects were analyzed retrospectively. All patients received 2mL blood collection from peripheral blood and 14ml of venous blood. The venous blood samples were divided into 7 groups, among which group 1 was tested immediately after collection, groups 2 and 3 were stored in refrigerator (4℃) and room temperature, groups 4 and 4 hours respectively, group 6 and 7 were treated with 1.6 mg/ml and 2.8 mg/ml anticoagulant respectively. Peripheral blood needs to be tested immediately. The root causes of common errors are summarized, and the influence of different blood collection location, placement time and anticoagulant concentration on the routine blood test indicators is discussed, and the corresponding solutions are summarized. Results: the results of this study showed that platelet content in peripheral blood samples was significantly lower than venous blood, with significantly different data between groups (P <0.05). Blood samples were retained for 2 hours after collection, the hemoglobin concentration and platelet content were lower than the 4-hour retained samples, and the data differences between groups were significant (P <0.05).Blood samples were stored in the refrigerator, the hemoglobin concentration was lower than those stored at room temperature, and there were significant differences between groups (P <0.05).After the blood samples were treated with 2.8 mg/ml anticoagulant concentration, the content of each index was significantly higher than that treated with 1.6 mg/ml, and the data between the two groups varied significantly (P <0.05).Among the routine blood tests, 120 subjects had the error in the routine blood test indicators, including the unreasonable anticoagulant concentration, long inspection time, unreasonable storage and personal factors of the subjects. Conclusion: in the routine blood test, many factors resulted in the test error. The hospital should clarify the main influencing factors, improve the efficiency and quality of routine blood test by strengthening the training of relevant personnel, actively communicating with the subjects, and making reasonable use of anticoagulant, reducing the probability of error, and provide reliable support for the clinical diagnosis and treatment of doctors.
文摘Objective: to study and analyze the application effect of different blood collection methods in routine blood tests.Methods: the study subjects were mainly 130 patients receiving routine blood test between January and June 2021. All patients were randomly divided into two groups, 65 in each group. The specific test results of the two groups were analyzed.Results: the effect of venous blood collection is more accurate and can be considered.Conclusion: in clinical aspects, routine blood test adopts intravenous blood sampling, less possibility of cross-infection, small test error, test results and more accurate, which can provide more reliable test data. Such blood collection method can be considered in clinical aspects.
基金Supported by Ningxia Agricultural Reclamation Group Science and Technology Innovation ProjectNew Feed Technology Promotion Project of Ningxia Agriculture and Rural DepartmentNingxia Feed Industry Expert Technical Service Group Project。
文摘[Objectives]This study was conducted to analyze effects of antimicrobial peptides added to the diet of Tan sheep on their production, slaughter performance and blood composition. [Methods] Ninety two four-month-old Tan sheep were randomly divided into two treatment groups according to their body weight, 46 in each group. The control check group(CK) was feed with conventional diet, and the experimental group was fed with the addition of antimicrobial peptide on the basis of the conventional diet, with the added amount of 2.5 g/sheep per day. The experimental period was 60 d. [Results] The incidence rate was 75.06% lower in the experimental group than in the CK. The average daily weight gain per sheep was 11.27% higher in the experimental group than in the CK(P<0.05). The feed conversion ratio was 8.45% lower in the experimental group than in the CK(P<0.05). The average daily gross profit per sheep was 12.12% higher in the experimental group than in the CK. For slaughter performance, the data difference of each item was not significant. The PH at 45 min and 24 h after slaughter was within the normal range of fresh mutton. The cooked meat percentage and water loss rate showed no significant differences(P>0.05). The marbling ranged from 2.45 to 2.50, indicating that the fat content was moderate, and the difference between groups was not significant(P>0.05). The flesh color ranged from 3.00 to 3.15, between light red and bright red, belonging to the normal color of mutton, and the difference between groups was not significant(P>0.05). The shear force was between 2.50 and 2.65, without a significant difference between groups(P>0.05). The white blood cells, lymphocytes and platelets in the experimental group were lower than those in the CK(P<0.01). The erythrocytes and hemoglobin in the erythrocyte group were higher than those in the CK(P<0.05). The neutrophils and monocytes in the experimental group were lower than those in the CK(P<0.05). [Conclusions] This study provides a technical basis for the rational use of antimicrobial peptides and their application in ruminants.
文摘Objective: to discuss the clinical value of new hemolysin and traditional hemolysin in blood routine examination. Methods: a total of 89 blood routine test subjects were selected from our hospital. The average control group (45 cases, using traditional hemolysin) and the study group (44 cases, using new hemolysin) were compared. Results: there were no statistically significant differences in the levels of red blood cells, white blood cells and platelets between the two groups (P > 0.05). The level of hemoglobin and satisfaction score in the study group were significantly higher than those in the control group (P < 0.05). The test time and cost in the study group were significantly lower than those in the control group (P < 0.05). Conclusion: the new hemolysin has more application value in routine blood test.
基金supported by the National Natural Science Foundation of China (Nos. 21572091 and 21472075)the Fundamental Research Funds for the Central Universities (No. lzujbky-2016-51) by Ministry of Education of China
文摘By modifying the salicylic-acid moiety with electron-withdrawing or –donating groups, three new terbium complexes（LⅠ·Tb, LⅡ·Tb, L·（Ⅲ）Tb） based on tripodal carboxylate ligands were synthesized. Due to different pull-push electronic effects of ligands, the fluorescence intensities of these terbium complexes significantly varied, that is： LⅡ·Tb 〉L（Ⅲ）·Tb〉 LⅠ·Tb. Meanwhile, the characteristic peaks at 492 nm（5D4→7F6） and 547 nm（5 D4→7F5） showed ＂Off–On–Off＂ fluorescence response to various p H conditions,which indicated that all of them can be used as the highly sensitive pH fluorescent probes. Notably, using LⅡ·Tb with the best fluorescence performance as a probe, some patients＇ urine samples can be easily monitored through the response triggered by pH value. Therefore, LⅡ·Tb has the potential to auxiliarily diagnose some diseases in clinical practice through p H detection of routine urine test.
文摘Hypercoagulation is not detected in clinical practice with routinely performed blood coagulation tests. More advanced laboratory analyses to detect or monitor hypercoagulation have not yet been introduced into routine clinical management. Thromboelastography assesses the influence of plasma factors and platelets during all phases of haemostasis, thus permits evaluation of hypo- and hyper- coagulation status. This prospective study included assessment of 35 patients with thrombotic complications （II-nd group）, compared with 34 healthy controls （I-st group）. Haemostasis was analyzed with routine clotting tests： protrombin time （PT）, activated partial thromboplastin time （APTT）, fibrinogen, platelets and rotation thromboelastography （ROTEM~） with measuring time to 20 min. All data are presented as mean and standard deviation （SD）. Statistical comparisons of samples were performed by student＇s t-test. The sensitivity, specificity, positive and negative predictive value of the parameters was calculated by using the receiver operator characteristic （ROC） curves for two groups. There was significant difference （P 〈 0.05） observed in the parameters of ROTEM： clot formation time （CFT）, a-angle, maximum clot firmness （MCF） and thrombodynamic potential index （TPI） in the patient＇s population compared to the healthy controls. No significant difference was observed in CT （ROTEM） and routine coagulation tests when the two groups were compared. Rotation thromboelastography analysis demonstrated to be a reliable method for diagnosis of hypercoagulable state.
文摘We present in this work how to use the dura palm kernel shell powders as loads for the elaboration by extrusion of PVC tubes. The transformation of dura palm kernel shells into micronized shell powder as well as its characterization was the subject of recent work. We carried out, the formulations by using the industrial scales of precision, the mixtures of the instrants with an industrial machine of mark HENSHLLE N˚2 MAIN 570762, the routine tests by ATG/DSC then by IRTF, the extrusion of the tubes with an extruder twin-screw with 9 rooms of transformation finally the tests of conformity by the observations and the analyses. We obtained for the formulations the dosage of 0%, 4.01%, 12.54%, 23.03%, 32.01%, 38.01%, 51.02% representing the percentage of hull powder in the mixture, the machine mixing gave perfectly homogeneous powders, the routine tests showed that the hull powder keeps all its properties until the end of the shaping whatever the percentage of hulls contained in the PVC, the extrusion gave tubes for each formulation and the conformity tests gave perfectly round tubes of diameter 90 × 82 mm, a coloration going from white grey at 0% to dark black at 51.02% showing the influence of the carbon black and the color of the shell powder according to its proportion. The infrared of the tubes obtained shows for each formulation a variation of the CH<sub>2</sub> and CH bonds and a decrease of the −OH bonds. The thermogravimetric analyses and the differential calorimetric analyses of the tubes of each formulation, show each time that the quantity of shell powders in the mixture influences the PVC tubes obtained. Thus, we obtain a variation of the phase temperatures according to the dosage, giving from 108.72<span style="white-space:normal;">˚</span>C to 76.56<span style="white-space:normal;">˚</span>C for the glass transition temperature and from 494.71<span style="white-space:normal;">˚</span>C to 414.56<span style="white-space:normal;">˚</span>C for the melting temperature, at the DSC and a progressive decrease of the mass following the heat absorption with each time 4 phases instead of 5 for the unloaded PVC tubes at the ATG according to the dosage.
基金the Special Project of State Key Laboratory of Dampness Syndrome of Chinese Medicine:Study on Criteria for Diagnosis of Dampness Syndrome of Idiopathic Membranous Nephropathy,Cohort Study on Pathogenesis and Material Basis of Dampness Syndrome of Idiopathic Membranous Nephropathy,Randomized Controlled Clinical Study of Sanqi Qushi Granule in Treatment of Membranous Nephropathy(No.SZ2021ZZ02,SZ2021ZZ09 and SZ2021ZZ36)the 2020 Guangdong Provincial Science and Technology Innovation Strategy Special Fund:Guangdong-Hong Kong-Macao Joint Lab(No.2020B1212030006)+2 种基金the Natural Science Foundation of Guangdong Province:Study on the Mechanism of Sanqi Qushi Prescription Delaying Podocellular Senescence in Membranous Nephropathy based on Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase-Stimulator of Interferon Genes-Nuclear Factor Kappa-B Signaling Pathway(No.2022A1515011628)the Guangzhou Science and Technology Plan Project:to Explore the Mechanism of Treating Membranous Nephropathy from the Perspective of Regulating Amino Acid Metabolism Disorder(No.2023A03J0746)Special Funding for Scientific and Technological Research on Traditional Chinese Medicine,Guangdong Provincial Hospital of Chinese Medicine:a Multimodular Machine Learning Prediction Model based on Pathological Image-transcriptomics and Traditional Chinese Medicine Syndromes was Used to Investigate the Prognostic Correlation of Long non-coding RNA Molecules in Nephropathy and the Intervention Mechanism of Sanqi Qushi Formula,to Investigate the Pathogenesis and Microbiological Mechanism of Dampness Syndrome of Membranous Nephropathy based on the Microecological Changes of Tongue Coating(No.YN2023MB02,YN2023MB10)。
文摘OBJECTIVE:To reach consensus on the diagnostic criteria of syndrome of dampness obstruction in idiopathic membranous nephropathy(IMN)patients by literature research and expert investigation(interviews and a Delphi method).METHODS:Our study was consistent with T/CACM 1336-2020.We searched the monographs and references published in the past 40 years(1983-2022),and established the diagnostic criteria pool of waterdampness syndrome and dampness-turbidity syndrome in Traditional Chinese Medicine(TCM)based on literature by using frequency statistics and correlation analysis.Expert investigation(interview method and two rounds of Delphi method)was used to form the diagnostic criteria of water-dampness syndrome and dampnessturbidity syndrome of idiopathic membranous nephropathy.Clinical diagnostic test research was carried out,and compared with“Diagnostic Criteria for dampness syndrome”(T/CACM 1454-2023)to evaluate the authenticity,reliability and clinical application value of the standard.RESULTS:A total of 122 relevant guides,standards,monographs and documents were included through searching books and Chinese databases.Four experts were interviewed and two rounds of delphi method(75 experts nationwide)were carried out.The experts'opinions are relatively concentrated and the differences are small.Based on the weight of each index,the diagnostic criteria indexes of water-dampness syndrome and dampness-turbidity syndrome were selected.After discussion by the core group members,the diagnostic model of"necessary symptoms and optional symptoms"was established,and the final diagnostic criteria of waterdampness syndrome and dampness-turbidity syndrome were established.One hundred and ninety-one inpatients and outpatients of Guangdong Provincial Hospital of Chinese Medicine from January 2021 to February 2023 were included in Diagnostic test study.There was no statistical difference in gender,age and course of disease(P>0.05).The sensitivity and specificity of the trial standard were 90.34%and 73.33%respectively,while the sensitivity and specificity of T/CACM 1454-2023 were 99.43%and 6.67%,respectively.CONCLUSIONS:The consensus-based diagnostic criteria for IMN can be widely incorporated in TCM.A further clinical study will be conducted to analyze the diagnosis value and cut-off score of our IMN criteria.
